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Rat IL-6 Quantikine SixPak (6 Plates) (1 PK)

货号: SR6000B 基本售价: 30090.6 元 规格: 1 PACK

产品信息

概述
货号SR6000B
描述The Quantikine Rat IL-6 Immunoassay is a 4.5 hour solid phase ELISA designed to measure rat IL-6 in cell culture supernates, rat serum, and plasma. It contains E. coli-expressed recombinant rat IL-6 and antibodies raised against the recombinant factor. This immunoassay has been shown to accurately quantitate the recombinant protein. Results obtained using natural rat IL-6 showed dose-response curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural rat IL-6.
别名B cell stimulatory factor-2; B-cell differentiation factor; BSF-2; BSF2CTL differentiation factor; CDF; HGFHSFIFNB2Hybridoma growth factor; IFN-beta-2; IL6; IL-6; IL-6B-cell stimulatory factor 2; Interferon beta-2; interleukin 6 (interferon, beta 2); interleukin BSF-2; interleukin-6; MGI-2A;
全称
Interleukin 6
反应种属Rat
目标/特异性Natural and recombinant rat IL-6
性能
供应商R&D Systems
Entrez Gene IDs
3569 (Human); 16193 (Mouse); 24498 (Rat); 399500 (Porcine); 280826 (Bovine); 403985 (Canine); 100034196 (Equine); 493687 (Feline); 100008733 (Rabbit)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

The Effects of Remifentanil on Expression of High Mobility Group Box 1 in Septic Rats
Authors: KH Seo, JW Choi, HS Jung, H Yoo, JD Joo
J. Korean Med. Sci, 2017;32(3):542-551.
Species: Rat
Sample Type: Serum

The extent of irradiation-induced long-term visceral organ damage depends on cranial/brain exposure.
Authors: Boittin F, Denis J, Mayol J, Martigne P, Raffin F, Coulon D, Grenier N, Drouet M, Herodin F
PLoS ONE, 2015;10(4):e0122900.
Species: Rats
Sample Type: Plasma

Systemic siRNA Nanoparticle-Based Drugs Combined with Radiofrequency Ablation for Cancer Therapy.
Authors: Ahmed M, Kumar G, Navarro G, Wang Y, Gourevitch S, Moussa M, Rozenblum N, Levchenko T, Galun E, Torchilin V, Goldberg S
PLoS ONE, 2015;10(7):e0128910.
Species: Rat
Sample Type: Serum

Effect of Silodosin, an Alpha1A-Adrenoceptor Antagonist, on Ventral Prostatic Hyperplasia in the Spontaneously Hypertensive Rat.
Authors: Shimizu S, Shimizu T, Tsounapi P, Higashi Y, Martin D, Nakamura K, Honda M, Inoue K, Saito M
PLoS ONE, 2015;10(8):e0133798.

Iron-hepcidin dysmetabolism, anemia and renal hypoxia, inflammation and fibrosis in the remnant kidney rat model.
Authors: Garrido P, Ribeiro S, Fernandes J, Vala H, Bronze-da-Rocha E, Rocha-Pereira P, Belo L, Costa E, Santos-Silva A, Reis F
PLoS ONE, 2015;10(4):e0124048.
Species: Rat
Sample Type: Serum

IL-17A is implicated in lipopolysaccharide-induced neuroinflammation and cognitive impairment in aged rats via microglial activation.
Authors: Sun J, Zhang S, Zhang X, Zhang X, Dong H, Qian Y
J Neuroinflammation, 2015;12(0):165.

Melatonin attenuates the TLR4-mediated inflammatory response through MyD88- and TRIF-dependent signaling pathways in an in vivo model of ovarian cancer.
Authors: Chuffa L, Fioruci-Fontanelli B, Mendes L, Ferreira Seiva F, Martinez M, Favaro W, Domeniconi R, Pinheiro P, Delazari Dos Santos L, Martinez F
BMC Cancer, 2015;15(0):34.
Species: Rat
Sample Type: Tissue Supernate

Electrical stimulation induces IL-6 in skeletal muscle through extracellular ATP by activating Ca(2+) signals and an IL-6 autocrine loop.
Authors: Bustamante M, Fernandez-Verdejo R, Jaimovich E, Buvinic S
Am J Physiol Endocrinol Metab, 2014;306(8):E869-82.
Species: Rat
Sample Type: Cell Culture Supernates

Perioperative aspirin improves neurological outcome after focal brain ischemia possibly via inhibition of Notch 1 in rat.
Authors: Wang Z, Huang W, Zuo Z
J Neuroinflammation, 2014;11(0):56.
Species: Rat
Sample Type: Whole Tissue

Microglia trigger astrocyte-mediated neuroprotection via purinergic gliotransmission.
Authors: Shinozaki Y, Nomura M, Iwatsuki K, Moriyama Y, Gachet C, Koizumi S
Sci Rep, 2014;4(0):4329.
Species: Rat
Sample Type: Cell Culture Supernates

Quiescent hepatic stellate cells functionally contribute to the hepatic innate immune response via TLR3.
Authors: Wilson C, Mann J, Walsh M, Perrugoria M, Oakley F, Wright M, Brignole C, Di Paolo D, Perri P, Ponzoni M, Karin M, Mann D
PLoS ONE, 2014;9(1):e83391.
Species: Rat
Sample Type: Cell Culture Supernates

Catalpol ameliorates sodium taurocholate-induced acute pancreatitis in rats via inhibiting activation of nuclear factor kappa B.
Authors: Xiao W, Yin G, Fan Y, Qiu L, Cang X, Yu G, Hu Y, Xing M, Wu D, Wang X, Hu G, Wan R
Int J Mol Sci, 2014;15(7):11957-72.
Species: Rat
Sample Type: Serum

Mechanical ventilation enhances HMGB1 expression in an LPS-induced lung injury model.
Authors: Ding N, Wang F, Xiao H, Xu L, She S
PLoS ONE, 2013;8(9):e74633.
Species: Rat
Sample Type: BALF

Early cardiac changes in a rat model of prediabetes: brain natriuretic peptide overexpression seems to be the best marker.
Authors: Nunes S, Soares E, Fernandes J, Viana S, Carvalho E, Pereira F, Reis F
Cardiovasc Diabetol, 2013;12(0):44.
Species: Rat
Sample Type: Serum

A short course of infusion of a hydrogen sulfide-donor attenuates endotoxemia induced organ injury via stimulation of anti-inflammatory pathways, with no additional protection from prolonged infusion.
Cytokine, 2013;61(2):614-21.
Species: Rat
Sample Type: BALF

Increased intrahepatic resistance in severe steatosis: endothelial dysfunction, vasoconstrictor overproduction and altered microvascular architecture.
Authors: Francque S, Laleman W, Verbeke L, Van Steenkiste C, Casteleyn C, Kwanten W, Van Dyck C
Lab Invest, 2012;92(10):1428-39.
Species: Rat
Sample Type: Serum

Keratinocyte expression of inflammatory mediators plays a crucial role in substance P-induced acute and chronic pain.
J Neuroinflammation, 2012;9(0):181.
Species: Rat
Sample Type: Tissue Homogenates

Vipera aspis venom reduces lethality and down-regulates tumor necrosis factor-alpha in a rat model of LPS-induced sepsis.
Authors: Frolkis I, Klein Y, Locker C, Adi N, Dahan E, Uretzsky G, Shapira I, Sorkine P
Cytokine, 2010;49(3):319-24.
Species: Rat
Sample Type: Serum

In vivo Angiotensin II AT1 receptor blockade selectively inhibits LPS-induced innate immune response and ACTH release in rat pituitary gland.
Authors: Sanchez-Lemus E, Benicky J, Pavel J, Saavedra JM
Brain Behav. Immun., 2009;23(7):945-57.
Species: Rat
Sample Type: Plasma

Mechanism of hepatoprotection in proestrus female rats following trauma-hemorrhage: heme oxygenase-1-derived normalization of hepatic inflammatory responses.
Authors: Yang S, Hu S, Chen J, Choudhry MA, Rue LW, Bland KI, Chaudry IH
J. Leukoc. Biol., 2009;85(6):1015-26.
Species: Rat
Sample Type: Serum

Hypercapnic acidosis attenuates shock and lung injury in early and prolonged systemic sepsis.
Authors: Costello J, Higgins B, Contreras M, Chonghaile MN, Hassett P, OToole D, Laffey JG
Crit. Care Med., 2009;37(8):2412-20.
Species: Rat
Sample Type: BALF

Trauma and hemorrhage-induced acute hepatic insulin resistance: dominant role of tumor necrosis factor-alpha.
Authors: Xu J, Kim HT, Ma Y, Zhao L, Zhai L, Kokorina N, Wang P, Messina JL
Endocrinology, 2008;149(5):2369-82.
Species: Rat
Sample Type: Serum

JAK/STAT3 pathway is activated in spinal cord microglia after peripheral nerve injury and contributes to neuropathic pain development in rat.
Authors: Dominguez E, Rivat C, Pommier B, Mauborgne A, Pohl M
J. Neurochem., 2008;107(1):50-60.
Species: Rat
Sample Type: Tissue Homogenates

Role of central beta-adrenergic receptors in regulating proinflammatory cytokine responses to a peripheral bacterial challenge.
Authors: Johnson JD, Cortez V, Kennedy SL, Foley TE, Hanson H, Fleshner M
Brain Behav. Immun., 2008;22(7):1078-86.
Species: Rat
Sample Type: Plasma

Induction of type 2 iodothyronine deiodinase in the mediobasal hypothalamus by bacterial lipopolysaccharide: role of corticosterone.
Authors: Sanchez E, Singru PS, Fekete C, Lechan RM
Endocrinology, 2008;149(5):2484-93.
Species: Rat
Sample Type: Serum

Regulation of liver cytochrome P450 by activation of brain dopaminergic system: physiological and pharmacological implications.
Authors: Wojcikowski J, Golembiowska K, Daniel WA
Biochem. Pharmacol., 2008;76(2):258-67.
Species: Rat
Sample Type: Plasma

Antithrombin inhibits bronchoalveolar activation of coagulation and limits lung injury during Streptococcus pneumoniae pneumonia in rats.
Authors: Choi G, Hofstra JJ, Roelofs JJ, Rijneveld AW, Bresser P, van der Zee JS, Florquin S, van der Poll T, Levi M, Schultz MJ
Crit. Care Med., 2008;36(1):204-10.
Species: Rat
Sample Type: BALF

Comprehensive gene expression profiling of rat lung reveals distinct acute and chronic responses to cigarette smoke inhalation.
Authors: Stevenson CS, Docx C, Webster R, Battram C, Hynx D, Giddings J, Cooper PR, Chakravarty P, Rahman I, Marwick JA, Kirkham PA, Charman C, Richardson DL, Nirmala NR, Whittaker P, Butler K
Am. J. Physiol. Lung Cell Mol. Physiol., 2007;293(5):L1183-93.
Species: Rat
Sample Type: BALF

Changes of gene expression of iron regulatory proteins during turpentine oil-induced acute-phase response in the rat.
Authors: Sheikh N, Dudas J, Ramadori G
Lab. Invest., 2007;87(7):713-25.
Species: Rat
Sample Type: Serum

ACE mediates ventilator-induced lung injury in rats via angiotensin II but not bradykinin.
Authors: Wosten-van Asperen RM, Lutter R, Haitsma JJ, Merkus MP, van Woensel JB, van der Loos CM, Florquin S, Lachmann B, Bos AP
Eur. Respir. J., 2007;31(2):363-71.
Species: Rat
Sample Type: BALF

Cell-based angiopoietin-1 gene therapy for acute lung injury.
Authors: McCarter SD, Mei SH, Lai PF, Zhang QW, Parker CH, Suen RS, Hood RD, Zhao YD, Deng Y, Han RN, Dumont DJ, Stewart DJ
Am. J. Respir. Crit. Care Med., 2007;175(10):1014-26.
Species: Rat
Sample Type: BALF

Natural anticoagulants limit lipopolysaccharide-induced pulmonary coagulation but not inflammation.
Authors: Choi G, Vlaar AP, Schouten M, Vant Veer C, van der Poll T, Levi M, Schultz MJ
Eur. Respir. J., 2007;30(3):423-8.
Species: Rat
Sample Type: Tissue Homogenates

Mechanism of the nongenomic effects of estrogen on intestinal myeloperoxidase activity following trauma-hemorrhage: up-regulation of the PI-3K/Akt pathway.
Authors: Yu HP, Hsieh YC, Suzuki T, Choudhry MA, Schwacha MG, Bland KI, Chaudry IH
J. Leukoc. Biol., 2007;82(3):774-80.
Species: Rat
Sample Type: Tissue Homogenates

Anti-rat soluble IL-6 receptor antibody down-regulates cardiac IL-6 and improves cardiac function following trauma-hemorrhage.
Authors: Yang S, Hu S, Choudhry MA, Rue LW, Bland KI, Chaudry IH
J. Mol. Cell. Cardiol., 2007;42(3):620-30.
Species: Rat
Sample Type: Plasma

The cytokine interleukin-6 is sufficient but not necessary to mimic the peripheral conditioning lesion effect on axonal growth.
Authors: Cao Z, Gao Y, Bryson JB, Hou J, Chaudhry N, Siddiq M, Martinez J, Spencer T, Carmel J, Hart RB, Filbin MT
J. Neurosci., 2006;26(20):5565-73.
Species: Rat
Sample Type: Cell Culture Supernates

Identification of astrocyte-expressed factors that modulate neural stem/progenitor cell differentiation.
Authors: Barkho BZ, Song H, Aimone JB
Stem Cells Dev., 2006;15(3):407-21.
Species: Rat
Sample Type: Cell Culture Supernates

Biomarker and drug-target discovery using proteomics in a new rat model of sepsis-induced acute renal failure.
Authors: Holly MK, Dear JW, Hu X, Schechter AN, Gladwin MT, Hewitt SM, Yuen PS, Star RA
Kidney Int., 2006;70(3):496-506.
Species: Rat
Sample Type: Serum

Glucosamine administration during resuscitation improves organ function after trauma hemorrhage.
Authors: Yang S, Zou LY, Bounelis P, Chaudry I, Chatham JC, Marchase RB
Shock, 2006;25(6):600-7.
Species: Rat
Sample Type: Plasma

Suppression of ocular inflammation in endotoxin-induced uveitis by inhibiting nonproteolytic activation of prorenin.
Authors: Satofuka S, Ichihara A, Nagai N, Yamashiro K, Koto T, Shinoda H, Noda K, Ozawa Y, Inoue M, Tsubota K, Suzuki F, Oike Y, Ishida S
Invest. Ophthalmol. Vis. Sci., 2006;47(6):2686-92.
Species: Rat
Sample Type: Tissue Homogenates

Effects of gabexate mesilate on serum inflammatory cytokines in rats with acute necrotizing pancreatitis.
Authors: Chen CC, Wang SS, Tsay SH, Lee FY, Lu RH, Chang FY, Lee SD
Cytokine, 2006;33(2):95-9.
Species: Rat
Sample Type: Serum

Interleukin-10 aerosol reduces proinflammatory mediators in bronchoalveolar fluid of endotoxemic rat.
Authors: Hofstetter C, Flondor M, Hoegl S, Muhl H, Zwissler B
Crit. Care Med., 2005;33(10):2317-22.
Species: Rat
Sample Type: BALF

Developmental changes induced by graded prenatal systemic hypoxic-ischemic insults in rats.
Authors: Robinson S, Petelenz K, Li Q, Cohen ML, Dechant A, Tabrizi N, Bucek M, Lust D, Miller RH
Neurobiol. Dis., 2005;18(3):568-81.
Species: Rat
Sample Type: Amniotic Fluid

A method for measuring multiple cytokines from small samples.
Authors: O'Connor KA
Brain Behav. Immun., 2004;18(3):274-80.
Species: Rat
Sample Type: CSF

Insulin attenuates the systemic inflammatory response in endotoxemic rats.
Authors: Jeschke MG, Klein D, Bolder U, Einspanier R
Endocrinology, 2004;145(9):4084-93.
Species: Rat
Sample Type: Tissue Homogenates

Insulin treatment improves hepatic morphology and function through modulation of hepatic signals after severe trauma.
Authors: Schubert T, Horch RE
Ann. Surg., 2004;240(2):340-9.
Species: Rat
Sample Type: Tissue Homogenates

HIV-1 gp120 stimulates proinflammatory cytokine-mediated pain facilitation via activation of nitric oxide synthase-I (nNOS).
Authors: Holguin A, O'Connor KA, Biedenkapp J, Campisi J, Wieseler-Frank J, Milligan ED, Hansen MK, Spataro L, Maksimova E, Bravmann C, Martin D, Fleshner M, Maier SF, Watkins LR
Pain, 2004;110(3):517-30.
Species: Rat
Sample Type: CSF

Anti-inflammatory effects of alpha-melanocyte-stimulating hormone against rat endotoxin-induced uveitis and the time course of inflammatory agents in aqueous humor.
Authors: Nishida T, Miyata S, Itoh Y, Mizuki N, Ohgami K, Shiratori K, Ilieva IB, Ohno S, Taylor AW
Int. Immunopharmacol., 2004;4(8):1059-66.
Species: Rat
Sample Type: Aqueous humor

Differential expression of cytokine genes and inducible nitric oxide synthase induced by opacity phenotype variants of Streptococcus pneumoniae during acute otitis media in the rat.
Authors: Long JP, Tong HH, Shannon PA, DeMaria TF
Infect. Immun., 2003;71(10):5531-40.
Species: Rat
Sample Type: middle ear effusion

Iron intake increases infarct volume after permanent middle cerebral artery occlusion in rats.
Authors: Castellanos M, Puig N, Carbonell T, Castillo J, Martinez J, Rama R, Davalos A
Brain Res., 2002;952(1):1-6.
Species: Rat
Sample Type: Serum

生物活性< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景IL-6 (Interleukin-6) is a pleiotropic cytokine that acts in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression. It contributes to chronic inflammation in obesity, insulin resistance, inflammatory bowel disease, arthritis, sepsis, and atherosclerosis. IL-6 signals through a receptor complex of IL-6 R alpha and gp130. gp130 is also a component of the receptors for CLC, CNTF, CT-1, IL-11, IL-27, LIF, and OSM. Soluble forms of IL-6 R alpha are generated by both alternative splicing and proteolytic cleavage. In a mechanism known as trans-signaling, complexes of soluble IL-6 and IL-6 R alpha elicit responses from gp130-expressing cells that lack cell surface IL-6 R alpha.
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参考文献
  • Adipocytokines
  • Cancer Biomarkers
  • Conventional/Classical Dendritic Cells
  • Cytokines and Receptors in Allergy and Asthma
  • Cytokines and Receptors in Angiogenesis
  • Cytokines and Receptors in Tfh Cell Differentiation and Function
  • Diabetes
  • gamma delta T Cells
  • Glucose Homeostasis
  • Helper T (Th) Cells
  • HIF Transcription Factors
  • IL-6 Family
  • Infectious Diseases
  • Inflammatory Mediators
  • Macrophage Activation Markers
  • Molecules Secreted by VSMC
  • Multiple Myeloma
  • Multiple Sclerosis and Myelin Related Molecules
  • Myeloid-derived Suppressor Cells (MDSC)
  • Neuroinflammation
  • Obesity
  • Plasmacytoid Dendritic Cells
  • T Cell Cytokine Signaling
  • Th17 Cells
  • Th22 Cells
  • Th9 Cells