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Human CD25/IL-2 R alpha Quantikine SixPak (6 Plates) (1 PK)

货号: SR2A00 基本售价: 31934.7 元 规格: 1 PACK

产品信息

概述
货号SR2A00
描述The Quantikine Human IL-2 sR alpha Immunoassay is a 3.5 hour solid phase ELISA designed to measure IL-2 sR alpha in cell culture supernates, serum, and plasma. It contains NS0-expressed recombinant human IL-2 sR alpha and antibodies raised against the recombinant factor. This immunoassay has been shown to accurately quantitate the recombinant factor. Results obtained using natural human IL-2 sR alpha showed linear curves that were parallel to the standard curves obtained using the recombinant Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural human IL-2 sR alpha.
别名CD25 antigen; CD25; IDDM10; IL-2 R alpha; IL-2 receptor subunit alpha; IL2R alpha; IL-2R subunit alpha; IL2R; IL2RA; IL-2Ra; IL-2-RA; IL2-RA; interleukin 2 receptor, alpha; interleukin-2 receptor subunit alpha; p55; TAC antigen; TCGFR;
全称
Interleukin 2 Receptor alpha
反应种属Human
目标/特异性Natural and recombinant human IL-2 sR alpha
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs
3559 (Human); 16184 (Mouse); 25704 (Rat); 403870 (Canine)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Incidence and Risk Factors for Developing Dengue-Associated Hemophagocytic Lymphohistiocytosis in Puerto Rico, 2008 - 2013
PLoS Negl Trop Dis, 2016;10(8):e0004939.
Species: Human
Sample Type: Serum

Stability of cytokines, chemokines and soluble activation markers in unprocessed blood stored under different conditions
Cytokine, 2016;84(0):17-24.
Species: Human
Sample Type: Plasma

Efficacy, durability, and response predictors of low-dose interleukin-2 therapy for chronic graft vs. host disease
Authors: J Koreth, HT Kim, KT Jones, PB Lange, CG Reynolds, MJ Chammas, K Dusenbury, J Whangbo, S Nikiforow, EP Alyea, P Armand, CS Cutler, VT Ho, YB Chen, D Avigan, BR Blazar, JH Antin, J Ritz, RJ Soiffer
Blood, 2016;0(0):.
Species: Human
Sample Type: Plasma

Augmented efficacy with the combination of blockade of the Notch-1 pathway, bortezomib and romidepsin in a murine MT-1 adult T-cell leukemia model.
Authors: Yu P, Petrus M, Ju W, Zhang M, Conlon K, Nakagawa M, Maeda M, Bamford R, Waldmann T
Leukemia, 2015;29(3):556-66.
Species: Human
Sample Type: Serum

Elevated levels of CXCL10 in the Periodic Fever, Aphthous stomatitis, Pharyngitis and cervical Adenitis syndrome (PFAPA) during and between febrile episodes; an indication of a persistent activation of the innate immune system.
Authors: Forsvoll J, Kristoffersen E, Oymar K
Pediatr Rheumatol Online J, 2013;11(1):38.
Species: Human
Sample Type: Plasma

Malignant transformation of CD4+ T lymphocytes mediated by oncogenic kinase NPM/ALK recapitulates IL-2-induced cell signaling and gene expression reprogramming.
Authors: Marzec M, Halasa K, Liu X, Wang H, Cheng M, Baldwin D, Tobias J, Schuster S, Woetmann A, Zhang Q, Turner S, Odum N, Wasik M
J Immunol, 2013;191(12):6200-7.
Species: Human
Sample Type: cell culture supernate

Human CD1c (BDCA-1)+ myeloid dendritic cells secrete IL-10 and display an immuno-regulatory phenotype and function in response to Escherichia coli.
Authors: Kassianos AJ, Hardy MY, Ju X, Vijayan D, Ding Y, Vulink AJ, McDonald KJ, Jongbloed SL, Wadley RB, Wells C, Hart DN, Radford KJ
Eur. J. Immunol., 2012;42(6):1512-22.
Species: Human
Sample Type: Cell Culture Supernates

Synergistic antitumor activity of anti-CD25 recombinant immunotoxin LMB-2 with chemotherapy.
Authors: Singh R, Zhang Y, Pastan I, Kreitman RJ
Clin. Cancer Res., 2012;18(1):152-60.
Species: Human
Sample Type: Serum

Phase 2 study of cladribine followed by rituximab in patients with hairy cell leukemia.
Authors: Ravandi F, OBrien S, Jorgensen J, Pierce S, Faderl S, Ferrajoli A, Koller C, Challagundla P, York S, Brandt M, Luthra R, Burger J, Thomas D, Keating M, Kantarjian H
Blood, 2011;118(14):3818-23.
Species: Human
Sample Type: Serum

A novel role for IL-22R1 as a driver of inflammation.
Authors: Savan R, McFarland AP, Reynolds DA
Blood, 2011;117(2):575-84.
Species: Mouse
Sample Type: Serum

Safety and clinical effect of subcutaneous human interleukin-21 in patients with metastatic melanoma or renal cell carcinoma: a phase I trial.
Authors: Schmidt H, Brown J, Mouritzen U, Selby P, Fode K, Svane IM, Cook GP, Mollerup DH, Geertsen PF
Clin. Cancer Res., 2010;16(21):5312-9.
Species: Human
Sample Type: Serum

Presence of IL-5 protein and IgE antibodies to staphylococcal enterotoxins in nasal polyps is associated with comorbid asthma.
Authors: Bachert C, Zhang N, Holtappels G, De Lobel L, Van Cauwenberge P, Liu S, Lin P, Bousquet J, Van Steen K
J. Allergy Clin. Immunol., 2010;126(5):962.
Species: Human
Sample Type: Tissue Homogenates

Defucosylated humanized anti-CCR4 monoclonal antibody KW-0761 as a novel immunotherapeutic agent for adult T-cell leukemia/lymphoma.
Authors: Ishii T, Ishida T, Utsunomiya A
Clin. Cancer Res., 2010;16(5):1520-31.
Species: Mouse
Sample Type: Plasma

Smoking, inflammatory patterns and postprandial hypertriglyceridemia.
Authors: Kabagambe EK, Ordovas JM, Tsai MY, Borecki IB, Hopkins PN, Glasser SP, Arnett DK
Atherosclerosis, 2009;203(2):633-9.
Species: Human
Sample Type: Serum

Urinary proinflammatory cytokine response in renal transplant recipients with polyomavirus BK viruria.
Authors: Sadeghi M, Daniel V, Schnitzler P, Lahdou I, Naujokat C, Zeier M, Opelz G
Transplantation, 2009;88(9):1109-16.
Species: Human
Sample Type: Urine

Effective treatment of a murine model of adult T-cell leukemia using depsipeptide and its combination with unmodified daclizumab directed toward CD25.
Authors: Chen J, Zhang M, Ju W, Waldmann TA
Blood, 2009;113(6):1287-93.
Species: Mouse
Sample Type: Serum

Inflammatory markers and incident fracture risk in older men and women: the Health Aging and Body Composition Study.
Authors: Cauley JA, Danielson ME, Boudreau RM, Forrest KY, Zmuda JM, Pahor M, Tylavsky FA, Cummings SR, Harris TB, Newman AB
J. Bone Miner. Res., 2007;22(7):1088-95.
Species: Human
Sample Type: Serum

Expression and release of soluble HLA-E is an immunoregulatory feature of endothelial cell activation.
Authors: Coupel S, Moreau A, Hamidou M, Horejsi V, Soulillou JP, Charreau B
Blood, 2007;109(7):2806-14.
Species: Human
Sample Type: Serum

Short communication: decreasing soluble CD30 and increasing IFN-gamma plasma levels are indicators of effective highly active antiretroviral therapy.
Authors: Sadeghi M, Susal C, Daniel V, Naujokat C, Zimmermann R, Huth-Kuhne A, Opelz G
AIDS Res. Hum. Retroviruses, 2007;23(7):886-90.
Species: Human
Sample Type: Plasma

An open-label, two-arm, phase I trial of recombinant human interleukin-21 in patients with metastatic melanoma.
Authors: Davis ID, Skrumsager BK, Cebon J, Nicholaou T, Barlow JW, Moller NP, Skak K, Lundsgaard D, Frederiksen KS, Thygesen P, McArthur GA
Clin. Cancer Res., 2007;13(12):3630-6.
Species: Human
Sample Type: Serum

Effective therapy for a murine model of human anaplastic large-cell lymphoma with the anti-CD30 monoclonal antibody, HeFi-1, does not require activating Fc receptors.
Authors: Zhang M, Yao Z, Zhang Z, Garmestani K, Goldman CK, Ravetch JV, Janik J, Brechbiel MW, Waldmann TA
Blood, 2006;108(2):705-10.
Species: Human
Sample Type: Serum

Effective treatment of a murine model of adult T-cell leukemia using 211At-7G7/B6 and its combination with unmodified anti-Tac (daclizumab) directed toward CD25.
Authors: Zhang Z, Zhang M, Garmestani K, Talanov VS, Plascjak PS, Beck B, Goldman C, Brechbiel MW, Waldmann TA
Blood, 2006;108(3):1007-12.
Species: Human
Sample Type: Serum

Activating Fc receptors are required for antitumor efficacy of the antibodies directed toward CD25 in a murine model of adult t-cell leukemia.
Authors: Zhang M, Zhang Z, Garmestani K, Goldman CK, Ravetch JV, Brechbiel MW, Carrasquillo JA, Waldmann TA
Cancer Res., 2004;64(16):5825-9.
Species: Human
Sample Type: Serum

Thymus and activation-regulated chemokine (TARC/CCL17) produced by mouse epidermal Langerhans cells is upregulated by TNF-alpha and IL-4 and downregulated by IFN-gamma.
Authors: Xiao T, Fujita H, Saeki H, Mitsui H, Sugaya M, Tada Y, Kakinuma T, Torii H, Nakamura K, Asahina A, Tamaki K
Cytokine, 2003;23(4):126-32.
Species: Human
Sample Type: Serum

Comparative analysis of CA125, tissue polypeptide specific antigen, and soluble interleukin-2 receptor alpha levels in sera, cyst, and ascitic fluids from patients with ovarian carcinoma.
Authors: Sedlaczek P, Frydecka I, Gabrys M, Van Dalen A, Einarsson R, Harlozinska A
Cancer, 2002;95(9):1886-93.
Species: Human
Sample Type: Ascites

Age-related autoantibody production in a nonhuman primate model.
Authors: Attanasio R, Brasky KM, Robbins SH, Jayashankar L, Nash RJ, Butler TM
Clin. Exp. Immunol., 2001;123(3):361-5.
Species: Primate-Papio cynocephalus anubis (baboon)
Sample Type: Serum

Medium-dose UVA1 cold-light phototherapy in the treatment of severe atopic dermatitis.
Authors: von Kobyletzki G, Pieck C, Hoffmann K, Freitag M, Altmeyer P
J. Am. Acad. Dermatol., 1999;41(6):931-7.
Species: Human
Sample Type: Serum

生物活性< 0.5% cross-reactivity observed with available related molecules.Cross-species reactivity not tested.
背景CD25/IL-2 receptor alpha is a transmembrane protein that associates with IL-2 R beta/CD122 and the Common gamma Chain/CD132 on activated T cells and regulatory T cells (Treg). The Common gamma chain is a shared subunit in the receptors for IL-4, -7, -9, -15, and -21. IL-2 R alpha is required for mediating IL-2 induced effects including T cell proliferation, activation induced cell death (AICD) of autoreactive naive T cells, and the development of CD4+CD25+ Treg which contribute to peripheral T cell homeostasis. A soluble form of IL-2 R alpha can be generated by proteolytic cleavage of the cell surface receptor.
运输条件Blue Ice
存放说明4℃
参考文献
  • Acute Lymphoblastic Leukemia
  • Acute Myeloid Leukemia
  • B Cell Activation
  • B Cell Markers
  • Cancer Biomarkers
  • Common gamma Chain Receptor Family
  • Cytokines and Receptors in Allergy and Asthma
  • Cytokines and Receptors in Tfh Cell Differentiation and Function
  • Group 1 ILCs
  • Group 2 ILCs
  • Isolation, Culture, and Identification of Natural Killer Cells
  • LTi Cells
  • Lymphoma
  • NCR+ILC3
  • NCR-ILC3
  • Neuroinflammation
  • Preeclampsia
  • Receptors in the Jak/STAT Pathway
  • Regulatory T Cells (Tregs)
  • T Cell Cytokine Signaling