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Human CCL17/TARC Quantikine SixPak (6 Plates) (1 PK)

货号: SDN00 基本售价: 31934.7 元 规格: 1 PACK

产品信息

概述
货号SDN00
描述The Quantikine Human TARC Immunoassay kit is a 3.5 hour solid phase ELISA designed to measure TARC in cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant human TARC and antibodies raised against the recombinant factor. It has been shown to accurately quantitate recombinant human TARC. Results obtained using natural human TARC showed linear curves that were parallel to the standard curves obtained using the recombinant Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural human TARC.
别名ABCD-2; CC chemokine TARC; C-C motif chemokine 17; CCL17; chemokine (C-C motif) ligand 17; MGC138273; SCYA17MGC138271; small inducible cytokine subfamily A (Cys-Cys), member 17; Small-inducible cytokine A17; T cell-directed CC chemokine; TARC; TARCA-152E5.3; Thymus and activation-regulated chemokine;
反应种属Human
目标/特异性Natural and recombinant human TARC
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs
6361 (Human); 20295 (Mouse)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Prognostic significance of pretreatment serum cytokines in classical Hodgkin lymphoma.
Authors: Marri P, Hodge L, Maurer M, Ziesmer S, Slager S, Habermann T, Link B, Cerhan J, Novak A, Ansell S
Clin Cancer Res, 2013;19(24):6812-9.
Species: Human
Sample Type: Serum

BAFF/APRIL system in pediatric OMS: relation to severity, neuroinflammation, and immunotherapy.
Authors: Pranzatelli, Michael, Tate, Elizabet, McGee, Nathan R, Travelstead, Anna L, Colliver, Jerry A, Ness, Jayne M, Ransohoff, Richard
J Neuroinflammation, 2013;10(0):10.
Species: Human
Sample Type: Serum

Regulatory T cells suppress T cell activation at the pathologic site of human visceral leishmaniasis.
Authors: Rai AK, Thakur CP, Singh A
PLoS ONE, 2012;7(2):e31551.
Species: Human
Sample Type: Serum

Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver.
Authors: Oo YH, Weston CJ, Lalor PF, Curbishley SM, Withers DR, Reynolds GM, Shetty S, Harki J, Shaw JC, Eksteen B, Hubscher SG, Walker LS, Adams DH
J. Immunol., 2010;184(6):2886-98.

Mepolizumab as a corticosteroid-sparing agent in lymphocytic variant hypereosinophilic syndrome.
Authors: Roufosse F, de Lavareille A, Schandene L, Cogan E, Georgelas A, Wagner L, Xi L, Raffeld M, Goldman M, Gleich GJ, Klion A
J. Allergy Clin. Immunol., 2010;126(4):828-835.
Species: Human
Sample Type: Serum

Brentuximab vedotin (SGN-35) for relapsed CD30-positive lymphomas.
Authors: Younes A, Bartlett NL, Leonard JP
N. Engl. J. Med., 2010;363(19):1812-21.
Species: Human
Sample Type: Serum

The imbalance in serum concentration of Th-1- and Th-2-derived chemokines as one of the factors involved in pathogenesis of atopic dermatitis.
Authors: Narbutt J, Lesiak A, Sysa-Jedrzeiowska A, Zakrzewski M, Bogaczewicz J, Stelmach I, Kuna P
Mediators Inflamm., 2009;2009(0):269541.
Species: Human
Sample Type: Serum

Increases in serum TARC/CCL17 levels are associated with progression-free survival in advanced melanoma patients in response to dendritic cell-based immunotherapy.
Authors: Cornforth AN, Lee GJ, Fowler AW, Carbonell DJ, Dillman RO
J. Clin. Immunol., 2009;29(5):657-64.
Species: Human
Sample Type: Serum

Phenotype of atopic dermatitis subjects with a history of eczema herpeticum.
Authors: Beck LA, Boguniewicz M, Hata T, Schneider LC, Hanifin J, Gallo R, Paller AS, Lieff S, Reese J, Zaccaro D, Milgrom H, Barnes KC, Leung DY
J. Allergy Clin. Immunol., 2009;124(2):260-9, 269.e1.
Species: Human
Sample Type: Serum

In vitro induction of a dendritic cell phenotype in primary human acute myelogenous leukemia (AML) blasts alters the chemokine release profile and increases the levels of T cell chemotactic CCL17 and CCL22.
Authors: Olsnes AM, Ryningen A, Ersvaer E, Bruserud Ø
J. Interferon Cytokine Res., 2008;28(5):297-310.
Species: Human
Sample Type: Cell Culture Supernates

Development of an in vitro potency bioassay for therapeutic IL-13 antagonists: the A-549 cell bioassay.
Authors: Miller R, Sadhukhan R, Wu C
J. Immunol. Methods, 2008;334(1):134-41.
Species: Human
Sample Type: Cell Culture Supernates

Specific recruitment of regulatory T cells into the CSF in lymphomatous and carcinomatous meningitis.
Authors: Haas J, Schopp L, Storch-Hagenlocher B, Fritzsching B, Jacobi C, Milkova L, Fritz B, Schwarz A, Suri-Payer E, Hensel M, Wildemann B
Blood, 2007;111(2):761-6.
Species: Human
Sample Type: CSF

Comparison of serum markers for allergic bronchopulmonary aspergillosis in cystic fibrosis.
Authors: Latzin P, Hartl D, Regamey N, Frey U, Schoeni MH, Casaulta C
Eur. Respir. J., 2007;31(1):36-42.
Species: Human
Sample Type: Serum

Circulating thymus- and activation-regulated chemokine/CCL17 is a useful biomarker for discriminating acute eosinophilic pneumonia from other causes of acute lung injury.
Authors: Miyazaki E, Nureki S, Ono E, Ando M, Matsuno O, Fukami T, Ueno T, Kumamoto T
Chest, 2007;131(6):1726-34.
Species: Human
Sample Type: BALF

Proteomics analysis of Hodgkin lymphoma: identification of new players involved in the cross-talk between HRS cells and infiltrating lymphocytes.
Authors: Ma Y, Visser L, Roelofsen H, de Vries M, Diepstra A, van Imhoff G, van der Wal T, Luinge M, Alvarez-Llamas G, Vos H, Poppema S, Vonk R, Van Den Berg A
Blood, 2007;111(4):2339-46.
Species: Human
Sample Type: Cell Culture Supernates

Functional diversity of T-cell subpopulations in subacute and chronic hypersensitivity pneumonitis.
Authors: Barrera L, Mendoza F, Zuniga J, Estrada A, Zamora AC, Melendro EI, Ramirez R, Pardo A, Selman M
Am. J. Respir. Crit. Care Med., 2007;177(1):44-55.
Species: Human
Sample Type: BALF

CD16+ monocyte-derived macrophages activate resting T cells for HIV infection by producing CCR3 and CCR4 ligands.
Authors: Ancuta P, Autissier P, Wurcel A, Zaman T, Stone D, Gabuzda D
J. Immunol., 2006;176(10):5760-71.
Species: Human
Sample Type: Cell Culture Supernates

Chemokines indicate allergic bronchopulmonary aspergillosis in patients with cystic fibrosis.
Authors: Hartl D, Latzin P, Zissel G, Krane M, Krauss-Etschmann S, Griese M
Am. J. Respir. Crit. Care Med., 2006;173(12):1370-6.
Species: Human
Sample Type: Serum

Der p, IL-4, and TGF-beta cooperatively induce EGFR-dependent TARC expression in airway epithelium.
Authors: Heijink IH, Marcel Kies P, van Oosterhout AJ, Postma DS, Kauffman HF, Vellenga E
Am. J. Respir. Cell Mol. Biol., 2006;36(3):351-9.
Species: Human
Sample Type: Cell Culture Supernates

Glucocorticoid-induced tumour necrosis factor receptor (GITR) and its ligand (GITRL) in atopic dermatitis.
Authors: Baumgartner-Nielsen J, Vestergaard C, Thestrup-Pedersen K
Acta Derm. Venereol., 2006;86(5):393-8.
Species: Human
Sample Type: Plasma

Serum levels of cutaneous T-cell attracting chemokine (CTACK) as a laboratory marker of the severity of atopic dermatitis in children.
Authors: Hon KL, Leung TF, Ma KC, Li AM, Wong Y, Fok TF
Clin. Exp. Dermatol., 2004;29(3):293-6.
Species: Human
Sample Type: Serum

CSF chemokine levels in relapsing neuromyelitis optica and multiple sclerosis.
Authors: Narikawa K, Misu T, Fujihara K, Nakashima I, Sato S, Itoyama Y
J. Neuroimmunol., 2004;149(1):182-6.
Species: Human
Sample Type: Serum

Increased macrophage-derived chemokine in exhaled breath condensate and plasma from children with asthma.
Authors: Leung TF, Wong GW, Ko FW, Lam CW, Fok TF
Clin. Exp. Allergy, 2004;34(5):786-91.
Species: Human
Sample Type: Plasma

Helper T-lymphocyte-related chemokines in healthy newborns.
Authors: Leung TF, Ng PC, Tam WH, Li CY, Wong E, Ma TP, Lam CW, Fok TF
Pediatr. Res., 2003;55(2):334-8.
Species: Human
Sample Type: Serum

Thymus and activation-regulated chemokine (TARC/CCL17) produced by mouse epidermal Langerhans cells is upregulated by TNF-alpha and IL-4 and downregulated by IFN-gamma.
Authors: Xiao T, Fujita H, Saeki H, Mitsui H, Sugaya M, Tada Y, Kakinuma T, Torii H, Nakamura K, Asahina A, Tamaki K
Cytokine, 2003;23(4):126-32.
Species: Human
Sample Type: Serum

Skewing of cytotoxic activity and chemokine production, but not of chemokine receptor expression, in human type-1/-2 gamma delta T lymphocytes.
Authors: D'Ambrosio D
Eur. J. Immunol., 2002;32(10):2934-43.
Species: Human
Sample Type: Cell Culture Supernates

Elevated levels of thymus and activation-regulated chemokine (TARC) in pleural effusion samples from patients infested with Paragonimus westermani.
Authors: Matsumoto N, Mukae H, Nakamura-Uchiyama F, Ashitani JI, Abe K, Katoh S, Kohno S, Nawa Y, Matsukura S
Clin. Exp. Immunol., 2002;130(2):314-8.
Species: Human
Sample Type: Pleural Effusion

Characterization of monocyte subtypes in the allergic form of atopic eczema/dermatitis syndrome.
Authors: Novak N, Allam P, Geiger E, Bieber T
Allergy, 2002;57(10):931-5.
Species: Human
Sample Type: Serum

A cytokine-to-chemokine axis between T lymphocytes and keratinocytes can favor Th1 cell accumulation in chronic inflammatory skin diseases.
Authors: Albanesi C, Scarponi C, Sebastiani S, Cavani A, Federici M, Sozzani S, Girolomoni G
J. Leukoc. Biol., 2001;70(4):617-23.
Species: Human
Sample Type: Cell Culture Supernates

Clonal Th2 cells associated with chronic hypereosinophilia: TARC-induced CCR4 down-regulation in vivo.
Authors: de Lavareille A, Roufosse F, Schandene L, Stordeur P, Cogan E, Goldman M
Eur. J. Immunol., 2001;31(4):1037-46.
Species: Human
Sample Type: Serum

生物活性< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景CCL17/TARC is a chemokine that interacts with CCR4 and CCR8 to induce the chemoattraction of activated Th2 cells, basophils, and NK cells. It is produced by thymic dendritic cells, lymph node dendritic cells, monocytes, CD4+ T cells, keratinocytes, fibroblasts, bronchial epithelial cells, and Reed-Sternberg cells. CCL17 promotes Th2 cell recruitment to sites of inflammation and induces platelet aggregation and degranulation.
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参考文献
  • CC Chemokines and Receptors
  • Chemokines and Receptors
  • Chemokines and Receptors in Allergy and Asthma
  • Macrophage Activation Markers
  • Regulatory T Cells (Tregs)
  • Th9 Cells