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Human CXCL1/GRO alpha Quantikine SixPak (6 Plates) (1 PK)

货号: SGR00B 基本售价: 29971.6 元 规格: 1 PK

产品信息

概述
货号SGR00B
描述The Quantikine Human CXCL1/GRO alpha Immunoassay is a 4.25-4.5 hour solid phase ELISA designed to measure human GRO alpha in cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant human GRO alpha and antibodies raised against the recombinant protein. This immunoassay has been shown to accurately quantitate the recombinant factor. Results obtained using natural human GRO alpha showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural human GRO alpha.
别名CINC1; CINC-1; CXCL1; GRO alpha; KC; MGSA-alpha;
目标/特异性Natural and recombinant human GRO alpha
性能
供应商R&D Systems
Entrez Gene IDs
2919 (Human); 14825 (Mouse); 81503 (Rat)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

MicroRNAs regulate cytokine responses in gingival epithelial cells
Infect Immun, 2016;0(0):.
Species: Human
Sample Type: Cell Culture Supernates

p53 and NF-kappaB coregulate proinflammatory gene responses in human macrophages.
Authors: Lowe J, Menendez D, Bushel P, Shatz M, Kirk E, Troester M, Garantziotis S, Fessler M, Resnick M
Cancer Res, 2016;74(8):2182-92.
Species: Human
Sample Type: Cell Culture Supernates

High salt primes a specific activation state of macrophages, M(Na).
Authors: Zhang W, Zheng X, DU L, Sun J, Shen Z, Shi C, Sun S, Zhang Z, Chen X, Qin M, Liu X, Tao J, Jia L, Fan H, Zhou B, Yu Y, Ying H, Hui L, Liu X, Yi X, Liu X, Zhang L, Duan S
Cell Res, 2015;25(8):893-910.
Species: Human
Sample Type: Cell Culture Supernates

Stromal cells positively and negatively modulate the growth of cancer cells: stimulation via the PGE2-TNFalpha-IL-6 pathway and inhibition via secreted GAPDH-E-cadherin interaction.
Authors: Kawada M, Inoue H, Ohba S, Yoshida J, Masuda T, Yamasaki M, Usami I, Sakamoto S, Abe H, Watanabe T, Yamori T, Shibasaki M, Nomoto A
PLoS ONE, 2015;10(3):e0119415.
Species: Human
Sample Type: Cell Culture Supernates

Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence.
Authors: Sapey E, Greenwood H, Walton G, Mann E, Love A, Aaronson N, Insall R, Stockley R, Lord J
Blood, 2014;123(2):239-48.
Species: Human
Sample Type: Sputum

Circulating levels of transforming growth factor-betaeta (TGF-beta) and chemokine (C-X-C motif) ligand-1 (CXCL1) as predictors of distant seeding of circulating tumor cells in patients with metastatic breast cancer.
Authors: Divella R, Daniele A, Savino E, Palma F, Bellizzi A, Giotta F, Simone G, Lioce M, Quaranta M, Paradiso A, Mazzocca A
Anticancer Res, 2013;33(4):1491-7.
Species: Human
Sample Type: Plasma

Influence of the CXCL1 rs4074 A allele on alcohol induced cirrhosis and HCC in patients of European descent.
Authors: Nischalke H, Berger C, Lutz P, Langhans B, Wolter F, Eisenhardt M, Kramer B, Kokordelis P, Glassner A, Muller T, Rosendahl J, Fischer J, Berg T, Grunhage F, Leifeld L, Soyka M, Nattermann J, Sauerbruch T, Stickel F, Spengler U
PLoS ONE, 2013;8(11):e80848.
Species: Human
Sample Type: Cell Culture Supernates

Targeted gene silencing using a follicle-stimulating hormone peptide-conjugated nanoparticle system improves its specificity and efficacy in ovarian clear cell carcinoma in vitro.
Authors: Hong S, Zhang X, Chen J, Zhou J, Zheng Y, Xu C
J Ovarian Res, 2013;6(1):80.
Species: Human
Sample Type: Cell Culture Supernates

Role of interleukin-32 in Helicobacter pylori-induced gastric inflammation.
Authors: Sakitani K, Hirata Y, Hayakawa Y, Serizawa T, Nakata W, Takahashi R, Kinoshita H, Sakamoto K, Nakagawa H, Akanuma M, Yoshida H, Maeda S, Koike K
Infect Immun, 2012;80(11):3795-803.
Species: Human
Sample Type: Cell Lysates

CXCR2 promotes ovarian cancer growth through dysregulated cell cycle, diminished apoptosis, and enhanced angiogenesis.
Authors: Yang G, Rosen DG, Liu G
Clin. Cancer Res., 2010;16(15):3875-86.
Species: Human
Sample Type: Cell Culture Supernates

A phase I trial of bortezomib with temozolomide in patients with advanced melanoma: toxicities, antitumor effects, and modulation of therapeutic targets.
Authors: Su Y, Amiri KI, Horton LW
Clin. Cancer Res., 2010;16(1):348-57.
Species: Human
Sample Type: Serum

Thymic stromal lymphopoietin induces chemotactic and prosurvival effects in eosinophils: implications in allergic inflammation.
Authors: Wong CK, Hu S, Cheung PF
Am. J. Respir. Cell Mol. Biol., 2010;43(3):305-15.
Species: Human
Sample Type: Cell Culture Supernates

Dysregulation of stromal derived factor 1/CXCR4 axis in the megakaryocytic lineage in essential thrombocythemia.
Authors: Salim JP, Goette NP, Lev PR, Chazarreta CD, Heller PG, Alvarez C, Molinas FC, Marta RF
Br. J. Haematol., 2009;144(1):69-77.
Species: Human
Sample Type: Plasma

Immunomodulation of nasal epithelial cells by Staphylococcus aureus-derived serine proteases.
Authors: Rudack C, Sachse F, Albert N, Becker K, von Eiff C
J. Immunol., 2009;183(11):7592-601.
Species: Human
Sample Type: Cell Culture Supernates

LPS induces GROalpha chemokine production via NF-kappaB in oral fibroblasts.
Authors: Jonsson D, Amisten S, Bratthall G, Holm A, Nilsson BO
Inflamm. Res., 2009;58(11):791-6.
Species: Human
Sample Type: Cell Culture Supernates

IL-8 as antibody therapeutic target in inflammatory diseases: reduction of clinical activity in palmoplantar pustulosis.
Authors: Skov L, Beurskens FJ, Zachariae CO, Reitamo S, Teeling J, Satijn D, Knudsen KM, Boot EP, Hudson D, Baadsgaard O, Parren PW, van de Winkel JG
J. Immunol., 2008;181(1):669-79.
Species: Human
Sample Type: palmoplantar pustulosis wash fluid

A potential role of the CXC chemokine GROalpha in atherosclerosis and plaque destabilization: downregulatory effects of statins.
Authors: Breland UM, Halvorsen B, Hol J, ØIe E, Paulsson-Berne G, Yndestad A, Smith C, Otterdal K, Hedin U, Waehre T, Sandberg WJ, Froland SS, Haraldsen G, Gullestad L, Damas JK, Hansson GK, Aukrust P
Arterioscler. Thromb. Vasc. Biol., 2008;28(5):1005-11.
Species: Human
Sample Type: Plasma

CT20126, a novel immunosuppressant, prevents collagen-induced arthritis through the down-regulation of inflammatory gene expression by inhibiting NF-kappaB activation.
Authors: Lee SJ, Nam WD, Na HJ, Cho YL, Ha KS, Hwang JY, Lee H, Kim SO, Kwon YG, Kim YM
Biochem. Pharmacol., 2008;76(1):79-90.
Species: Human
Sample Type: Cell Culture Supernates

Duffy antigen modifies the chemokine response in human endotoxemia.
Authors: Mayr FB, Spiel AO, Leitner JM, Firbas C, Kliegel T, Jilma-Stohlawetz P, Derendorf H, Jilma B
Crit. Care Med., 2008;36(1):159-65.
Species: Human
Sample Type: Plasma

MMP-12 induces IL-8/CXCL8 secretion through EGFR and ERK1/2 activation in epithelial cells.
Authors: Le Quement C, Guenon I, Gillon JY, Lagente V, Boichot E
Am. J. Physiol. Lung Cell Mol. Physiol., 2008;294(6):L1076-84.
Species: Human
Sample Type: Cell Culture Supernates

The human IL-17F/IL-17A heterodimeric cytokine signals through the IL-17RA/IL-17RC receptor complex.
Authors: Wright JF, Bennett F, Li B, Brooks J, Luxenberg DP, Whitters MJ, Tomkinson KN, Fitz LJ, Wolfman NM, Collins M, Dunussi-Joannopoulos K, Chatterjee-Kishore M, Carreno BM
J. Immunol., 2008;181(4):2799-805.
Species: Human
Sample Type: Cell Culture Supernates

L5, the most electronegative subfraction of plasma LDL, induces endothelial vascular cell adhesion molecule 1 and CXC chemokines, which mediate mononuclear leukocyte adhesion.
Authors: Abe Y, Fornage M, Yang CY, Bui-Thanh NA, Wise V, Chen HH, Rangaraj G, Ballantyne CM
Atherosclerosis, 2007;192(1):56-66.
Species: Human
Sample Type: Cell Culture Supernates

Th1/Th2 cytokines reciprocally regulate in vitro pulmonary angiogenesis via CXC chemokine synthesis.
Authors: Matsuda A, Fukuda S, Matsumoto K, Saito H
Am. J. Respir. Cell Mol. Biol., 2007;38(2):168-75.
Species: Human
Sample Type: Cell Culture Supernates

Proliferation, differentiation, and cytokine secretion of human umbilical cord blood-derived mononuclear cells in vitro.
Authors: Neuhoff S, Moers J, Rieks M, Grunwald T, Jensen A, Dermietzel R, Meier C
Exp. Hematol., 2007;35(7):1119-31.
Species: Human
Sample Type: Cell Culture Supernates

Role of interleukin-8 and growth-regulated oncogene-alpha in the chemotactic migration of all-trans retinoic acid-treated promyelocytic leukemic cells toward alveolar epithelial cells.
Authors: Tsai WH, Hsu HC, Lin CC, Ho CK, Kou YR
Crit. Care Med., 2007;35(3):879-85.
Species: Human
Sample Type: Cell Culture Supernates

Exhaled breath condensate levels of 8-isoprostane, growth related oncogene alpha and monocyte chemoattractant protein-1 in patients with chronic obstructive pulmonary disease.
Authors: Ko FW, Lau CY, Leung TF, Wong GW, Lam CW, Hui DS
Respir Med, 2006;100(4):630-8.
Species: Human
Sample Type: Exhaled Breath Condensate (EBC)

Different angiogenic activity in pulmonary sarcoidosis and idiopathic pulmonary fibrosis.
Authors: Antoniou KM, Tzouvelekis A, Alexandrakis MG, Sfiridaki K, Tsiligianni I, Rachiotis G, Tzanakis N, Bouros D, Milic-Emili J, Siafakas NM
Chest, 2006;130(4):982-8.
Species: Human
Sample Type: BALF

IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis.
Authors: Numasaki M, Watanabe M, Suzuki T, Takahashi H, Nakamura A, McAllister F, Hishinuma T, Goto J, Lotze MT, Kolls JK, Sasaki H
J. Immunol., 2005;175(9):6177-89.
Species: Human
Sample Type: Cell Culture Supernates

ELR+ CXC chemokines in human milk.
Authors: Maheshwari A, Christensen RD, Calhoun DA
Cytokine, 2003;24(3):91-102.
Species: Human
Sample Type: Serum

TNFalpha-induced macrophage chemokine secretion is more dependent on NF-kappaB expression than lipopolysaccharides-induced macrophage chemokine secretion.
Authors: Ciesielski CJ, Andreakos E, Foxwell BM, Feldmann M
Eur. J. Immunol., 2002;32(7):2037-45.
Species: Human
Sample Type: Cell Culture Supernates

Il-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation.
Authors: Hurst SM, Wilkinson TS, McLoughlin RM, Jones S, Horiuchi S, Yamamoto N, Rose-John S, Fuller GM, Topley N, Jones SA
Immunity, 2001;14(6):705-14.
Species: Human
Sample Type: Cell Culture Supernates

High EMT Signature Score of Invasive Non-Small Cell Lung Cancer (NSCLC) Cells Correlates with NFkappaB Driven Colony-Stimulating Factor 2 (CSF2/GM-CSF) Secretion by Neighboring Stromal Fibroblasts.
Authors: Rudisch A, Dewhurst M, Horga L, Kramer N, Harrer N, Dong M, van der Kuip H, Wernitznig A, Bernthaler A, Dolznig H, Sommergruber W
PLoS ONE, 0;10(4):e0124283.
Species: Human
Sample Type: Cell Culture Supernates

生物活性< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景CXCL1/GRO alpha, also known as KC in mouse and CINC-1 in rat, is a member of the CXC family of chemokines. Human CXCL1/GRO alpha is 107 amino acids (aa) in length with a predicted molecular weight of 11 kDa. The mouse and rat orthologs share 57% and 59% amino acid sequence identity with the human protein, respectively. Genome-wide analysis suggests that the protein encoded by the mouse Cxcl3 gene is homologous to human CXCL1/GRO alpha protein. Human CXCL1/GRO alpha can be cleaved into three isoforms CXCL1/GRO alpha (aa 4-73), CXCL1/GRO alpha (aa 5-73), and CXCL1/GRO alpha (aa 6-73) which show higher activity than the full length protein. CXCL1/GRO alpha is secreted by mast cells and macrophages whereupon it acts as a chemoattractant for neutrophils.
运输条件Blue Ice
存放说明4℃
参考文献
  • Chemokines and Receptors in Allergy and Asthma
  • Chemokines and Receptors in Angiogenesis
  • CXC Chemokines and Receptors
  • Inflammatory Mediators
  • Macrophage Activation Markers