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Human sTNF RII/TNFRSF1B Quantikine SixPak (6 Plates) (1 PK)

货号: SRT200 基本售价: 31934.7 元 规格: 1 PACK

产品信息

概述
货号SRT200
描述The Quantikine Human sTNF RII Immunoassay is a 3.5 or 4.5 hour solid phase ELISA designed to measure human sTNF RII in cell culture supernates, serum, plasma, or urine. It contains E. coli-expressed recombinant human sTNF RII as well as antibodies raised against this polypeptide. The recombinant protein represents the non-glycosylated, N-terminal methionyl form of the naturally occurring human soluble Type II receptor for TNF, minus 53 amino acids from the proline-rich region of the protein just exterior to the transmembrane domain, with an apparent molecular weight of approximately 19.8 kDa. This immunoassay has been shown to accurately quantitate the recombinant soluble sTNF RII. Results obtained using natural sTNF RII showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural sTNF RII. Since the measurement of human sTNF RII by this immunoassay is insensitive to added TNF-alpha or TNF-beta, it is probable that this measurement corresponds to the total amount of the soluble receptor present in samples, (i.e. the total amount of free receptor plus the total amount of receptor bound to TNF).
别名CD120b antigen; CD120b; Etanercept; p75 TNF receptor; p75TBPII; p75TNFR; soluble TNFR1B variant 1; TNF RII; TNFBRp80 TNF-alpha receptor; TNF-R2; TNFR2TNFR1B; TNF-R75; TNFR80; TNFRII; TNF-RII; TNF-R-II; TNFR-II; TNFRSF1B; tumor necrosis factor beta receptor; tumor necrosis factor binding protein 2; Tumor necrosis factor receptor 2; tumor necrosis factor receptor superfamily member 1B; tumor necrosis factor receptor superfamily, member 1B; Tumor necrosis factor receptor type II;
全称
Tumor Necrosis Factor Receptor II
反应种属Human
目标/特异性Natural and recombinant human sTNF RII
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs
7133 (Human); 21938 (Mouse); 156767 (Rat)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Inflammatory Markers and the Risk of Hip and Vertebral Fractures in Men: the Osteoporotic Fractures in Men (MrOS)
J Bone Miner Res, 2016;0(0):.
Species: Human
Sample Type: Serum

Local TNF causes NFATc1-dependent cholesterol-mediated podocyte injury
J Clin Invest, 2016;0(0):.
Species: Human
Sample Type: Serum

Altered Monocyte and Endothelial Cell Adhesion Molecule Expression Is Linked to Vascular Inflammation in Human Immunodeficiency Virus Infection
Authors: M Kulkarni, E Bowman, J Gabriel, T Amburgy, E Mayne, DA Zidar, C Maierhofer, AN Turner, JA Bazan, SL Koletar, MM Lederman, SF Sieg, NT Funderburg
Open Forum Infect Dis, 2016;3(4):ofw224.
Species: Human
Sample Type: Plasma

Association between serum soluble tumor necrosis factor-? receptors and early childhood obesity
Authors: S Ouyang, W Li, Z Liu, Y Li, S Li, J Wu
Endocr J, 2016;0(0):.
Species: Human
Sample Type: Serum

Stability of cytokines, chemokines and soluble activation markers in unprocessed blood stored under different conditions
Cytokine, 2016;84(0):17-24.
Species: Human
Sample Type: Plasma

Prevalent peripheral arterial disease and inflammatory burden
BMC Geriatr, 2016;16(1):213.
Species: Human
Sample Type: Serum

Anti-Drug Antibodies, Drug Levels, Interleukin-6 and Soluble TNF Receptors in Rheumatoid Arthritis Patients during the First 6 Months of Treatment with Adalimumab or Infliximab: A Descriptive Cohort Study
PLoS ONE, 2016;11(9):e0162316.
Species: Human
Sample Type: Serum

Anti-TNF-? Drugs Differently Affect the TNF?-sTNFR System and Monocyte Subsets in Patients with Psoriasis
PLoS ONE, 2016;11(12):e0167757.
Species: Human
Sample Type: Plasma

Reliability of Potential Pain Biomarkers in the Saliva of Healthy Subjects: Inter-Individual Differences and Intersession Variability
PLoS ONE, 2016;11(12):e0166976.
Species: Human
Sample Type: Saliva

Circulating TNF receptors 1 and 2 are associated with the severity of renal interstitial fibrosis in IgA nephropathy.
Authors: Sonoda Y, Gohda T, Suzuki Y, Omote K, Ishizaka M, Matsuoka J, Tomino Y
PLoS ONE, 2015;10(4):e0122212.
Species: Human
Sample Type: Serum

Plasma TNF-alpha and Soluble TNF Receptor Levels after Doxorubicin with or without Co-Administration of Mesna-A Randomized, Cross-Over Clinical Study.
Authors: Hayslip J, Dressler E, Weiss H, Taylor T, Chambers M, Noel T, Miriyala S, Keeney J, Ren X, Sultana R, Vore M, Butterfield D, St Clair D, Moscow J
PLoS ONE, 2015;10(4):e0124988.
Species: Human
Sample Type: Plasma

Late Antiretroviral Therapy (ART) Initiation Is Associated with Long-Term Persistence of Systemic Inflammation and Metabolic Abnormalities.
Authors: Ghislain M, Bastard J, Meyer L, Capeau J, Fellahi S, Gerard L, May T, Simon A, Vigouroux C, Goujard C
PLoS ONE, 2015;10(12):e0144317.
Species: Human
Sample Type: Serum

A case-control study of pre-operative levels of serum neutrophil gelatinase-associated lipocalin and other potential inflammatory markers in colorectal cancer.
Authors: Duvillard L, Ortega-Deballon P, Bourredjem A, Scherrer M, Mantion G, Delhorme J, Deguelte-Lardiere S, Petit J, Bonithon-Kopp C
BMC Cancer, 2014;14(0):912.
Species: Human
Sample Type: Serum

Circulating levels of tumor necrosis factor-alpha receptor 2 are increased in heart failure with preserved ejection fraction relative to heart failure with reduced ejection fraction: evidence for a divergence in pathophysiology.
Authors: Putko B, Wang Z, Lo J, Anderson T, Becher H, Dyck J, Kassiri Z, Oudit G
PLoS ONE, 2014;9(6):e99495.
Species: Human
Sample Type: Plasma

Negative and competitive social interactions are related to heightened proinflammatory cytokine activity.
Authors: Chiang JJ, Eisenberger NI, Seeman TE, Taylor SE
Proc. Natl. Acad. Sci. U.S.A., 2012;109(6):1878-82.
Species: Human
Sample Type: Plasma

Inflammatory markers and the risk of hip fracture: the Women's Health Initiative.
Authors: Barbour KE, Boudreau R, Danielson ME, Youk AO, Wactawski-Wende J, Greep NC, LaCroix AZ, Jackson RD, Wallace RB, Bauer DC, Allison MA, Cauley JA
J. Bone Miner. Res., 2012;27(5):1167-76.
Species: Human
Sample Type: Serum

Compensated inflammation in systemic juvenile idiopathic arthritis: role of alternatively activated macrophages.
Authors: Shimizu M, Yachie A
Cytokine, 2012;60(1):226-32.
Species: Human
Sample Type: Serum

Inflammation marker and risk of pancreatic cancer: a nested case-control study within the EPIC cohort.
Authors: Grote VA, Kaaks R, Nieters A, Tjonneland A, Halkjaer J, Overvad K, Skjelbo Nielsen MR, Boutron-Ruault MC, Clavel-Chapelon F, Racine A, Teucher B, Becker S, Pischon T, Boeing H, Trichopoulou A, Cassapa C, Stratigakou V, Palli D, Krogh V, Tumino R, Vineis P, Panico S, Rodriguez L, Duell EJ, Sanchez MJ, Dorronsoro M, Navarro C, Gurrea AB, Siersema PD, Peeters PH, Ye W, Sund M, Lindkvist B, Johansen D, Khaw KT, Wareham N, Allen NE, Travis RC, Fedirko V, Jenab M, Michaud DS, Chuang SC, Romaguera D, Bueno-de-Mesquita HB, Rohrmann S
Br. J. Cancer, 2012;106(11):1866-74.
Species: Human
Sample Type: Serum

Elevated CSF levels of TACE activity and soluble TNF receptors in subjects with mild cognitive impairment and patients with Alzheimer's disease.
Authors: Jiang H, Hampel H, Prvulovic D, Wallin A, Blennow K, Li R, Shen Y
Mol Neurodegener, 2011;6(0):69.
Species: Human
Sample Type: CSF

Procalcitonin as an early marker of bacterial infection in neutropenic febrile children with acute lymphoblastic leukemia.
Authors: Hatzistilianou M, Rekliti A, Athanassiadou F, Catriu D
Inflamm. Res., 2010;59(5):339-47.
Species: Human
Sample Type: Serum

Adrenomedullin and endothelin-1 are related to inflammation in chronic heart failure.
Authors: Gombos T, Forhecz Z, Pozsonyi Z, Wallentin S, Papassotiriou J, Kunde J, Morgenthaler NG, Janoskuti L, Prohaszka Z
Inflamm. Res., 2009;58(6):298-305.
Species: Human
Sample Type: Serum

Biomarkers of inflammation and development of rheumatoid arthritis in women from two prospective cohort studies.
Authors: Karlson EW, Chibnik LB, Tworoger SS, Lee IM, Buring JE, Shadick NA, Manson JE, Costenbader KH
Arthritis Rheum., 2009;60(3):641-52.
Species: Human
Sample Type: Plasma

Neurobiological correlates of coping through emotional approach.
Authors: Master SL, Amodio DM, Stanton AL, Yee CM, Hilmert CJ, Taylor SE
Brain Behav. Immun., 2009;23(1):27-35.
Species: Human
Sample Type: Saliva

Cross-sectional relations of multiple inflammatory biomarkers to peripheral arterial disease: The Framingham Offspring Study.
Authors: Murabito JM, Keyes MJ, Guo CY, Keaney JF, Vasan RS, DAgostino RB, Benjamin EJ
Atherosclerosis, 2009;203(2):509-14.
Species: Human
Sample Type: Plasma

Comparing Type D personality and older age as correlates of tumor necrosis factor-alpha dysregulation in chronic heart failure.
Authors: Denollet J, Vrints CJ, Conraads VM
Brain Behav. Immun., 2008;22(5):736-43.
Species: Human
Sample Type: Plasma

Selective functional exhaustion of hematopoietic progenitor cells in the bone marrow of patients with postinfarction heart failure.
Authors: Kissel CK, Lehmann R, Assmus B, Aicher A, Honold J, Fischer-Rasokat U, Heeschen C, Spyridopoulos I, Dimmeler S, Zeiher AM
J. Am. Coll. Cardiol., 2007;49(24):2341-9.
Species: Human
Sample Type: Serum

Serum interleukin-18 and soluble tumour necrosis factor receptor 2 are associated with disease severity in patients with paracoccidioidomycosis.
Authors: Corvino CL, Mamoni RL, Fagundes GZ, Blotta MH
Clin. Exp. Immunol., 2007;147(3):483-90.
Species: Human
Sample Type: Serum

Muscle atrophy and hypertrophy signaling in patients with chronic obstructive pulmonary disease.
Authors: Doucet M, Russell AP, Leger B, Debigare R, Joanisse DR, Caron MA, LeBlanc P, Maltais F
Am. J. Respir. Crit. Care Med., 2007;176(3):261-9.
Species: Human
Sample Type: Plasma

Inflammatory markers and incident fracture risk in older men and women: the Health Aging and Body Composition Study.
Authors: Cauley JA, Danielson ME, Boudreau RM, Forrest KY, Zmuda JM, Pahor M, Tylavsky FA, Cummings SR, Harris TB, Newman AB
J. Bone Miner. Res., 2007;22(7):1088-95.
Species: Human
Sample Type: Serum

Human intestinal intraepithelial lymphocytes keep TNF alpha levels low by cell uptake and feedback inhibition of transcription.
Authors: Ebert EC, Mehta V
Cell. Immunol., 2006;241(1):7-13.
Species: Human
Sample Type: Cell Culture Supernates

Proinflammatory cytokines, insulin resistance, and insulin secretion in chronic hepatitis C patients: A case-control study.
Authors: Lecube A, Hernandez C, Genesca J, Simo R
Diabetes Care, 2006;29(5):1096-101.
Species: Human
Sample Type: Serum

Changes in HIV RNA viral load, CD4+ T-cell counts, and levels of immune activation markers associated with anti-tuberculosis therapy and cotrimoxazole prophylaxis among HIV-infected tuberculosis patients in Abidjan, Cote d'Ivoire.
Authors: Kalou M, Sassan-Morokro M, Abouya L, Bile C, Maurice C, Maran M, Tossou O, Roels T, Greenberg AE, Wiktor SZ, Nkengasong JN
J. Med. Virol., 2005;75(2):202-8.
Species: Human
Sample Type: Serum

Experimental heatstroke in baboon: analysis of the systemic inflammatory response.
Authors: Bouchama A, Ollivier V, Roberts G, Al Mohanna F, de Prost D, Eldali A, Saussereau E, El-Sayed R, Chollet-Martin S
Shock, 2005;24(4):332-5.
Species: Primate- Papio hamadryas (Hamadyras Baboon)
Sample Type: Plasma

Levels of soluble cytokine factors in temporomandibular joint effusions seen on magnetic resonance images.
Authors: Kaneyama K, Segami N, Sun W, Sato J, Fujimura K
Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2005;99(4):411-8.
Species: Human
Sample Type: Synovial Fluid

Regulation of peritoneal and systemic neutrophil-derived tumor necrosis factor-alpha release in patients with severe peritonitis: role of tumor necrosis factor-alpha converting enzyme cleavage.
Authors: Kermarrec N, Selloum S, Plantefeve G, Chosidow D, Paoletti X, Lopez A, Mantz J, Desmonts JM, Gougerot-Pocidalo MA, Chollet-Martin S
Crit. Care Med., 2005;33(6):1359-64.
Species: Human
Sample Type: Cell Culture Supernates

Analysis of tumor necrosis factor-alpha, interleukin-6, interleukin-1beta, soluble tumor necrosis factor receptors I and II, interleukin-6 soluble receptor, interleukin-1 soluble receptor type II, interleukin-1 receptor antagonist, and protein in the synovial fluid of patients with temporomandibular joint disorders.
Authors: Kaneyama K, Segami N, Sun W, Sato J, Fujimura K
Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2005;99(3):276-84.
Species: Human
Sample Type: Synovial Fluid

Growth hormone-induced reduction of soluble apoptosis mediators is associated with reverse cardiac remodelling and improvement of exercise capacity in patients with idiopathic dilated cardiomyopathy.
Authors: Parissis JT, Adamopoulos S, Karatzas D, Paraskevaidis J, Livanis E, Kremastinos D
Eur J Cardiovasc Prev Rehabil, 2005;12(2):164-8.
Species: Human
Sample Type: Plasma

Pro- and anti-inflammatory responses in respiratory syncytial virus bronchiolitis.
Authors: McNamara PS, Flanagan BF, Selby AM, Hart CA, Smyth RL
Eur. Respir. J., 2004;23(1):106-12.
Species: Human
Sample Type: BALF

Immunological effects of induced shame and guilt.
Authors: Dickerson SS, Kemeny ME, Aziz N, Kim KH, Fahey JL
Psychosom Med, 2004;66(1):124-31.
Species: Human
Sample Type: Saliva

Arenavirus-mediated liver pathology: acute lymphocytic choriomeningitis virus infection of rhesus macaques is characterized by high-level interleukin-6 expression and hepatocyte proliferation.
Authors: Lukashevich IS, Tikhonov I, Rodas JD, Zapata JC, Yang Y, Djavani M, Salvato MS
J. Virol., 2003;77(3):1727-37.
Species: Primate - Macaca mulatta (Rhesus monkey)
Sample Type: Serum

Functional and phenotypic changes in circulating lymphocytes from hospitalized zambian children with measles.
Authors: Ryon JJ, Moss WJ, Monze M, Griffin DE
Clin. Diagn. Lab. Immunol., 2002;9(5):994-1003.
Species: Human
Sample Type: Plasma

Age-related autoantibody production in a nonhuman primate model.
Authors: Attanasio R, Brasky KM, Robbins SH, Jayashankar L, Nash RJ, Butler TM
Clin. Exp. Immunol., 2001;123(3):361-5.
Species: Primate-Papio cynocephalus anubis (baboon)
Sample Type: Serum

Tumour necrosis factor alpha and its soluble receptors in juvenile chronic arthritis.
Authors: Rooney M, Varsani H, Martin K, Lombard PR, Dayer JM, Woo P
Rheumatology (Oxford), 2000;39(4):432-8.
Species: Human
Sample Type: Serum

An analysis of 14 molecular markers for monitoring osteoarthritis: segregation of the markers into clusters and distinguishing osteoarthritis at baseline.
Authors: Otterness IG, Swindell AC, Zimmerer RO, Poole AR, Ionescu M, Weiner E
Osteoarthr. Cartil., 2000;8(3):180-5.
Species: Human
Sample Type: Serum

生物活性< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景TNF RII (Tumor Necrosis Factor Receptor II), also known as TNFRSF1B, p75/p80, and CD120b, is a widely expressed receptor for membrane-associated TNF-alpha and Lymphotoxin-alpha. Its activation initiates pro-inflammatory and pro-survival responses via NFkB-dependent signaling pathways, although it may also induce apoptosis.
运输条件Blue Ice
存放说明4℃
参考文献
  • Adipocytokines
  • Cell Structure and Signaling Molecules
  • Co-stimulatory and Co-inhibitory Molecules
  • Cytokines and Receptors in Allergy and Asthma
  • Cytokines and Receptors in Angiogenesis
  • Cytokines in Lipid/Cholesterol Metabolism
  • Diabetes
  • Diabetic Peripheral Neuropathy
  • Endothelial Cell Markers
  • Neuroinflammation
  • Obesity
  • Regulation of Apoptosis by TNF Superfamily Members
  • Regulation of Natural Killer Cell Co-stimulation by TNF Superfamily Members
  • Regulation of T Cell Co-stimulation by TNF Superfamily Members
  • Regulatory T Cells (Tregs)
  • T Cell Cytokine Signaling
  • TNF Superfamily
  • TNF Superfamily Receptors