Serum Markers of Epithelial Mesenchymal Transition as Predictors of HCV-induced Liver Fibrosis, Cirrhosis and Hepatocellular Carcinoma.
Authors: Zoheiry M, Hasan S, El-Ahwany E, Nagy F, Taleb H, Nosseir M, Magdy M, Meshaal S, El-Talkawy M, Raafat I
Electron Physician, 2015;7(8):1626-37.
Species: Human
Sample Type: Serum

Circulating bone morphogenetic protein-7 and transforming growth factor-beta1 are better predictors of renal end points in patients with type 2 diabetes mellitus.
Authors: Wong M, Perkovic V, Woodward M, Chalmers J, Li Q, Hillis G, Yaghobian Azari D, Jun M, Poulter N, Hamet P, Williams B, Neal B, Mancia G, Cooper M, Pollock C
Kidney Int, 2013;83(2):278-84.
Species: Human
Sample Type: Plasma

Association of bone morphogenetic proteins with spinal fusion in ankylosing spondylitis.
Authors: Chen HA, Chen CH, Lin YJ, Chen PC, Chen WS, Lu CL, Chou CT
J. Rheumatol., 2010;37(10):2126-32.
Species: Human
Sample Type: Serum

Bone morphogenetic protein 7 is elevated in patients with chronic liver disease and exerts fibrogenic effects on human hepatic stellate cells.
Authors: Tacke F, Gabele E, Bataille F, Schwabe RF, Hellerbrand C, Klebl F, Straub RH, Luedde T, Manns MP, Trautwein C, Brenner DA, Scholmerich J, Schnabl B
Dig. Dis. Sci., 2007;52(12):3404-15.
Species: Human
Sample Type: Plasma

Bone morphogenetic protein 7 inhibits tumor growth of human uveal melanoma in vivo.
Authors: Notting I, Buijs J, Mintardjo R, van der Horst G, Vukicevic S, Lowik C, Schalij-Delfos N, Keunen J, Van Der Pluijm G
Invest. Ophthalmol. Vis. Sci., 2007;48(11):4882-9.
Species: Human
Sample Type: Cell Culture Supernates

Bone morphogenetic protein 7 in the development and treatment of bone metastases from breast cancer.
Authors: Buijs JT, Henriquez NV, van Overveld PG, van der Horst G, Que I, Schwaninger R, Rentsch C, ten Dijke P, Cleton-Jansen AM, Driouch K, Lidereau R, Bachelier R, Vukicevic S, Clezardin P, Papapoulos SE, Cecchini MG, Lowik CW, Van Der Pluijm G
Cancer Res., 2007;67(18):8742-51.
Species: Human
Sample Type: Cell Culture Supernates

Combination of scaffold and adenovirus vectors expressing bone morphogenetic protein-7 for alveolar bone regeneration at dental implant defects.
Authors: Zhang Y, Song J, Shi B, Wang Y, Chen X, Huang C, Yang X, Xu D, Cheng X, Chen X
Biomaterials, 2007;28(31):4635-42.
Species: Human
Sample Type: Cell Culture Supernates

BMPs are secreted signaling molecules that comprise a subfamily of the TGF-beta superfamily and were originally identified as regulators of cartilage and bone formation. There are at least 20 structurally and functionally related BMPs, most of which play roles in embryogenesis and morphogenesis of various tissues and organs. Biologically active BMPs are usually homodimers containing a characteristic cysteine knot structure. Heterodimers, BMP-2/BMP-7 and BMP-4/BMP-7 have also been suggested to exist and function in vivo. They are more potent inducers of bone formation than their respective homodimers. In addition, heterodimers, but not homodimers, are ventral mesoderm inducers. Heterodimer activity may be mediated by a different or additional receptor subtype.

Decapentaplegic (Dpp) is one of at least five TGF-beta superfamily ligands identified in the Drosophila genome. Dpp, a functional ortholog of mammalian BMP-2 and BMP-4, is a morphogen and plays an essential role in Drosophila development. Dpp regulates embryonic dorsal-ventral polarity and is required for gut morphogenesis and outgrowth and patterning of imaginal disks.

• BMP Family
• BMPs (Bone Morphogenetic Proteins)
• Early Mesodermal Lineage Markers
• Mesenchymal to Epithelial Transition
• Negative Regulators of EMT
• Neural Crest Cell Markers
• TGF-beta Superfamily