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Human IL-17 Quantikine SixPak (6 Plates) (1 PK)

货号: S1700 基本售价: 31934.7 元 规格: 1 PACK

产品信息

概述
货号S1700
描述The Quantikine Human IL-17 Immunoassay is a 4.5 hour solid phase ELISA designed to measure human IL-17 in cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant human IL-17 and antibodies raised against the recombinant factor. This immunoassay has been shown to quantitate recombinant human IL-17 accurately. Results obtained using natural human IL-17 showed linear curves that were parallel to the standard curves obtained using the recombinant Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural human IL-17.
别名CTLA-8; CTLA8cytotoxic T-lymphocyte-associated serine esterase 8; Cytotoxic T-lymphocyte-associated antigen 8; IL17; IL-17; IL17A; IL-17Acytotoxic T-lymphocyte-associated protein 8; IL-17CTLA-8; IL17interleukin-17A; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); interleukin 17A;
全称
Interleukin 17
反应种属Human
目标/特异性Natural and recombinant human IL-17
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs
3605 (Human); 16171 (Mouse); 301289 (Rat); 481837 (Canine)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

High serum resistin associates with intrahepatic inflammation and necrosis: an index of disease severity for patients with chronic HBV infection
Authors: Z Meng, Y Zhang, Z Wei, P Liu, J Kang, Y Zhang, D Ma, C Ke, Y Chen, J Luo, Z Gong
BMC Gastroenterol, 2017;17(1):6.
Species: Human
Sample Type: Serum

Lacrimal gland-derived IL-22 regulates IL-17-mediated ocular mucosal inflammation
Authors: YW Ji, SK Mittal, HS Hwang, EJ Chang, JH Lee, Y Seo, A Yeo, H Noh, HS Lee, SK Chauhan, HK Lee
Mucosal Immunol, 2017;0(0):.
Species: Human
Sample Type: Cell Culture Supernates

Expression of human gene coding ROR?T receptor depends on the Sp2 transcription factor
Authors: Marcin Ratajewski
J Leukoc Biol, 2016;0(0):.
Species: Human
Sample Type: Cell Culture Supernates

Downregulation of proinflammatory cytokines in HTLV-1-infected T cells by Resveratrol
J Exp Clin Cancer Res, 2016;35(1):118.
Species: Human
Sample Type: Cell Culture Supernates

CCL20-CCR6 Cytokine Network Facilitate Treg Activity in Advanced Grades and Metastatic Variants of Hepatocellular Carcinoma.
Authors: Li W, Liu H
Scand J Immunol, 2015;83(1):33-7.
Species: Human
Sample Type: Tissue Homgenates

The impact of concomitant pulmonary infection on immune dysregulation in Pneumocystis jirovecii pneumonia.
Authors: Chou C, Lin F, Tsai H, Chang S
BMC Pulm Med, 2014;14(0):182.
Species: Human
Sample Type: BALF

Overexpression of IL-17RC associated with ocular sarcoidosis.
Authors: Wu W, Jin M, Wang Y, Liu B, Shen D, Chen P, Hannes S, Li Z, Hirani S, Jawad S, Sen H, Chan C, Nussenblatt R, Wei L
J Transl Med, 2014;12(0):152.
Species: Human
Sample Type: Serum

Exogenous IFN-beta regulates the RANKL-c-Fos-IFN-beta signaling pathway in the collagen antibody-induced arthritis model.
Authors: Zhao R, Chen N, Zhou X, Miao P, Hu C, Qian L, Yu Q, Zhang J, Nie H, Chen X, Li P, Xu R, Xiao L, Zhang X, Liu J, Zhang D
J Transl Med, 2014;12(1):330.
Species: Human
Sample Type: Serum

Elevated serum levels of interleukin-17A in children with autism.
Authors: Al-Ayadhi LY, Mostafa GA
J Neuroinflammation, 2012;9(1):158.
Species: Human
Sample Type: Serum

Complement component C5a Promotes Expression of IL-22 and IL-17 from Human T cells and its Implication in Age-related Macular Degeneration.
Authors: Liu B, Wei L, Meyerle C, Tuo J, Sen HN, Li Z, Chakrabarty S, Agron E, Chan CC, Klein ML, Chew E, Ferris F, Nussenblatt RB
J Transl Med, 2011;9(0):111.
Species: Human
Sample Type: Serum

Kinetics of circulating Th17 cytokines and adipokines in psoriasis patients.
Authors: Nakajima H, Nakajima K, Tarutani M, Morishige R, Sano S
Arch. Dermatol. Res., 2011;303(6):451-5.
Species: Human
Sample Type: Serum

Expression of the T helper 17-associated cytokines IL-17A and IL-17F in asthma and COPD.
Authors: Doe C, Bafadhel M, Siddiqui S, Desai D, Mistry V, Rugman P, McCormick M, Woods J, May R, Sleeman MA, Anderson IK, Brightling CE
Chest, 2011;138(5):1140-7.
Species: Human
Sample Type: Sputum

Identification of human NK17/NK1 cells.
Authors: Pandya AD, Al-Jaderi Z, Hoglund RA, Holmoy T, Harbo HF, Norgauer J, Maghazachi AA
PLoS ONE, 2011;6(10):e26780.
Species: Human
Sample Type: Cell Culture Supernates

IL-22, but not IL-17, dominant environment in cutaneous T-cell lymphoma.
Authors: Miyagaki T, Sugaya M, Suga H, Kamata M, Ohmatsu H, Fujita H, Asano Y, Tada Y, Kadono T, Sato S
Clin. Cancer Res., 2011;17(24):7529-38.
Species: Human
Sample Type: Serum

Preclinical Evaluation of Local JAK1 and JAK2 Inhibition in Cutaneous Inflammation.
Authors: Fridman JS, Scherle PA, Collins R, Burn T, Neilan CL, Hertel D, Contel N, Haley P, Thomas B, Shi J, Collier P, Rodgers JD, Shepard S, Metcalf B, Hollis G, Newton RC, Yeleswaram S, Friedman SM, Vaddi K
J. Invest. Dermatol., 2011;131(9):1838-44.
Species: Human
Sample Type: Cell Culture Supernates

Cytokine Response Patterns in Severe Pandemic 2009 H1N1 and Seasonal Influenza among Hospitalized Adults.
Authors: Lee N, Wong CK, Chan PK, Chan MC, Wong RY, Lun SW, Ngai KL, Lui GC, Wong BC, Lee SK, Choi KW, Hui DS
PLoS ONE, 2011;6(10):e26050.
Species: Human
Sample Type: Plasma

Subnormal cytokine profile in the tear fluid of keratoconus patients.
Authors: Jun AS, Cope L, Speck C, Feng X, Lee S, Meng H, Hamad A, Chakravarti S
PLoS ONE, 2011;6(1):e16437.
Species: Human
Sample Type: Tears

Presence of IL-5 protein and IgE antibodies to staphylococcal enterotoxins in nasal polyps is associated with comorbid asthma.
Authors: Bachert C, Zhang N, Holtappels G, De Lobel L, Van Cauwenberge P, Liu S, Lin P, Bousquet J, Van Steen K
J. Allergy Clin. Immunol., 2010;126(5):962.
Species: Human
Sample Type: Tissue Homogenates

Opposing roles of IL-17A and IL-25 in the regulation of TSLP production in human nasal epithelial cells.
Authors: Xu G, Zhang L, Wang DY, Xu R, Liu Z, Han DM, Wang XD, Zuo KJ, Li HB
Allergy, 2010;65(5):581-9.
Species: Human
Sample Type: nasal lavage

B7-h3 augments the inflammatory response and is associated with human sepsis.
Authors: Zhang G, Wang J, Kelly J
J. Immunol., 2010;185(6):3677-84.
Species: Human
Sample Type: Plasma

An antiinflammatory dietary mix modulates inflammation and oxidative and metabolic stress in overweight men: a nutrigenomics approach.
Authors: Bakker GC, van Erk MJ, Pellis L, Wopereis S, Rubingh CM, Cnubben NH, Kooistra T, van Ommen B, Hendriks HF
Am. J. Clin. Nutr., 2010;91(4):1044-59.
Species: Human
Sample Type: Plasma

Regulating human Th17 cells via differential expression of IL-1 receptor.
Authors: Lee WW, Kang SW, Choi J
Blood, 2010;115(3):530-40.
Species: Human
Sample Type: Cell Culture Supernates

Intervention of an inflammation amplifier, triggering receptor expressed on myeloid cells 1, for treatment of autoimmune arthritis.
Authors: Murakami Y, Akahoshi T, Aoki N, Toyomoto M, Miyasaka N, Kohsaka H
Arthritis Rheum., 2009;60(6):1615-23.
Species: Human
Sample Type: Serum

Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling.
Authors: Boniface K, Bak-Jensen KS, Li Y, Blumenschein WM, McGeachy MJ, McClanahan TK, McKenzie BS, Kastelein RA, Cua DJ, de Waal Malefyt R
J. Exp. Med., 2009;206(3):535-48.
Species: Human
Sample Type: Cell Culture Supernates

IL-17 in atopic eczema: linking allergen-specific adaptive and microbial-triggered innate immune response.
Authors: Eyerich K, Pennino D, Scarponi C, Foerster S, Nasorri F, Behrendt H, Ring J, Traidl-Hoffmann C, Albanesi C, Cavani A
J. Allergy Clin. Immunol., 2009;123(1):59-66.e4.
Species: Human
Sample Type: Cell Culture Supernates

Interleukin 17: an unlikely marker of acute coronary syndrome?
Authors: Patel KD, Murphy RT, White M, Gasparro D, Kelleher DP, Ryan T, McManus R, Ryan AW
Atherosclerosis, 2009;205(1):33-4.
Species: Human
Sample Type: Serum

Urinary proinflammatory cytokine response in renal transplant recipients with polyomavirus BK viruria.
Authors: Sadeghi M, Daniel V, Schnitzler P, Lahdou I, Naujokat C, Zeier M, Opelz G
Transplantation, 2009;88(9):1109-16.
Species: Human
Sample Type: Urine

The Th17 cytokine IL-22 induces IL-20 production in keratinocytes: a novel immunological cascade with potential relevance in psoriasis.
Authors: Wolk K, Witte E, Warszawska K, Schulze-Tanzil G, Witte K, Philipp S, Kunz S, Docke WD, Asadullah K, Volk HD, Sterry W, Sabat R
Eur. J. Immunol., 2009;39(12):3570-81.
Species: Human
Sample Type: Serum

IL-17 induces monocyte migration in rheumatoid arthritis.
Authors: Shahrara S, Pickens SR, Dorfleutner A, Pope RM
J. Immunol., 2009;182(6):3884-91.
Species: Human
Sample Type: Synovial Fluid

Serum interleukin-17 levels are related to clinical severity in allergic rhinitis.
Authors: Ciprandi G, De Amici M, Murdaca G, Fenoglio D, Ricciardolo F, Marseglia G, Tosca M
Allergy, 2009;64(9):1375-8.
Species: Human
Sample Type: Serum

Memory Th-17 cells specific for C. albicans are persistent in human peripheral blood.
Authors: Zhou M, Yang B, Ma R, Wu C
Immunol. Lett., 2008;118(1):72-81.
Species: Human
Sample Type: Cell Culture Supernates

Serum levels of MMP-3 and cathepsin K in patients with ankylosing spondylitis: effect of TNFalpha antagonist therapy.
Authors: Wendling D, Cedoz JP, Racadot E
Joint Bone Spine, 2008;75(5):559-62.
Species: Human
Sample Type: Serum

Linking genetic susceptibility to Crohns disease with Th17 cell function: IL-22 serum levels are increased in Crohns disease and correlate with disease activity and IL23R genotype status.
Authors: Schmechel S, Konrad A, Diegelmann J, Glas J, Wetzke M, Paschos E, Lohse P, Goke B, Brand S
Inflamm. Bowel Dis., 2008;14(2):204-12.
Species: Human
Sample Type: Serum

Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes.
Authors: Pene J, Chevalier S, Preisser L, Venereau E, Guilleux MH, Ghannam S, Moles JP, Danger Y, Ravon E, Lesaux S, Yssel H, Gascan H
J. Immunol., 2008;180(0):7423.
Species: Human
Sample Type: Cell Culture Supernates

Increased numbers of circulating polyfunctional Th17 memory cells in patients with seronegative spondylarthritides.
Authors: Jandus C, Bioley G, Rivals JP, Dudler J, Speiser D, Romero P
Arthritis Rheum., 2008;58(8):2307-17.
Species: Human
Sample Type: Cell Culture Supernates

IL-22 induces lipopolysaccharide-binding protein in hepatocytes: a potential systemic role of IL-22 in Crohn's disease.
Authors: Wolk K, Witte E, Hoffmann U, Doecke WD, Endesfelder S, Asadullah K, Sterry W, Volk HD, Wittig BM, Sabat R
J. Immunol., 2007;178(9):5973-81.
Species: Human
Sample Type: Cell Culture Supernates

IL-1alpha and IL-1beta are endogenous mediators linking cell injury to the adaptive alloimmune response.
Authors: Rao DA, Tracey KJ, Pober JS
J. Immunol., 2007;179(10):6536-46.
Species: Human
Sample Type: Cell Culture Supernates

IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production.
Authors: Vaknin-Dembinsky A, Balashov K, Weiner HL
J. Immunol., 2006;176(12):7768-74.
Species: Human
Sample Type: Cell Culture Supernates

Levels of interleukin-17 in gingival crevicular fluid and in supernatants of cellular cultures of gingival tissue from patients with chronic periodontitis.
Authors: Vernal R, Dutzan N, Chaparro A, Puente J, Antonieta Valenzuela M, Gamonal J
J. Clin. Periodontol., 2005;32(4):383-9.
Species: Human
Sample Type: Gingival Crevicular Fluid (GCF)

Cytokine profile in Behcet's disease patients. Relationship with disease activity.
Authors: Hamzaoui K, Hamzaoui A, Guemira F, Bessioud M, Hamza M, Ayed K
Scand. J. Rheumatol., 2002;31(4):205-10.
Species: Human
Sample Type: Serum

Stimulation of 92-kd gelatinase (matrix metalloproteinase 9) production by interleukin-17 in human monocyte/macrophages: a possible role in rheumatoid arthritis.
Authors: Jovanovic DV, Martel-Pelletier J, Di Battista JA, Mineau F, Jolicoeur FC, Benderdour M, Pelletier JP
Arthritis Rheum., 2000;43(5):1134-44.
Species: Human
Sample Type: Synovial Fluid

生物活性< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景The IL-17 family is comprised of at least six proinflammatory cytokines that share a conserved cysteine-knot structure but diverge at the N-terminus. IL-17 family members are glycoproteins secreted as dimers that induce local cytokine production and recruit granulocytes to sites of inflammation. IL-17 is induced by IL-15 and IL-23, mainly in activated CD4+ T cells distinct from Th1 or Th2 cells. IL-17F is the most homologous to IL-17, but is induced only by IL-23 in activated monocytes. IL-17B binds the IL-17B receptor, but not the IL-17 receptor; it is most homologous with IL-17D, which is expressed by resting CD4+ T cells and CD19+ B cells. IL-17E is mainly produced by Th2 cells and recruits eosinophils to lung tissue. IL-17C has a very restricted expression pattern but has been detected in adult prostate and fetal kidney libraries.
运输条件Blue Ice
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参考文献
  • B Cell Chemotaxis, Migration, and Adhesion
  • Cytokines and Receptors in Tfh Cell Differentiation and Function
  • gamma delta T Cells
  • Helper T (Th) Cells
  • IL-17 Family
  • LTi Cells
  • Macrophage Activation Markers
  • Molecules Secreted by VSMC
  • Multiple Sclerosis and Myelin Related Molecules
  • Natural Killer T (NKT) Cells
  • NCR-ILC3
  • Neuroinflammation
  • T Cell Cytokine Signaling
  • Th17 Cells