| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. TIE2-mediated tyrosine phosphorylation of H4 regulates DNA damage response by recruiting ABL1
Sci Adv, 2016;2(4):e1501290.
Species: Human
Sample Type: Cell Lysates
Human neural stem cell-induced endothelial morphogenesis requires autocrine/paracrine and juxtacrine signaling
Sci Rep, 2016;6(0):29029.
Species: Human
Sample Type: Cell Culture Supernates
Angiopoietin-2, Angiopoietin-1 and subclinical cardiovascular disease in Chronic Kidney Disease
Sci Rep, 2016;6(0):39400.
Species: Human
Sample Type: Serum
Neovascularization Potential of Blood Outgrowth Endothelial Cells From Patients With Stable Ischemic Heart Failure Is Preserved
Authors: D Dauwe, B Pelacho, A Wibowo, AS Walravens, K Verdonck, H Gillijns, E Caluwe, P Pokreisz, N van Gastel, G Carmeliet, M Depypere, F Maes, N Vanden Dri, W Droogne, J Van Cleemp, J Vanhaecke, F Prosper, C Verfaillie, A Luttun, S Janssens
J Am Heart Assoc, 2016;5(4):.
Species: Human
Sample Type: Cell Culture Supernates
Angiopoietin/Tie2 Dysbalance Is Associated with Acute Kidney Injury after Cardiac Surgery Assisted by Cardiopulmonary Bypass.
Authors: Jongman R, van Klarenbosch J, Molema G, Zijlstra J, de Vries A, van Meurs M
PLoS ONE, 2015;10(8):e0136205.
Species: Human
Sample Type: Plasma
Mechanism of angiopoietin-1 upregulation in Kaposi's sarcoma-associated herpesvirus-infected PEL cell lines.
Authors: Zheng X, Ohsaki E, Ueda K
J Virol, 2015;89(9):4786-97.
Species: Human
Sample Type: Cell Culture Supernates
Kidney function, endothelial activation and atherosclerosis in black and white Africans with rheumatoid arthritis.
Authors: Dessein, Patrick, Hsu, Hon-Chun, Tsang, Linda, Millen, Aletta M, Woodiwiss, Angela J, Norton, Gavin R, Solomon, Ahmed, Gonzalez-Gay, Miguel A
PLoS ONE, 2015;10(3):e0121693.
Species: Human
Sample Type: Plasma
Combining bevacizumab and chemoradiation in rectal cancer. Translational results of the AXEBeam trial.
Authors: Verstraete M, Debucquoy A, Dekervel J, Van Pelt J, Verslype C, Devos E, Chiritescu G, Dumon K, DHoore A, Gevaert O, Sagaert X, Van Cutsem E, Haustermans K
Br J Cancer, 2015;112(8):1314-25.
Species: Human
Sample Type: Whole Blood
A randomized phase II study of capecitabine-based chemoradiation with or without bevacizumab in resectable locally advanced rectal cancer: clinical and biological features.
Authors: Salazar R, Capdevila J, Laquente B, Manzano J, Pericay C, Villacampa M, Lopez C, Losa F, Safont M, Gomez A, Alonso V, Escudero P, Gallego J, Sastre J, Gravalos C, Biondo S, Palacios A, Aranda E
BMC Cancer, 2015;15(0):60.
Species: Human
Sample Type: Plasma
Serum angiopoietin-2 and soluble VEGFR-2 levels predict malignancy of ovarian neoplasm and poor prognosis in epithelial ovarian cancer.
Authors: Sallinen H, Heikura T, Koponen J, Kosma V, Heinonen S, Yla-Herttuala S, Anttila M
BMC Cancer, 2014;14(0):696.
Species: Human
Sample Type: Serum
Angiopoietin-2 and angiopoietin-2/angiopoietin-1 ratio as indicators of potential severity of Plasmodium vivax malaria in patients with thrombocytopenia.
Authors: Gomes L, Alves-Junior E, Rodrigues-Jesus C, Nery A, Gasquez-Martin T, Fontes C
PLoS ONE, 2014;9(10):e109246.
Species: Human
Sample Type: Serum
Association of angiopoietin-2 with renal outcome in chronic kidney disease.
Authors: Tsai, Yi-Chun, Chiu, Yi-Wen, Tsai, Jer-Chia, Kuo, Hung-Tie, Lee, Su-Chu, Hung, Chi-Chih, Lin, Ming-Yen, Hwang, Shang-Jy, Kuo, Mei-Chua, Chen, Hung-Chu
PLoS ONE, 2014;9(10):e108862.
Species: Human
Sample Type: Plasma
Mobilization of circulating endothelial progenitor cells correlates with the clinical course of hantavirus disease.
Authors: Krautkramer E, Grouls S, Hettwer D, Rafat N, Tonshoff B, Zeier M
J Virol, 2014;88(1):483-9.
Clinical outcome, proteome kinetics and angiogenic factors in serum after thermoablation of colorectal liver metastases.
Authors: Wertenbroek, Marieke, Schepers, Marianne, Kamminga-Rasker, Hannetta, Bottema, Jan T, Muller Kobold, Anneke C, Roelofsen, Han, de Jong, Koert P
BMC Cancer, 2013;13(1):266.
Species: Human
Sample Type: Serum
Intermediate monocytes but not TIE2-expressing monocytes are a sensitive diagnostic indicator for colorectal cancer.
Authors: Schauer D, Starlinger P, Reiter C, Jahn N, Zajc P, Buchberger E, Bachleitner-Hofmann T, Bergmann M, Stift A, Gruenberger T, Brostjan C
PLoS ONE, 2012;7(9):e44450.
Species: Human
Sample Type: Plasma
Impaired function of the Tie-2 receptor contributes to vascular leakage and lethality in anthrax.
Proc Natl Acad Sci U S A, 2012;109(25):10024-9.
Species: Primate - Papio cynocephalus (Yellow Baboon)
Sample Type: Serum
Plasma biomarkers as predictors of outcome in patients with advanced hepatocellular carcinoma.
Authors: Llovet JM, Pena CE, Lathia CD, Shan M, Meinhardt G, Bruix J, Pallota MG, Zarba JJ, Boyer M, Riordan S, Strickland A, Tebbutt N, Thomson B, Borbath I, De Greve J, Van Laethem J-, Van Steenbergen W, Van Vlierberghe H, Barrios C, Cosme de Oliveira A, Kotzev I, Takov D, Tchernev K, Burak K, Ma M, Metrakos P, Olweny C, Sherman M, Gamargo Garate C, Martinez-Castillo J, Beaugrand M, Bennouna J, Blanc J-, Bronowicki J-, Degos F, Dominguez S, Grange J-, Hillon P, Raoul J-, Seitz J-, Blum H, Buggisch P, Caspary W, Dollinger M, Gerken G, Goke B, Gregor M, Greten T, Haussinger D, Hilgard P, Scherübl J, Scheulen M, Schmid R, Spengler U, Wiest R, Zeuzem S, Arvanitakis C, Germanidis G, Katsos I, Figer A, Stemmer S, Amadori D, Bolondi L, Cognetti F, Craxi A, Farinati F, Gridelli C, Martoni A, Mazzaferro V, Porta C, Ricci S, Sangiovanni A, Santoro A, Trevisani F, Cisnero Garza LE, Gane E, ODonnell A, Leon J, Lozano A, Jassem J, Rydzewska G, Szawlowski A, Tomczak P, Badulescu F, Miron L, Kubyshkin V, Bruix J, Forner A, Bustamante Schneider J, Diago M, Montero Alvarez JL, Pascual S, RuÃÂz del Arbol L, Sangro B, Solá R, Tabernero J, Muellhaupt B, Roth A, Jeffry Evans TR, Falk S, Meyer T, Reeves H, Ross P, Befeler A, Boyer T, Britten C, Byrne T, Garcia-Tsao G, Gold P, Goldenberg A, Heuman D, Kennedy P, Koch A, Llovet JM, Marrero J, Schilsky M, Schwartz J, Schwartz M
Clin. Cancer Res., 2012;18(8):2290-300.
Species: Human
Sample Type: Plasma
Expansion of human cardiac stem cells in physiological oxygen improves cell production efficiency and potency for myocardial repair.
Authors: Li TS, Cheng K, Malliaras K, Matsushita N, Sun B, Marban L, Zhang Y, Marban E
Cardiovasc. Res., 2011;89(1):157-65.
Species: Human
Sample Type: Cell Culture Supernates
Circulating angiopoietin-2 and soluble Tie-2 in type 2 diabetes mellitus: a cross-sectional study.
Authors: Rasul S, Reiter MH, Ilhan A, Lampichler K, Wagner L, Kautzky-Willer A
Cardiovasc Diabetol, 2011;10(0):55.
Species: Human
Sample Type: Plasma
Association of angiopoietin-2, C-reactive protein and markers of obesity and insulin resistance with survival outcome in colorectal cancer.
Authors: Volkova E, Willis JA, Wells JE, Robinson BA, Dachs GU, Currie MJ
Br. J. Cancer, 2011;104(1):51-9.
Species: Human
Sample Type: Serum
Changes in circulating levels and ratios of angiopoietins during pregnancy but not during the menstrual cycle and controlled ovarian stimulation.
Authors: Hurliman AK, Speroff L, Stouffer RL, Patton PE, Lee A, Molskness TA
Fertil. Steril., 2010;93(5):1493-9.
Species: Human
Sample Type: Serum
Effect of prostaglandin F2 alpha on local luteotropic and angiogenic factors during induced functional luteolysis in the bovine corpus luteum.
Authors: Berisha B, Meyer HH, Schams D
Biol. Reprod., 2010;82(5):940-7.
Species: Bovine
Sample Type: Tissue Homogenates
Defective angiogenesis in hypoplastic human fetal lungs correlates with nitric oxide synthase deficiency that occurs despite enhanced angiopoietin-2 and VEGF.
Authors: Boucherat O, Franco-Montoya ML, Delacourt C, Martinovic J, Masse V, Elie C, Thebaud B, Benachi A, Bourbon JR
Am. J. Physiol. Lung Cell Mol. Physiol., 2010;298(6):L849-56.
Species: Human
Sample Type: Tissue Homogenates
Signs of reduced angiogenic activity after surgical removal of deeply infiltrating endometriosis.
Authors: Bourlev V, Iljasova N, Adamyan L, Larsson A, Olovsson M
Fertil. Steril., 2010;94(1):52-7.
Species: Human
Sample Type: Serum
Angiopoietin-2 plasma dosage predicts time to first treatment and overall survival in chronic lymphocytic leukemia.
Authors: Maffei R, Martinelli S, Santachiara R
Blood, 2010;116(4):584-92.
Species: Human
Sample Type: Plasma
Colorectal resection is associated with persistent proangiogenic plasma protein changes: postoperative plasma stimulates in vitro endothelial cell growth, migration, and invasion.
Authors: Shantha Kumara HM, Feingold D, Kalady M, Dujovny N, Senagore A, Hyman N, Cekic V, Whelan RL
Ann. Surg., 2009;249(6):973-7.
Species: Human
Sample Type: Plasma
Increased plasma EPO and MIP-1 alpha are associated with recruitment of vascular progenitors but not CD34(+) cells in autologous peripheral blood stem cell grafts.
Authors: Labonte L, Li Y, Yang L, Gillingham A, Halpenny M, Giulivi A, Sills T, Evans K, Zanke B, Allan DS
Exp. Hematol., 2009;37(6):673-8.
Species: Human
Sample Type: Plasma
Angiopoietin-2 levels are associated with disease progression in metastatic malignant melanoma.
Authors: Helfrich I, Edler L, Sucker A, Thomas M, Christian S, Schadendorf D, Augustin HG
Clin. Cancer Res., 2009;15(4):1384-92.
Species: Human
Sample Type: Serum
Changes in vascular endothelial growth factor, angiopoietins, and Tie-2 levels with G-CSF stimulation in healthy donors.
Authors: Serefhanoglu S, Goker H, Buyukasik Y, Turgut M, Sayinalp N, Haznedaroglu IC, Aksu S, Akman U, Ozcebe OI
Ann. Hematol., 2009;88(7):667-71.
Species: Human
Sample Type: Plasma
Plasma levels of soluble Tie2 and vascular endothelial growth factor distinguish critical limb ischemia from intermittent claudication in patients with peripheral arterial disease.
Authors: Findley CM, Mitchell RG, Duscha BD, Annex BH, Kontos CD
J. Am. Coll. Cardiol., 2008;52(5):387-93.
Species: Human
Sample Type: Plasma
Angiopoietin-2 is associated with decreased endothelial nitric oxide and poor clinical outcome in severe falciparum malaria.
Authors: Yeo TW, Lampah DA, Gitawati R, Tjitra E, Kenangalem E, Piera K, Price RN, Duffull SB, Celermajer DS, Anstey NM
Proc. Natl. Acad. Sci. U.S.A., 2008;105(44):17097-102.
Species: Human
Sample Type: Plasma
Structural stability of neoangiogenic intramyocardial microvessels supports functional recovery in chronic ischemic myocardium.
Authors: Shim WS, Lim SY, Li SQ, Gu Y, Ong HC, Song IC, Chuah SC, Wong P
J. Mol. Cell. Cardiol., 2008;45(1):70-80.
Species: Porcine
Sample Type: Tissue Homogenates
Angiopoietin-2, marker and mediator of endothelial activation with prognostic significance early after trauma?
Authors: Ganter MT, Cohen MJ, Brohi K, Chesebro BB, Staudenmayer KL, Rahn P, Christiaans SC, Bir ND, Pittet JF
Ann. Surg., 2008;247(2):320-6.
Species: Human
Sample Type: Plasma
Isolation and characterization of CD146+ multipotent mesenchymal stromal cells.
Authors: Sorrentino A, Ferracin M, Castelli G, Biffoni M, Tomaselli G, Baiocchi M, Fatica A, Negrini M, Peschle C, Valtieri M
Exp. Hematol., 2008;36(8):1035-46.
Species: Human
Sample Type: Cell Culture Supernates
Serum concentrations of angiogenic cytokines in Waldenstrom macroglobulinaemia: the ration of angiopoietin-1 to angiopoietin-2 and angiogenin correlate with disease severity.
Authors: Anagnostopoulos A, Eleftherakis-Papaiakovou V, Kastritis E, Tsionos K, Bamias A, Meletis J, Dimopoulos MA, Terpos E
Br. J. Haematol., 2007;137(6):560-8.
Species: Human
Sample Type: Serum
Kaposis sarcoma-associated herpesvirus-encoded interleukin-6 and G-protein-coupled receptor regulate angiopoietin-2 expression in lymphatic endothelial cells.
Authors: Vart RJ, Nikitenko LL, Lagos D, Trotter MW, Cannon M, Bourboulia D, Gratrix F, Takeuchi Y, Boshoff C
Cancer Res., 2007;67(9):4042-51.
Species: Human
Sample Type: Cell Culture Supernates
Marrow angiogenesis-associated factors as prognostic biomarkers in patients with acute myelogenous leukaemia.
Authors: Lee CY, Tien HF, Hu CY, Chou WC, Lin LI
Br. J. Cancer, 2007;97(7):877-82.
Species: Human
Sample Type: Plasma
Serum angiopoietin-2 as a clinical marker for lung cancer.
Authors: Park JH, Park KJ, Kim YS, Sheen SS, Lee KS, Lee HN, Oh YJ, Hwang SC
Chest, 2007;132(1):200-6.
Species: Human
Sample Type: Serum
Changes in plasma vascular endothelial growth factor, angiopoietins, and their receptors following surgery for breast cancer.
Authors: Caine GJ, Stonelake PS, Lip GY, Blann AD
Cancer Lett., 2007;248(1):131-6.
Species: Human
Sample Type: Plasma
Significant decrease in angiopoietin-1 and angiopoietin-2 after radical prostatectomy in prostate cancer patients.
Authors: Caine GJ, Ryan P, Lip GY, Blann AD
Cancer Lett., 2007;251(2):296-301.
Species: Human
Sample Type: Plasma
Roles of angiopoietin-1 and angiopoietin-2 on airway microvascular permeability in asthmatic patients.
Authors: Kanazawa H, Nomura S, Asai K
Chest, 2007;131(4):1035-41.
Species: Human
Sample Type: Sputum
Relationship of soluble CD40 ligand to vascular endothelial growth factor, angiopoietins, and tissue factor in atrial fibrillation: a link among platelet activation, angiogenesis, and thrombosis?
Authors: Choudhury A, Freestone B, Patel J, Lip GY
Chest, 2007;132(6):1913-9.
Species: Human
Sample Type: Plasma
Angiopoietin-2 as a contributing factor of exercise-induced bronchoconstriction in asthmatic patients receiving inhaled corticosteroid therapy.
Authors: Kanazawa H, Tochino Y, Asai K
J. Allergy Clin. Immunol., 2007;121(2):390-5.
Species: Human
Sample Type: Sputum
Oncostatin M induces angiogenesis and cartilage degradation in rheumatoid arthritis synovial tissue and human cartilage cocultures.
Authors: Fearon U, Mullan R, Markham T, Connolly M, Sullivan S, Poole AR, FitzGerald O, Bresnihan B, Veale DJ
Arthritis Rheum., 2006;54(10):3152-62.
Species: Human
Sample Type: Cell Culture Supernates
Circulating levels of total angiopoietin-2 and the soluble Tie-2 receptor in women during ovarian stimulation and early gestation.
Authors: Molskness TA, Stouffer RL, Burry KA, Gorrill MJ, Lee DM, Patton PE
Fertil. Steril., 2006;86(5):1531-3.
Species: Human
Sample Type: Serum
Differential levels of soluble angiopoietin-2 and Tie-2 in patients with haematological malignancies.
Authors: Quartarone E, Alonci A, Allegra A, Bellomo G, Calabro L, DAngelo A, Del Fabro V, Grasso A, Cincotta M, Musolino C
Eur. J. Haematol., 2006;77(6):480-5.
Species: Human
Sample Type: Serum
Differential expression of angiopoietin-1, angiopoietin-2, and Tie receptors in placentas from pregnancies complicated by placenta accreta.
Authors: Tseng JJ, Hsu SL, Ho ES, Hsieh YT, Wen MC, Chou MM
Am. J. Obstet. Gynecol., 2006;194(2):564-71.
Species: Human
Sample Type: Tissue Homogenates
Angiopoietin 1 (Ang-1), angiopoietin 2 (Ang-2) and Tie-2 (a receptor tyrosine kinase) concentrations in peripheral blood of patients with thyroid cancers.
Authors: Niedzwiecki S, Stepien T, Kopec K, Kuzdak K, Komorowski J, Krupinski R, Stepien H
Cytokine, 2006;36(5):291-5.
Species: Human
Sample Type: Serum
Circulating endothelial cells and angiogenic serum factors during neoadjuvant chemotherapy of primary breast cancer.
Authors: Furstenberger G, von Moos R, Lucas R, Thurlimann B, Senn HJ, Hamacher J, Boneberg EM
Br. J. Cancer, 2006;94(4):524-31.
Species: Human
Sample Type: Serum
Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death.
Authors: Bhandari V, Choo-Wing R, Lee CG, Zhu Z, Nedrelow JH, Chupp GL, Zhang X, Matthay MA, Ware LB, Homer RJ, Lee PJ, Geick A, de Fougerolles AR, Elias JA
Nat. Med., 2006;12(11):1286-93.
Species: Human
Sample Type: Plasma
Potential role of soluble angiopoietin-2 and Tie-2 in patients with inflammatory bowel disease.
Authors: Koutroubakis IE, Xidakis C, Karmiris K, Sfiridaki A, Kandidaki E, Kouroumalis EA
Eur. J. Clin. Invest., 2006;36(2):127-32.
Species: Human
Sample Type: Serum
IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis.
Authors: Numasaki M, Watanabe M, Suzuki T, Takahashi H, Nakamura A, McAllister F, Hishinuma T, Goto J, Lotze MT, Kolls JK, Sasaki H
J. Immunol., 2005;175(9):6177-89.
Species: Human
Sample Type: Cell Culture Supernates
Vitreous levels of angiopoietin 2 and vascular endothelial growth factor in patients with proliferative diabetic retinopathy.
Authors: Watanabe D, Suzuma K, Suzuma I, Ohashi H, Ojima T, Takagi H
Am. J. Ophthalmol., 2005;139(3):476-81.
Species: Human
Sample Type: Vitreous Humor
Bi-directional cell contact-dependent regulation of gene expression between endothelial cells and osteoblasts in a three-dimensional spheroidal coculture model.
Authors: Stahl A, Wenger A, Weber H, Stark GB, Augustin HG, Finkenzeller G
Biochem. Biophys. Res. Commun., 2004;322(2):684-92.
Species: Human
Sample Type: Cell Culture Supernates
Angiopoietin-1 and angiopoietin-2 as clinically informative prognostic biomarkers of morbidity and mortality in severe sepsis*
Authors: Ricciuto DR, Dos Santos CC, Hawkes M, Toltl LJ, Conroy AL, Rajwans N, Lafferty EI, Cook DJ, Fox-Robichaud A, Kahnamoui K, Kain KC, Liaw PC, Liles WC
Crit. Care Med., 0;0(0):.
Species: Human
Sample Type: Plasma
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