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Human CXCL10/IP-10 Quantikine SixPak (6 Plates) (1 PK)

货号: SIP100 基本售价: 31934.7 元 规格: 1 PACK

产品信息

概述
货号SIP100
描述The Quantikine Human IP-10 Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human IP-10 in cell culture supernates, serum, plasma, saliva, and urine. It contains E. coli-expressed recombinant human IP-10 and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human IP-10 showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring IP-10.
别名C7; chemokine (C-X-C motif) ligand 10; CRG2; CRG-2; CXCL10; gIP-10; IFI10; INP10; IP-10; mob-1; SCYB10;
反应种属Human
目标/特异性Natural and recombinant human IP-10
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs
3627 (Human); 15945 (Mouse)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

The therapeutic HIV Env C5/gp41 vaccine candidate Vacc-C5 induces specific T cell regulation in a phase I/II clinical study
Authors: K Brekke, M Sommerfelt, M Ökvist, AM Dyrhol-Rii, D Kvale
BMC Infect. Dis, 2017;17(1):228.
Species: Human
Sample Type: Serum

Predictive Value of Serum IFN-? inducible Protein-10 and IFN-?/IL-4 Ratio for Liver Fibrosis Progression in CHB Patients
Authors: Y Wang, W Yu, C Shen, W Wang, L Zhang, F Liu, H Sun, Y Zhao, H Che, C Zhao
Sci Rep, 2017;7(0):40404.
Species: Human
Sample Type: Serum

Case-control, exploratory study of cerebrospinal fluid chemokines/cytokines and lymphocyte subsets in childhood Tourette syndrome with positive streptococcal markers
Authors: MR Pranzatell, ED Tate, TJ Allison
Cytokine, 2017;96(0):49-53.
Species: Human
Sample Type: CSF

Transcript-activated collagen matrix as sustained mRNA delivery system for bone regeneration
J Control Release, 2016;239(0):137-148.
Species: Human
Sample Type: Cell Culture Supernates

Elevated Basal Pre-infection CXCL10 in Plasma and in the Small Intestine after Infection Are Associated with More Rapid HIV/SIV Disease Onset
PLoS Pathog, 2016;12(8):e1005774.
Species: Human
Sample Type: Plasma

Randomized Trial Evaluating the Impact of Ribavirin Mono-Therapy and Double Dosing on Viral Kinetics, Ribavirin Pharmacokinetics and Anemia in Hepatitis C Virus Genotype 1 Infection
PLoS ONE, 2016;11(5):e0155142.
Species: Human
Sample Type: Plasma

Extracellular Histones Induce Chemokine Production in Whole Blood Ex Vivo and Leukocyte Recruitment In Vivo.
Authors: Westman J, Papareddy P, Dahlgren M, Chakrakodi B, Norrby-Teglund A, Smeds E, Linder A, Morgelin M, Johansson-Lindbom B, Egesten A, Herwald H
PLoS Pathog, 2015;11(12):e1005319.
Species: Human
Sample Type: Plasma

Small Ubiquitin-like Modifier Alters IFN Response.
Authors: Maarifi G, Maroui M, Dutrieux J, Dianoux L, Nisole S, Chelbi-Alix M
J Immunol, 2015;195(5):2312-24.
Species: Human
Sample Type: Cell Culture Supernates

Left Ventricular Dysfunction and CXCR3 Ligands in Hypertension: From Animal Experiments to a Population-Based Pilot Study.
Authors: Altara R, Gu Y, Struijker-Boudier H, Thijs L, Staessen J, Blankesteijn W
PLoS ONE, 2015;10(10):e0141394.
Species: Human
Sample Type: Plasma

Effective Apical Infection of Differentiated Human Bronchial Epithelial Cells and Induction of Proinflammatory Chemokines by the Highly Pneumotropic Human Adenovirus Type 14p1.
Authors: Lam E, Ramke M, Warnecke G, Schrepfer S, Kopfnagel V, Dobner T, Heim A
PLoS ONE, 2015;10(7):e0131201.
Species: Human
Sample Type: Cell Culture Supernates

Elevated plasma soluble CD14 and skewed CD16+ monocyte distribution persist despite normalisation of soluble CD163 and CXCL10 by effective HIV therapy: a changing paradigm for routine HIV laboratory monitoring?
Authors: Castley, Alison, Berry, Cassandr, French, Martyn, Fernandez, Sonia, Krueger, Romano, Nolan, David
PLoS ONE, 2014;9(12):e115226.
Species: Human
Sample Type: Plasma

Improving membrane based multiplex immunoassays for semi-quantitative detection of multiple cytokines in a single sample.
Authors: Altara, Raffaele, Manca, Marco, Hessel, Marleen, Janssen, Ben J, Struijker-Boudier, Harry H, Hermans, Rob J J, Blankesteijn, W Matthi
BMC Biotechnol, 2014;14(0):63.
Species: Human
Sample Type: Serum

Randomized comparison of single dose of recombinant human IL-12 versus placebo for restoration of hematopoiesis and improved survival in rhesus monkeys exposed to lethal radiation.
Authors: Gluzman-Poltorak Z, Mendonca S, Vainstein V, Kha H, Basile L
J Hematol Oncol, 2014;7(0):31.
Species: Primate - Macaca mulatta (Rhesus monkey)
Sample Type: Plasma

CXCL10 gene promoter polymorphism -1447A>G correlates with plasma CXCL10 levels and is associated with male susceptibility to cerebral malaria.
Authors: Wilson N, Driss A, Solomon W, Dickinson-Copeland C, Salifu H, Jain V, Singh N, Stiles J
PLoS ONE, 2013;8(12):e81329.
Species: Human
Sample Type: Plasma

Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis.
Authors: Chaturvedi, Pallavi, Gilkes, Daniele, Wong, Carmen C, Luo, Weibo, Zhang, Huafeng, Wei, Hong, Takano, Naoharu, Schito, Luana, Levchenko, Andre, Semenza, Gregg L
J Clin Invest, 2013;123(1):189-205.
Species: Human
Sample Type: Cell Culture Supernates

A20/TNFAIP3 inhibits NF-kappaB activation induced by the Kaposi's sarcoma-associated herpesvirus vFLIP oncoprotein.
Authors: Sakakibara S, Espigol-Frigole G, Gasperini P, Uldrick T, Yarchoan R, Tosato G
Oncogene, 2013;32(10):1223-32.
Species: Human
Sample Type: Whole Cells

Increased CXCL9 serum levels in hepatitis C-related mixed cryoglobulinemia, with autoimmune thyroiditis, associated with high levels of CXCL10.
Authors: Antonelli A, Fallahi P, Ferrari S, Colaci M, Giuggioli D, Saraceno G, Benvenga S, Ferri C
J Interferon Cytokine Res, 2013;33(12):739-45.
Species: Human
Sample Type: Serum

Expression of CXCR3 and its ligands CXCL9, -10 and -11 in paediatric opsoclonus-myoclonus syndrome.
Authors: Pranzatelli M, Tate E, McGee N, Travelstead A, Verhulst S, Ransohoff R
Clin Exp Immunol, 2013;172(3):427-36.
Species: Human
Sample Type: Serum

Cleaved/associated TLR3 represents the primary form of the signaling receptor.
Authors: Toscano F, Estornes Y, Virard F, Garcia-Cattaneo A, Pierrot A, Vanbervliet B, Bonnin M, Ciancanelli M, Zhang S, Funami K, Seya T, Matsumoto M, Pin J, Casanova J, Renno T, Lebecque S
J Immunol, 2013;190(2):764-73.
Species: Human
Sample Type: cell culture supernate

BAFF/APRIL system in pediatric OMS: relation to severity, neuroinflammation, and immunotherapy.
Authors: Pranzatelli, Michael, Tate, Elizabet, McGee, Nathan R, Travelstead, Anna L, Colliver, Jerry A, Ness, Jayne M, Ransohoff, Richard
J Neuroinflammation, 2013;10(0):10.
Species: Human
Sample Type: Serum

Evaluation of IL-28B Polymorphisms and Serum IP-10 in Hepatitis C Infected Chimpanzees.
Authors: Verstrepen B, De Groot N, Groothuismink Z, Verschoor E, de Groen R, Bogers W, Janssen H, Mooij P, Bontrop R, Koopman G, Boonstra A
PLoS ONE, 2012;7(10):e46645.
Species: Human
Sample Type: Serum

USP18 is a key regulator of the interferon-driven gene network modulating pancreatic beta cell inflammation and apoptosis.
Authors: Santin I, Moore F, Grieco F, Marchetti P, Brancolini C, Eizirik D
Cell Death Dis, 2012;3(0):e419.
Species: Human
Sample Type: Cell Culture Supernates

Circulating chemokine (CXC motif) ligand (CXCL)9 is increased in aggressive chronic autoimmune thyroiditis, in association with CXCL10.
Authors: Antonelli A, Ferrari SM, Frascerra S, Galetta F, Franzoni F, Corrado A, Miccoli M, Benvenga S, Paolicchi A, Ferrannini E, Fallahi P
Cytokine, 2011;55(2):288-93.
Species: Human
Sample Type: Serum

Human cytomegalovirus IE1 protein elicits a type II interferon-like host cell response that depends on activated STAT1 but not interferon-gamma.
Authors: Knoblach T, Grandel B, Seiler J, Nevels M, Paulus C
PLoS Pathog., 2011;7(4):e1002016.
Species: Human
Sample Type: Cell Culture Supernates

Evidence for a pathophysiological role of keratinocyte-derived type III interferon (IFN-lambda) in cutaneous lupus erythematosus.
Authors: Zahn S, Rehkamper C, Kummerer BM, Ferring-Schmidt S, Bieber T, Tuting T, Wenzel J
J. Invest. Dermatol., 2011;131(1):133-40.
Species: Human
Sample Type: Cell Culture Supernates

Phagocytosis of apoptotic cells modulates mesenchymal stem cells osteogenic differentiation to enhance IL-17 and RANKL expression on CD4+ T cells.
Authors: Tso GH, Law HK, Tu W
Stem Cells, 2010;28(5):939-54.
Species: Human
Sample Type: Cell Culture Supernates

Interleukin-1beta, C-x-C motif ligand 10, and interferon-gamma serum levels in mixed cryoglobulinemia with or without autoimmune thyroiditis.
Authors: Antonelli A, Ferri C, Ferrari SM, De Marco S, Di Domenicantonio A, Centanni M, Pupilli C, Villa E, Menichetti F, Fallahi P
J. Interferon Cytokine Res., 2010;30(11):835-42.
Species: Human
Sample Type: Serum

NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway.
Authors: Watanabe T, Asano N, Fichtner-Feigl S, Gorelick PL, Tsuji Y, Matsumoto Y, Chiba T, Fuss IJ, Kitani A, Strober W
J. Clin. Invest., 2010;120(5):1645-62.
Species: Human
Sample Type: Cell Culture Supernates

Serum IP-10 as a biomarker of human rhinovirus infection at exacerbation of COPD.
Authors: Quint JK, Donaldson GC, Goldring JJ, Baghai-Ravary R, Hurst JR, Wedzicha JA
Chest, 2010;137(4):812-22.
Species: Human
Sample Type: Serum

Expression of CXCL9, -10, -11, and CXCR3 in the tear film and ocular surface of patients with dry eye syndrome.
Authors: Yoon KC, Park CS, You IC, Choi HJ, Lee KH, Im SK, Park HY, Pflugfelder SC
Invest. Ophthalmol. Vis. Sci., 2010;51(2):643-50.
Species: Human
Sample Type: Tears

CD14-independent responses induced by a synthetic lipid A mimetic.
Authors: Legat A, Thomas S, Hermand P, Van Mechelen M, Goldman M, De Wit D
Eur J Immunol, 2010;40(3):797-802.
Species: Human
Sample Type: Cell Culture Supernates

Cerebrospinal fluid in HIV-1 systemic viral controllers: absence of HIV-1 RNA and intrathecal inflammation.
Authors: Probasco JC, Deeks SG, Lee E, Hoh R, Hunt PW, Liegler T, Price RW, Spudich SS
AIDS, 2010;24(7):1001-5.
Species: Human
Sample Type: CSF

Synthesis and immunological activities of novel agonists of toll-like receptor 9.
Authors: Struthers M, Bett AJ, Wisniewski T, Dubey SA, Precopio M, Jiang W, Sun Z, Wang H, Nowak I, Putta MR, Yu D, Tang JX, Kandimalla ER, Agrawal S, Casimiro DR
Cell. Immunol., 2010;263(1):105-13.
Species: Primate - Macaca mulatta (Rhesus monkey)
Sample Type: Cell Culture Supernates

The major outer membrane protein of a periodontopathogen induces IFN-beta and IFN-stimulated genes in monocytes via lipid raft and TANK-binding kinase 1/IFN regulatory factor-3.
Authors: Lee SH, Kim JS, Jun HK
J. Immunol., 2009;182(9):5823-35.
Species: Human
Sample Type: Cell Culture Supernates

Villitis of unknown etiology is associated with a distinct pattern of chemokine up-regulation in the feto-maternal and placental compartments: implications for conjoint maternal allograft rejection and maternal anti-fetal graft-versus-host disease.
Authors: Kim MJ, Romero R, Kim CJ, Tarca AL, Chhauy S, LaJeunesse C, Lee DC, Draghici S, Gotsch F, Kusanovic JP, Hassan SS, Kim JS
J. Immunol., 2009;182(6):3919-27.
Species: Human
Sample Type: Plasma

Phenotype of atopic dermatitis subjects with a history of eczema herpeticum.
Authors: Beck LA, Boguniewicz M, Hata T, Schneider LC, Hanifin J, Gallo R, Paller AS, Lieff S, Reese J, Zaccaro D, Milgrom H, Barnes KC, Leung DY
J. Allergy Clin. Immunol., 2009;124(2):260-9, 269.e1.
Species: Human
Sample Type: Serum

CXCR3 ligands are augmented during the pathogenesis of pulmonary sarcoidosis.
Authors: Busuttil A, Weigt SS, Keane MP, Xue YY, Palchevskiy V, Burdick MD, Huang C, Zisman DA, Fishbein M, Lynch JP, Strieter RM, Elashoff RM, Belperio JA
Eur. Respir. J., 2009;34(3):676-86.
Species: Human
Sample Type: BALF

The imbalance in serum concentration of Th-1- and Th-2-derived chemokines as one of the factors involved in pathogenesis of atopic dermatitis.
Authors: Narbutt J, Lesiak A, Sysa-Jedrzeiowska A, Zakrzewski M, Bogaczewicz J, Stelmach I, Kuna P
Mediators Inflamm., 2009;2009(0):269541.
Species: Human
Sample Type: Serum

CXCL10 and CCL2 chemokine serum levels in patients with hepatitis C associated with autoimmune thyroiditis.
Authors: Antonelli A, Ferri C, Fallahi P, Ferrari SM, Frascerra S, Pampana A, Panicucci E, Carpi A, Nicolini A, Ferrannini E
J. Interferon Cytokine Res., 2009;29(6):345-51.
Species: Human
Sample Type: Serum

Chemokine production and chemokine receptor expression by human glioma cells: role of CXCL10 in tumour cell proliferation.
Authors: Maru SV, Holloway KA, Flynn G, Lancashire CL, Loughlin AJ, Male DK, Romero IA
J. Neuroimmunol., 2008;199(1):35-45.
Species: Human
Sample Type: Cell Culture Supernates

Agonists of proteinase-activated receptor-2 enhance IFN-gamma-inducible effects on human monocytes: role in influenza A infection.
Authors: Feld M, Shpacovitch VM, Ehrhardt C, Kerkhoff C, Hollenberg MD, Vergnolle N, Ludwig S, Steinhoff M
J. Immunol., 2008;180(10):6903-10.
Species: Human
Sample Type: Cell Culture Supernates

The antibacterial chemokine MIG/CXCL9 is constitutively expressed in epithelial cells of the male urogenital tract and is present in seminal plasma.
Authors: Linge HM, Collin M, Giwercman A, Malm J, Bjartell A, Egesten A
J. Interferon Cytokine Res., 2008;28(3):191-6.
Species: Human
Sample Type: seminal plasma

Endometrial NK cells are special immature cells that await pregnancy.
Authors: Manaster I, Mizrahi S, Goldman-Wohl D, Sela HY, Stern-Ginossar N, Lankry D, Gruda R, Hurwitz A, Bdolah Y, Haimov-Kochman R, Yagel S, Mandelboim O
J. Immunol., 2008;181(3):1869-76.
Species: Human
Sample Type: Cell Culture Supernates

Evidence for a pathogenetic role of interleukin-18 in cutaneous lupus erythematosus.
Authors: Wang D, Drenker M, Eiz-Vesper B, Werfel T, Wittmann M
Arthritis Rheum., 2008;58(10):3205-15.
Species: Human
Sample Type: Cell Culture Supernates

In vitro induction of a dendritic cell phenotype in primary human acute myelogenous leukemia (AML) blasts alters the chemokine release profile and increases the levels of T cell chemotactic CCL17 and CCL22.
Authors: Olsnes AM, Ryningen A, Ersvaer E, Bruserud Ø
J. Interferon Cytokine Res., 2008;28(5):297-310.
Species: Human
Sample Type: Cell Culture Supernates

Urinary fractalkine is a marker of acute rejection.
Authors: Peng W, Chen J, Jiang Y, Wu J, Shou Z, He Q, Wang Y, Chen Y, Wang H
Kidney Int., 2008;74(11):1454-60.
Species: Human
Sample Type: Urine

The alarm anti-protease, secretory leukocyte protease inhibitor, is a proliferation and survival factor for ovarian cancer cells.
Authors: Simpkins FA, Devoogdt NM, Rasool N, Tchabo NE, Alejandro EU, Kamrava MM, Kohn EC
Carcinogenesis, 2007;29(3):466-72.
Species: Human
Sample Type: Cell Culture Supernates

Serum interleukin-18 and soluble tumour necrosis factor receptor 2 are associated with disease severity in patients with paracoccidioidomycosis.
Authors: Corvino CL, Mamoni RL, Fagundes GZ, Blotta MH
Clin. Exp. Immunol., 2007;147(3):483-90.
Species: Human
Sample Type: Serum

Polymorphisms in the chemokine (C-X-C motif) ligand 10 are associated with invasive aspergillosis after allogeneic stem-cell transplantation and influence CXCL10 expression in monocyte-derived dendritic cells.
Authors: Mezger M, Steffens M, Beyer M, Manger C, Eberle J, Toliat MR, Wienker TF, Ljungman P, Hebart H, Dornbusch HJ, Einsele H, Loeffler J
Blood, 2007;111(2):534-6.
Species: Human
Sample Type: Serum

Functional diversity of T-cell subpopulations in subacute and chronic hypersensitivity pneumonitis.
Authors: Barrera L, Mendoza F, Zuniga J, Estrada A, Zamora AC, Melendro EI, Ramirez R, Pardo A, Selman M
Am. J. Respir. Crit. Care Med., 2007;177(1):44-55.
Species: Human
Sample Type: BALF

CXCR3 and CCR5 chemokines in induced sputum from patients with COPD.
Authors: Costa C, Rufino R, Traves SL, Lapa E Silva JR, Barnes PJ, Donnelly LE
Chest, 2007;133(1):26-33.
Species: Human
Sample Type: Saliva

Phase 2 study of pegylated liposomal doxorubicin in combination with interleukin-12 for AIDS-related Kaposi sarcoma.
Authors: Little RF, Aleman K, Kumar P, Wyvill KM, Pluda JM, Read-Connole E, Wang V, Pittaluga S, Catanzaro AT, Steinberg SM, Yarchoan R
Blood, 2007;110(13):4165-71.
Species: Human
Sample Type: Serum

Chemokines CXCL10 and CXCL11 in the cerebrospinal fluid of patients with tick-borne encephalitis.
Authors: Lepej SZ, Misic-Majerus L, Jeren T, Rode OD, Remenar A, Sporec V, Vince A
Acta Neurol. Scand., 2007;115(2):109-14.

Toll-like receptors 3 and 4 are expressed by human bone marrow-derived mesenchymal stem cells and can inhibit their T-cell modulatory activity by impairing Notch signaling.
Authors: Liotta F, Angeli R, Cosmi L, Fili L, Manuelli C, Frosali F, Mazzinghi B, Maggi L, Pasini A, Lisi V, Santarlasci V, Consoloni L, Angelotti ML, Romagnani P, Parronchi P, Krampera M, Maggi E, Romagnani S, Annunziato F
Stem Cells, 2007;26(1):279-89.
Species: Human
Sample Type: Cell Culture Supernates

IFN-gamma alters the response of Borrelia burgdorferi-activated endothelium to favor chronic inflammation.
Authors: Dame TM, Orenzoff BL, Palmer LE, Furie MB
J. Immunol., 2007;178(2):1172-9.
Species: Human
Sample Type: Cell Culture Supernates

First in human phase I trial of 852A, a novel systemic toll-like receptor 7 agonist, to activate innate immune responses in patients with advanced cancer.
Authors: Dudek AZ, Yunis C, Harrison LI, Kumar S, Hawkinson R, Cooley S, Vasilakos JP, Gorski KS, Miller JS
Clin. Cancer Res., 2007;13(23):7119-25.
Species: Human
Sample Type: Serum

Prolactin enhances interferon-gamma-induced production of CXC ligand 9 (CXCL9), CXCL10, and CXCL11 in human keratinocytes.
Authors: Kanda N, Watanabe S
Endocrinology, 2007;148(5):2317-25.
Species: Human
Sample Type: Cell Culture Supernates

Proteomics analysis of Hodgkin lymphoma: identification of new players involved in the cross-talk between HRS cells and infiltrating lymphocytes.
Authors: Ma Y, Visser L, Roelofsen H, de Vries M, Diepstra A, van Imhoff G, van der Wal T, Luinge M, Alvarez-Llamas G, Vos H, Poppema S, Vonk R, Van Den Berg A
Blood, 2007;111(4):2339-46.
Species: Human
Sample Type: Cell Culture Supernates

Th1/Th2 cytokines reciprocally regulate in vitro pulmonary angiogenesis via CXC chemokine synthesis.
Authors: Matsuda A, Fukuda S, Matsumoto K, Saito H
Am. J. Respir. Cell Mol. Biol., 2007;38(2):168-75.
Species: Human
Sample Type: Cell Culture Supernates

Airway dendritic cell phenotypes in inflammatory diseases of the human lung.
Authors: Lommatzsch M, Bratke K, Bier A, Julius P, Kuepper M, Luttmann W, Virchow JC
Eur. Respir. J., 2007;30(5):878-86.
Species: Human
Sample Type: BALF

Ras-induced modulation of CXCL10 and its receptor splice variant CXCR3-B in MDA-MB-435 and MCF-7 cells: relevance for the development of human breast cancer.
Authors: Datta D, Flaxenburg JA, Laxmanan S, Geehan C, Grimm M, Waaga-Gasser AM, Briscoe DM, Pal S
Cancer Res., 2006;66(19):9509-18.
Species: Human
Sample Type: Cell Culture Supernates

The apoptotic-cell receptor CR3, but not alphavbeta5, is a regulator of human dendritic-cell immunostimulatory function.
Authors: Skoberne M, Somersan S, Almodovar W, Truong T, Petrova K, Henson PM, Bhardwaj N
Blood, 2006;108(3):947-55.
Species: Human
Sample Type: Cell Culture Supernates

Different angiogenic activity in pulmonary sarcoidosis and idiopathic pulmonary fibrosis.
Authors: Antoniou KM, Tzouvelekis A, Alexandrakis MG, Sfiridaki K, Tsiligianni I, Rachiotis G, Tzanakis N, Bouros D, Milic-Emili J, Siafakas NM
Chest, 2006;130(4):982-8.
Species: Human
Sample Type: BALF

Induction of dendritic cell maturation by pertussis toxin and its B subunit differentially initiate Toll-like receptor 4-dependent signal transduction pathways.
Authors: Wang ZY, Yang D, Chen Q, Leifer CA, Segal DM, Su SB, Caspi RR, Howard ZO, Oppenheim JJ
Exp. Hematol., 2006;34(8):1115-24.
Species: Human
Sample Type: Cell Culture Supernates

Deoxycytidyl-deoxyguanosine oligonucleotide classes A, B, and C induce distinct cytokine gene expression patterns in rhesus monkey peripheral blood mononuclear cells and distinct alpha interferon responses in TLR9-expressing rhesus monkey plasmacytoid dendritic cells.
Authors: Abel K, Wang Y, Fritts L, Sanchez E, Chung E, Fitzgerald-Bocarsly P, Krieg AM, Miller CJ
Clin. Diagn. Lab. Immunol., 2005;12(5):606-21.
Species: Primate - Macaca mulatta (Rhesus monkey)
Sample Type: Cell Culture Supernates

CpG oligonucleotides induce strong humoral but only weak CD4+ T cell responses to protein antigens in rhesus macaques in vivo.
Authors: Hartmann G, Marschner A, Viveros PR, Stahl-Hennig C, Eisenblatter M, Suh YS, Endres S, Tenner-Racz K, Uberla K, Racz P, Steinman RM, Ignatius R
Vaccine, 2005;23(25):3310-7.
Species: Primate - Macaca mulatta (Rhesus monkey)
Sample Type: Plasma

Simian human immunodeficiency virus-associated pneumonia correlates with increased expression of MCP-1, CXCL10, and viral RNA in the lungs of rhesus macaques.
Authors: Sui Y, Li S, Pinson D, Adany I, Li Z, Villinger F, Narayan O, Buch S
Am. J. Pathol., 2005;166(2):355-65.
Species: Primate - Macaca mulatta (Rhesus monkey)
Sample Type: Tissue Homogenates

IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis.
Authors: Numasaki M, Watanabe M, Suzuki T, Takahashi H, Nakamura A, McAllister F, Hishinuma T, Goto J, Lotze MT, Kolls JK, Sasaki H
J. Immunol., 2005;175(9):6177-89.
Species: Human
Sample Type: Cell Culture Supernates

Increased expression of CXCR3 and CCR5 on memory CD4+ T-cells migrating into the cerebrospinal fluid of patients with neuroborreliosis: the role of CXCL10 and CXCL11.
Authors: Lepej SZ, Rode OD, Jeren T, Vince A, Remenar A, Barsic B
J. Neuroimmunol., 2005;163(1):128-34.
Species: Human
Sample Type: Serum

CXCR3 and CCR5 positive T-cell recruitment in acute human renal allograft rejection.
Authors: Panzer U, Reinking RR, Steinmetz OM, Zahner G, Sudbeck U, Fehr S, Pfalzer B, Schneider A, Thaiss F, Mack M, Conrad S, Huland H, Helmchen U, Stahl RA
Transplantation, 2004;78(9):1341-50.
Species: Human
Sample Type: Urine

Involvement of the CXCL12/CXCR4 pathway in the advanced liver disease that is associated with hepatitis C virus or hepatitis B virus.
Authors: Wald O, Pappo O, Safadi R, Dagan-Berger M, Beider K, Wald H, Franitza S, Weiss I, Avniel S, Boaz P, Hanna J, Zamir G, Eid A, Mandelboim O, Spengler U, Galun E, Peled A
Eur. J. Immunol., 2004;34(4):1164-74.
Species: Human
Sample Type: Plasma

Enhanced generation of helper T type 1 and 2 chemokines in allergen-induced asthma.
Authors: Liu L, Jarjour NN, Busse WW, Kelly EA
Am. J. Respir. Crit. Care Med., 2004;169(10):1118-24.
Species: Human
Sample Type: BALF

Helper T-lymphocyte-related chemokines in healthy newborns.
Authors: Leung TF, Ng PC, Tam WH, Li CY, Wong E, Ma TP, Lam CW, Fok TF
Pediatr. Res., 2003;55(2):334-8.
Species: Human
Sample Type: Serum

Phenotypic and functional analysis of T cells homing into the CSF of subjects with inflammatory diseases of the CNS.
Authors: Giunti D, Borsellino G, Benelli R, Marchese M, Capello E, Valle MT, Pedemonte E, Noonan D, Albini A, Bernardi G, Mancardi GL, Battistini L, Uccelli A
J. Leukoc. Biol., 2003;73(5):584-90.
Species: Human
Sample Type: CSF

TNFalpha-induced macrophage chemokine secretion is more dependent on NF-kappaB expression than lipopolysaccharides-induced macrophage chemokine secretion.
Authors: Ciesielski CJ, Andreakos E, Foxwell BM, Feldmann M
Eur. J. Immunol., 2002;32(7):2037-45.
Species: Human
Sample Type: Cell Culture Supernates

Il-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation.
Authors: Hurst SM, Wilkinson TS, McLoughlin RM, Jones S, Horiuchi S, Yamamoto N, Rose-John S, Fuller GM, Topley N, Jones SA
Immunity, 2001;14(6):705-14.
Species: Human
Sample Type: Cell Culture Supernates

生物活性< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景IP-10 was originally identified as an IFN-gamma-inducible gene in monocytes, fibroblasts and endothelial cells. The mouse homolog of human IP-10, CRG-2, shares approximately 67% amino acid sequence identity with human IP-10. The amino acid sequence of IP-10 identified the protein as a member of the CXC chemokine subfamily.
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参考文献
  • Chemokines and Receptors
  • Chemokines and Receptors in Allergy and Asthma
  • Chemokines and Receptors in Angiogenesis
  • CXC Chemokines and Receptors
  • Infectious Diseases
  • Macrophage Activation Markers
  • Molecules Secreted by VSMC
  • Neuroinflammation
  • Regulatory T Cells (Tregs)