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Human Free BDNF Quantikine SixPak (6 Plates) (1 PK)

货号: SBD00 基本售价: 32598.9 元 规格: 1 PACK

产品信息

概述
货号SBD00
描述The Quantikine Human BDNF Immunoassay is a 3.5 hour solid phase ELISA designed to measure human BDNF in cell culture supernates, serum, and plasma. It contains recombinant human BDNF expressed in Sf 21 cells and antibodies raised against the recombinant factor. This immunoassay has been shown to quantitate the recombinant BDNF accurately. Results obtained measuring natural human BDNF showed dose-response curves that were parallel to the standard curves obtained using the recombinant Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural human BDNF.
别名Abrineurin; ANON2; BDNF; brain-derived neurotrophic factor; BULN2; MGC34632; neurotrophin;
全称
Brain-derived Neurotrophic Factor
反应种属Human
目标/特异性Natural and recombinant human BDNF
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs
627 (Human); 12064 (Mouse); 24225 (Rat)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Feasibility and Efficiency of Human Bone Marrow Stromal Cell Culture with Allogeneic Platelet Lysate-Supplementation for Cell Therapy against Stroke
Stem Cells Int, 2016;2016(0):6104780.
Species: Human
Sample Type: Cell Culture Supernates

Exploring the Association between Serum BDNF and Attempted Suicide
Sci Rep, 2016;6(0):25229.
Species: Human
Sample Type: Serum

Human neural stem cell-induced endothelial morphogenesis requires autocrine/paracrine and juxtacrine signaling
Sci Rep, 2016;6(0):29029.
Species: Human
Sample Type: Cell Culture Supernates

The BDNF Val66Met polymorphism and plasma brain-derived neurotrophic factor levels in Han Chinese heroin-dependent patients.
Authors: Chen, Shiou-La, Lee, Sheng-Yu, Chang, Yun-Hsua, Wang, Tzu-Yun, Chen, Shih-Hen, Chu, Chun-Hsi, Chen, Po See, Yang, Yen Kuan, Hong, Jau-Shyo, Lu, Ru-Band
Sci Rep, 2015;5(0):8148.
Species: Human
Sample Type: Plasma

Serum brain-derived neurotrophic factor levels and personality traits in patients with major depression.
Authors: Nomoto H, Baba H, Satomura E, Maeshima H, Takebayashi N, Namekawa Y, Suzuki T, Arai H
BMC Psychiatry, 2015;15(0):33.
Species: Human
Sample Type: Serum

Effects of exercise and milk fat globule membrane (MFGM) supplementation on body composition, physical function, and hematological parameters in community-dwelling frail Japanese women: a randomized double blind, placebo-controlled, follow-up trial.
Authors: Kim H, Suzuki T, Kim M, Kojima N, Ota N, Shimotoyodome A, Hase T, Hosoi E, Yoshida H
PLoS ONE, 2015;10(2):e0116256.
Species: Human
Sample Type: Serum

Measurement of the levels of leptin, BDNF associated with polymorphisms LEP G2548A, LEPR Gln223Arg and BDNF Val66Met in Thai with metabolic syndrome.
Authors: Suriyaprom, Kanjana, Tungtrongchitr, Rungsunn, Thawnasom, Kittisak
Diabetol Metab Syndr, 2014;6(1):6.
Species: Human
Sample Type: Serum

Bortezomib-induced peripheral neuropathy is related to altered levels of brain-derived neurotrophic factor in the peripheral blood of patients with multiple myeloma.
Authors: Azoulay, David, Lavie, David, Horowitz, Netanel, Suriu, Celia, Gatt, Moshe E, Akria, Luiza, Perlman, Riki, Braester, Andrei, Ben-Yehuda, Dina
Br J Haematol, 2014;164(3):454-6.
Species: Human
Sample Type: Serum

A longitudinal study of alterations of hippocampal volumes and serum BDNF levels in association to atypical antipsychotics in a sample of first-episode patients with schizophrenia.
Authors: Rizos E, Papathanasiou M, Michalopoulou P, Laskos E, Mazioti A, Kastania A, Vasilopoulou K, Nikolaidou P, Margaritis D, Papageorgiou C, Liappas I
PLoS ONE, 2014;9(2):e87997.
Species: Human
Sample Type: Serum

Serum BDNF levels in relation to illness severity, suicide attempts, and central serotonin activity in patients with major depressive disorder: a pilot study.
Authors: Park Y, Lee B, Um T, Kim S
PLoS ONE, 2014;9(3):e91061.
Species: Human
Sample Type: Serum

Brain-derived neurotrophic factor in human subjects with function-altering melanocortin-4 receptor variants.
Authors: Hohenadel M, Thearle M, Grice B, Huang H, Dai M, Tao Y, Hunter L, Palaguachi G, Mou Z, Kim R, Tsang M, Haack K, Voruganti V, Cole S, Butte N, Comuzzie A, Muller Y, Baier L, Krakoff J, Knowler W, Yanovski J, Han J
Int J Obes (Lond), 2014;38(8):1068-74.
Species: Human
Sample Type: Serum

Ex vivo expansion of bovine corneal endothelial cells in xeno-free medium supplemented with platelet releasate.
Authors: Chou M, Burnouf T, Wang T
PLoS ONE, 2014;9(6):e99145.
Species: Human
Sample Type: Cell Culture Supernates

A randomized controlled trial of multicomponent exercise in older adults with mild cognitive impairment.
Authors: Suzuki T, Shimada H, Makizako H, Doi T, Yoshida D, Ito K, Shimokata H, Washimi Y, Endo H, Kato T
PLoS ONE, 2013;8(4):e61483.
Species: Human
Sample Type: Serum

Brain-derived neurotrophic factor is increased in serum and skin levels of patients with chronic spontaneous urticaria.
Authors: Rossing K, Novak N, Mommert S, Pfab F, Gehring M, Wedi B, Kapp A, Raap U
Clin. Exp. Allergy, 2011;41(10):1392-1399.
Species: Human
Sample Type: Serum

Exercise training increases size of hippocampus and improves memory.
Authors: Erickson KI, Voss MW, Prakash RS
Proc. Natl. Acad. Sci. U.S.A., 2011;108(7):3017-22.
Species: Human
Sample Type: Serum

CD34+ progenitor cells likely are involved in the good functional recovery after intracerebral hemorrhage in humans.
Authors: Sobrino T, Arias S, Perez-Mato M, Agulla J, Brea D, Rodriguez-Yanez M, Castillo J
J. Neurosci. Res., 2011;89(7):979-85.
Species: Human
Sample Type: Serum

Androgen regulates brain-derived neurotrophic factor in spinal motoneurons and their target musculature.
Authors: Verhovshek T, Cai Y, Osborne MC, Sengelaub DR
Endocrinology, 2010;151(1):253-61.
Species: Rat
Sample Type: Tissue Homogenates

BDNF mediated TrkB activation is a survival signal for transitional cell carcinoma cells.
Authors: Huang YT, Lai PC, Wu CC, Hsu SH, Cheng CC, Lan YF, Chiu TH
Int. J. Oncol., 2010;36(6):1469-76.
Species: Human
Sample Type: Cell Culture Supernates

Endurance training enhances BDNF release from the human brain.
Authors: Seifert T, Brassard P, Wissenberg M, Rasmussen P, Nordby P, Stallknecht B, Adser H, Jakobsen AH, Pilegaard H, Nielsen HB, Secher NH
Am. J. Physiol. Regul. Integr. Comp. Physiol., 2010;298(2):R372-7.
Species: Human
Sample Type: Plasma

Coevolution of prostate cancer and bone stroma in three-dimensional coculture: implications for cancer growth and metastasis.
Authors: Sung SY, Hsieh CL, Law A, Zhau HE, Pathak S, Multani AS, Lim S, Coleman IM, Wu LC, Figg WD, Dahut WL, Nelson P, Lee JK, Amin MB, Lyles R, Johnstone PA, Marshall FF, Chung LW
Cancer Res., 2008;68(23):9996-10003.
Species: Human
Sample Type: Serum

Spinal adenosine A2a receptor activation elicits long-lasting phrenic motor facilitation.
Authors: Golder FJ, Ranganathan L, Satriotomo I, Hoffman M, Lovett-Barr MR, Watters JJ, Baker-Herman TL, Mitchell GS
J. Neurosci., 2008;28(9):2033-42.
Species: Rat
Sample Type: Tissue Homogenates

Decreased brain-derived neurotrophic factor (BDNF)- and beta-thromboglobulin (beta-TG)- blood levels in Alzheimers disease.
Authors: Laske C, Stransky E, Leyhe T, Eschweiler GW, Schott K, Langer H, Gawaz M
Thromb. Haemost., 2006;96(1):102-3.
Species: Human
Sample Type: Serum

Transcranial magnetic stimulation and BDNF plasma levels in amyotrophic lateral sclerosis.
Authors: Angelucci F, Oliviero A, Pilato F, Saturno E, Dileone M, Versace V, Musumeci G, Batocchi AP, Tonali PA, Di Lazzaro V
Neuroreport, 2004;15(4):717-20.
Species: Human
Sample Type: Serum

Perinatal changes of brain-derived neurotrophic factor in pre- and fullterm neonates.
Authors: Malamitsi-Puchner A, Economou E, Rigopoulou O, Boutsikou T
Early Hum. Dev., 2004;76(1):17-22.
Species: Human
Sample Type: Serum

Intravenous administration of marrow stromal cells (MSCs) increases the expression of growth factors in rat brain after traumatic brain injury.
Authors: Mahmood A, Lu D, Chopp M
J. Neurotrauma, 2004;21(1):33-9.
Species: Rat
Sample Type: Tissue Homogenates

AF5, a CNS cell line immortalized with an N-terminal fragment of SV40 large T: growth, differentiation, genetic stability, and gene expression.
Authors: Truckenmiller ME, Vawter MP, Zhang P, Conejero-Goldberg C, Dillon-Carter O, Morales N, Cheadle C, Becker KG, Freed WJ
Exp. Neurol., 2002;175(0):318.
Species: Rat
Sample Type: Cell Culture Supernates

Daily serum and salivary BDNF levels correlate with morning-evening personality type in women and are affected by light therapy.
Authors: Tirassa P, Iannitelli A, Sornelli F, Cirulli F, Mazza M, Calza A, Alleva E, Branchi I, Aloe L, Bersani G, Pacitti F
Riv Psichiatr, 0;47(6):527-34.

生物活性Cross-reactivity observed with 1 or more available related molecules.< 50% cross-species reactivity observed with species tested.
背景BDNF (Brain-Derived Neurotrophic Factor) is a secreted protein that regulates many aspects of neuronal development and function in the nervous system. It is produced as proBDNF in response to neuronal activity or inflammatory stimulation and is then cleaved before associating into a homodimer. It is expressed throughout the nervous system as well as by fibroblasts, megakaryocytes/platelets, and smooth muscle cells. BDNF regulates neural stem cell survival and differentiation, axon/dendrite differentiation, synapse formation and maturation, and refinement of developing circuits. It is also a key regulator of synaptic plasticity and late-phase long-term potentiation. BDNF signals through the TrkB and NGF R/TNFRSF16 receptors. Secreted proBDNF can bind to NGF R/TNFRSF16 and induce long-term depression and cell apoptosis.
运输条件Blue Ice
存放说明4℃
参考文献
  • Adult Neurogenesis
  • Developmental Factors Implicated in Neurodegeneration
  • Diabetes
  • Diabetic Peripheral Neuropathy
  • Neurotrophic Factors and Receptors
  • Neurotrophin/Trk Family
  • Obesity
  • VPS10P-domain Family