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Human CXCL12/SDF-1 alpha Quantikine SixPak (6 Plates) (1 PK)

货号: SSA00 基本售价: 31934.7 元 规格: 1 PACK

产品信息

概述
货号SSA00
描述The Quantikine Human SDF-1 alpha Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human SDF-1 alpha in cell culture supernates and platelet-poor plasma. It contains E. coli-expressed recombinant human SDF-1 alpha and antibodies raised against the recombinant factor. It has been shown to accurately quantitate recombinant human SDF-1 alpha. Results obtained using natural SDF-1 alpha showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural SDF-1 alpha.
别名CXCL12 chemokine (C-X-C motif) ligand 12; CXCL12/SDF-1 alpha; IRH; PBSF; SCYB12; SDF1 alpha; SDF1; SDF1a; SDF1B; TLSF; TPAR1;
反应种属Human
目标/特异性Natural and recombinant SDF-1 alpha
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs
6387 (Human); 20315 (Mouse); 493806 (Feline)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

The brain-penetrating CXCR4 antagonist, PRX177561, increases the antitumor effects of bevacizumab and sunitinib in preclinical models of human glioblastoma
Authors: GL Gravina, A Mancini, F Marampon, A Colapietro, S Delle Mona, R Sferra, F Vitale, PJ Richardson, L Patient, S Burbidge, C Festuccia
J Hematol Oncol, 2017;10(1):5.
Species: Human
Sample Type: Cell Culture Supernates

Beneficial Effects of Reconstituted High-Density Lipoprotein (rHDL) on Circulating CD34+ Cells in Patients after an Acute Coronary Syndrome
Authors: C Gebhard, E Rh‚aume, C Berry, G Brand, AE Kernalegue, G Th‚berge-J, MA Alam, CY Lee, L Boileau, M Chabot-Bla, MC Guertin, MA Lavoie, J Gr‚goire, R Ibrahim, P LAllier, JC Tardif
PLoS ONE, 2017;12(1):e0168448.
Species: Human
Sample Type: Serum

Vildagliptin, but not glibenclamide, increases circulating endothelial progenitor cell number: a 12-month randomized controlled trial in patients with type 2 diabetes
Authors: A Dei Cas, V Spigoni, M Cito, R Aldigeri, V Ridolfi, E Marchesi, M Marina, E Derlindati, R Aloe, RC Bonadonna, I Zavaroni
Cardiovasc Diabetol, 2017;16(1):27.
Species: Human
Sample Type: Plasma

High throughput chemical library screening identifies a novel p110-? inhibitor that potentiates the anti-myeloma effect of bortezomib
Oncotarget, 2016;7(25):38523-38538.
Species: Human
Sample Type: Cell Culture Supernates

Impact of Hyperglycemia and Low Oxygen Tension on Adipose-Derived Stem Cells Compared with Dermal Fibroblasts and Keratinocytes: Importance for Wound Healing in Type 2 Diabetes
PLoS ONE, 2016;11(12):e0168058.
Species: Human
Sample Type: Cell Culture Supernates

Innovative Flow Cytometry Allows Accurate Identification of Rare Circulating Cells Involved in Endothelial Dysfunction
PLoS ONE, 2016;11(8):e0160153.
Species: Human
Sample Type: Plasma

Circulating Fibrocytes Are Increased in Neonates with Bronchopulmonary Dysplasia
Authors: Chun Li
PLoS ONE, 2016;11(6):e0157181.
Species: Human
Sample Type: Plasma

Early pancreatic cancer lesions suppress pain through CXCL12-mediated chemoattraction of Schwann cells
Proc. Natl. Acad. Sci. U.S.A, 2016;0(0):.
Species: Human
Sample Type: Cell Lysates

BH3 mimetics suppress CXCL12 expression in human malignant peripheral nerve sheath tumor cells
Authors: CD Graham, N Kaza, HC Pruitt, LM Gibson, BJ Klocke, LA Shevde, SL Carroll, KA Roth
Oncotarget, 2016;0(0):.
Species: Human
Sample Type: Cell Culture Supernates

Human neural stem cell-induced endothelial morphogenesis requires autocrine/paracrine and juxtacrine signaling
Sci Rep, 2016;6(0):29029.
Species: Human
Sample Type: Cell Culture Supernates

Improved tumor vascularization after anti-VEGF therapy with carboplatin and nab-paclitaxel associates with survival in lung cancer.
Authors: Heist, Rebecca, Duda, Dan G, Sahani, Dushyant, Ancukiewicz, Marek, Fidias, Panos, Sequist, Lecia V, Temel, Jennifer, Shaw, Alice T, Pennell, Nathan A, Neal, Joel W, Gandhi, Leena, Lynch, Thomas J, Engelman, Jeffrey, Jain, Rakesh K
Proc Natl Acad Sci U S A, 2015;112(5):1547-52.
Species: Human
Sample Type: Plasma

Chronic hyperglycemia induces trans-differentiation of human pancreatic stellate cells and enhances the malignant molecular communication with human pancreatic cancer cells.
Authors: Kiss K, Baghy K, Spisak S, Szanyi S, Tulassay Z, Zalatnai A, Lohr J, Jesenofsky R, Kovalszky I, Firneisz G
PLoS ONE, 2015;10(5):e0128059.
Species: Human
Sample Type: Cell Culture Supernates

Detailed characterization of multiple myeloma circulating tumor cells shows unique phenotypic, cytogenetic, functional, and circadian distribution profile.
Authors: Paiva B, Paino T, Sayagues J, Garayoa M, San-Segundo L, Martin M, Mota I, Sanchez M, Barcena P, Aires-Mejia I, Corchete L, Jimenez C, Garcia-Sanz R, Gutierrez N, Ocio E, Mateos M, Vidriales M, Orfao A, San Miguel J
Blood, 2015;122(22):3591-8.
Species: Human
Sample Type: Plasma

Transmissible cytotoxicity of multiple myeloma cells by cord blood-derived NK cells is mediated by vesicle trafficking.
Authors: Martin-Antonio B, Najjar A, Robinson S, Chew C, Li S, Yvon E, Thomas M, Mc Niece I, Orlowski R, Munoz-Pinedo C, Bueno C, Menendez P, Fernandez de Larrea C, Urbano-Ispizua A, Shpall E, Shah N
Cell Death Differ, 2015;22(1):96-107.
Species: Human
Sample Type: Cell Culture Supernates

Elevated plasma CXCL12alpha is associated with a poorer prognosis in pulmonary arterial hypertension.
Authors: McCullagh B, Costello C, Li L, OConnell C, Codd M, Lawrie A, Morton A, Kiely D, Condliffe R, Elliot C, McLoughlin P, Gaine S
PLoS ONE, 2015;10(4):e0123709.
Species: Human
Sample Type: Plasma

Remodeling of extracellular matrix by normal and tumor-associated fibroblasts promotes cervical cancer progression.
Authors: Fullar A, Dudas J, Olah L, Hollosi P, Papp Z, Sobel G, Karaszi K, Paku S, Baghy K, Kovalszky I
BMC Cancer, 2015;15(0):256.
Species: Human
Sample Type: Cell Culture Supernates

EphB4 Expressing Stromal Cells Exhibit an Enhanced Capacity for Hematopoietic Stem Cell Maintenance.
Authors: Nguyen T, Arthur A, Panagopoulos R, Paton S, Hayball J, Zannettino A, Purton L, Matsuo K, Gronthos S
Stem Cells, 2015;33(9):2838-49.
Species: Human
Sample Type: Cell Culture Supernates

SDF-1alpha is a novel autocrine activator of platelets operating through its receptor CXCR4.
Authors: Walsh T, Harper M, Poole A
Cell Signal, 2015;27(1):37-46.
Species: Human
Sample Type: Cell Culture Supernates

Mobilization of circulating endothelial progenitor cells correlates with the clinical course of hantavirus disease.
Authors: Krautkramer E, Grouls S, Hettwer D, Rafat N, Tonshoff B, Zeier M
J Virol, 2014;88(1):483-9.
Species: Human
Sample Type: Plasma

Expression and functional characterization of NOD2 in decidual stromal cells isolated during the first trimester of pregnancy.
Authors: Zhang Y, Chen H, Sun C, Wang H, Liu M, Li Y, Nie X, Du M, Li D, Zhang J
PLoS ONE, 2014;9(6):e99612.
Species: Human
Sample Type: Cell Culture Supernates

Surgical sutures filled with adipose-derived stem cells promote wound healing.
Authors: Reckhenrich A, Kirsch B, Wahl E, Schenck T, Rezaeian F, Harder Y, Foehr P, Machens H, Egana J
PLoS ONE, 2014;9(3):e91169.
Species: Human
Sample Type: Cell Culture Supernates

The Spiegelmer NOX-A12, a novel CXCL12 inhibitor, interferes with chronic lymphocytic leukemia cell motility and causes chemosensitization.
Authors: Hoellenriegel J, Zboralski D, Maasch C, Rosin N, Wierda W, Keating M, Kruschinski A, Burger J
Blood, 2014;123(7):1032-9.
Species: Mouse
Sample Type: cell supernates

Oxygen regulates human cytotrophoblast migration by controlling chemokine and receptor expression.
Authors: Schanz A, Red-Horse K, Hess A, Baston-Bust D, Heiss C, Krussel J
Placenta, 2014;35(12):1089-94.
Species: Human
Sample Type: Cell Culture Supernates

Expression of and transcript variants and in epithelial ovarian cancer.
Authors: Jaszczynska-Nowinka K, Rucinski M, Ziolkowska A, Markowska A, Malendowicz L
Oncol Lett, 2014;7(5):1618-1624.
Species: Human
Sample Type: Plasma

Bone marrow fibroblasts parallel multiple myeloma progression in patients and mice: in vitro and in vivo studies.
Authors: Frassanito M, Rao L, Moschetta M, Ria R, di Marzo L, De Luisi A, Racanelli V, Catacchio I, Berardi S, Basile A, Menu E, Ruggieri S, Nico B, Ribatti D, Fumarulo R, Dammacco F, Vanderkerken K, Vacca A
, 2014;0(0):.
Species: Human
Sample Type: Cell Culture Supernates

Prostate stromal cells express the progesterone receptor to control cancer cell mobility.
Authors: Yu, Yue, Lee, Jennifer, Xie, Ning, Li, Estelle, Hurtado-Coll, Antonio, Fazli, Ladan, Cox, Michael, Plymate, Stephen, Gleave, Martin, Dong, Xuesen
PLoS ONE, 2014;9(3):e92714.
Species: Human
Sample Type: Cell Culture Supernates

Altered features and increased chemosensitivity of human breast cancer cells mediated by adipose tissue-derived mesenchymal stromal cells.
Authors: Kucerova L, Skolekova S, Matuskova M, Bohac M, Kozovska Z
BMC Cancer, 2013;13(0):535.
Species: Human
Sample Type: Cell Culture Supernates

BAFF/APRIL system in pediatric OMS: relation to severity, neuroinflammation, and immunotherapy.
Authors: Pranzatelli, Michael, Tate, Elizabet, McGee, Nathan R, Travelstead, Anna L, Colliver, Jerry A, Ness, Jayne M, Ransohoff, Richard
J Neuroinflammation, 2013;10(0):10.
Species: Human
Sample Type: Serum

Intranasal delivery of mesenchymal stem cells significantly extends survival of irradiated mice with experimental brain tumors.
Authors: Balyasnikova I, Prasol M, Ferguson S, Han Y, Ahmed A, Gutova M, Tobias A, Mustafi D, Rincon E, Zhang L, Aboody K, Lesniak M
Mol Ther, 2013;22(1):140-8.
Species: Human
Sample Type: Cell Lysates

Elevated cerebral spinal fluid cytokine levels in boys with cerebral adrenoleukodystrophy correlates with MRI severity.
Authors: Lund TC, Stadem PS, Panoskaltsis-Mortari A, Raymond G, Miller WP, Tolar J, Orchard PJ
PLoS ONE, 2012;7(2):e32218.
Species: Human
Sample Type: Serum

A dynamic inflammatory cytokine network in the human ovarian cancer microenvironment.
Authors: Kulbe H, Chakravarty P, Leinster DA, Charles KA, Kwong J, Thompson RG, Coward JI, Schioppa T, Robinson SC, Gallagher WM, Galletta L, Salako MA, Smyth JF, Hagemann T, Brennan DJ, Bowtell DD, Balkwill FR
Cancer Res., 2012;72(1):66-75.
Species: Human
Sample Type: Cell Culture Supernates

Involvement of the CXCR7/CXCR4/CXCL12 axis in the malignant progression of human neuroblastoma.
Authors: Liberman J, Sartelet H, Flahaut M, Muhlethaler-Mottet A, Coulon A, Nyalendo C, Vassal G, Joseph J, Gross N
PLoS ONE, 2012;7(8):e43665.
Species: Human
Sample Type: Tissue Homogenates

BMP9 regulates endoglin-dependent chemokine responses in endothelial cells.
Authors: Young, Kira, Conley, Barbara, Romero, Diana, Tweedie, Eric, ONeill, Christin, Pinz, Ilka, Brogan, Louise, Lindner, Volkhard, Liaw, Lucy, Vary, Calvin P
Blood, 2012;120(20):4263-73.
Species: Human
Sample Type: Cell Culture Supernates

Breast milk from Tanzanian women has divergent effects on cell-free and cell-associated HIV-1 infection in vitro.
Authors: Lyimo M, Mosi M, Housman M, Zain-Ul-Abideen M, Lee F, Howell A, Connor R
PLoS ONE, 2012;7(8):e43815.
Species: Human
Sample Type: Milk

Alveolar fibrocyte percentage is an independent predictor of poor outcome in patients with acute lung injury.
Authors: Quesnel C, Piednoir P, Gelly J, Nardelli L, Garnier M, Lecon V, Lasocki S, Bouadma L, Philip I, Elbim C, Mentre F, Soler P, Crestani B, Dehoux M
Crit. Care Med., 2012;40(1):21-8.
Species: Human
Sample Type: BALF

Inflammation associated with obesity: relationship with blood and bone marrow endothelial cells.
Authors: McGuire TR, Brusnahan SK, Bilek LD, Jackson JD, Kessinger MA, Berger AM, Garvin KL, OKane BJ, Tuljapurkar SR, Sharp JG
Obesity (Silver Spring), 2011;19(11):2130-6.
Species: Human
Sample Type: Plasma

Levels of circulating CD45(dim)CD34(+)VEGFR2(+) progenitor cells correlate with outcome in metastatic renal cell carcinoma patients treated with tyrosine kinase inhibitors.
Authors: Farace F, Gross-Goupil M, Tournay E, Taylor M, Vimond N, Jacques N, Billiot F, Mauguen A, Hill C, Escudier B
Br. J. Cancer, 2011;104(7):1144-50.
Species: Human
Sample Type: Plasma

Phase I and pharmacokinetic study of sunitinib in pediatric patients with refractory solid tumors: a childrens oncology group study.
Authors: Dubois SG, Shusterman S, Ingle AM, Ahern CH, Reid JM, Wu B, Baruchel S, Glade-Bender J, Ivy P, Grier HE, Adamson PC, Blaney SM
Clin. Cancer Res., 2011;17(15):5113-22.
Species: Human
Sample Type: Plasma

Hypoxia-inducible factors in human pulmonary arterial hypertension: a link to the intrinsic myeloid abnormalities.
Authors: Farha S, Asosingh K, Xu W, Sharp J, George D, Comhair S, Park M, Tang WH, Loyd JE, Theil K, Tubbs R, Hsi E, Lichtin A, Erzurum SC
Blood, 2011;117(13):3485-93.
Species: Human
Sample Type: Plasma

Expansion of human cardiac stem cells in physiological oxygen improves cell production efficiency and potency for myocardial repair.
Authors: Li TS, Cheng K, Malliaras K, Matsushita N, Sun B, Marban L, Zhang Y, Marban E
Cardiovasc. Res., 2011;89(1):157-65.
Species: Human
Sample Type: Cell Culture Supernates

Novel insight into stem cell mobilization-plasma sphingosine-1-phosphate is a major chemoattractant that directs the egress of hematopoietic stem progenitor cells from the bone marrow and its level in peripheral blood increases during mobilization due to activation of complement cascade/membrane attack complex.
Authors: Ratajczak MZ, Lee H, Wysoczynski M, Wan W, Marlicz W, Laughlin MJ, Kucia M, Janowska-Wieczorek A, Ratajczak J
Leukemia, 2010;24(5):976-85.
Species: Human
Sample Type: Plasma

Distraction osteogenesis induces endothelial progenitor cell mobilization without inflammatory response in man.
Authors: Lee DY, Cho TJ, Lee HR, Park MS, Yoo WJ, Chung CY, Choi IH
Bone, 2010;46(3):673-9.
Species: Human
Sample Type: Plasma

Phagocytosis of apoptotic cells modulates mesenchymal stem cells osteogenic differentiation to enhance IL-17 and RANKL expression on CD4+ T cells.
Authors: Tso GH, Law HK, Tu W
Stem Cells, 2010;28(5):939-54.
Species: Human
Sample Type: Cell Culture Supernates

Differential effect of ischaemic preconditioning on mobilisation and recruitment of haematopoietic and mesenchymal stem cells in porcine myocardial ischaemia-reperfusion.
Authors: Gyongyosi M, Posa A, Pavo N, Hemetsberger R, Kvakan H, Steiner-Boker S, Petrasi Z, Manczur F, Pavo IJ, Edes IF, Wojta J, Glogar D, Huber K
Thromb. Haemost., 2010;104(2):376-84.
Species: Human
Sample Type: Plasma

Stromal cell-derived factor-1 is essential for photoreceptor cell protection in retinal detachment.
Authors: Otsuka H, Arimura N, Sonoda S
Am. J. Pathol., 2010;177(5):2268-77.
Species: Human
Sample Type: Vitreous Humor

Glioblastoma and endothelial cells cross-talk, mediated by SDF-1, enhances tumour invasion and endothelial proliferation by increasing expression of cathepsins B, S, and MMP-9.
Authors: Kenig S, Alonso MB, Mueller MM, Lah TT
Cancer Lett., 2010;289(1):53-61.
Species: Human
Sample Type: Cell Culture Supernates

Intratumoral induction of CD103 triggers tumor-specific CTL function and CCR5-dependent T-cell retention.
Authors: Franciszkiewicz K, Le Floch A, Jalil A, Vigant F, Robert T, Vergnon I, Mackiewicz A, Benihoud K, Validire P, Chouaib S, Combadiere C, Mami-Chouaib F
Cancer Res., 2009;69(15):6249-55.
Species: Human
Sample Type: Cell Culture Supernates

Functional interaction of plasmacytoid dendritic cells with multiple myeloma cells: a therapeutic target.
Authors: Chauhan D, Singh AV, Brahmandam M, Carrasco R, Bandi M, Hideshima T, Bianchi G, Podar K, Tai YT, Mitsiades C, Raje N, Jaye DL, Kumar SK, Richardson P, Munshi N, Anderson KC
Cancer Cell, 2009;16(4):309-23.
Species: Human
Sample Type: Cell Culture Supernates

Efficacy, safety, and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma: a phase II study.
Authors: Zhu AX, Sahani DV, Duda DG, di Tomaso E, Ancukiewicz M, Catalano OA, Sindhwani V, Blaszkowsky LS, Yoon SS, Lahdenranta J, Bhargava P, Meyerhardt J, Clark JW, Kwak EL, Hezel AF, Miksad R, Abrams TA, Enzinger PC, Fuchs CS, Ryan DP, Jain RK
J. Clin. Oncol., 2009;27(18):3027-35.
Species: Human
Sample Type: Plasma

Targeted disruption of the CXCL12/CXCR4 axis inhibits osteolysis in a murine model of myeloma-associated bone loss.
Authors: Diamond P, Labrinidis A, Martin SK, Farrugia AN, Gronthos S, To LB, Fujii N, OLoughlin PD, Evdokiou A, Zannettino AC
J. Bone Miner. Res., 2009;24(7):1150-61.
Species: Human
Sample Type: Plasma

Dysregulation of stromal derived factor 1/CXCR4 axis in the megakaryocytic lineage in essential thrombocythemia.
Authors: Salim JP, Goette NP, Lev PR, Chazarreta CD, Heller PG, Alvarez C, Molinas FC, Marta RF
Br. J. Haematol., 2009;144(1):69-77.
Species: Human
Sample Type: Plasma

The imbalance in serum concentration of Th-1- and Th-2-derived chemokines as one of the factors involved in pathogenesis of atopic dermatitis.
Authors: Narbutt J, Lesiak A, Sysa-Jedrzeiowska A, Zakrzewski M, Bogaczewicz J, Stelmach I, Kuna P
Mediators Inflamm., 2009;2009(0):269541.
Species: Human
Sample Type: Serum

Nodal lymphangiogenesis and metastasis: Role of tumor-induced lymphatic vessel activation in extramammary Paget's disease.
Authors: Hirakawa S, Detmar M, Kerjaschki D, Nagamatsu S, Matsuo K, Tanemura A, Kamata N, Higashikawa K, Okazaki H, Kameda K, Nishida-Fukuda H, Mori H, Hanakawa Y, Sayama K, Shirakata Y, Tohyama M, Tokumaru S, Katayama I, Hashimoto K
Am. J. Pathol., 2009;175(5):2235-48.
Species: Human
Sample Type: Cell Culture Supernates

Activation of critical, host-induced, metabolic and stress pathways marks neutrophil entry into cystic fibrosis lungs.
Authors: Makam M, Diaz D, Laval J, Gernez Y, Conrad CK, Dunn CE, Davies ZA, Moss RB, Herzenberg LA, Herzenberg LA, Tirouvanziam R
Proc. Natl. Acad. Sci. U.S.A., 2009;106(14):5779-83.
Species: Human
Sample Type: Plasma

Tissue inhibitor of metalloproteinase-3 via oncolytic herpesvirus inhibits tumor growth and vascular progenitors.
Authors: Mahller YY, Vaikunth SS, Ripberger MC, Baird WH, Saeki Y, Cancelas JA, Crombleholme TM, Cripe TP
Cancer Res., 2008;68(4):1170-9.
Species: Human
Sample Type: Plasma

Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseases.
Authors: Hartl D, Krauss-Etschmann S, Koller B, Hordijk PL, Kuijpers TW, Hoffmann F, Hector A, Eber E, Marcos V, Bittmann I, Eickelberg O, Griese M, Roos D
J. Immunol., 2008;181(11):8053-67.
Species: Human
Sample Type: BALF

Isolation and characterization of CD146+ multipotent mesenchymal stromal cells.
Authors: Sorrentino A, Ferracin M, Castelli G, Biffoni M, Tomaselli G, Baiocchi M, Fatica A, Negrini M, Peschle C, Valtieri M
Exp. Hematol., 2008;36(8):1035-46.
Species: Human
Sample Type: Cell Culture Supernates

Rapid chemotherapy-induced acute endothelial progenitor cell mobilization: implications for antiangiogenic drugs as chemosensitizing agents.
Authors: Shaked Y, Henke E, Roodhart JM, Mancuso P, Langenberg MH, Colleoni M, Daenen LG, Man S, Xu P, Emmenegger U, Tang T, Zhu Z, Witte L, Strieter RM, Bertolini F, Voest EE, Benezra R, Kerbel RS
Cancer Cell, 2008;14(3):263-73.

Tissue engineering for full-thickness burns: a dermal substitute from bench to bedside.
Authors: Kellouche S, Martin C, Korb G, Rezzonico R, Bouard D, Benbunan M, Dubertret L, Soler C, Legrand C, Dosquet C
Biochem. Biophys. Res. Commun., 2007;363(3):472-8.
Species: Human
Sample Type: Cell Culture Supernates

Cross-talk between paracrine-acting cytokine and chemokine pathways promotes malignancy in benign human prostatic epithelium.
Authors: Ao M, Franco OE, Park D, Raman D, Williams K, Hayward SW
Cancer Res., 2007;67(9):4244-53.
Species: Human
Sample Type: Cell Culture Supernates

Fucoidan ingestion increases the expression of CXCR4 on human CD34+ cells.
Authors: Irhimeh MR, Fitton JH, Lowenthal RM
Exp. Hematol., 2007;35(6):989-94.

Tumor necrosis factor alpha as a new target for renal cell carcinoma: two sequential phase II trials of infliximab at standard and high dose.
Authors: Harrison ML, Obermueller E, Maisey NR, Hoare S, Edmonds K, Li NF, Chao D, Hall K, Lee C, Timotheadou E, Charles K, Ahern R, King DM, Eisen T, Corringham R, DeWitte M, Balkwill F, Gore M
J. Clin. Oncol., 2007;25(29):4542-9.
Species: Human
Sample Type: Plasma

Role of the CXCL12/CXCR4 axis in peritoneal carcinomatosis of gastric cancer.
Authors: Yasumoto K, Koizumi K, Kawashima A, Saitoh Y, Arita Y, Shinohara K, Minami T, Nakayama T, Sakurai H, Takahashi Y, Yoshie O, Saiki I
Cancer Res., 2006;66(4):2181-7.
Species: Human
Sample Type: Ascites

Importance of recruitment of bone marrow-derived CXCR4+ cells in post-infarct cardiac repair mediated by G-CSF.
Authors: Misao Y, Takemura G, Arai M, Ohno T, Onogi H, Takahashi T, Minatoguchi S, Fujiwara T, Fujiwara H
Cardiovasc. Res., 2006;71(3):455-65.
Species: Rabbit
Sample Type: Serum

Serum levels of syndecan-1 in B-cell chronic lymphocytic leukemia: correlation with the extent of angiogenesis and disease-progression risk in early disease.
Authors: Molica S, Vitelli G, Mirabelli R, Digiesu G, Giannarelli D, Cuneo A, Ribatti D, Vacca A
Leuk. Lymphoma, 2006;47(6):1034-40.
Species: Human
Sample Type: Serum

Recruitment of osteoclast precursors by stromal cell derived factor-1 (SDF-1) in giant cell tumor of bone.
Authors: Liao TS, Yurgelun MB, Chang SS, Zhang HZ, Murakami K, Blaine TA, Parisien MV, Kim W, Winchester RJ, Lee FY
J. Orthop. Res., 2005;23(1):203-9.
Species: Human
Sample Type: Cell Culture Supernates

IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis.
Authors: Numasaki M, Watanabe M, Suzuki T, Takahashi H, Nakamura A, McAllister F, Hishinuma T, Goto J, Lotze MT, Kolls JK, Sasaki H
J. Immunol., 2005;175(9):6177-89.
Species: Human
Sample Type: Cell Culture Supernates

SDF-1 is both necessary and sufficient to promote proliferative retinopathy.
Authors: Butler JM, Guthrie SM, Koc M, Afzal A, Caballero S, Brooks HL, Mames RN, Segal MS, Grant MB, Scott EW
J. Clin. Invest., 2005;115(1):86-93.
Species: Human
Sample Type: Vitreous Humor

Natural killer T cells infiltrate neuroblastomas expressing the chemokine CCL2.
Authors: Metelitsa LS, Wu HW, Wang H, Yang Y, Warsi Z, Asgharzadeh S, Groshen S, Wilson SB, Seeger RC
J. Exp. Med., 2004;199(9):1213-21.
Species: Human
Sample Type: Cell Culture Supernates

Recapitulation of B cell differentiation in the central nervous system of patients with multiple sclerosis.
Authors: Casazza S, Zappia E, Pistorio A, Gambini C
Proc. Natl. Acad. Sci. U.S.A., 2004;101(30):11064-9.
Species: Human
Sample Type: CSF

Involvement of the CXCL12/CXCR4 pathway in the advanced liver disease that is associated with hepatitis C virus or hepatitis B virus.
Authors: Wald O, Pappo O, Safadi R, Dagan-Berger M, Beider K, Wald H, Franitza S, Weiss I, Avniel S, Boaz P, Hanna J, Zamir G, Eid A, Mandelboim O, Spengler U, Galun E, Peled A
Eur. J. Immunol., 2004;34(4):1164-74.
Species: Human
Sample Type: Plasma

Increased circulating hematopoietic and endothelial progenitor cells in the early phase of acute myocardial infarction.
Authors: Massa M, Rosti V, Ferrario M, Campanelli R, Ramajoli I, Rosso R, De Ferrari GM, Ferlini M, Goffredo L, Bertoletti A, Klersy C, Pecci A, Moratti R, Tavazzi L
Blood, 2004;105(1):199-206.
Species: Human
Sample Type: Plasma

Vitreous levels of vascular endothelial growth factor and stromal-derived factor 1 in patients with diabetic retinopathy and cystoid macular edema before and after intraocular injection of triamcinolone.
Authors: Brooks HL, Caballero S, Newell CK, Steinmetz RL, Watson D, Segal MS, Harrison JK, Scott EW, Grant MB
Arch. Ophthalmol., 2004;122(12):1801-7.
Species: Human
Sample Type: Vitreous Humor

Phenotypic and functional analysis of T cells homing into the CSF of subjects with inflammatory diseases of the CNS.
Authors: Giunti D, Borsellino G, Benelli R, Marchese M, Capello E, Valle MT, Pedemonte E, Noonan D, Albini A, Bernardi G, Mancardi GL, Battistini L, Uccelli A
J. Leukoc. Biol., 2003;73(5):584-90.
Species: Human
Sample Type: CSF

Stromal-derived factor 1 inhibits the cycling of very primitive human hematopoietic cells in vitro and in NOD/SCID mice.
Authors: Cashman J, Clark-Lewis I, Eaves A, Eaves C
Blood, 2002;99(3):792-9.
Species: Human
Sample Type: Cell Culture Supernates

生物活性Cross-reactivity observed with 1 or more available related molecules.Cross-species reactivity not tested.
背景CXCL12/Stromal Cell-derived Factor 1 (SDF-1) is a member of the CXC chemokine ligand superfamily. Six alternatively spliced CXCL12/SDF-1 isoforms have been identified including, CXCL12/SDF-1 alpha, CXCL12/SDF-1 beta, and CXCL12/SDF-1 gamma. CXCL12/SDF-1 alpha is 89 amino acids (aa) in length with a predicted molecular weight of 10 kDa, CXCL12/SDF-1 beta is 93 aa in length with a predicted molecular weight of 10.6 kDa, and CXCL12/SDF-1 gamma is 119 aa in length with a predicted molecular weight of 13.7 kDa. The mouse CXCL12/SDF-1 orthologs share 99% aa sequence identity with the human protein. The alpha and beta isoforms are ubiquitously expressed while the gamma isoform is primarily expressed in the heart. CXCL12/SDF-1 isoforms are chemotactic for T lymphocytes and monocytes. It is cardio protective and has also been shown to hinder CXCR4-mediated HIV infection of T cells.
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参考文献
  • B Cell Chemotaxis, Migration, and Adhesion
  • Chemokines and Receptors
  • CXC Chemokines and Receptors
  • Hepatic Endoderm
  • Infectious Diseases
  • Neuroinflammation