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Mouse/Rat IGF-I Quantikine SixPak (6 Plates) (1 PK)

货号: SMG100 基本售价: 30090.6 元 规格: 1 PACK

产品信息

概述
货号SMG100
描述The Quantikine Mouse/Rat IGF-I Immunoassay is a 4.5 hour solid-phase ELISA designed to measure mouse and rat IGF-I in cell culture supernates, tissue homogenates, serum, and plasma. It contains E. coli-expressed recombinant mouse IGF-I and antibodies raised against the recombinant factor. This immunoassay has been shown to accurately quantitate the recombinant factor. Results obtained using natural mouse and rat IGF-I showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring mouse/rat IGF-I.
别名IBP1; IGF1; IGF-1; IGF1A; IGFI; IGF-I; IGF-IA; IGF-IB; insulin-like growth factor 1 (somatomedin C); insulin-like growth factor 1; insulin-like growth factor I; insulin-like growth factor IA; insulin-like growth factor IB; Mechano growth factor; MGF; Somatomedin A; Somatomedin C; somatomedin-C;
全称
Insulin-like Growth Factor I
反应种属Mouse/Rat
目标/特异性Natural and recombinant mouse and rat IGF-I
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs
3479 (Human); 16000 (Mouse); 24482 (Rat)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Dose-dependency and reversibility of radiation-induced injury in cardiac explant-derived cells of mice
Authors: L Luo, C Yan, Y Urata, AS Hasan, S Goto, CY Guo, S Zhang, TS Li
Sci Rep, 2017;7(0):40959.
Species: Mouse
Sample Type: Cell Culture Supernates

Mosaic expression of Atrx in the mouse central nervous system causes memory deficits
Authors: RJ Tamming, JR Siu, Y Jiang, MA Prado, F Beier, NG B?rub?
Dis Model Mech, 2017;10(2):119-126.
Species: Mouse
Sample Type: Plasma

Metformin inhibits the proliferation of benign prostatic epithelial cells
Authors: Z Wang, X Xiao, R Ge, J Li, CW Johnson, C Rassoulian, AF Olumi
PLoS ONE, 2017;12(3):e0173335.
Species: Mouse
Sample Type: Cell Culture Supernates

Protective effect of maternal uteroplacental insufficiency on oxygen-induced retinopathy in offspring: removing bias of premature birth
Authors: S Becker, H Wang, B Yu, R Brown, X Han, RH Lane, ME Hartnett
Sci Rep, 2017;7(0):42301.
Species: Rat
Sample Type: Serum

Radiation Exposure Decreases the Quantity and Quality of Cardiac Stem Cells in Mice
PLoS ONE, 2016;11(5):e0152179.
Species: Mouse
Sample Type: Cell culture media

Cluster Differentiating 36 (CD36) Deficiency Attenuates Obesity-Associated Oxidative Stress in the Heart
PLoS ONE, 2016;11(5):e0155611.
Species: Mouse
Sample Type: Plasma

Space radiation exposure persistently increased leptin and IGF1 in serum and activated leptin-IGF1 signaling axis in mouse intestine
Sci Rep, 2016;6(0):31853.
Species: Mouse
Sample Type: Serum

IGF-1 degradation by mouse mast cell protease 4 promotes cell death and adverse cardiac remodeling days after a myocardial infarction
Authors: Thor Tejada
Proc Natl Acad Sci USA, 2016;0(0):.
Species: Mouse
Sample Type: Serum

Single ingestion of soy ?-conglycinin induces increased postprandial circulating FGF21 levels exerting beneficial health effects
Authors: Tsutomu Hashidume
Sci Rep, 2016;6(0):28183.
Species: Mouse
Sample Type: Serum

First steps to define murine amniotic fluid stem cell microenvironment
Sci Rep, 2016;6(0):37080.
Species: Mouse
Sample Type: Amniotic Fluid

Positive Prehabilitative Effect of Intense Treadmill Exercise for Ameliorating Cancer Cachexia Symptoms in a Mouse Model
J Cancer, 2016;7(15):2378-2387.
Species: Mouse
Sample Type: Plasma

Fibroblast growth factor 21 has no direct role in regulating fertility in female mice
Mol Metab, 2016;5(8):690-8.
Species: Mouse
Sample Type: Plasma

The histone deacetylase inhibitor, sodium butyrate, exhibits neuroprotective effects for ischemic stroke in middle-aged female rats
J Neuroinflammation, 2016;13(1):300.
Species: Rat
Sample Type: Serum

MeCP2 Affects Skeletal Muscle Growth and Morphology through Non Cell-Autonomous Mechanisms.
Authors: Conti V, Gandaglia A, Galli F, Tirone M, Bellini E, Campana L, Kilstrup-Nielsen C, Rovere-Querini P, Brunelli S, Landsberger N
PLoS ONE, 2015;10(6):e0130183.
Species: Mouse
Sample Type: Plasma

Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan.
Authors: Baker D, Childs B, Durik M, Wijers M, Sieben C, Zhong J, Saltness R, Jeganathan K, Verzosa G, Pezeshki A, Khazaie K, Miller J, van Deursen J
Nature, 2015;530(7589):184-9.
Species: Mouse
Sample Type: Serum

Microglial Kv1.3 Channels and P2Y12 Receptors Differentially Regulate Cytokine and Chemokine Release from Brain Slices of Young Adult and Aged Mice.
Authors: Charolidi N, Schilling T, Eder C
PLoS ONE, 2015;10(5):e0128463.
Species: Mouse
Sample Type: Cell Culture Supernates

Glucose intolerance in aging male IGFBP-3 transgenic mice: differential effects of human IGFBP-3 and its mutant IGFBP-3 devoid of IGF binding ability.
Authors: Nguyen K, Yao X, Erickson A, Mishra S, Nyomba B
Endocrinology, 2015;156(2):462-74.
Species: Mouse
Sample Type: Serum

The order of concurrent endurance and resistance exercise modifies mTOR signaling and protein synthesis in rat skeletal muscle.
Authors: Ogasawara R, Sato K, Matsutani K, Nakazato K, Fujita S
Am J Physiol Endocrinol Metab, 2014;306(10):E1155-62.
Species: Rat
Sample Type: Serum

The small-molecule BGP-15 protects against heart failure and atrial fibrillation in mice.
Authors: Sapra, Geeta, Tham, Yow Keat, Cemerlang, Nelly, Matsumoto, Aya, Kiriazis, Helen, Bernardo, Bianca C, Henstridge, Darren C, Ooi, Jenny Y, Pretorius, Lynette, Boey, Esther J, Lim, Lydia, Sadoshima, Junichi, Meikle, Peter J, Mellet, Natalie, Woodcock, Elizabet, Marasco, Silvana, Ueyama, Tomomi, Du, Xiao-Jun, Febbraio, Mark A, McMullen, Julie R
Nat Commun, 2014;5(0):5705.
Species: Mouse
Sample Type: Plasma

Survival of neural stem cell grafts in the lesioned spinal cord is enhanced by a combination of treadmill locomotor training via insulin-like growth factor-1 signaling.
Authors: Hwang D, Shin H, Kwon M, Choi J, Ryu B, Kim B
J Neurosci, 2014;34(38):12788-800.
Species: Rat
Sample Type: Serum

The peroxisome proliferator-activated receptor (PPAR) alpha agonist fenofibrate suppresses chemically induced lung alveolar proliferative lesions in male obese hyperlipidemic mice.
Authors: Kuno T, Hata K, Takamatsu M, Hara A, Hirose Y, Takahashi S, Imaida K, Tanaka T
Int J Mol Sci, 2014;15(5):9160-72.
Species: Mouse
Sample Type: Plasma

Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through the induction of FGF21 as a myokine.
Authors: Keipert S, Ost M, Johann K, Imber F, Jastroch M, van Schothorst E, Keijer J, Klaus S
Am J Physiol Endocrinol Metab, 2014;306(5):E469-82.
Species: Mouse
Sample Type: Plasma

Calorie restriction decreases murine and human pancreatic tumor cell growth, nuclear factor-kappaB activation, and inflammation-related gene expression in an insulin-like growth factor-1-dependent manner.
Authors: Harvey A, Lashinger L, Hays D, Harrison L, Lewis K, Fischer S, Hursting S
PLoS ONE, 2014;9(5):e94151.
Species: Mouse
Sample Type: Serum

HGF signaling impacts severity of Pseudomonas aeruginosa keratitis.
Authors: Jiang X, McClellan S, Barrett R, Foldenauer M, Hazlett L
Invest Ophthalmol Vis Sci, 2014;55(4):2180-90.
Species: Mouse
Sample Type: Tissue Homogenates

Bone resorption is regulated by cell-autonomous negative feedback loop of Stat5-Dusp axis in the osteoclast.
Authors: Hirose J, Masuda H, Tokuyama N, Omata Y, Matsumoto T, Yasui T, Kadono Y, Hennighausen L, Tanaka S
J Exp Med, 2014;211(1):153-63.
Species: Mouse
Sample Type: Serum

IGF2 ameliorates amyloidosis, increases cholinergic marker expression and raises BMP9 and neurotrophin levels in the hippocampus of the APPswePS1dE9 Alzheimer's disease model mice.
Authors: Mellott T, Pender S, Burke R, Langley E, Blusztajn J
PLoS ONE, 2014;9(4):e94287.
Species: Mouse
Sample Type: Tissue Homogenates

Long-term physiological alterations and recovery in a mouse model of separation associated with time-restricted feeding: a tool to study anorexia nervosa related consequences.
Authors: Zgheib S, Mequinion M, Lucas S, Leterme D, Ghali O, Tolle V, Zizzari P, Bellefontaine N, Legroux-Gerot I, Hardouin P, Broux O, Viltart O, Chauveau C
PLoS ONE, 2014;9(8):e103775.
Species: Mouse
Sample Type: Plasma

Overlapping dose responses of spermatogenic and extragonadal testosterone actions jeopardize the principle of hormonal male contraception.
Authors: Oduwole O, Vydra N, Wood N, Samanta L, Owen L, Keevil B, Donaldson M, Naresh K, Huhtaniemi I
FASEB J, 2014;28(6):2566-76.
Species: Mouse
Sample Type: Serum

Viral expression of insulin-like growth factor I E-peptides increases skeletal muscle mass but at the expense of strength.
Authors: Brisson, Becky K, Spinazzola, Janelle, Park, SooHyun, Barton, Elisabet
Am J Physiol Endocrinol Metab, 2014;306(8):E965-74.
Species: Mouse
Sample Type: Tissue Homogenates

Sonic hedgehog gene therapy increases the ability of the dystrophic skeletal muscle to regenerate after injury.
Authors: Piccioni A, Gaetani E, Palladino M, Gatto I, Smith R, Neri V, Marcantoni M, Giarretta I, Silver M, Straino S, Capogrossi M, Landolfi R, Pola R
Gene Ther, 2014;21(4):413-21.
Species: Mouse
Sample Type: cell supernates

The dwarf phenotype in GH240B mice, haploinsufficient for the autism candidate gene Neurobeachin, is caused by ectopic expression of recombinant human growth hormone.
Authors: Nuytens, Kim, Tuand, Krizia, Fu, Quili, Stijnen, Pieter, Pruniau, Vincent, Meulemans, Sandra, Vankelecom, Hugo, Creemers, John W M
PLoS ONE, 2014;9(10):e109598.
Species: Mouse
Sample Type: Plasma

Lipid profiling and transcriptomic analysis reveals a functional interplay between estradiol and growth hormone in liver.
Authors: Fernandez-Perez L, Santana-Farre R, de Mirecki-Garrido M, Garcia I, Guerra B, Mateo-Diaz C, Iglesias-Gato D, Diaz-Chico J, Flores-Morales A, Diaz M
PLoS ONE, 2014;9(5):e96305.
Species: Rat
Sample Type: Serum

IGF1 receptor signaling regulates adaptive radioprotection in glioma stem cells.
Authors: Osuka S, Sampetrean O, Shimizu T, Saga I, Onishi N, Sugihara E, Okubo J, Fujita S, Takano S, Matsumura A, Saya H
Stem Cells, 2013;31(4):627-40.
Species: Mouse
Sample Type: Cell Lysate

Growth hormone secretion is correlated with neuromuscular innervation rather than motor neuron number in early-symptomatic male amyotrophic lateral sclerosis mice.
Authors: Steyn, F J, Lee, K, Fogarty, M J, Veldhuis, J D, McCombe, P A, Bellingham, M C, Ngo, S T, Chen, C
Endocrinology, 2013;154(12):4695-706.
Species: Mouse
Sample Type: Plasma

SIRT1 regulates adaptive response of the growth hormone--insulin-like growth factor-I axis under fasting conditions in liver.
Authors: Yamamoto, Masaaki, Iguchi, Genzo, Fukuoka, Hidenori, Suda, Kentaro, Bando, Hironori, Takahashi, Michiko, Nishizawa, Hitoshi, Seino, Susumu, Takahashi, Yutaka
Proc Natl Acad Sci U S A, 2013;110(37):14948-53.
Species: Mouse
Sample Type: Serum

BMP9 ameliorates amyloidosis and the cholinergic defect in a mouse model of Alzheimer's disease.
Authors: Burke R, Norman T, Haydar T, Slack B, Leeman S, Blusztajn J, Mellott T
Proc Natl Acad Sci U S A, 2013;110(48):19567-72.
Species: Mouse
Sample Type: Tissue Homogenates

Effects of breastfeeding on body composition and maturational tempo in the rat.
Authors: Crispel, Yonatan, Katz, Oren, Ben-Yosef, Dafna, Hochberg, Zeev
BMC Med, 2013;11(0):114.
Species: Rat
Sample Type: Serum

The restorative effects of adipose-derived mesenchymal stem cells on damaged ovarian function.
Authors: Takehara, Yuji, Yabuuchi, Akiko, Ezoe, Kenji, Kuroda, Tomoko, Yamadera, Rie, Sano, Chiaki, Murata, Nana, Aida, Takuya, Nakama, Ken, Aono, Fumihito, Aoyama, Naoki, Kato, Keiich, Kato, Osamu
Lab Invest, 2013;93(2):181-93.
Species: Rat
Sample Type: Cell Culture Supernates

Fish oil slows prostate cancer xenograft growth relative to other dietary fats and is associated with decreased mitochondrial and insulin pathway gene expression.
Authors: Lloyd J, Masko E, Wu C, Keenan M, Pilla D, Aronson W, Chi J, Freedland S
Prostate Cancer Prostatic Dis, 2013;16(4):285-91.
Species: Mouse
Sample Type: Serum

Splicing factor SRSF3 is crucial for hepatocyte differentiation and metabolic function.
Authors: Sen S, Jumaa H, Webster N
Nat Commun, 2013;4(0):1336.
Species: Mouse
Sample Type: Serum

Strontium fructose 1,6-diphosphate prevents bone loss in a rat model of postmenopausal osteoporosis via the OPG/RANKL/RANK pathway.
Authors: Ma B, Zhang Q, Wu D, Wang YL, Hu YY, Cheng YP, Yang ZD, Zheng YY, Ying HJ
Acta Pharmacol. Sin., 2012;33(4):479-89.
Species: Rat
Sample Type: Serum

Cytosolic Malic Enzyme 1 (ME1) Mediates High Fat Diet-Induced Adiposity, Endocrine Profile, and Gastrointestinal Tract Proliferation-Associated Biomarkers in Male Mice.
Authors: Al-Dwairi, Ahmed, Pabona, John Mar, Simmen, Rosalia, Simmen, Frank A
PLoS ONE, 2012;7(10):e46716.
Species: Mouse
Sample Type: Serum

Physiological roles of group X-secreted phospholipase A2 in reproduction, gastrointestinal phospholipid digestion, and neuronal function.
Authors: Sato H, Isogai Y, Masuda S
J. Biol. Chem., 2011;286(13):11632-48.
Species: Mouse
Sample Type: Serum

Peripheral SMN restoration is essential for long-term rescue of a severe spinal muscular atrophy mouse model.
Authors: Hua Y, Sahashi K, Rigo F
Nature, 2011;478(7367):123-6.
Species: Mouse
Sample Type: Serum

Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy.
Authors: Maurer GD, Brucker DP, Bahr O, Harter PN, Hattingen E, Walenta S, Mueller-Klieser W, Steinbach JP, Rieger J
BMC Cancer, 2011;11(0):315.
Species: Mouse
Sample Type: Serum

Human IGF Binding Protein-3 Overexpression Impairs Glucose Regulation in Mice via an Inhibition of Insulin Secretion.
Authors: Nguyen KH, Yao XH, Moulik S, Mishra S, Nyomba BL
Endocrinology, 2011;152(6):2184-96.
Species: Mouse
Sample Type: Plasma

Rim2alpha determines docking and priming States in insulin granule exocytosis.
Authors: Yasuda T, Shibasaki T, Minami K
Cell Metab., 2010;12(2):117-29.
Species: Mouse
Sample Type: Serum

Myocytic androgen receptor controls the strength but not the mass of limb muscles.
Authors: Chambon C, Duteil D, Vignaud A, Ferry A, Messaddeq N, Malivindi R, Kato S, Chambon P, Metzger D
Proc. Natl. Acad. Sci. U.S.A., 2010;107(32):14327-32.
Species: Mouse
Sample Type: Plasma

Galectin-3 contributes to neonatal hypoxic-ischemic brain injury.
Authors: Doverhag C, Hedtjarn M, Poirier F, Mallard C, Hagberg H, Karlsson A, Savman K
Neurobiol. Dis., 2010;38(1):36-46.
Species: Mouse
Sample Type: Tissue Homogenates

Attenuation of AD-like neuropathology by harnessing peripheral immune cells: local elevation of IL-10 and MMP-9.
Authors: Koronyo-Hamaoui M, Ko MK, Koronyo Y, Azoulay D, Seksenyan A, Kunis G, Pham M, Bakhsheshian J, Rogeri P, Black KL, Farkas DL, Schwartz M
J. Neurochem., 2009;111(6):1409-24.
Species: Mouse
Sample Type: Tissue Homogenates

Insulin-like growth factor-1 improves survival in sepsis via enhanced hepatic bacterial clearance.
Authors: Ashare A, Nymon AB, Doerschug KC, Morrison JM, Monick MM, Hunninghake GW
Am. J. Respir. Crit. Care Med., 2008;178(2):149-57.
Species: Mouse
Sample Type: Serum

Reduction in hypophyseal growth hormone and prolactin expression due to deficiency in ghrelin receptor signaling is associated with Pit-1 suppression: Relevance to the immune system.
Authors: Yang H, Dixit VD, Patel K, Vandanmagsar B, Collins G, Sun Y, Smith RG, Taub DD
Brain Behav. Immun., 2008;0(0):.
Species: Mouse
Sample Type: Serum

Modulation of melanocortin signaling ameliorates uremic cachexia.
Authors: Cheung WW, Rosengren S, Boyle DL, Mak RH
Kidney Int., 2008;74(2):180-6.
Species: Mouse
Sample Type: Tissue Homogenates

Low-dose GH supplementation reduces the TLR2 and TNF-alpha expressions in visceral fat.
Authors: Kubota Y, Unoki H, Bujo H, Rikihisa N, Udagawa A, Yoshimoto S, Ichinose M, Saito Y
Biochem. Biophys. Res. Commun., 2008;368(1):81-7.
Species: Mouse
Sample Type: Plasma

Inhibition of rho family functions by lovastatin promotes myelin repair in ameliorating experimental autoimmune encephalomyelitis.
Authors: Paintlia AS, Paintlia MK, Singh AK, Singh I
Mol. Pharmacol., 2008;73(5):1381-93.
Species: Rat
Sample Type: Serum

Ovariectomy is protective against renal injury in the high-salt-fed older mRen2.Lewis rat.
Authors: Yamaleyeva LM, Pendergrass KD, Pirro NT, Gallagher PE, Groban L, Chappell MC
Am. J. Physiol. Heart Circ. Physiol., 2007;293(4):H2064-71.
Species: Rat
Sample Type: Plasma

Wheel running and fluoxetine antidepressant treatment have differential effects in the hippocampus and the spinal cord.
Authors: Engesser-Cesar C, Anderson AJ, Cotman CW
Neuroscience, 2007;144(3):1033-44.
Species: Mouse
Sample Type: Serum

Ghrelin promotes thymopoiesis during aging.
Authors: Dixit VD, Yang H, Sun Y, Weeraratna AT, Youm YH, Smith RG, Taub DD
J. Clin. Invest., 2007;117(10):2778-90.
Species: Mouse
Sample Type: Serum

Peripheral elevation of IGF-1 fails to alter Abeta clearance in multiple in vivo models.
Authors: Lanz TA, Salatto CT, Semproni AR, Marconi M, Brown TM, Richter KE, Schmidt K, Nelson FR, Schachter JB
Biochem. Pharmacol., 2007;75(5):1093-103.
Species: Rat
Sample Type: Plasma

GRP94 is essential for mesoderm induction and muscle development because it regulates insulin-like growth factor secretion.
Authors: Wanderling S, Simen BB, Ostrovsky O, Ahmed NT, Vogen SM, Gidalevitz T, Argon Y
Mol. Biol. Cell, 2007;18(10):3764-75.
Species: Mouse
Sample Type: Cell Culture Supernates

Microcytosis in ank/ank mice and the role of ANKH in promoting erythroid differentiation.
Authors: Wang J, Wang C, Tsui HW, Las Heras F, Cheng EY, Iscove NN, Chiu B, Inman RD, Pritzker KP, Tsui FW
Exp. Cell Res., 2007;313(20):4120-9.
Species: Mouse
Sample Type: Serum

生物活性< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景

Insulin-like growth factor (IGF)-I (also known as somatomedin C and somatomedin A) and IGF-II (multiplication stimulating activity or MSA) belong to the family of insulin-like growth factors that are structurally homologous to proinsulin. Mature IGF-I and IGF-II share approximately 70% sequence identity. Both IGF-I and IGF-II are expressed in many tissues and cell types and may have autocrine, paracrine and endocrine functions. Mature IGF-I and IGF-II are highly conserved between the human, bovine and porcine proteins (100% identity), and exhibit cross-species activity.

The IGFL (insulin-like growth factor-like) family includes four small (~11 kDa), probably secreted family members in humans and one in mouse. This family shares A and B chain cysteine motifs with the IGF superfamily, and has an additional cysteine motif within an uncleaved region corresponding to the C peptide of the IGF family.

运输条件Blue Ice
存放说明4℃
参考文献
  • ALS Related Molecules
  • Cancer Biomarkers
  • Cytokines in Lipid/Cholesterol Metabolism
  • Diabetes and Obesity Research
  • Endocrine Regulation of Lipid Metabolism
  • gamma delta T Cells
  • Glucose Homeostasis
  • IGF Family
  • IGF Ligands
  • Insulin-like Growth Factor (IGF) and Receptors
  • Metabolic Peptide Hormones and Regulators
  • Preeclampsia
  • Protein/Peptide Hormones and Regulators
  • Reproduction