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Human CCL11/Eotaxin Quantikine SixPak (6 Plates) (1 PK)

货号: STX00 基本售价: 31934.7 元 规格: 1 PACK

产品信息

概述
货号STX00
描述The Quantikine Human Eotaxin Immunoassay is a 3.5 hour solid phase ELISA designed to measure human Eotaxin in cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant human Eotaxin and antibodies raised against the recombinant factor. This immunoassay has been shown to quantitate recombinant human Eotaxin accurately. Results obtained measuring natural human eotaxin showed dose-response curves that were parallel to the standard curves obtained using the recombinant Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural human Eotaxin.
别名C-C motif chemokine 11; CCL11; chemokine (C-C motif) ligand 11; Eosinophil chemotactic protein; Eotaxin; eotaxin-1; MGC22554; SCYA11Small-inducible cytokine A11; small inducible cytokine subfamily A (Cys-Cys), member 11 (eotaxin);
反应种属Human
目标/特异性Natural and recombinant human Eotaxin
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs
6356 (Human); 20292 (Mouse)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Hydroxycarbamide reduces eosinophil adhesion and degranulation in sickle cell anaemia patients.
Authors: Pallis F, Conran N, Fertrin K, Olalla Saad S, Costa F, Franco-Penteado C
Br J Haematol, 2014;164(2):286-95.
Species: Human
Sample Type: Plasma

Increased Eotaxin and MCP-1 Levels in Serum from Individuals with Periodontitis and in Human Gingival Fibroblasts Exposed to Pro-Inflammatory Cytokines.
Authors: Bostrom E, Kindstedt E, Sulniute R, Palmqvist P, Majster M, Holm C, Zwicker S, Clark R, Onell S, Johansson I, Lerner U, Lundberg P
PLoS ONE, 2013;10(8):e0134608.
Species: Human
Sample Type: Cell Culture Supernates

Anti-inflammatory effects of methoxyphenolic compounds on human airway cells.
Authors: Houser KR, Johnson DK, Ishmael FT
J Inflamm (Lond), 2012;9(0):6.
Species: Human
Sample Type: Cell Culture Supernates

Leukotriene D4 and interleukin-13 cooperate to increase the release of eotaxin-3 by airway epithelial cells.
Authors: Provost V, Langlois A, Chouinard F, Rola-Pleszczynski M, Chakir J, Flamand N, Laviolette M
PLoS ONE, 2012;7(8):e43544.
Species: Human
Sample Type: Cell Culture Supernates

Eotaxins and CCR3 interaction regulates the Th2 environment of cutaneous T-cell lymphoma.
Authors: Miyagaki T, Sugaya M, Fujita H
J. Invest. Dermatol., 2010;130(9):2304-11.
Species: Human
Sample Type: Serum

Opposing roles of IL-17A and IL-25 in the regulation of TSLP production in human nasal epithelial cells.
Authors: Xu G, Zhang L, Wang DY, Xu R, Liu Z, Han DM, Wang XD, Zuo KJ, Li HB
Allergy, 2010;65(5):581-9.
Species: Human
Sample Type: Cell Culture Supernates

Presence of IL-5 protein and IgE antibodies to staphylococcal enterotoxins in nasal polyps is associated with comorbid asthma.
Authors: Bachert C, Zhang N, Holtappels G, De Lobel L, Van Cauwenberge P, Liu S, Lin P, Bousquet J, Van Steen K
J. Allergy Clin. Immunol., 2010;126(5):962.
Species: Human
Sample Type: Tissue Homogenates

Staphylococcus aureus in nasal lavage and biopsy of patients with chronic rhinosinusitis.
Authors: Niederfuhr A, Kirsche H, Deutschle T, Poppert S, Riechelmann H, Wellinghausen N
Allergy, 2008;63(10):1359-67.
Species: Human
Sample Type: nasal lavage

Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseases.
Authors: Hartl D, Krauss-Etschmann S, Koller B, Hordijk PL, Kuijpers TW, Hoffmann F, Hector A, Eber E, Marcos V, Bittmann I, Eickelberg O, Griese M, Roos D
J. Immunol., 2008;181(11):8053-67.
Species: Human
Sample Type: BALF

Circulating thymus- and activation-regulated chemokine/CCL17 is a useful biomarker for discriminating acute eosinophilic pneumonia from other causes of acute lung injury.
Authors: Miyazaki E, Nureki S, Ono E, Ando M, Matsuno O, Fukami T, Ueno T, Kumamoto T
Chest, 2007;131(6):1726-34.
Species: Human
Sample Type: BALF

Computed tomographic scan-diagnosed chronic obstructive pulmonary disease-emphysema: eotaxin-1 is associated with bronchodilator response and extent of emphysema.
Authors: Miller M, Ramsdell J, Friedman PJ, Cho JY, Renvall M, Broide DH
J. Allergy Clin. Immunol., 2007;120(5):1118-25.
Species: Human
Sample Type: BALF

Effect of IL-6 trans-signaling on the pro-remodeling phenotype of airway smooth muscle.
Authors: Ammit AJ, Moir LM, Oliver BG, Hughes JM, Alkhouri H, Ge Q, Burgess JK, Black JL, Roth M
Am. J. Physiol. Lung Cell Mol. Physiol., 2007;292(1):L199-206.
Species: Human
Sample Type: Cell Culture Supernates

Cerebrospinal fluid eotaxin and eotaxin-2 levels in human eosinophilic meningitis associated with angiostrongyliasis.
Authors: Intapan PM, Niwattayakul K, Sawanyawisuth K, Chotmongkol V, Maleewong W
Cytokine, 2007;39(2):138-41.
Species: Human
Sample Type: CSF

Relationship between eosinophilia and levels of chemokines (CCL5 and CCL11) and IL-5 in bronchoalveolar lavage fluid of patients with mustard gas-induced pulmonary fibrosis.
Authors: Emad A, Emad Y
J. Clin. Immunol., 2007;27(6):605-12.
Species: Human
Sample Type: BALF

Systemic responses after bronchial aspirin challenge in sensitive patients with asthma.
Authors: Makowska JS, Grzegorczyk J, Bienkiewicz B, Wozniak M, Kowalski ML
J. Allergy Clin. Immunol., 2007;121(2):348-54.
Species: Human
Sample Type: Serum

Effect of IL-13 receptor alpha2 levels on the biological activity of IL-13 variant R110Q.
Authors: Andrews AL, Bucchieri F, Arima K, Izuhara K, Holgate ST, Davies DE, Holloway JW
J. Allergy Clin. Immunol., 2007;120(1):91-7.
Species: Human
Sample Type: Cell Culture Supernates

IL-13 receptor alpha 2: a regulator of IL-13 and IL-4 signal transduction in primary human fibroblasts.
Authors: Andrews AL, Nasir T, Bucchieri F, Holloway JW, Holgate ST, Davies DE
J. Allergy Clin. Immunol., 2006;118(4):858-65.
Species: Human
Sample Type: Cell Culture Supernates

Mast cell beta-tryptase selectively cleaves eotaxin and RANTES and abrogates their eosinophil chemotactic activities.
Authors: Pang L, Nie M, Corbett L, Sutcliffe A, Knox AJ
J. Immunol., 2006;176(6):3788-95.
Species: Human
Sample Type: Cell Culture Supernates

Regulatory mechanisms of galectin-9 and eotaxin-3 synthesis in epidermal keratinocytes: possible involvement of galectin-9 in dermal eosinophilia of Th1-polarized skin inflammation.
Authors: Igawa K, Satoh T, Hirashima M, Yokozeki H
Allergy, 2006;61(12):1385-91.
Species: Human
Sample Type: Cell Culture Supernates

Markers of eosinophilic inflammation and risk prediction in patients with coronary artery disease.
Authors: Falcone C, Minoretti P, D'Angelo A, Buzzi MP, Coen E, Emanuele E, Aldeghi A, Olivieri V, Geroldi D
Eur. J. Clin. Invest., 2006;36(4):211-7.
Species: Human
Sample Type: Plasma

Airway inflammation during stable and acutely exacerbated chronic obstructive pulmonary disease.
Authors: Fujimoto K, Yasuo M, Urushibata K, Hanaoka M, Koizumi T, Kubo K
Eur. Respir. J., 2005;25(4):640-6.
Species: Human
Sample Type: Sputum

Respiratory syncytial virus and other respiratory viruses during the first 3 months of life promote a local TH2-like response.
Authors: Kristjansson S, Bjarnarson SP, Wennergren G, Palsdottir AH, Arnadottir T, Haraldsson A, Jonsdottir I
J. Allergy Clin. Immunol., 2005;116(4):805-11.
Species: Human
Sample Type: Nasopharyngeal Secretions

Enhanced monocyte chemoattractant protein-3/CC chemokine ligand-7 in usual interstitial pneumonia.
Authors: Choi ES, Jakubzick C, Carpenter KJ, Kunkel SL, Evanoff H, Martinez FJ, Flaherty KR, Toews GB, Colby TV, Kazerooni EA, Gross BH, Travis WD, Hogaboam CM
Am. J. Respir. Crit. Care Med., 2004;170(5):508-15.
Species: Human
Sample Type: Cell Culture Supernates

Regulation of the interleukin-5 receptor alpha-subunit on peripheral blood eosinophils from healthy subjects.
Authors: Hellman C, Hallden G, Hylander B, Lundahl J
Clin. Exp. Immunol., 2003;131(1):75-81.
Species: Human
Sample Type: Peritoneal Fluid

CCR5-binding chemokines modulate CXCL12 (SDF-1)-induced responses of progenitor B cells in human bone marrow through heterologous desensitization of the CXCR4 chemokine receptor.
Authors: Honczarenko M, Le Y, Glodek AM, Silberstein LE
Blood, 2002;100(7):2321-9.
Species: Human
Sample Type: Cell Culture Supernates

生物活性< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景CCL11/Eotaxin is a chemokine that interacts with CCR3 to induce eosinophil, basophil, dendritic cell, and Th2 cell chemoattraction during inflammatory and allergic reactions. Its production is upregulated in airway epithelium, alveolar macrophages, eosinophils, smooth muscle cells, chondrocytes, and fibroblasts following allergen or inflammatory challenge. CCL11 is also involved in the growth of myeloid cell progenitors and the differentiation of mast cells.
运输条件Blue Ice
存放说明4℃
参考文献
  • Adult Neurogenesis
  • Airway Inflammation and Remodeling
  • CC Chemokines and Receptors
  • Chemokines and Receptors
  • Chemokines and Receptors in Allergy and Asthma
  • Chemokines and Receptors in Angiogenesis
  • Eosinophils
  • Macrophage Activation Markers
  • Molecules Secreted by VSMC