一抗

克隆类型
多抗单抗
产品类型
标签抗体磷酸化抗体内参抗体甲基化抗体乙酰化抗体药物与化合物抗体植物抗体
研究领域
肿瘤心血管细胞生物免疫学发育生物学染色质和核信号微生物学细胞凋亡信号转导干细胞神经生物学生长因子和激素糖尿病内分泌病转运蛋白植物细菌及病毒转录调节因子海洋生物上皮细胞趋化因子结合蛋白细胞表面分子G蛋白偶联受体胶原蛋白糖蛋白交换蛋白细胞分化血管内皮细胞细胞类型标志物内皮细胞淋巴细胞T-淋巴细胞B-淋巴细胞细胞粘附分子肿瘤细胞生物标志物骨髓细胞细胞骨架跨膜蛋白细胞因子自然杀伤细胞树突状细胞标志物脂蛋白新陈代谢锌指蛋白通道蛋白细胞周期蛋白激酶和磷酸酶昆虫线粒体环指蛋白细胞自噬细胞膜受体药物及化合物泛素干扰素G蛋白信号细胞膜蛋白Alzheimers表观遗传学细胞外基质合成与降解

标记一抗

标记类型
HRPBiotinGoldRBITCAPFITCCy3Cy5Cy5.5Cy7PEPE-Cy3PE-Cy5PE-Cy5.5PE-Cy7APCAlexa Fluor 350Alexa Fluor 488Alexa Fluor 555Alexa Fluor 594Alexa Fluor 647

二抗

克隆类型
多抗单抗
产品分类
二抗二抗血清

标记二抗

标记类型
HRPBiotinGoldRBITCAPFITCCy3Cy5Cy5.5Cy7PEPE-Cy3PE-Cy5PE-Cy5.5PE-Cy7APCAlexa Fluor 350Alexa Fluor 488Alexa Fluor 555Alexa Fluor 594Alexa Fluor 647

蛋白质与多肽

产品分类
蛋白质多肽

标记蛋白质与多肽

所有产品
全部标记蛋白质与多肽

正常动物血清及免疫球蛋白

产品分类
正常动物血清免疫球蛋白

试剂盒

产品分类
ELISA试剂盒

常用试剂

产品分类
免疫组化常用试剂免疫印迹常用试剂常用显色试剂细胞生物学试剂分子生物学生化试剂

亲和层析柱

所有产品
亲和层析柱

配套试剂

所有产品
常用配套试剂

ELISA试剂盒

人ELISA试剂盒 大鼠ELISA试剂盒 小鼠ELISA试剂盒 牛ELISA试剂盒 鸡ELISA试剂盒 植物ELISA试剂盒 猴ELISA试剂盒 猪ELISA试剂盒 山羊ELISA试剂盒 马ELISA试剂盒 仓鼠ELISA试剂盒 绵羊ELISA试剂盒 兔子ELISA试剂盒 犬ELISA试剂盒 豚鼠ELISA试剂盒 其他ELISA试剂盒

生化试剂

色素类 分离材料及耗材 维生素 染色剂 碳水化合物 植物激素及核酸 抗生素 蛋白质 氨基酸 测试盒 其他生物试剂 缓冲剂 表面活性剂

血浆

血浆

血清

Sigma胎牛血清 gibco胎牛血清 Hyclone血清 人血清 国产新生牛血清 国产胎牛血清 其他血清

细胞

其它细胞 仓鼠细胞 猴细胞 大鼠细胞 人细胞 狗细胞 小鼠细胞 猫细胞 鸡细胞

标准品

对照品 农药标准品 标准物质 食品 无机溶液标准物质 有机溶液标准物质

抗体

兔抗 鼠抗 IgY抗体 IgA抗体 IgG抗体 二抗 一抗

裂解血

裂解血

培养基

美国药典培养基 化妆品检验培养基 大肠杆菌、大肠菌群 金黄色葡萄球菌检验 消毒灭菌效果评价 临床检验用培养基 中华人民共和国药典 欧洲药典(EP) 饮用天然矿泉水检验方法 微生物检验 霉菌、酵母菌 肠球菌、链球菌 沙门氏菌、志贺氏菌 弧菌 弯曲杆菌 李斯特氏菌 产气荚膜梭菌 阪崎肠杆菌 乳酸菌、双歧杆菌 小肠结肠炎耶尔森氏菌 蜡样芽孢杆菌检验 小肠结肠炎耶尔森氏菌检验 一次性试管、液体培养基 乳酸菌检验 菌落总数测定、无菌检验 显色培养基 植物组培

产品中心

当前位置:首页>产品中心

Human PDGF-BB Quantikine SixPak (6 Plates) (1 PK)

货号: SBB00 基本售价: 32598.9 元 规格: 1 PACK

产品信息

概述
货号SBB00
描述The Quantikine Human PDGF-BB Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human PDGF-BB in cell culture supernates, serum, or plasma. It contains E. coli-expressed recombinant human PDGF-BB and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human PDGF-BB showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural human PDGF-BB.
别名PDGFBB; PDGF-BB;
全称
Platelet-derived Growth Factor BB
反应种属Human
目标/特异性Natural and recombinant human PDGF-BB
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs
5155 (Human); 24628 (Rat)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Short term storage stability at room temperature of two different platelet-rich plasma preparations from equine donors and potential impact on growth factor concentrations
Authors: G Hauschild, F Geburek, G Gosheger, M Eveslage, D Serrano, A Streitbrg, S Johannlke, D Menzel, R Mischke
BMC Vet. Res, 2017;13(1):7.
Species: Horse
Sample Type: Plasma

Unaltered Angiogenesis-Regulating Activities of Platelets in Mild Type 2 Diabetes Mellitus despite a Marked Platelet Hyperreactivity
PLoS ONE, 2016;11(9):e0162405.
Species: Human
Sample Type: Cell Culture Supernates

Human neural stem cell-induced endothelial morphogenesis requires autocrine/paracrine and juxtacrine signaling
Sci Rep, 2016;6(0):29029.
Species: Human
Sample Type: Cell Culture Supernates

Feasibility and Efficiency of Human Bone Marrow Stromal Cell Culture with Allogeneic Platelet Lysate-Supplementation for Cell Therapy against Stroke
Stem Cells Int, 2016;2016(0):6104780.
Species: Human
Sample Type: Cell Culture Supernates

Neovascularization Potential of Blood Outgrowth Endothelial Cells From Patients With Stable Ischemic Heart Failure Is Preserved
Authors: D Dauwe, B Pelacho, A Wibowo, AS Walravens, K Verdonck, H Gillijns, E Caluwe, P Pokreisz, N van Gastel, G Carmeliet, M Depypere, F Maes, N Vanden Dri, W Droogne, J Van Cleemp, J Vanhaecke, F Prosper, C Verfaillie, A Luttun, S Janssens
J Am Heart Assoc, 2016;5(4):.
Species: Human
Sample Type: Cell Culture Supernates

The systemic influence of platelet-derived growth factors on bone marrow mesenchymal stem cells in fracture patients.
Authors: Tan, Hiang Bo, Giannoudis, Peter V, Boxall, Sally A, McGonagle, Dennis, Jones, Elena
BMC Med, 2015;13(0):6.
Species: Human
Sample Type: Serum

Combining bevacizumab and chemoradiation in rectal cancer. Translational results of the AXEBeam trial.
Authors: Verstraete M, Debucquoy A, Dekervel J, Van Pelt J, Verslype C, Devos E, Chiritescu G, Dumon K, DHoore A, Gevaert O, Sagaert X, Van Cutsem E, Haustermans K
Br J Cancer, 2015;112(8):1314-25.
Species: Human
Sample Type: Whole Blood

Temsirolimus inhibits proliferation and migration in retinal pigment epithelial and endothelial cells via mTOR inhibition and decreases VEGF and PDGF expression.
Authors: Liegl, Raffael, Koenig, Susanna, Siedlecki, Jakob, Haritoglou, Christos, Kampik, Anselm, Kernt, Marcus
PLoS ONE, 2014;9(2):e88203.
Species: Human
Sample Type: Cell Culture Supernates

Increased pericyte coverage mediated by endothelial-derived fibroblast growth factor-2 and interleukin-6 is a source of smooth muscle-like cells in pulmonary hypertension.
Authors: Ricard N, Tu L, Le Hiress M, Huertas A, Phan C, Thuillet R, Sattler C, Fadel E, Seferian A, Montani D, Dorfmuller P, Humbert M, Guignabert C
Circulation, 2014;129(15):1586-97.
Species: Human
Sample Type: Cell Culture Supernates

Regulation of T cell proliferation by JMJD6 and PDGF-BB during chronic hepatitis B infection.
Authors: Chen C, Feng X, Liao H, Jin W, Zhang J, Wang Y, Gong L, Liu J, Yuan X, Zhao B, Zhang D, Chen G, Wan Y, Guo J, Yan H, He Y
Sci Rep, 2014;4(0):6359.

Systemic upregulation of PDGF-B in patients with neovascular AMD.
Authors: Zehetner C, Kirchmair R, Neururer S, Kralinger M, Bechrakis N, Kieselbach G
Invest Ophthalmol Vis Sci, 2014;55(1):337-44.
Species: Human
Sample Type: Plasma

Functional and differential proteomic analyses to identify platelet derived factors affecting ex vivo expansion of mesenchymal stromal cells.
Authors: Kinzebach S, Dietz L, Kluter H, Thierse H, Bieback K
BMC Cell Biol, 2013;14(0):48.
Species: Human
Sample Type: Cell Lysates

Human bone marrow-derived mesenchymal stem cells suppress human glioma growth through inhibition of angiogenesis.
Authors: Ho I, Toh H, Ng W, Teo Y, Guo C, Hui K, Lam P
Stem Cells, 2013;31(1):146-55.
Species: Human
Sample Type: Tissue Lysate

Observations on the microvasculature of bone defects filled with biodegradable nanoparticulate hydroxyapatite.
Authors: Kilian O, Wenisch S, Karnati S, Baumgart-Vogt E, Hild A, Fuhrmann R, Jonuleit T, Dingeldein E, Schnettler R, Franke RP
Biomaterials, 2008;29(24):3429-37.
Species: Porcine
Sample Type: Plasma

Statins restore ischemic limb blood flow in diabetic microangiopathy via eNOS/NO upregulation but not via PDGF-BB expression.
Authors: Fujii T, Onimaru M, Yonemitsu Y, Kuwano H, Sueishi K
Am. J. Physiol. Heart Circ. Physiol., 2008;294(6):H2785-91.
Species: Human
Sample Type: Cell Culture Supernates

Dynamic change in phosphorylated platelet-derived growth factor receptor in peripheral blood leukocytes following docetaxel therapy predicts progression-free and overall survival in prostate cancer.
Authors: Mathew P, Thall PF, Wen S, Bucana C, Jones D, Horne E, Oh WK, Morris MJ, Lee YC, Logothetis CJ, Lin SH, Fidler IJ
Br. J. Cancer, 2008;99(9):1426-32.
Species: Human
Sample Type: Plasma

Antifibrotic action of pirfenidone and prednisolone: different effects on pulmonary cytokines and growth factors in bleomycin-induced murine pulmonary fibrosis.
Authors: Oku H, Shimizu T, Kawabata T, Nagira M, Hikita I, Ueyama A, Matsushima S, Torii M, Arimura A
Eur. J. Pharmacol., 2008;590(1):400-8.
Species: Mouse
Sample Type: Tissue Homogenates

Human bone marrow activates the Akt pathway in metastatic prostate cells through transactivation of the alpha-platelet-derived growth factor receptor.
Authors: Dolloff NG, Russell MR, Loizos N, Fatatis A
Cancer Res., 2007;67(2):555-62.
Species: Human
Sample Type: Cell Culture Supernates

TF/FVIIa transactivate PDGFRbeta to regulate PDGF-BB-induced chemotaxis in different cell types: involvement of Src and PLC.
Authors: Siegbahn A, Johnell M, Nordin A, Aberg M, Velling T
Arterioscler. Thromb. Vasc. Biol., 2007;28(1):135-41.
Species: Porcine
Sample Type: Cell Culture Supernates

Proliferation, differentiation, and cytokine secretion of human umbilical cord blood-derived mononuclear cells in vitro.
Authors: Neuhoff S, Moers J, Rieks M, Grunwald T, Jensen A, Dermietzel R, Meier C
Exp. Hematol., 2007;35(7):1119-31.
Species: Human
Sample Type: Cell Culture Supernates

Quantitative assessment of growth factors in reaming aspirate, iliac crest, and platelet preparation.
Authors: Herrmann S, Green J, Weber T, Scharfenberger A
Bone, 2006;39(5):1156-63.
Species: Human
Sample Type: Plasma

Tumor-driven paracrine platelet-derived growth factor receptor alpha signaling is a key determinant of stromal cell recruitment in a model of human lung carcinoma.
Authors: Tejada ML, Yu L, Dong J, Jung K, Meng G, Peale FV, Frantz GD, Hall L, Liang X, Gerber HP, Ferrara N
Clin. Cancer Res., 2006;12(9):2676-88.
Species: Human
Sample Type: Cell Culture Supernates

Effects of simvastatin on angiogenic growth factors released at the site of microvascular injury.
Authors: Undas A, Celinska-Lowenhoff M, Stepien E, Nizankowski R, Tracz W, Szczeklik A
Thromb. Haemost., 2006;95(6):1045-7.
Species: Human
Sample Type: Plasma

Platelet-derived growth factor-BB controls epithelial tumor phenotype by differential growth factor regulation in stromal cells.
Authors: Lederle W, Stark HJ, Skobe M, Fusenig NE, Mueller MM
Am. J. Pathol., 2006;169(5):1767-83.
Species: Human
Sample Type: Cell Culture Supernates

Expression of PDGF and their receptors in human retinal pigment epithelial cells and fibroblasts: regulation by TGF-beta.
Authors: Nagineni CN, Kutty V, Detrick B, Hooks JJ
J. Cell. Physiol., 2005;203(1):35-43.
Species: Human
Sample Type: Cell Culture Supernates

IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis.
Authors: Numasaki M, Watanabe M, Suzuki T, Takahashi H, Nakamura A, McAllister F, Hishinuma T, Goto J, Lotze MT, Kolls JK, Sasaki H
J. Immunol., 2005;175(9):6177-89.
Species: Human
Sample Type: Cell Culture Supernates

Shear stress-stimulated endothelial cells induce smooth muscle cell chemotaxis via platelet-derived growth factor-BB and interleukin-1alpha.
Authors: Dardik A, Yamashita A, Aziz F, Asada H, Sumpio BE
J. Vasc. Surg., 2005;41(2):321-31.
Species: Bovine
Sample Type: Cell Culture Supernates

Smad3 is required for dedifferentiation of retinal pigment epithelium following retinal detachment in mice.
Authors: Saika S, Kono-Saika S, Tanaka T, Yamanaka O, Ohnishi Y, Sato M, Muragaki Y, Ooshima A, Yoo J, Flanders KC, Roberts AB
Lab. Invest., 2004;84(10):1245-58.
Species: Human
Sample Type: Cell Culture Supernates

Dual regulation of proliferation and growth arrest in prostatic stromal cells by transforming growth factor-beta1.
Authors: Zhou W, Park I, Pins M, Kozlowski JM, Jovanovic B, Zhang J, Lee C, Ilio K
Endocrinology, 2003;144(10):4280-4.
Species: Human
Sample Type: Cell Lysates

Ovariectomy increases mitogens and platelet-induced proliferation of arterial smooth muscle.
Authors: Bracamonte MP, Rud KS, Owen WG, Miller VM
Am. J. Physiol. Heart Circ. Physiol., 2002;283(3):H853-60.
Species: Porcine
Sample Type: Cell Lysates

生物活性Cross-reactivity observed with 1 or more available related molecules.< 50% cross-species reactivity observed with species tested.
背景The platelet-derived growth factor (PDGF) family of disulfide-linked dimeric proteins consists of four homodimeric proteins, PDGF-AA, PDGF-BB, PDGF-CC and PDGF-DD, and one heterodimeric protein, PDGF-AB. Members of this protein family act mainly on connective tissue. The dimeric isoforms of PDGF are expressed by different cell types and at different times during embryonic development. All PDGF isoforms are synthesized as inactive precursors and are processed to active forms that contain a PDGF/VEGF cysteine knot domain. Only PDGF-C and PDGF-D, also named spinal cord-derived growth factors SCDGF and SCDGF-B, also contain an N-terminal CUB domain. Mature PDGF dimers bind and induce the homo- or hetero-dimerization of two receptor tyrosine kinases (PDGF R alpha and R beta).
运输条件Blue Ice
存放说明4℃
参考文献
  • PDGF Family
  • PDGF Family Ligands
  • Platelets