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Human BAFF/BLyS/TNFSF13B Quantikine SixPak (6 Plates) (1 PK)

货号: SBLYS0B 基本售价: 32598.9 元 规格: 1 PACK

产品信息

概述
货号SBLYS0B
描述The Quantikine Human BAFF/BLyS Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human BAFF/BLyS in cell culture supernates, serum, and plasma. It contains NS0-expressed recombinant human BAFF/BLyS and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human BAFF/BLyS showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring human BAFF.
别名ApoL related ligand TALL-1; B lymphocyte stimulator; BAFF; BAFFB-cell activating factor; B-cell-activating factor; BLyS; BLYSB-lymphocyte stimulator; CD257 antigen; CD257; Dendritic cell-derived TNF-like molecule; DTL; TALL1; TALL-1delta BAFF; TALL1Delta4 BAFF; THANK; TNF- and APOL-related leukocyte expressed ligand 1; TNF and ApoL-related leukocyte expressed ligand 1; TNF homolog that activates apoptosis; TNFSF13B; TNFSF20; tumor necrosis factor (ligand) superfamily, member 13b; tumor necrosis factor (ligand) superfamily, member 20; tumor necrosis factor ligand superfamily member 13B; tumor necrosis factor superfamily, member 13b; tumor necrosis factor-like protein ZTNF4; ZTNF4;
全称
B cell Activating Factor
反应种属Human
目标/特异性Natural and recombinant human BAFF/BLyS
性能
供应商R&D Systems
Entrez Gene IDs
10673 (Human); 24099 (Mouse); 498666 (Rat)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Intrathecal Th17- and B cell-associated cytokine and chemokine responses in relation to clinical outcome in Lyme neuroborreliosis: a large retrospective study
Authors: P Gyllemark, P Forsberg, J Ernerudh, AJ Henningsso
J Neuroinflammation, 2017;14(1):27.
Species: Human
Sample Type: Serum

BAFF Index and CXCL13 levels in the cerebrospinal fluid associate respectively with intrathecal IgG synthesis and cortical atrophy in multiple sclerosis at clinical onset
Authors: M Puthenpara, L Federle, S Miante, A Zito, E Toffanin, S Ruggero, M Ermani, S Pravato, D Poggiali, P Perini, F Rinaldi, P Gallo
J Neuroinflammation, 2017;14(1):11.
Species: Human
Sample Type: Serum

Effect of FCGR polymorphism on the occurrence of late-onset neutropenia and flare-free survival in rheumatic patients treated with rituximab
Authors: S Ajeganova, D Tesfa, H Hägglund, B Fadeel, I Vedin, AL Zignego, J Palmblad
Arthritis Res. Ther, 2017;19(1):44.
Species: Human
Sample Type: Serum

Case-control, exploratory study of cerebrospinal fluid chemokines/cytokines and lymphocyte subsets in childhood Tourette syndrome with positive streptococcal markers
Authors: MR Pranzatell, ED Tate, TJ Allison
Cytokine, 2017;96(0):49-53.
Species: Human
Sample Type: CSF

Plasmacytoid dendritic cells and myeloid cells differently contribute to BAFF over-expression during primary HIV infection.
Authors: Borhis G, Burelout C, Chaoul N, Smith N, Goujard C, Meyer L, Paul S, Saoudin H, Hosmalin A, Gilbert C, Herbeuval J, Richard Y
AIDS, 2016;30(0):365-376.
Species: Human
Sample Type: Cell Culture Supernates

Serum B-cell activating factor predicts prognosis in nasal type, extranodal NK/T cell lymphoma
Cytokine, 2016;88(0):196-198.
Species: Human
Sample Type: Serum

A distinct plasmablast and na�ve B-cell phenotype in primary immune thrombocytopenia
Haematologica, 2016;101(6):698-706.
Species: Human
Sample Type: Serum

The strength of the antibody response to the nematode Ascaris lumbricoides inversely correlates with levels of B-Cell Activating Factor (BAFF).
Authors: Bornacelly, Adriana, Mercado, Dilia, Acevedo, Nathalie, Caraballo, Luis
BMC Immunol, 2014;15(0):22.
Species: Human
Sample Type: Plasma

The B lymphocyte differentiation factor (BAFF) is expressed in the airways of children with CF and in lungs of mice infected with Pseudomonas aeruginosa.
Authors: Neill, Daniel R, Saint, Gemma L, Bricio-Moreno, Laura, Fothergill, Joanne L, Southern, Kevin W, Winstanley, Craig, Christmas, Stephen, Slupsky, Joseph R, McNamara, Paul S, Kadioglu, Aras, Flanagan, Brian F
PLoS ONE, 2014;9(5):e95892.
Species: Human
Sample Type: BALF

Neutrophil-mediated IFN activation in the bone marrow alters B cell development in human and murine systemic lupus erythematosus.
Authors: Palanichamy A, Bauer J, Yalavarthi S, Meednu N, Barnard J, Owen T, Cistrone C, Bird A, Rabinovich A, Nevarez S, Knight J, Dedrick R, Rosenberg A, Wei C, Rangel-Moreno J, Liesveld J, Sanz I, Baechler E, Kaplan M, Anolik J
J Immunol, 2014;192(3):906-18.
Species: Human
Sample Type: Cell Culture Supernates

BAFF and BAFF receptor levels correlate with B cell subset activation and redistribution in controlled human malaria infection.
Authors: Scholzen A, Teirlinck A, Bijker E, Roestenberg M, Hermsen C, Hoffman S, Sauerwein R
J Immunol, 2014;192(8):3719-29.
Species: Human
Sample Type: Plasma

BAFF/APRIL system in pediatric OMS: relation to severity, neuroinflammation, and immunotherapy.
Authors: Pranzatelli, Michael, Tate, Elizabet, McGee, Nathan R, Travelstead, Anna L, Colliver, Jerry A, Ness, Jayne M, Ransohoff, Richard
J Neuroinflammation, 2013;10(0):10.
Species: Human
Sample Type: Serum

Role of BAFF in Opsoclonus-Myoclonus syndrome, a bridge between cancer and autoimmunity.
Authors: Raffaghello L, Fuhlhuber V, Bianchi G, Conte M, Blaes F, Gambini C, Pistoia V
J Leukoc Biol, 2013;94(1):183-91.
Species: Human
Sample Type: Whole Cells

IFN-beta therapy modulates B-cell and monocyte crosstalk via TLR7 in multiple sclerosis patients.
Authors: Giacomini E, Severa M, Rizzo F, Mechelli R, Annibali V, Ristori G, Riccieri V, Salvetti M, Coccia E
Eur J Immunol, 2013;43(7):1963-72.
Species: Human
Sample Type: Serum

Active chronic sarcoidosis is characterized by increased transitional blood B cells, increased IL-10-producing regulatory B cells and high BAFF levels.
Authors: Saussine A, Tazi A, Feuillet S, Rybojad M, Juillard C, Bergeron A, Dessirier V, Bouhidel F, Janin A, Bensussan A, Bagot M, Bouaziz J
PLoS ONE, 2012;7(8):e43588.
Species: Human
Sample Type: Serum

B-cell activating factor levels in rheumatoid arthritis patients in response to treatment with biologics.
J. Interferon Cytokine Res., 2012;32(7):338-40.
Species: Human
Sample Type: Serum

IL-15 Expression on RA Synovial Fibroblasts Promotes B Cell Survival.
Authors: Benito-Miguel M, Garcia-Carmona Y, Balsa A, Bautista-Caro MB, Arroyo-Villa I, Cobo-Ibanez T, Bonilla-Hernan MG, De Ayala CP, Sanchez-Mateos P, Martin-Mola E, Miranda-Carus ME
PLoS ONE, 2012;7(7):e40620.
Species: Human
Sample Type: Cell Culture Supernates

Default in plasma and intestinal IgA responses during acute infection by simian immunodeficiency virus.
Authors: Chaoul N, Burelout C, Peruchon S, van Buu B, Laurent P, Proust A, Raphael M, Garraud O, Le Grand R, Prevot S, Richard Y
Retrovirology, 2012;9(0):43.
Species: Primate - cynomolgus macaques
Sample Type: Plasma

BAFF levels are increased in lesional skin and sera in patients with cutaneous T-cell lymphoma.
Authors: Ohmatsu H, Sugaya M, Miyagaki T, Suga H, Fujita H, Asano Y, Tada Y, Kadono T, Sato S
Br. J. Dermatol., 2012;167(2):359-67.
Species: Human
Sample Type: Serum

Recovery of B-cell homeostasis after rituximab in chronic graft-versus-host disease.
Authors: Sarantopoulos S, Stevenson KE, Kim HT
Blood, 2011;117(7):2275-83.
Species: Human
Sample Type: Plasma

Significant differences in B-cell subpopulations characterize patients with chronic graft-versus-host disease-associated dysgammaglobulinemia.
Authors: Kuzmina Z, Greinix HT, Weigl R, Kormoczi U, Rottal A, Frantal S, Eder S, Pickl WF
Blood, 2011;117(7):2265-74.
Species: Human
Sample Type: Plasma

Primary B-cell deficiencies reveal a link between human IL-17-producing CD4 T-cell homeostasis and B-cell differentiation.
Authors: Barbosa RR, Silva SP, Silva SL, Melo AC, Pedro E, Barbosa MP, Pereira-Santos MC, Victorino RM, Sousa AE
PLoS ONE, 2011;6(8):e22848.
Species: Human
Sample Type: Serum

Peripheral blood B cell subset skewing is associated with altered cell cycling and intrinsic resistance to apoptosis and reflects a state of immune activation in chronic hepatitis C virus infection.
Authors: Sugalski JM, Rodriguez B, Moir S
J. Immunol., 2010;185(5):3019-27.
Species: Human
Sample Type: Serum

B-cell reconstitution and BAFF after alemtuzumab (Campath-1H) treatment of multiple sclerosis.
Authors: Thompson SA, Jones JL, Cox AL, Compston DA, Coles AJ
J. Clin. Immunol., 2010;30(1):99-105.
Species: Human
Sample Type: Serum

BAFF is increased in renal transplant patients following treatment with alemtuzumab.
Authors: Bloom D, Chang Z, Pauly K
Am. J. Transplant., 2009;9(8):1835-45.
Species: Human
Sample Type: Serum

Rituximab mediates a strong elevation of B-cell-activating factor associated with increased pathogen-specific IgG but not autoantibodies in pemphigus vulgaris.
Authors: Nagel A, Podstawa E, Eickmann M, Muller HH, Hertl M, Eming R
J. Invest. Dermatol., 2009;129(9):2202-10.
Species: Human
Sample Type: Serum

Elevation of B cell-activating factor belonging to the tumour necrosis factor [corrected] family (BAFF) in haemophilia A patients with inhibitor.
Authors: Takeda T, Sakurai Y, Tatsumi K, Kato J, Kasuda S, Yoshioka A, Shima M
Thromb. Haemost., 2009;101(2):408-10.
Species: Human
Sample Type: Plasma

Functional interaction of plasmacytoid dendritic cells with multiple myeloma cells: a therapeutic target.
Authors: Chauhan D, Singh AV, Brahmandam M, Carrasco R, Bandi M, Hideshima T, Bianchi G, Podar K, Tai YT, Mitsiades C, Raje N, Jaye DL, Kumar SK, Richardson P, Munshi N, Anderson KC
Cancer Cell, 2009;16(4):309-23.
Species: Human
Sample Type: Cell Culture Supernates

BAFF and APRIL expression in B-cell chronic lymphocytic leukemia: correlation with biological and clinical features.
Authors: Bojarska-Junak A, Hus I, Chocholska S, Wasik-Szczepanek E, Sieklucka M, Dmoszynska A, Rolinski J
Leuk. Res., 2009;33(10):1319-27.
Species: Human
Sample Type: Plasma

Elevated B-cell activating factor BAFF, but not APRIL, correlates with CSF cerebellar autoantibodies in pediatric opsoclonus-myoclonus syndrome.
Authors: Fuhlhuber V, Bick S, Kirsten A, Hahn A, Gerriets T, Tschernatsch M, Kaps M, Preissner KT, Blaes F, Altenkamper S
J. Neuroimmunol., 2009;210(1):87-91.
Species: Human
Sample Type: Serum

Altered B-cell homeostasis and excess BAFF in human chronic graft-versus-host disease.
Authors: Sarantopoulos S, Stevenson KE, Kim HT, Cutler CS, Bhuiya NS, Schowalter M, Ho VT, Alyea EP, Koreth J, Blazar BR, Soiffer RJ, Antin JH, Ritz J
Blood, 2009;113(16):3865-74.
Species: Human
Sample Type: Plasma

BAFF may modulate the rate of B-cell repopulation after rituximab therapy for acute renal transplant rejection.
Authors: Zarkhin V, Li L, Sarwal MM
Transplantation, 2009;88(10):1229-30.
Species: Human
Sample Type: Serum

Evidence of a role for B cell-activating factor of the TNF family in the pathogenesis of chronic rhinosinusitis with nasal polyps.
Authors: Kato A, Peters A, Suh L, Carter R, Harris KE, Chandra R, Conley D, Grammer LC, Kern R, Schleimer RP
J. Allergy Clin. Immunol., 2008;121(6):1385-92, 1392.
Species: Human
Sample Type: nasal lavage

Abnormal cytokine production by bone marrow stromal cells of multiple myeloma patients in response to RPMI8226 myeloma cells.
Authors: Zdzisinska B, Bojarska-Junak A, Dmoszynska A, Kandefer-Szerszen M
Arch. Immunol. Ther. Exp. (Warsz.), 2008;56(3):207-21.
Species: Human
Sample Type: Cell Culture Supernates

Targeting MEK1/2 blocks osteoclast differentiation, function and cytokine secretion in multiple myeloma.
Authors: Breitkreutz I, Raab MS, Vallet S, Hideshima T, Raje N, Chauhan D, Munshi NC, Richardson PG, Anderson KC
Br. J. Haematol., 2007;139(1):55-63.
Species: Human
Sample Type: Cell Culture Supernates

Role of B-cell-activating factor in adhesion and growth of human multiple myeloma cells in the bone marrow microenvironment.
Authors: Tai YT, Li XF, Breitkreutz I, Song W, Neri P, Catley L, Podar K, Hideshima T, Chauhan D, Raje N, Schlossman R, Richardson P, Munshi NC, Anderson KC
Cancer Res., 2006;66(13):6675-82.
Species: Human
Sample Type: Cell Culture Supernates

生物活性< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景BAFF (B-cell activating factor), also known as BLyS, TALL-1, THANK, and TNFSF13B, is a TNF superfamily ligand that plays a critical role in the development and survival of B lineage cells. It can be expressed as a homotrimer or as a heteromer in association with the related protein APRIL. It is produced by many hematopoietic cell types, and a soluble form can be released by activated neutrophils. Both BAFF and APRIL signal through the receptors BCMA and TACI, and BAFF additionally signals through BAFF R. Mice that overexpress BAFF exhibit elevated B cell numbers, increased formation and size of germinal centers, and symptoms of autoimmunity. In addition, BAFF costimulates T cell activation, promotes a Th1 biased immune response, and promotes the expansion of Treg cells.
运输条件Blue Ice
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参考文献
  • Co-stimulatory and Co-inhibitory Molecules
  • Regulation of Apoptosis by TNF Superfamily Members
  • Regulation of B Cell Activation and Homeostasis by TNF Superfamily Members
  • Regulation of T Cell Co-stimulation by TNF Superfamily Members
  • TNF Superfamily
  • TNF Superfamily Ligands