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Human IL-1ra/IL-1F3 Quantikine SixPak (6 Plates) (1 PK)

货号: SRA00B 基本售价: 31934.7 元 规格: 1 PACK

产品信息

概述
货号SRA00B
描述The Quantikine Human IL-1ra Immunoassay is a 4.5 hour solid phase ELISA designed to measure IL-1ra in cell culture supernates, serum, and plasma. It contains E. coli-derived recombinant human IL-1ra as well as antibodies raised against the recombinant factor. This immunoassay has been shown to accurately quantitate recombinant human IL-1ra. Results obtained using natural human IL-1ra showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural human IL-1ra.
别名DIRA; ICIL-1RA; IL1F3; IL-1F3; IL1ra; IL-1ra; IL-1ra3; IL1RN; IL-1RN; interleukin 1 receptor antagonist; IRAP; MVCD4;
全称
Interleukin 1 Receptor Antagonist
反应种属Human
目标/特异性Natural and recombinant human IL-1ra
性能
供应商R&D Systems
Entrez Gene IDs
3557 (Human); 16181 (Mouse); 60582 (Rat); 397499 (Porcine)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Lipopolysaccharide-Induced Chorioamnionitis Promotes IL-1-Dependent Inflammatory FOXP3+ CD4+ T Cells in the Fetal Rhesus Macaque
Authors: CM Rueda, P Presicce, CM Jackson, LA Miller, SG Kallapur, AH Jobe, CA Chougnet
J Immunol, 2016;0(0):.
Species: Primate - Rhesus Monkey
Sample Type: Plasma

Stability of cytokines, chemokines and soluble activation markers in unprocessed blood stored under different conditions
Cytokine, 2016;84(0):17-24.
Species: Human
Sample Type: Plasma

IL-1 receptor antagonist reduces endotoxin-induced airway inflammation in healthy volunteers.
Authors: Hernandez M, Mills K, Almond M, Todoric K, Aleman M, Zhang H, Zhou H, Peden D
J Allergy Clin Immunol, 2015;135(2):379-85.
Species: Human
Sample Type: Plasma

The effect of a Diabetes-Specific Cognitive Behavioral Treatment Program (DIAMOS) for patients with diabetes and subclinical depression: results of a randomized controlled trial.
Authors: Hermanns N, Schmitt A, Gahr A, Herder C, Nowotny B, Roden M, Ohmann C, Kruse J, Haak T, Kulzer B
Diabetes Care, 2015;38(4):551-60.
Species: Human
Sample Type: Serum

Crucial role of IL1beta and C3a in the in vitro-response of multipotent mesenchymal stromal cells to inflammatory mediators of polytrauma.
Authors: Hengartner N, Fiedler J, Schrezenmeier H, Huber-Lang M, Brenner R
PLoS ONE, 2015;10(1):e0116772.
Species: Human
Sample Type: Cell Culture Supernates

Differential Patterns and Determinants of Cardiac Autonomic Nerve Dysfunction during Endotoxemia and Oral Fat Load in Humans.
Authors: Ziegler D, Strom A, Strassburger K, Nowotny B, Zahiragic L, Nowotny P, Carstensen-Kirberg M, Herder C, Szendroedi J, Roden M
PLoS ONE, 2015;10(4):e0124242.
Species: Human
Sample Type: Serum

Association between Inflammation and Cardiac Geometry in Chronic Kidney Disease: Findings from the CRIC Study.
Authors: Gupta J, Dominic E, Fink J, Ojo A, Barrows I, Reilly M, Townsend R, Joffe M, Rosas S, Wolman M, Patel S, Keane M, Feldman H, Kusek J, Raj D
PLoS ONE, 2015;10(4):e0124772.
Species: Human
Sample Type: Plasma

The impact of concomitant pulmonary infection on immune dysregulation in Pneumocystis jirovecii pneumonia.
Authors: Chou C, Lin F, Tsai H, Chang S
BMC Pulm Med, 2014;14(0):182.
Species: Human
Sample Type: BALF

Role of diacylglycerol activation of PKCtheta in lipid-induced muscle insulin resistance in humans.
Authors: Szendroedi J, Yoshimura T, Phielix E, Koliaki C, Marcucci M, Zhang D, Jelenik T, Muller J, Herder C, Nowotny P, Shulman G, Roden M
Proc Natl Acad Sci U S A, 2014;111(26):9597-602.
Species: Human
Sample Type: Plasma

The expression of cytokines and chemokines in the blood of patients with severe weight loss from anorexia nervosa: an exploratory study.
Authors: Pisetsky D, Trace S, Brownley K, Hamer R, Zucker N, Roux-Lombard P, Dayer J, Bulik C
Cytokine, 2014;69(1):110-5.
Species: Human
Sample Type: Cell Culture Supernates

Race modifies the association between adiposity and inflammation in patients with chronic kidney disease: findings from the chronic renal insufficiency cohort study.
Authors: Wing M, Yang W, Teal V, Navaneethan S, Tao K, Ojo A, Guzman N, Reilly M, Wolman M, Rosas S, Cuevas M, Fischer M, Lustigova E, Master S, Xie D, Appleby D, Joffe M, Kusek J, Feldman H, Raj D
Obesity (Silver Spring), 2014;22(5):1359-66.
Species: Human
Sample Type: Plasma

Association between traffic-related air pollution, subclinical inflammation and impaired glucose metabolism: results from the SALIA study.
Authors: Teichert T, Vossoughi M, Vierkotter A, Sugiri D, Schikowski T, Schulte T, Roden M, Luckhaus C, Herder C, Kramer U
PLoS ONE, 2013;8(12):e83042.
Species: Human
Sample Type: Plasma

Opium addiction increases interleukin 1 receptor antagonist (IL-1Ra) in the coronary artery disease patients.
Authors: Saadat, Habiboll, Ziai, Seyed Al, Ghanemnia, Maryam, Namazi, Mohammad, Safi, Morteza, Vakili, Hosein, Dabbagh, Ali, Gholami, Omid
PLoS ONE, 2012;7(9):e44939.
Species: Human
Sample Type: Plasma

Altered monocyte activation markers in Tourette's syndrome: a case-control study.
Authors: Matz J, Krause DL, Dehning S, Riedel M, Gruber R, Schwarz MJ, Muller N
BMC Psychiatry, 2012;12(0):29.
Species: Human
Sample Type: Serum

Time-course of changes in inflammatory response after whole-body cryotherapy multi exposures following severe exercise.
Authors: Pournot H, Bieuzen F, Louis J, Fillard JR, Barbiche E, Hausswirth C
PLoS ONE, 2011;6(7):e22748.
Species: Human
Sample Type: Plasma

SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity.
Authors: Rutanen J, Yaluri N, Modi S, Pihlajamaki J, Vanttinen M, Itkonen P, Kainulainen S, Yamamoto H, Lagouge M, Sinclair DA, Elliott P, Westphal C, Auwerx J, Laakso M
Diabetes, 2010;59(4):829-35.
Species: Human
Sample Type: Plasma

Accelerated increase in serum interleukin-1 receptor antagonist starts 6 years before diagnosis of type 2 diabetes: Whitehall II prospective cohort study.
Authors: Carstensen M, Herder C, Kivimaki M, Jokela M, Roden M, Shipley MJ, Witte DR, Brunner EJ, Tabak AG
Diabetes, 2010;59(5):1222-7.
Species: Human
Sample Type: Serum

Changes in cytokine levels during acute hyperinsulinemia in offspring of type 2 diabetic subjects.
Authors: Ruotsalainen E, Stancakova A, Vauhkonen I, Salmenniemi U, Pihlajamaki J, Punnonen K, Laakso M
Atherosclerosis, 2010;210(2):536-41.
Species: Human
Sample Type: Plasma

The detrimental effects of IFN-alpha on vasculogenesis in lupus are mediated by repression of IL-1 pathways: potential role in atherogenesis and renal vascular rarefaction.
Authors: Thacker SG, Berthier CC, Mattinzoli D, Rastaldi MP, Kretzler M, Kaplan MJ
J. Immunol., 2010;185(7):4457-69.
Species: Human
Sample Type: Serum

RAS mutations affect tumor necrosis factor-induced apoptosis in colon carcinoma cells via ERK-modulatory negative and positive feedback circuits along with non-ERK pathway effects.
Authors: Kreeger PK, Mandhana R, Alford SK, Haigis KM, Lauffenburger DA
Cancer Res., 2009;69(20):8191-9.
Species: Human
Sample Type: Cell Culture Supernates

In vivo regulation of interleukin 1beta in patients with cryopyrin-associated periodic syndromes.
Authors: Lachmann HJ, Lowe P, Felix SD, Rordorf C, Leslie K, Madhoo S, Wittkowski H, Bek S, Hartmann N, Bosset S, Hawkins PN, Jung T
J. Exp. Med., 2009;206(5):1029-36.
Species: Human
Sample Type: Plasma

IL-1 mediates pulmonary and systemic inflammatory responses to chorioamnionitis induced by lipopolysaccharide.
Authors: Kallapur SG, Nitsos I, Moss TJ, Polglase GR, Pillow JJ, Cheah FC, Kramer BW, Newnham JP, Ikegami M, Jobe AH
Am. J. Respir. Crit. Care Med., 2009;179(10):955-61.
Species: Ovine
Sample Type: Amniotic Fluid

Urinary proinflammatory cytokine response in renal transplant recipients with polyomavirus BK viruria.
Authors: Sadeghi M, Daniel V, Schnitzler P, Lahdou I, Naujokat C, Zeier M, Opelz G
Transplantation, 2009;88(9):1109-16.
Species: Human
Sample Type: Urine

Toll-like receptor-mediated production of IL-1Ra is negatively regulated by GSK3 via the MAPK ERK1/2.
Authors: Rehani K, Wang H, Garcia CA, Kinane DF, Martin M
J. Immunol., 2009;182(1):547-53.
Species: Human
Sample Type: Cell Culture Supernates

Self-esteem levels and cardiovascular and inflammatory responses to acute stress.
Authors: ODonnell K, Brydon L, Wright CE, Steptoe A
Brain Behav. Immun., 2008;0(0):.
Species: Human
Sample Type: Plasma

Evidence for a pathogenetic role of interleukin-18 in cutaneous lupus erythematosus.
Authors: Wang D, Drenker M, Eiz-Vesper B, Werfel T, Wittmann M
Arthritis Rheum., 2008;58(10):3205-15.
Species: Human
Sample Type: Cell Culture Supernates

Short communication: decreasing soluble CD30 and increasing IFN-gamma plasma levels are indicators of effective highly active antiretroviral therapy.
Authors: Sadeghi M, Susal C, Daniel V, Naujokat C, Zimmermann R, Huth-Kuhne A, Opelz G
AIDS Res. Hum. Retroviruses, 2007;23(7):886-90.
Species: Human
Sample Type: Plasma

First in human phase I trial of 852A, a novel systemic toll-like receptor 7 agonist, to activate innate immune responses in patients with advanced cancer.
Authors: Dudek AZ, Yunis C, Harrison LI, Kumar S, Hawkinson R, Cooley S, Vasilakos JP, Gorski KS, Miller JS
Clin. Cancer Res., 2007;13(23):7119-25.
Species: Human
Sample Type: Serum

P2X receptor characterization and IL-1/IL-1Ra release from human endothelial cells.
Authors: Wilson HL, Varcoe RW, Stokes L, Holland KL, Francis SE, Dower SK, Surprenant A, Crossman DC
Br. J. Pharmacol., 2007;151(1):115-27.
Species: Human
Sample Type: Cell Culture Supernates

PRO 2000 elicits a decline in genital tract immune mediators without compromising intrinsic antimicrobial activity.
Authors: Keller MJ, Guzman E, Hazrati E, Kasowitz A, Cheshenko N, Wallenstein S, Cole AL, Cole AM, Profy AT, Wira CR, Hogarty K, Herold BC
AIDS, 2007;21(4):467-76.
Species: Human
Sample Type: cervicovaginal lavage

Regulation of hepatocyte growth factor secretion by fibroblasts in patients with acute lung injury.
Authors: Quesnel C, Marchand-Adam S, Fabre A, Marchal-Somme J, Philip I, Lasocki S, Lecon V, Crestani B, Dehoux M
Am. J. Physiol. Lung Cell Mol. Physiol., 2007;294(2):L334-43.
Species: Human
Sample Type: BALF

Decreased levels of peritoneal interleukin-1 receptor antagonist in patients with endometriosis and disease-related dysmenorrhea.
Authors: Zhang X, Wen J, Deng L, Lin J
Fertil. Steril., 2007;88(3):594-9.
Species: Human
Sample Type: Serum

Low concentration of interleukin-1beta induces FLICE-inhibitory protein-mediated beta-cell proliferation in human pancreatic islets.
Authors: Maedler K, Schumann DM, Sauter N, Ellingsgaard H, Bosco D, Baertschiger R, Iwakura Y, Oberholzer J, Wollheim CB, Gauthier BR, Donath MY
Diabetes, 2006;55(10):2713-22.
Species: Human
Sample Type: Cell Culture Supernates

Circulating and synovial levels of IGF-I, cytokines, physical function and anthropometry differ in women awaiting total knee arthroplasty when compared to men.
Authors: Pagura SM, Thomas SG, Woodhouse LJ, Ezzat S, Marks P
J. Orthop. Res., 2005;23(2):397-405.
Species: Human
Sample Type: Synovial Fluid

Strong inflammatory cytokine response in male and strong anti-inflammatory response in female kidney transplant recipients with urinary tract infection.
Authors: Sadeghi M, Daniel V, Naujokat C, Wiesel M, Hergesell O, Opelz G
Transpl. Int., 2005;18(2):177-85.
Species: Human
Sample Type: Plasma

Levels of soluble cytokine factors in temporomandibular joint effusions seen on magnetic resonance images.
Authors: Kaneyama K, Segami N, Sun W, Sato J, Fujimura K
Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2005;99(4):411-8.
Species: Human
Sample Type: Synovial Fluid

Experimental heatstroke in baboon: analysis of the systemic inflammatory response.
Authors: Bouchama A, Ollivier V, Roberts G, Al Mohanna F, de Prost D, Eldali A, Saussereau E, El-Sayed R, Chollet-Martin S
Shock, 2005;24(4):332-5.
Species: Primate- Papio hamadryas (Hamadyras Baboon)
Sample Type: Plasma

Effects of the active metabolite of leflunomide, A77 1726, on cytokine release and the MAPK signalling pathway in human rheumatoid arthritis synoviocytes.
Authors: Vergne-Salle</LastName><F P</Initial, Vergne-Salle P, Leger DY, Bertin P, Treves R, Beneytout JL, Liagre B
Cytokine, 2005;31(5):335-48.
Species: Human
Sample Type: Cell Culture Supernates

Determinants of plasma leptin concentration in postmenopausal women.
Authors: Brooks-Asplund EM, Tupper CE, Daun JM, Kenney WL, Cannon JG
Mech. Ageing Dev., 2004;125(2):117-9.
Species: Human
Sample Type: Cell Culture Supernates

Effects of scaling and root planing on the amounts of interleukin-1 and interleukin-1 receptor antagonist and the mRNA expression of interleukin-1beta in gingival crevicular fluid and gingival tissues.
Authors: Yoshinari N, Kawase H, Mitani A, Ito M, Sugiishi S, Matsuoka M, Shirozu N, Ishihara Y, Bito B, Hiraga M, Arakawa K, Noguchi T
J. Periodont. Res., 2004;39(3):158-67.
Species: Human
Sample Type: Gingival Crevicular Fluid (GCF)

Guiding the vaginal microbicide trials with biomarkers of inflammation.
Authors: Fichorova RN
J. Acquir. Immune Defic. Syndr., 2004;37(0):S184-93.
Species: Human
Sample Type: cervicovaginal lavage

IL-1 beta, IL-1 receptor antagonist and soluble type II IL-1 receptor in synovial fluid of patients with temporomandibular disorders.
Authors: Tominaga K, Habu M, Sukedai M, Hirota Y, Takahashi T, Fukuda J
Arch. Oral Biol., 2004;49(6):493-9.
Species: Human
Sample Type: Synovial Fluid

CD14 is an acute-phase protein.
Authors: Bas S, Gauthier BR, Spenato U, Stingelin S, Gabay C
J. Immunol., 2004;172(7):4470-9.
Species: Human
Sample Type: Serum

Impact of increased occlusal contact, interleukin-1 genotype, and periodontitis severity on gingival crevicular fluid IL-1beta levels.
Authors: McDevitt MJ, Russell CM, Schmid MJ, Reinhardt RA
J. Periodontol., 2003;74(9):1302-7.
Species: Human
Sample Type: Gingival Crevicular Fluid (GCF)

生物活性< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景IL-1ra (IL-1 receptor antagonist) is a widely expressed acute phase protein that serves to dampen inflammation. IL-1ra binds to both IL-1 RI and IL-1 RII. It competitively inhibits IL-1 (alpha or beta) binding to IL-1 RI and does not trigger recruitment of the accessory molecule IL-1 R AcP or activation of IL-1 RI signaling. IL-1ra blocks the proinflammatory actions of IL-1 including Prostaglandin E2 and IL-6 release from endothelial cells, fever generation, thrombocytosis, the production of hepatic acute phase proteins, and neutrophil expansion and infiltration.
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参考文献
  • Cytokine and Growth Factor Receptors on VSMC
  • Cytokines and Receptors in Allergy and Asthma
  • Cytokines and Receptors in Angiogenesis
  • IL-1 Family
  • Macrophage Activation Markers
  • Neuroinflammation