Dysregulated serum IL-23 and SIRT1 activity in peripheral blood mononuclear cells of patients with rheumatoid arthritis.
Authors: Wendling D, Abbas W, Godfrin-Valnet M, Kumar A, Guillot X, Khan K, Vidon C, Coquard L, Toussirot E, Prati C, Herbein G
PLoS ONE, 2015;10(3):e0119981.
Species: Human
Sample Type: Serum

Free IL-12p40 monomer is a polyfunctional adaptor for generating novel IL-12-like heterodimers extracellularly.
Authors: Abdi K, Singh N, Spooner E, Kessler B, Radaev S, Lantz L, Xiao T, Matzinger P, Sun P, Ploegh H
J Immunol, 2014;192(12):6028-36.
Species: Mouse
Sample Type: Cell culture supernatant

Co-culture of human bronchial fibroblasts and CD4+ T cells increases Th17 cytokine signature.
Authors: Loubaki L, Hadj-Salem I, Fakhfakh R, Jacques E, Plante S, Boisvert M, Aoudjit F, Chakir J
PLoS ONE, 2013;8(12):e81983.
Species: Human
Sample Type: cell culture supernate

Direct and indirect impairment of human dendritic cell function by virulent Francisella tularensis Schu S4.
Authors: Chase JC, Celli J, Bosio CM
Infect. Immun., 2009;77(1):180-95.
Species: Human
Sample Type: Cell Culture Supernates

Evidence for a pathogenetic role of interleukin-18 in cutaneous lupus erythematosus.
Authors: Wang D, Drenker M, Eiz-Vesper B, Werfel T, Wittmann M
Arthritis Rheum., 2008;58(10):3205-15.
Species: Human
Sample Type: Cell Culture Supernates

Distinct subsets of human invariant NKT cells differentially regulate T helper responses via dendritic cells.
Authors: Liu TY, Uemura Y, Suzuki M, Narita Y, Hirata S, Ohyama H, Ishihara O, Matsushita S
Eur. J. Immunol., 2008;38(4):1012-23.
Species: Human
Sample Type: Cell Culture Supernates

The 3'UTR 1188 A/C polymorphism in the interleukin-12p40 gene (IL-12B) is associated with lepromatous leprosy in the west of Mexico.
Authors: Alvarado-Navarro A, Montoya-Buelna M, Munoz-Valle JF, Lopez-Roa RI, Guillen-Vargas C, Fafutis-Morris M
Immunol. Lett., 2008;118(2):148-51.
Species: Human
Sample Type: Serum

1, 25 Dihydroxyvitamin D3 modulated cytokine response in pulmonary tuberculosis.
Authors: Vidyarani M, Selvaraj P, Jawahar MS, Narayanan PR
Cytokine, 2007;40(2):128-34.
Species: Human
Sample Type: Cell Culture Supernates

Chemokines CXCL10 and CXCL11 in the cerebrospinal fluid of patients with tick-borne encephalitis.
Authors: Lepej SZ, Misic-Majerus L, Jeren T, Rode OD, Remenar A, Sporec V, Vince A
Acta Neurol. Scand., 2007;115(2):109-14.
Species: Human
Sample Type: Serum

Placental growth factor down-regulates type 1 T helper immune response by modulating the function of dendritic cells.
Authors: Lin YL, Liang YC, Chiang BL
J. Leukoc. Biol., 2007;82(6):1473-80.
Species: Human
Sample Type: Cell Culture Supernates

Impairment of human NK cell cytotoxic activity and cytokine release by cigarette smoke.
Authors: Mian MF, Lauzon NM, Stampfli MR, Mossman KL, Ashkar AA
J. Leukoc. Biol., 2007;83(3):774-84.
Species: Human
Sample Type: Cell Culture Supernates

First in human phase I trial of 852A, a novel systemic toll-like receptor 7 agonist, to activate innate immune responses in patients with advanced cancer.
Authors: Dudek AZ, Yunis C, Harrison LI, Kumar S, Hawkinson R, Cooley S, Vasilakos JP, Gorski KS, Miller JS
Clin. Cancer Res., 2007;13(23):7119-25.
Species: Human
Sample Type: Serum

Oral resiquimod in chronic HCV infection: safety and efficacy in 2 placebo-controlled, double-blind phase IIa studies.
Authors: Pockros PJ, Guyader D, Patton H, Tong MJ, Wright T, McHutchison JG, Meng TC
J. Hepatol., 2007;47(2):174-82.
Species: Human
Sample Type: Serum

IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production.
Authors: Vaknin-Dembinsky A, Balashov K, Weiner HL
J. Immunol., 2006;176(12):7768-74.
Species: Human
Sample Type: Cell Culture Supernates

Bordetella pertussis inhibition of interleukin-12 (IL-12) p70 in human monocyte-derived dendritic cells blocks IL-12 p35 through adenylate cyclase toxin-dependent cyclic AMP induction.
Authors: Spensieri F, Fedele G, Fazio C, Nasso M, Stefanelli P, Mastrantonio P, Ausiello CM
Infect. Immun., 2006;74(5):2831-8.
Species: Human
Sample Type: Cell Culture Supernates

Elevation of IL-12 p40 and its antibody in myasthenia gravis with thymoma.
Authors: Yoshikawa H, Sato K, Edahiro S, Furukawa Y, Maruta T, Iwasa K, Watanabe H, Takaoka S, Suzuki Y, Takamori M, Yamada M
J. Neuroimmunol., 2006;175(1):169-75.
Species: Human
Sample Type: Serum

Induction of dendritic cell maturation by pertussis toxin and its B subunit differentially initiate Toll-like receptor 4-dependent signal transduction pathways.
Authors: Wang ZY, Yang D, Chen Q, Leifer CA, Segal DM, Su SB, Caspi RR, Howard ZO, Oppenheim JJ
Exp. Hematol., 2006;34(8):1115-24.
Species: Human
Sample Type: Cell Culture Supernates

Human complete Stat-1 deficiency is associated with defective type I and II IFN responses in vitro but immunity to some low virulence viruses in vivo.
Authors: Chapgier A, Wynn RF, Jouanguy E, Filipe-Santos O, Zhang S, Feinberg J, Hawkins K, Casanova JL, Arkwright PD
J. Immunol., 2006;176(8):5078-83.
Species: Human
Sample Type: Plasma

Experimental heatstroke in baboon: analysis of the systemic inflammatory response.
Authors: Bouchama A, Ollivier V, Roberts G, Al Mohanna F, de Prost D, Eldali A, Saussereau E, El-Sayed R, Chollet-Martin S
Shock, 2005;24(4):332-5.
Species: Primate- Papio hamadryas (Hamadyras Baboon)
Sample Type: Plasma

Cytokines and adhesion molecules in multiple sclerosis patients treated with interferon-beta1b.
Authors: Jensen J, Krakauer M, Sellebjerg F
Cytokine, 2005;29(1):24-30.
Species: Human
Sample Type: Plasma

HIV-1 protein Vpr suppresses IL-12 production from human monocytes by enhancing glucocorticoid action: potential implications of Vpr coactivator activity for the innate and cellular immunity deficits observed in HIV-1 infection.
Authors: Mirani M, Elenkov I, Volpi S, Hiroi N, Chrousos GP, Kino T
J. Immunol., 2002;169(11):6361-8.
Species: Human
Sample Type: Cell Culture Supernates

Interleukin 12 (IL-12), also known as natural killer cell stimulatory factor (NKSF) or cytotoxic lymphocyte maturation factor (CLMF), is a heterodimeric pleiotropic cytokine made up of a 40 kDa (p40) subunit and a 35 kDa (p35) subunit. The IL-12 p40 subunit is shared by IL-23, another heterodimeric cytokine that has biological activities similar to, as well as distinct from, IL-12. IL-12 is produced by macrophages and B cells and has been shown to have multiple effects on T cells and natural killer (NK) cells. While mouse IL-12 is active on both human and mouse cells, human IL-12 is not active on mouse cells.

• Cytokines and Receptors in Allergy and Asthma
• Cytokines and Receptors in Angiogenesis
• gamma delta T Cells
• IL-12 Family
• Th1 Cells
• Th17 Cells