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Human IL-6 R alpha Quantikine SixPak (6 Plates) (1 PK)

货号: SR600 基本售价: 31934.7 元 规格: 1 PACK

产品信息

概述
货号SR600
描述The Quantikine Human IL-6 sR Immunoassay is a 4.5 hour solid phase ELISA designed to measure human IL-6 sR in cell culture supernates, serum, plasma, and urine. It contains recombinant human IL-6 sR produced in Sf 21 cells and antibodies raised against this protein. This kit has been shown to accurately quantitate the recombinant soluble IL-6 R. Results obtained using natural IL-6 sR showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural IL-6 sR. Since the measurement of human IL-6 sR by this immunoassay is insensitive to added recombinant human IL-6, it is probable that this measurement corresponds to the total amount of the soluble receptor present in samples ( i.e. the total amount of free receptor plus the total amount of receptor bound to IL-6).
别名CD126; IL-6 R alpha; IL6R alpha; IL6R; IL-6Ra;
全称
Interleukin 6 Receptor alpha
反应种属Human
目标/特异性Natural and recombinant human IL-6 sR
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs
3570 (Human); 16194 (Mouse)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

A Novel IL6 Antibody Sensitizes Multiple Tumor Types to Chemotherapy Including Trastuzumab-Resistant Tumors.
Authors: Zhong H, Davis A, Ouzounova M, Carrasco R, Chen C, Breen S, Chang Y, Huang J, Liu Z, Yao Y, Hurt E, Moisan J, Fung M, Tice D, Clouthier S, Xiao Z, Wicha M, Korkaya H, Hollingsworth R
Cancer Res, 2016;76(2):480-90.
Species: Human
Sample Type: Cell Culture Supernates

IL-6 trans-signaling is another pathway to upregulate Osteopontin
Cytokine, 2016;90(0):88-95.
Species: Human
Sample Type: Cell culture supernatant

Inflammatory Markers and the Risk of Hip and Vertebral Fractures in Men: the Osteoporotic Fractures in Men (MrOS)
J Bone Miner Res, 2016;0(0):.
Species: Human
Sample Type: Serum

Prevalent peripheral arterial disease and inflammatory burden
BMC Geriatr, 2016;16(1):213.
Species: Human
Sample Type: Serum

Stromal cells positively and negatively modulate the growth of cancer cells: stimulation via the PGE2-TNFalpha-IL-6 pathway and inhibition via secreted GAPDH-E-cadherin interaction.
Authors: Kawada M, Inoue H, Ohba S, Yoshida J, Masuda T, Yamasaki M, Usami I, Sakamoto S, Abe H, Watanabe T, Yamori T, Shibasaki M, Nomoto A
PLoS ONE, 2015;10(3):e0119415.
Species: Human
Sample Type: Cell Culture Supernates

Bruton tyrosine kinase inhibition is a novel therapeutic strategy targeting tumor in the bone marrow microenvironment in multiple myeloma.
Authors: Tai Y, Chang B, Kong S, Fulciniti M, Yang G, Calle Y, Hu Y, Lin J, Zhao J, Cagnetta A, Cea M, Sellitto M, Zhong M, Wang Q, Acharya C, Carrasco D, Buggy J, Elias L, Treon S, Matsui W, Richardson P, Munshi N, Anderson K
Blood, 2012;120(9):1877-87.
Species: Human
Sample Type: recombinant IL-6 R in mouse serum

Inflammatory markers and the risk of hip fracture: the Women's Health Initiative.
Authors: Barbour KE, Boudreau R, Danielson ME, Youk AO, Wactawski-Wende J, Greep NC, LaCroix AZ, Jackson RD, Wallace RB, Bauer DC, Allison MA, Cauley JA
J. Bone Miner. Res., 2012;27(5):1167-76.
Species: Human
Sample Type: Serum

Maternal country of origin, breast milk characteristics and potential influences on immunity in offspring.
Authors: Holmlund U, Amoudruz P, Johansson MA, Haileselassie Y, Ongoiba A, Kayentao K, Traore B, Doumbo S, Schollin J, Doumbo O, Montgomery SM, Sverremark-Ekstrom E
Clin. Exp. Immunol., 2010;162(3):500-9.
Species: Human
Sample Type: Milk

Soluble and membrane levels of molecules involved in the interaction between clonal plasma cells and the immunological microenvironment in multiple myeloma and their association with the characteristics of the disease.
Authors: Perez-Andres M, Almeida J, Martin-Ayuso M, De Las Heras N, Moro MJ, Martin-Nunez G, Galende J, Cuello R, Abuin I, Moreno I, Dominguez M, Hernandez J, Mateo G, San Miguel JF, Orfao A
Int. J. Cancer, 2009;124(2):367-75.
Species: Human
Sample Type: Plasma

Urinary proinflammatory cytokine response in renal transplant recipients with polyomavirus BK viruria.
Authors: Sadeghi M, Daniel V, Schnitzler P, Lahdou I, Naujokat C, Zeier M, Opelz G
Transplantation, 2009;88(9):1109-16.
Species: Human
Sample Type: Urine

Functional interaction of plasmacytoid dendritic cells with multiple myeloma cells: a therapeutic target.
Authors: Chauhan D, Singh AV, Brahmandam M, Carrasco R, Bandi M, Hideshima T, Bianchi G, Podar K, Tai YT, Mitsiades C, Raje N, Jaye DL, Kumar SK, Richardson P, Munshi N, Anderson KC
Cancer Cell, 2009;16(4):309-23.
Species: Human
Sample Type: Serum

Interleukin-6 in the bone marrow microenvironment promotes the growth and survival of neuroblastoma cells.
Authors: Ara T, Song L, Shimada H, Keshelava N, Russell HV, Metelitsa LS, Groshen SG, Seeger RC, DeClerck YA
Cancer Res., 2009;69(1):329-37.
Species: Human
Sample Type: Serum

Daily family assistance and inflammation among adolescents from Latin American and European backgrounds.
Authors: Fuligni AJ, Telzer EH, Bower J, Irwin MR, Kiang L, Cole SW
Brain Behav. Immun., 2009;23(6):803-9.
Species: Human
Sample Type: Plasma

Interleukin-6 and soluble interleukin-6 receptor levels as markers of disease extent and prognosis in neuroblastoma.
Authors: Egler RA, Burlingame SM, Nuchtern JG, Russell HV
Clin. Cancer Res., 2008;14(21):7028-34.
Species: Human
Sample Type: Plasma

Improved prediction of disease relapse after radical prostatectomy through a panel of preoperative blood-based biomarkers.
Authors: Shariat SF, Karam JA, Walz J, Roehrborn CG, Montorsi F, Margulis V, Saad F, Slawin KM, Karakiewicz PI
Clin. Cancer Res., 2008;14(12):3785-91.
Species: Human
Sample Type: Plasma

Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils.
Authors: Chalaris A, Rabe B, Paliga K, Lange H, Laskay T, Fielding CA, Jones SA, Rose-John S, Scheller J
Blood, 2007;110(6):1748-55.
Species: Human
Sample Type: Cell Culture Supernates

Inflammatory markers and incident fracture risk in older men and women: the Health Aging and Body Composition Study.
Authors: Cauley JA, Danielson ME, Boudreau RM, Forrest KY, Zmuda JM, Pahor M, Tylavsky FA, Cummings SR, Harris TB, Newman AB
J. Bone Miner. Res., 2007;22(7):1088-95.
Species: Human
Sample Type: Serum

Short communication: decreasing soluble CD30 and increasing IFN-gamma plasma levels are indicators of effective highly active antiretroviral therapy.
Authors: Sadeghi M, Susal C, Daniel V, Naujokat C, Zimmermann R, Huth-Kuhne A, Opelz G
AIDS Res. Hum. Retroviruses, 2007;23(7):886-90.
Species: Human
Sample Type: Plasma

Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis.
Authors: Richards PJ, Nowell MA, Horiuchi S, McLoughlin RM, Fielding CA, Grau S, Yamamoto N, Ehrmann M, Rose-John S, Williams AS, Topley N, Jones SA
Arthritis Rheum., 2006;54(5):1662-72.
Species: Human
Sample Type: Serum

Effect of influenza vaccine on markers of inflammation and lipid profile.
Authors: Tsai MY, Hanson NQ, Straka RJ, Hoke TR, Ordovas JM, Peacock JM, Arends VL, Arnett DK
J. Lab. Clin. Med., 2005;145(6):323-7.
Species: Human
Sample Type: Plasma

Strong inflammatory cytokine response in male and strong anti-inflammatory response in female kidney transplant recipients with urinary tract infection.
Authors: Sadeghi M, Daniel V, Naujokat C, Wiesel M, Hergesell O, Opelz G
Transpl. Int., 2005;18(2):177-85.
Species: Human
Sample Type: Plasma

Levels of soluble cytokine factors in temporomandibular joint effusions seen on magnetic resonance images.
Authors: Kaneyama K, Segami N, Sun W, Sato J, Fujimura K
Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2005;99(4):411-8.
Species: Human
Sample Type: Synovial Fluid

Circulating interleukin-6 family cytokines and their receptors in patients with congestive heart failure.
Authors: Hirota H, Izumi M, Hamaguchi T, Sugiyama S, Murakami E, Kunisada K, Fujio Y, Oshima Y, Nakaoka Y, Yamauchi-Takihara K
Heart Vessels, 2004;19(5):237-41.
Species: Human
Sample Type: Plasma

Arenavirus-mediated liver pathology: acute lymphocytic choriomeningitis virus infection of rhesus macaques is characterized by high-level interleukin-6 expression and hepatocyte proliferation.
Authors: Lukashevich IS, Tikhonov I, Rodas JD, Zapata JC, Yang Y, Djavani M, Salvato MS
J. Virol., 2003;77(3):1727-37.
Species: Primate - Macaca mulatta (Rhesus monkey)
Sample Type: Serum

Effects of IL-6 variants in multiple myeloma: growth inhibition and induction of apoptosis in primary cells.
Authors: Petrucci MT, Ricciardi MR, Gregorj C, Ciapponi L, Savino R, Ciliberto G, Tafuri A
Leuk. Lymphoma, 2002;43(12):2369-75.
Species: Human
Sample Type: Serum

Interleukin-6 is a major effector molecule of short-term G-CSF treatment inducing bone metabolism and an acute-phase response.
Authors: Carstanjen D, Regenfus M, Muller C, Salama A
Exp. Hematol., 2001;29(7):812-21.
Species: Human
Sample Type: Plasma

Ovariectomy does not induce osteopenia through interleukin-6 in rhesus monkeys (Macaca mulatta).
Authors: Keller ET, Binkley NC, Stebler BA, Hall DM, Johnston GM, Zhang J, Ershler WB
Bone, 2000;26(1):55-62.
Species: Primate - Macaca mulatta (Rhesus monkey)
Sample Type: Bone Marrow Fluid

Discriminant power of combined cerebrospinal fluid tau protein and of the soluble interleukin-6 receptor complex in the diagnosis of Alzheimers disease.
Authors: Hampel H, Teipel SJ, Padberg F, Haslinger A, Riemenschneider M, Schwarz MJ, Kotter HU, Scheloske M, Buch K, Stubner S, Dukoff R, Lasser R, Moller N, Sunderland T, Rapoport SI, Moller HJ
Brain Res., 1999;823(1):104-12.
Species: Human
Sample Type: CSF

Interleukin-6 and the soluble IL-6 receptor are decreased in cerebrospinal fluid of geriatric patients with major depression: no alteration of soluble gp130.
Authors: Stubner S, Schon T, Padberg F, Teipel SJ, Schwarz MJ, Haslinger A, Buch K, Dukoff R, Lasser R, Moller N, Sunderland T, Rapoport SI, Moller HJ, Hampel H
Neurosci. Lett., 1999;259(3):145-8.
Species: Human
Sample Type: CSF

生物活性< 0.5% cross-reactivity observed with available related molecules.Cross-species reactivity not tested.
背景IL-6 R alpha is a transmembrane subunit of the receptor for Interleukin-6. It associates with gp130 which is a shared component of the receptors for CLC, CNTF, CT-1, IL-11, IL-27, LIF, and OSM. Soluble forms of IL-6 R alpha are generated by both alternative splicing and proteolytic cleavage. In a mechanism known as trans-signaling, complexes of soluble IL-6 and IL-6 R alpha elicit responses from gp130-expressing cells that lack cell surface IL-6 R alpha. IL-6 plays important roles in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression. IL-6, along with TNF-alpha and IL-1, drives the acute inflammatory response and the transition from acute inflammation to either acquired immunity or chronic inflammatory disease. When dysregulated, it contributes to chronic inflammation in obesity, insulin resistance, inflammatory bowel disease, arthritis, sepsis, and atherosclerosis.
运输条件Blue Ice
存放说明4℃
参考文献
  • B Cell Activation
  • Cancer Stem Cell Markers
  • Cytokines and Receptors in Allergy and Asthma
  • Cytokines and Receptors in Angiogenesis
  • Cytokines and Receptors in Tfh Cell Differentiation and Function
  • Diabetes
  • IL-6 Family
  • Immune Regulatory Molecules on Endothelial Cells
  • Monocyte Markers
  • Multiple Sclerosis and Myelin Related Molecules
  • Myeloid-derived Suppressor Cells (MDSC)
  • Neuroinflammation
  • Obesity
  • Receptors in the Jak/STAT Pathway
  • T Cell Cytokine Signaling
  • Th17 Cells
  • Th22 Cells