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Human sTNF RI/TNFRSF1A Quantikine SixPak (6 Plates) (1 PK)

货号: SRT100 基本售价: 31934.7 元 规格: 1 PACK

产品信息

概述
货号SRT100
描述The Quantikine Human sTNF RI Immunoassay is a 4.5 hour solid phase ELISA designed to measure sTNF RI in cell culture supernates, serum, plasma, and urine. It contains E. coli-expressed recombinant human sTNF RI, as well as antibodies raised against this polypeptide. The recombinant protein represents the non-glycosylated, N-terminal methionyl form of the naturally occurring human soluble Type I receptor for TNF with an apparent molecular weight of approximately 18.6 kDa. This immunoassay has been shown to accurately quantitate the recombinant sTNF RI. Results obtained on samples containing natural sTNF RI showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values of natural sTNF RI. Since the measurement of human sTNF RI by this immunoassay is relatively insensitive to added TNF-alpha or TNF-beta, it is probable that this measurement corresponds to the total amount of the soluble receptor present in samples (i.e. the total amount of free receptor plus the total amount of receptor bound to TNF).
别名CD120a antigen; CD120a; FPF; p55; p55-R; p60; TNF RI; TNFARMGC19588; TNF-R; TNF-R1; TNFR1TBP1; TNFR55; TNF-R55; TNFR60; TNFRI; TNF-RI; TNF-R-I; TNFR-I; TNFRSF1A; tumor necrosis factor binding protein 1; Tumor necrosis factor receptor 1; tumor necrosis factor receptor 1A isoform beta; tumor necrosis factor receptor superfamily member 1A; tumor necrosis factor receptor superfamily, member 1A; tumor necrosis factor receptor type 1; Tumor necrosis factor receptor type I; tumor necrosis factor-alpha receptor;
全称
Tumor Necrosis Factor Receptor I
反应种属Human
目标/特异性Natural and recombinant human sTNF RI
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs
7132 (Human); 21937 (Mouse); 25625 (Rat); 102135285 (Cynomolgus Monkey)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Anti-TNF-? Drugs Differently Affect the TNF?-sTNFR System and Monocyte Subsets in Patients with Psoriasis
PLoS ONE, 2016;11(12):e0167757.
Species: Human
Sample Type: Plasma

Prevalent peripheral arterial disease and inflammatory burden
BMC Geriatr, 2016;16(1):213.
Species: Human
Sample Type: Serum

Association between serum soluble tumor necrosis factor-? receptors and early childhood obesity
Authors: S Ouyang, W Li, Z Liu, Y Li, S Li, J Wu
Endocr J, 2016;0(0):.
Species: Human
Sample Type: Serum

Inflammatory Markers and the Risk of Hip and Vertebral Fractures in Men: the Osteoporotic Fractures in Men (MrOS)
J Bone Miner Res, 2016;0(0):.
Species: Human
Sample Type: Serum

Local TNF causes NFATc1-dependent cholesterol-mediated podocyte injury
J Clin Invest, 2016;0(0):.
Species: Human
Sample Type: Serum

Altered Monocyte and Endothelial Cell Adhesion Molecule Expression Is Linked to Vascular Inflammation in Human Immunodeficiency Virus Infection
Authors: M Kulkarni, E Bowman, J Gabriel, T Amburgy, E Mayne, DA Zidar, C Maierhofer, AN Turner, JA Bazan, SL Koletar, MM Lederman, SF Sieg, NT Funderburg
Open Forum Infect Dis, 2016;3(4):ofw224.
Species: Human
Sample Type: Plasma

Anti-Drug Antibodies, Drug Levels, Interleukin-6 and Soluble TNF Receptors in Rheumatoid Arthritis Patients during the First 6 Months of Treatment with Adalimumab or Infliximab: A Descriptive Cohort Study
PLoS ONE, 2016;11(9):e0162316.
Species: Human
Sample Type: Serum

Late Antiretroviral Therapy (ART) Initiation Is Associated with Long-Term Persistence of Systemic Inflammation and Metabolic Abnormalities.
Authors: Ghislain M, Bastard J, Meyer L, Capeau J, Fellahi S, Gerard L, May T, Simon A, Vigouroux C, Goujard C
PLoS ONE, 2015;10(12):e0144317.
Species: Human
Sample Type: Serum

T. vaginalis Infection Is Associated with Increased IL-8 and TNFr1 Levels but with the Absence of CD38 and HLADR Activation in the Cervix of ESN.
Authors: Jarrett O, Brady K, Modur S, Plants J, Landay A, Ghassemi M, Golub E, Spear G, Novak R
PLoS ONE, 2015;10(6):e0130146.
Species: Human
Sample Type: Cervical Fluid

Plasma TNF-alpha and Soluble TNF Receptor Levels after Doxorubicin with or without Co-Administration of Mesna-A Randomized, Cross-Over Clinical Study.
Authors: Hayslip J, Dressler E, Weiss H, Taylor T, Chambers M, Noel T, Miriyala S, Keeney J, Ren X, Sultana R, Vore M, Butterfield D, St Clair D, Moscow J
PLoS ONE, 2015;10(4):e0124988.
Species: Human
Sample Type: Plasma

Circulating TNF receptors 1 and 2 are associated with the severity of renal interstitial fibrosis in IgA nephropathy.
Authors: Sonoda Y, Gohda T, Suzuki Y, Omote K, Ishizaka M, Matsuoka J, Tomino Y
PLoS ONE, 2015;10(4):e0122212.
Species: Human
Sample Type: Serum

A case-control study of pre-operative levels of serum neutrophil gelatinase-associated lipocalin and other potential inflammatory markers in colorectal cancer.
Authors: Duvillard L, Ortega-Deballon P, Bourredjem A, Scherrer M, Mantion G, Delhorme J, Deguelte-Lardiere S, Petit J, Bonithon-Kopp C
BMC Cancer, 2014;14(0):912.
Species: Human
Sample Type: Serum

The expression of cytokines and chemokines in the blood of patients with severe weight loss from anorexia nervosa: an exploratory study.
Authors: Pisetsky D, Trace S, Brownley K, Hamer R, Zucker N, Roux-Lombard P, Dayer J, Bulik C
Cytokine, 2014;69(1):110-5.
Species: Human
Sample Type: Cell Culture Supernates

Circulating levels of tumor necrosis factor-alpha receptor 2 are increased in heart failure with preserved ejection fraction relative to heart failure with reduced ejection fraction: evidence for a divergence in pathophysiology.
Authors: Putko B, Wang Z, Lo J, Anderson T, Becher H, Dyck J, Kassiri Z, Oudit G
PLoS ONE, 2014;9(6):e99495.
Species: Human
Sample Type: Plasma

Risk of ESRD and all cause mortality in type 2 diabetes according to circulating levels of FGF-23 and TNFR1.
Authors: Lee J, Gohda T, Walker W, Skupien J, Smiles A, Holak R, Jeong J, McDonnell K, Krolewski A, Niewczas M
PLoS ONE, 2013;8(3):e58007.
Species: Human
Sample Type: Plasma

IL-18-based combinatorial adjuvants promote the intranodal production of CCL19 by NK cells and dendritic cells of cancer patients.
Authors: Wong J, Muthuswamy R, Bartlett D, Kalinski P
Oncoimmunology, 2013;2(9):e26245.
Species: Human
Sample Type: Whole Cells

Dynamics of immune reconstitution and activation markers in HIV+ treatment-naive patients treated with raltegravir, tenofovir disoproxil fumarate and emtricitabine.
Authors: Funderburg N, Andrade A, Chan E, Rosenkranz S, Lu D, Clagett B, Pilch-Cooper H, Rodriguez B, Feinberg J, Daar E, Mellors J, Kuritzkes D, Jacobson J, Lederman M
PLoS ONE, 2013;8(12):e83514.
Species: Human
Sample Type: Plasma

Inflammatory markers and the risk of hip fracture: the Women's Health Initiative.
Authors: Barbour KE, Boudreau R, Danielson ME, Youk AO, Wactawski-Wende J, Greep NC, LaCroix AZ, Jackson RD, Wallace RB, Bauer DC, Allison MA, Cauley JA
J. Bone Miner. Res., 2012;27(5):1167-76.
Species: Human
Sample Type: Serum

Compensated inflammation in systemic juvenile idiopathic arthritis: role of alternatively activated macrophages.
Authors: Shimizu M, Yachie A
Cytokine, 2012;60(1):226-32.
Species: Human
Sample Type: Serum

Inflammation marker and risk of pancreatic cancer: a nested case-control study within the EPIC cohort.
Authors: Grote VA, Kaaks R, Nieters A, Tjonneland A, Halkjaer J, Overvad K, Skjelbo Nielsen MR, Boutron-Ruault MC, Clavel-Chapelon F, Racine A, Teucher B, Becker S, Pischon T, Boeing H, Trichopoulou A, Cassapa C, Stratigakou V, Palli D, Krogh V, Tumino R, Vineis P, Panico S, Rodriguez L, Duell EJ, Sanchez MJ, Dorronsoro M, Navarro C, Gurrea AB, Siersema PD, Peeters PH, Ye W, Sund M, Lindkvist B, Johansen D, Khaw KT, Wareham N, Allen NE, Travis RC, Fedirko V, Jenab M, Michaud DS, Chuang SC, Romaguera D, Bueno-de-Mesquita HB, Rohrmann S
Br. J. Cancer, 2012;106(11):1866-74.
Species: Human
Sample Type: Serum

Cytokine Response Patterns in Severe Pandemic 2009 H1N1 and Seasonal Influenza among Hospitalized Adults.
Authors: Lee N, Wong CK, Chan PK, Chan MC, Wong RY, Lun SW, Ngai KL, Lui GC, Wong BC, Lee SK, Choi KW, Hui DS
PLoS ONE, 2011;6(10):e26050.
Species: Human
Sample Type: Plasma

Elevated CSF levels of TACE activity and soluble TNF receptors in subjects with mild cognitive impairment and patients with Alzheimer's disease.
Authors: Jiang H, Hampel H, Prvulovic D, Wallin A, Blennow K, Li R, Shen Y
Mol Neurodegener, 2011;6(0):69.
Species: Human
Sample Type: CSF

Matrix metalloproteinase-9 and plasminogen activator inhibitor-1 are associated with right ventricular structure and function: the MESA-RV Study.
Authors: Kawut SM, Barr RG, Johnson WC
Biomarkers, 2010;15(8):731-8.
Species: Human
Sample Type: Plasma

Adrenomedullin and endothelin-1 are related to inflammation in chronic heart failure.
Authors: Gombos T, Forhecz Z, Pozsonyi Z, Wallentin S, Papassotiriou J, Kunde J, Morgenthaler NG, Janoskuti L, Prohaszka Z
Inflamm. Res., 2009;58(6):298-305.
Species: Human
Sample Type: Serum

Change in plasma tumor necrosis factor receptor 1 levels in the first week after myeloablative allogeneic transplantation correlates with severity and incidence of GVHD and survival.
Authors: Choi SW, Kitko CL, Braun T, Paczesny S, Yanik G, Mineishi S, Krijanovski O, Jones D, Whitfield J, Cooke K, Hutchinson RJ, Ferrara JL, Levine JE
Blood, 2008;112(4):1539-42.
Species: Human
Sample Type: Plasma

Comparing Type D personality and older age as correlates of tumor necrosis factor-alpha dysregulation in chronic heart failure.
Authors: Denollet J, Vrints CJ, Conraads VM
Brain Behav. Immun., 2008;22(5):736-43.
Species: Human
Sample Type: Plasma

Selective effects of CPAP on sleep apnoea-associated manifestations.
Authors: Vgontzas AN, Zoumakis E, Bixler EO, Lin HM, Collins B, Basta M, Pejovic S, Chrousos GP
Eur. J. Clin. Invest., 2008;38(8):585-95.
Species: Human
Sample Type: Plasma

Microparticles of human atherosclerotic plaques enhance the shedding of the tumor necrosis factor-alpha converting enzyme/ADAM17 substrates, tumor necrosis factor and tumor necrosis factor receptor-1.
Authors: Canault M, Leroyer AS, Peiretti F, Leseche G, Tedgui A, Bonardo B, Alessi MC, Boulanger CM, Nalbone G
Am. J. Pathol., 2007;171(5):1713-23.
Species: Human
Sample Type: Cell Culture Supernates

Selective functional exhaustion of hematopoietic progenitor cells in the bone marrow of patients with postinfarction heart failure.
Authors: Kissel CK, Lehmann R, Assmus B, Aicher A, Honold J, Fischer-Rasokat U, Heeschen C, Spyridopoulos I, Dimmeler S, Zeiher AM
J. Am. Coll. Cardiol., 2007;49(24):2341-9.
Species: Human
Sample Type: Serum

Muscle atrophy and hypertrophy signaling in patients with chronic obstructive pulmonary disease.
Authors: Doucet M, Russell AP, Leger B, Debigare R, Joanisse DR, Caron MA, LeBlanc P, Maltais F
Am. J. Respir. Crit. Care Med., 2007;176(3):261-9.
Species: Human
Sample Type: Plasma

Inflammatory markers and incident fracture risk in older men and women: the Health Aging and Body Composition Study.
Authors: Cauley JA, Danielson ME, Boudreau RM, Forrest KY, Zmuda JM, Pahor M, Tylavsky FA, Cummings SR, Harris TB, Newman AB
J. Bone Miner. Res., 2007;22(7):1088-95.
Species: Human
Sample Type: Serum

Serum interleukin-18 and soluble tumour necrosis factor receptor 2 are associated with disease severity in patients with paracoccidioidomycosis.
Authors: Corvino CL, Mamoni RL, Fagundes GZ, Blotta MH
Clin. Exp. Immunol., 2007;147(3):483-90.
Species: Human
Sample Type: Serum

Proinflammatory cytokines, insulin resistance, and insulin secretion in chronic hepatitis C patients: A case-control study.
Authors: Lecube A, Hernandez C, Genesca J, Simo R
Diabetes Care, 2006;29(5):1096-101.
Species: Human
Sample Type: Serum

Neutrophils from patients with TNFRSF1A mutations display resistance to tumor necrosis factor-induced apoptosis: pathogenetic and clinical implications.
Authors: D'Osualdo A
Arthritis Rheum., 2006;54(3):998-1008.
Species: Human
Sample Type: Cell Culture Supernates

Regulation of peritoneal and systemic neutrophil-derived tumor necrosis factor-alpha release in patients with severe peritonitis: role of tumor necrosis factor-alpha converting enzyme cleavage.
Authors: Kermarrec N, Selloum S, Plantefeve G, Chosidow D, Paoletti X, Lopez A, Mantz J, Desmonts JM, Gougerot-Pocidalo MA, Chollet-Martin S
Crit. Care Med., 2005;33(6):1359-64.
Species: Human
Sample Type: Cell Culture Supernates

Growth hormone-induced reduction of soluble apoptosis mediators is associated with reverse cardiac remodelling and improvement of exercise capacity in patients with idiopathic dilated cardiomyopathy.
Authors: Parissis JT, Adamopoulos S, Karatzas D, Paraskevaidis J, Livanis E, Kremastinos D
Eur J Cardiovasc Prev Rehabil, 2005;12(2):164-8.
Species: Human
Sample Type: Plasma

Levels of soluble cytokine factors in temporomandibular joint effusions seen on magnetic resonance images.
Authors: Kaneyama K, Segami N, Sun W, Sato J, Fujimura K
Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2005;99(4):411-8.
Species: Human
Sample Type: Synovial Fluid

Effects of the active metabolite of leflunomide, A77 1726, on cytokine release and the MAPK signalling pathway in human rheumatoid arthritis synoviocytes.
Authors: Vergne-Salle</LastName><F P</Initial, Vergne-Salle P, Leger DY, Bertin P, Treves R, Beneytout JL, Liagre B
Cytokine, 2005;31(5):335-48.
Species: Human
Sample Type: Cell Culture Supernates

Analysis of tumor necrosis factor-alpha, interleukin-6, interleukin-1beta, soluble tumor necrosis factor receptors I and II, interleukin-6 soluble receptor, interleukin-1 soluble receptor type II, interleukin-1 receptor antagonist, and protein in the synovial fluid of patients with temporomandibular joint disorders.
Authors: Kaneyama K, Segami N, Sun W, Sato J, Fujimura K
Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2005;99(3):276-84.
Species: Human
Sample Type: Synovial Fluid

Experimental heatstroke in baboon: analysis of the systemic inflammatory response.
Authors: Bouchama A, Ollivier V, Roberts G, Al Mohanna F, de Prost D, Eldali A, Saussereau E, El-Sayed R, Chollet-Martin S
Shock, 2005;24(4):332-5.
Species: Primate- Papio hamadryas (Hamadyras Baboon)
Sample Type: Plasma

Release of full-length 55-kDa TNF receptor 1 in exosome-like vesicles: a mechanism for generation of soluble cytokine receptors.
Authors: Hawari FI, Rouhani FN, Cui X, Yu ZX, Buckley C, Kaler M, Levine SJ
Proc. Natl. Acad. Sci. U.S.A., 2004;101(5):1297-302.
Species: Human
Sample Type: Cell Culture Supernates

Pro- and anti-inflammatory responses in respiratory syncytial virus bronchiolitis.
Authors: McNamara PS, Flanagan BF, Selby AM, Hart CA, Smyth RL
Eur. Respir. J., 2004;23(1):106-12.
Species: Human
Sample Type: BALF

Gene transfer of tumor necrosis factor inhibitor improves the function of lung allografts.
Authors: Tagawa T, Kozower BD, Kanaan SA, Daddi N, Muraoka M, Oka T, Ritter JH, Patterson GA
J. Thorac. Cardiovasc. Surg., 2004;127(6):1558-63.
Species: Human
Sample Type: Tissue Homogenates

Arenavirus-mediated liver pathology: acute lymphocytic choriomeningitis virus infection of rhesus macaques is characterized by high-level interleukin-6 expression and hepatocyte proliferation.
Authors: Lukashevich IS, Tikhonov I, Rodas JD, Zapata JC, Yang Y, Djavani M, Salvato MS
J. Virol., 2003;77(3):1727-37.
Species: Primate - Macaca mulatta (Rhesus monkey)
Sample Type: Serum

Age-related autoantibody production in a nonhuman primate model.
Authors: Attanasio R, Brasky KM, Robbins SH, Jayashankar L, Nash RJ, Butler TM
Clin. Exp. Immunol., 2001;123(3):361-5.
Species: Primate-Papio cynocephalus anubis (baboon)
Sample Type: Serum

Tumour necrosis factor alpha and its soluble receptors in juvenile chronic arthritis.
Authors: Rooney M, Varsani H, Martin K, Lombard PR, Dayer JM, Woo P
Rheumatology (Oxford), 2000;39(4):432-8.
Species: Human
Sample Type: Serum

Proinflammatory cytokines increase in sepsis after anti-adhesion molecule therapy.
Authors: Welty-Wolf KE, Carraway MS, Ghio A, Kantrow SP, Huang YC, Piantadosi CA
Shock, 2000;13(5):404-9.
Species: Primate- Papio cynocephalus (Baboon)
Sample Type: Serum

An analysis of 14 molecular markers for monitoring osteoarthritis: segregation of the markers into clusters and distinguishing osteoarthritis at baseline.
Authors: Otterness IG, Swindell AC, Zimmerer RO, Poole AR, Ionescu M, Weiner E
Osteoarthr. Cartil., 2000;8(3):180-5.
Species: Human
Sample Type: Serum

生物活性< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景TNF RI (TNF receptor 1; TNF R-p55/p60) is a transmembrane receptor for TNF-alpha and Lymphotoxin-alpha/TNF-beta. A soluble decoy form of the receptor is shed by ADAM-17/TACE in response to inflammatory stimulation. TNF RI signaling through NFkB is essential for the development of lymph node germinal centers and Peyer’s patches and for combating intracellular pathogens such as Listeria.
运输条件Blue Ice
存放说明4℃
参考文献
  • Adipocytokines
  • Cell Structure and Signaling Molecules
  • Cytokine and Growth Factor Receptors on VSMC
  • Cytokines and Receptors in Allergy and Asthma
  • Cytokines and Receptors in Angiogenesis
  • Cytokines in Lipid/Cholesterol Metabolism
  • Diabetes
  • Diabetic Peripheral Neuropathy
  • EMT Induction
  • Endothelial Cell Markers
  • Neuroinflammation
  • Obesity
  • Regulation of Apoptosis by TNF Superfamily Members
  • T Cell Cytokine Signaling
  • TNF Superfamily Receptors