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Human MMP-9 Quantikine SixPak (6 Plates) (1 PK)

货号: SMP900 基本售价: 29971.6 元 规格: 1 PACK

产品信息

概述
货号SMP900
描述The Quantikine Human MMP-9 Immunoassay is a 3.5 hour solid phase ELISA designed to measure MMP-9 (92 kDa pro- and 82 kDa active forms but not the 65 kDa form) in cell culture supernates, saliva, serum, plasma, and urine. It is calibrated with CHO cell-expressed recombinant human pro-MMP-9 and the antibodies were raised against the recombinant factor. Natural human MMP-9 showed dose-response curves that were parallel to the standard curves obtained using the recombinant Quantikine kit standards, indicating that this kit can be used to determine relative mass values of natural human MMP-9.
别名92 kDa gelatinase; 92 kDa type IV collagenase; CLG4B; EC 3.4.24; EC 3.4.24.35; Gelatinase B; GELB; macrophage gelatinase; MANDP2; matrix metallopeptidase 9; matrix metalloproteinase 9; matrix metalloproteinase-9; MMP9; MMP-9; type V collagenase;
全称
Matrix Metalloproteinase 9
反应种属Human
目标/特异性Natural and recombinant human 92 kDa Pro-MMP-9 and the 82 kDa active MMP-9
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs
4318 (Human); 17395 (Mouse); 81687 (Rat)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Association of Toll-Like Receptor 4 on Human Monocyte Subsets and Vulnerability Characteristics of Coronary Plaque as Assessed by 64-Slice Multidetector Computed Tomography
Authors: Y Ozaki, T Imanishi, S Hosokawa, T Nishiguchi, A Taruya, T Tanimoto, A Kuroi, T Yamano, Y Matsuo, Y Ino, H Kitabata, T Kubo, A Tanaka, T Akasaka
Circ. J, 2017;0(0):.
Species: Human
Sample Type: Plasma

Serelaxin as a potential treatment for renal dysfunction in cirrhosis: Preclinical evaluation and results of a randomized phase 2 trial
Authors: VK Snowdon, NJ Lachlan, AM Hoy, PW Hadoke, SI Semple, D Patel, W Mungall, TJ Kendall, A Thomson, RJ Lennen, MA Jansen, CM Moran, A Pellicoro, P Ramachandr, I Shaw, RL Aucott, T Severin, R Saini, J Pak, D Yates, N Dongre, JS Duffield, DJ Webb, JP Iredale, PC Hayes, JA Fallowfiel
PLoS Med, 2017;14(2):e1002248.
Species: Human
Sample Type: Serum

Differential diagnosis of lung cancer, its metastasis and chronic obstructive pulmonary disease based on serum Vegf, Il-8 and MMP-9
Sci Rep, 2016;6(0):36065.
Species: Human
Sample Type: Serum

The C-terminus of IGFBP-5 suppresses tumor growth by inhibiting angiogenesis
Sci Rep, 2016;6(0):39334.
Species: Human
Sample Type: Cell Culture Supernates

Data on clinical significance of second trimester inflammatory biomarkers in the amniotic fluid in predicting preterm delivery
Data Brief, 2016;9(0):47-50.
Species: Human
Sample Type: Amniotic Fluid

A multiplex immunoassay for the non-invasive detection of bladder cancer.
Authors: Shimizu Y, Furuya H, Bryant Greenwood P, Chan O, Dai Y, Thornquist M, Goodison S, Rosser C
J Transl Med, 2016;14(1):31.
Species: Human
Sample Type: Urine

Metallothionein-3 Increases Triple-Negative Breast Cancer Cell Invasiveness via Induction of Metalloproteinase Expression.
Authors: Kmiecik A, Pula B, Suchanski J, Olbromski M, Gomulkiewicz A, Owczarek T, Kruczak A, Ambicka A, Rys J, Ugorski M, Podhorska-Okolow M, Dziegiel P
PLoS ONE, 2015;10(5):e0124865.
Species: Human
Sample Type: Cell Culture Supernates

Targeting the WASF3-CYFIP1 Complex Using Stapled Peptides Suppresses Cancer Cell Invasion.
Authors: Teng Y, Bahassan A, Dong D, Hanold L, Ren X, Kennedy E, Cowell J
Cancer Res, 2015;76(4):965-73.
Species: Human
Sample Type: Cell Culture Supernates

Simultaneous multi-analyte urinary protein assay for bladder cancer detection.
Authors: Rosser, Charles, Dai, Yunfeng, Miyake, Makito, Zhang, Ge, Goodison, Steve
BMC Biotechnol, 2014;14(0):24.
Species: Human
Sample Type: Urine

TLR ligands stimulation protects MSC from NK killing.
Authors: Giuliani M, Bennaceur-Griscelli A, Nanbakhsh A, Oudrhiri N, Chouaib S, Azzarone B, Durrbach A, Lataillade J
Stem Cells, 2014;32(1):290-300.
Species: Human
Sample Type: Cell Culture Supernates

Icariin ameliorates cigarette smoke induced inflammatory responses via suppression of NF-kappaB and modulation of GR in vivo and in vitro.
Authors: Li L, Sun J, Xu C, Zhang H, Wu J, Liu B, Dong J
PLoS ONE, 2014;9(8):e102345.
Species: Human
Sample Type: BALF

Role of serum VEGFA, TIMP2, MMP2 and MMP9 in monitoring response to adjuvant radiochemotherapy in patients with primary cervical cancer--results of a companion protocol of the randomized NOGGO-AGO phase III clinical trial.
Authors: Braicu E, Gasimli K, Richter R, Nassir M, Kummel S, Blohmer J, Yalcinkaya I, Chekerov R, Ignat I, Ionescu A, Mentze M, Fotopoulou C, Pop C, Lichtenegger W, Sehouli J
Anticancer Res, 2014;34(1):385-91.
Species: Human
Sample Type: Serum

KML001 inhibits cell proliferation and invasion in pancreatic cancer cells through suppression of NF-kappaB and VEGF-C.
Authors: Yang M, Kim H, Lee K, Yang S, Lee J, Lee K, Rhee J
Anticancer Res, 2014;34(7):3469-74.
Species: Human
Sample Type: Cell culture supernatant

Identification of a distinct glucocorticosteroid-insensitive pulmonary macrophage phenotype in patients with chronic obstructive pulmonary disease.
Authors: Chana K, Fenwick P, Nicholson A, Barnes P, Donnelly L
J Allergy Clin Immunol, 2014;133(1):207-16.e1-11.
Species: Human
Sample Type: cell culture supernate

Expression and Y435-phosphorylation of Abelson interactor 1 (Abi1) promotes tumour cell adhesion, extracellular matrix degradation and invasion by colorectal carcinoma cells.
Authors: Steinestel K, Bruderlein S, Lennerz J, Steinestel J, Kraft K, Propper C, Meineke V, Moller P
Mol Cancer, 2014;13(0):145.
Species: Human
Sample Type: Cell Culture Supernates

The biochemical value of urinary metalloproteinases 3 and 9 in diagnosis and prognosis of bladder cancer in Egypt.
Authors: El-Sharkawi, Fathia, El Sabah, Mahmoud, Hassan, Zeinab, Khaled, Hussein
J Biomed Sci, 2014;21(0):72.
Species: Human
Sample Type: Urine

Antiproliferative, antiinvasive, and proapoptotic activity of folate receptor alpha-targeted liposomal doxorubicin in nonfunctional pituitary adenoma cells.
Authors: Liu X, Ma S, Dai C, Cai F, Yao Y, Yang Y, Feng M, Deng K, Li G, Ma W, Xin B, Lian W, Xiang G, Zhang B, Wang R
Endocrinology, 2013;154(4):1414-23.
Species: Human
Sample Type: Cell Culture Supernates

Role of serum concentration of VEGFR1 and TIMP2 on clinical outcome in primary cervical cancer: results of a companion protocol of the randomized, NOGGO-AGO phase III adjuvant trial of simultaneous cisplatin-based radiochemotherapy vs. carboplatin and paclitaxel containing sequential radiotherapy.
Authors: Braicu E, Fotopoulou C, Chekerov R, Richter R, Blohmer J, Kummel S, Stamatian F, Yalcinkaya I, Mentze M, Lichtenegger W, Sehouli J
Cytokine, 2013;61(3):755-8.
Species: Human
Sample Type: Serum

Selective blockade of matrix metalloprotease-14 with a monoclonal antibody abrogates invasion, angiogenesis, and tumor growth in ovarian cancer.
Authors: Kaimal R, Aljumaily R, Tressel S, Pradhan R, Covic L, Kuliopulos A, Zarwan C, Kim Y, Sharifi S, Agarwal A
Cancer Res, 2013;73(8):2457-67.
Species: Human
Sample Type: Cell Culture Supernates

Validation and quality control of ELISAs for the use with human saliva samples.
Authors: Jaedicke KM, Taylor JJ, Preshaw PM
J. Immunol. Methods, 2012;377(1):62-5.
Species: Human
Sample Type: Saliva

A multi-analyte assay for the non-invasive detection of bladder cancer.
Authors: Goodison, Steve, Chang, Myron, Dai, Yunfeng, Urquidi, Virginia, Rosser, Charles
PLoS ONE, 2012;7(10):e47469.
Species: Human
Sample Type: Urine

Cerebrospinal Fluid Neopterin as Marker of the Meningo-Encephalitic Stage of Trypanosoma brucei gambiense Sleeping Sickness.
Authors: Tiberti N, Hainard A, Lejon V, Courtioux B, Matovu E, Enyaru JC, Robin X, Turck N, Kristensson K, Ngoyi DM, Vatunga GM, Krishna S, Buscher P, Bisser S, Ndungu JM, Sanchez JC
PLoS ONE, 2012;7(7):e40909.
Species: Human
Sample Type: CSF

Increased levels of leukocyte-derived MMP-9 in patients with stable angina pectoris.
Authors: Jonasson S, Lundberg A, Kalvegren H, Bergstrom I, Szymanowski A, Jonasson L
PLoS ONE, 2011;6(4):e19340.
Species: Human
Sample Type: Serum

Characterization of innate immune signalling receptors in virus-induced acute asthma.
Authors: Wood LG, Simpson JL, Wark PA, Powell H, Gibson PG
Clin. Exp. Allergy, 2011;41(5):640-8.
Species: Human
Sample Type: Saliva

Cyclooxygenase-2 inhibitor blocks the production of West Nile virus-induced neuroinflammatory markers in astrocytes.
Authors: Verma S, Kumar M, Nerurkar VR
J. Gen. Virol., 2011;92(0):507-15.
Species: Human
Sample Type: Cell Culture Supernates

Biomarkers of extracellular matrix metabolism (MMP-9 and TIMP-1) and risk of stroke, myocardial infarction, and cause-specific mortality: cohort study.
Authors: Hansson J, Vasan RS, Arnlov J, Ingelsson E, Lind L, Larsson A, Michaelsson K, Sundstrom J
PLoS ONE, 2011;6(1):e16185.
Species: Human
Sample Type: Serum

Leptin administered in physiological or pharmacological doses does not regulate circulating angiogenesis factors in humans.
Authors: Aronis KN, Diakopoulos KN, Fiorenza CG
Diabetologia, 2011;54(9):2358-67.
Species: Human
Sample Type: Serum

Double-blind, randomized, multicentre, and active comparator controlled investigation of the effect of Pioglitazone, Metformin, and the combination of both on cardiovascular risk in patients with type 2 diabetes receiving stable basal insulin therapy: the PIOCOMB study.
Authors: Hanefeld M, Pfutzner A, Forst T, Kleine I, Fuchs W
Cardiovasc Diabetol, 2011;10(0):65.
Species: Human
Sample Type: Serum

Mannitol challenge for assessment of airway responsiveness, airway inflammation and inflammatory phenotype in asthma.
Authors: Wood LG, Powell H, Gibson PG
Clin. Exp. Allergy, 2010;40(2):232-41.
Species: Human
Sample Type: Saliva

Primary human acute myelogenous leukemia cells release matrix metalloproteases and their inhibitors: release profile and pharmacological modulation.
Authors: Reikvam H, Hatfield KJ, Oyan AM, Kalland KH, Kittang AO, Bruserud O
Eur. J. Haematol., 2010;84(3):239-51.
Species: Human
Sample Type: Cell Culture Supernates

Inhibition of EGFR pathway signaling and the metastatic potential of breast cancer cells by PA-MSHA mediated by type 1 fimbriae via a mannose-dependent manner.
Authors: Liu ZB, Hou YF, Zhu J
Oncogene, 2010;29(20):2996-3009.
Species: Human
Sample Type: Cell Culture Supernates

Elevated serum matrix metalloproteinase-3 and -7 in H. pylori-related gastric cancer can be biomarkers correlating with a poor survival.
Authors: Yeh YC, Sheu BS, Cheng HC, Wang YL, Yang HB, Wu JJ
Dig. Dis. Sci., 2010;55(6):1649-57.
Species: Human
Sample Type: Serum

Circulating matrix metalloproteinase-3 and metalloproteinase-9 and tissue Doppler measures of diastolic dysfunction to risk stratify patients with systolic heart failure.
Authors: Buralli S, Dini FL, Ballo P, Conti U, Fontanive P, Duranti E, Metelli MR, Marzilli M, Taddei S
Am. J. Cardiol., 2010;105(6):853-6.
Species: Human
Sample Type: Plasma

High matrix metalloproteinase production correlates with immune activation and leukocyte migration in leprosy reactional lesions.
Authors: Teles RM, Teles RB, Amadeu TP, Moura DF, Mendonca-Lima L, Ferreira H, Santos IM, Nery JA, Sarno EN, Sampaio EP
Infect. Immun., 2010;78(3):1012-21.
Species: Human
Sample Type: Serum

Matrix metalloproteinase-9 and plasminogen activator inhibitor-1 are associated with right ventricular structure and function: the MESA-RV Study.
Authors: Kawut SM, Barr RG, Johnson WC
Biomarkers, 2010;15(8):731-8.
Species: Human
Sample Type: Plasma

The effect of aspirin desensitization on novel biomarkers in aspirin-exacerbated respiratory diseases.
Authors: Katial RK, Strand M, Prasertsuntarasai T, Leung R, Zheng W, Alam R
J. Allergy Clin. Immunol., 2010;126(4):738-44.
Species: Human
Sample Type: Sputum

Cerebrospinal fluid u-plasminogen activator and matrix metalloproteinase-9 levels in human eosinophilic meningitis associated with angiostrongyliasis.
Authors: Sanpool O, Intapan PM, Thanchomnang T
Cytokine, 2010;51(3):294-7.
Species: Human
Sample Type: CSF

Plasma haemoxygenase-1 in coronary artery disease. A comparison with angiogenin, matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1 and vascular endothelial growth factor.
Authors: Idriss NK, Lip GY, Balakrishnan B
Thromb. Haemost., 2010;104(5):1029-37.
Species: Human
Sample Type: Plasma

Broad regulation of matrix and adhesion molecules in THP-1 human macrophages by nitroglycerin.
Authors: Krishnatry AS, Brazeau DA, Fung HL
Nitric Oxide, 2010;22(1):11-7.
Species: Human
Sample Type: Cell Culture Supernates

In vitro secretion of matrix metalloprotease 9 is a prognostic marker in childhood acute lymphoblastic leukemia.
Authors: Schneider P, Costa O, Legrand E
Leuk. Res., 2010;34(1):24-31.
Species: Human
Sample Type: Cell Culture Supernates

Abnormalities in metalloproteinase pathways and IGF-I axis: a link between birth weight, hypertension, and vascular damage in childhood.
Authors: Sesso R, Franco MC
Am. J. Hypertens., 2010;23(1):6-11.
Species: Human
Sample Type: Plasma

Orange juice neutralizes the proinflammatory effect of a high-fat, high-carbohydrate meal and prevents endotoxin increase and Toll-like receptor expression.
Authors: Ghanim H, Sia CL, Upadhyay M, Korzeniewski K, Viswanathan P, Abuaysheh S, Mohanty P, Dandona P
Am. J. Clin. Nutr., 2010;91(4):940-9.
Species: Human
Sample Type: Serum

The diagnostic value of matrix metalloproteinase 9 (MMP-9) and tissue inhibitor of matrix metalloproteinases 1 (TIMP-1) determination in the sera of colorectal adenoma and cancer patients.
Authors: Mroczko B, Groblewska M, Okulczyk B, Kedra B, Szmitkowski M
Int J Colorectal Dis, 2010;25(10):1177-84.
Species: Human
Sample Type: Serum

Non-conventional markers of atherosclerosis before and after gastric banding surgery.
Authors: Hanusch-Enserer U, Zorn G, Wojta J, Kopp CW, Prager R, Koenig W, Schillinger M, Roden M, Huber K
Eur. Heart J., 2009;30(12):1516-24.
Species: Human
Sample Type: Plasma

Arginase I-producing myeloid-derived suppressor cells in renal cell carcinoma are a subpopulation of activated granulocytes.
Authors: Rodriguez PC, Ernstoff MS, Hernandez C, Atkins M, Zabaleta J, Sierra R, Ochoa AC
Cancer Res., 2009;69(4):1553-60.
Species: Human
Sample Type: Plasma

A TLR2 agonist in German cockroach frass activates MMP-9 release and is protective against allergic inflammation in mice.
Authors: Page K, Ledford JR, Zhou P, Wills-Karp M
J. Immunol., 2009;183(5):3400-8.
Species: Human
Sample Type: Cell Culture Supernates

Serum levels of matrix metalloproteinases -1,-2,-3 and -9 in thoracic aortic diseases and acute myocardial ischemia.
Authors: Karapanagiotidis GT, Antonitsis P, Charokopos N, Foroulis CN, Anastasiadis K, Rouska E, Argiriadou H, Rammos K, Papakonstantinou C
J Cardiothorac Surg, 2009;4(0):59.
Species: Human
Sample Type: Serum

Immunomodulation by chronobiologically-based glucocorticoids treatment for multiple sclerosis relapses.
Authors: Glass-Marmor L, Paperna T, Galboiz Y, Miller A
J. Neuroimmunol., 2009;210(1):124-7.
Species: Human
Sample Type: Serum

A urinary biomarker profile for children with HIV-associated renal diseases.
Authors: Soler-Garcia AA, Rakhmanina NY, Mattison PC, Ray PE
Kidney Int., 2009;76(2):207-14.
Species: Human
Sample Type: Urine

Matrix metalloproteinase-9, -10, and tissue inhibitor of matrix metalloproteinases-1 blood levels as biomarkers of severity and mortality in sepsis.
Authors: Lorente L, Martin MM, Labarta L, Diaz C, Sole-Violan J, Blanquer J, Orbe J, Rodriguez JA, Jimenez A, Borreguero-Leon JM, Belmonte F, Medina JC, Lliminana MC, Ferrer-Aguero JM, Ferreres J, Mora ML, Lubillo S, Sanchez M, Barrios Y, Sierra A, Paramo JA
Crit Care, 2009;13(5):R158.
Species: Human
Sample Type: Serum

Proteinase-activated receptor (PAR)-2 activation impacts bone resorptive properties of human osteoarthritic subchondral bone osteoblasts.
Authors: Amiable N, Tat SK, Lajeunesse D, Duval N, Pelletier JP, Martel-Pelletier J, Boileau C
Bone, 2009;44(6):1143-50.
Species: Human
Sample Type: Cell Culture Supernates

Significant elevation of plasma matrix metalloproteinase-9 level and its ratio to matrix metalloproteinase-2 in patients with pelvic inflammatory disease.
Authors: Wang PH, Tsai HT, Tee YT, Lin LY, Yang SF, Hsieh YS
Fertil. Steril., 2009;92(5):1679-84.
Species: Human
Sample Type: Plasma

A plant stanol yogurt drink alone or combined with a low-dose statin lowers serum triacylglycerol and non-HDL cholesterol in metabolic syndrome patients.
Authors: Plat J, Brufau G, Dallinga-Thie GM, Dasselaar M, Mensink RP
J. Nutr., 2009;139(6):1143-9.
Species: Human
Sample Type: Plasma

Serum matrix metalloproteinases in adult CF patients: Relation to pulmonary exacerbation.
Authors: Roderfeld M, Rath T, Schulz R, Seeger W, Tschuschner A, Graf J, Roeb E
J. Cyst. Fibros., 2009;8(5):338-47.
Species: Human
Sample Type: Serum

Gender specific associations between matrix metalloproteinases and inflammatory markers in post myocardial infarction patients.
Authors: Samnegard A, Hulthe J, Silveira A, Ericsson CG, Hamsten A, Eriksson P
Atherosclerosis, 2009;202(2):550-6.
Species: Human
Sample Type: Serum

Gene transfer of matrix metalloproteinase-9 induces tumor regression of breast cancer in vivo.
Authors: Bendrik C, Robertson J, Gauldie J, Dabrosin C
Cancer Res., 2008;68(9):3405-12.
Species: Human
Sample Type: Tissue Homogenates

Targeting a metalloprotease-PAR1 signaling system with cell-penetrating pepducins inhibits angiogenesis, ascites, and progression of ovarian cancer.
Authors: Agarwal A, Covic L, Sevigny LM, Kaneider NC, Lazarides K, Azabdaftari G, Sharifi S, Kuliopulos A
Mol. Cancer Ther., 2008;7(9):2746-57.
Species: Human
Sample Type: ovarian ascites

Urinary biomarkers predict brain tumor presence and response to therapy.
Authors: Smith ER, Zurakowski D, Saad A, Scott RM, Moses MA
Clin. Cancer Res., 2008;14(8):2378-86.
Species: Human
Sample Type: Urine

Impact of acute exposure to tobacco smoke on gelatinases in the bronchoalveolar space.
Authors: Glader P, Eldh B, Bozinovski S, Andelid K, Sjostrand M, Malmhall C, Anderson GP, Riise GC, Qvarfordt I, Linden A
Eur. Respir. J., 2008;32(3):644-50.
Species: Human
Sample Type: BALF

Lysyl oxidase activity in the ocular tissues and the role of LOX in proliferative diabetic retinopathy and rhegmatogenous retinal detachment.
Authors: Coral K, Angayarkanni N, Madhavan J, Bharathselvi M, Ramakrishnan S, Nandi K, Rishi P, Kasinathan N, Krishnakumar S
Invest. Ophthalmol. Vis. Sci., 2008;49(11):4746-52.
Species: Human
Sample Type: Vitreous Humor

Activation of the osteopontin/matrix metalloproteinase-9 pathway correlates with prostate cancer progression.
Authors: Castellano G, Malaponte G, Mazzarino MC, Figini M, Marchese F, Gangemi P, Travali S, Stivala F, Canevari S, Libra M
Clin. Cancer Res., 2008;14(22):7470-80.
Species: Human
Sample Type: Plasma

The angiogenic response is dictated by beta3 integrin on bone marrow-derived cells.
Authors: Feng W, McCabe NP, Mahabeleshwar GH, Somanath PR, Phillips DR, Byzova TV
J. Cell Biol., 2008;183(6):1145-57.
Species: Mouse
Sample Type: Cell Lysates

Matrix metalloproteinase 9 is a mediator of epidermal growth factor-dependent e-cadherin loss in ovarian carcinoma cells.
Authors: Cowden Dahl KD, Symowicz J, Ning Y, Gutierrez E, Fishman DA, Adley BP, Stack MS, Hudson LG
Cancer Res., 2008;68(12):4606-13.
Species: Human
Sample Type: Ascites

Hypoxia-induced mediators of stem/progenitor cell trafficking are increased in children with hemangioma.
Authors: Kleinman ME, Greives MR, Churgin SS, Blechman KM, Chang EI, Ceradini DJ, Tepper OM, Gurtner GC
Arterioscler. Thromb. Vasc. Biol., 2007;27(12):2664-70.
Species: Human
Sample Type: Plasma

Borrelia burgdorferi-induced monocyte chemoattractant protein-1 production in vivo and in vitro.
Authors: Zhao Z, McCloud B, Fleming R, Klempner MS
Biochem. Biophys. Res. Commun., 2007;358(2):528-33.
Species: Human
Sample Type: Tissue Homogenates

ROCK-II mediates colon cancer invasion via regulation of MMP-2 and MMP-13 at the site of invadopodia as revealed by multiphoton imaging.
Authors: Vishnubhotla R, Sun S, Huq J, Bulic M, Ramesh A, Guzman G, Cho M, Glover SC
Lab. Invest., 2007;87(11):1149-58.
Species: Human
Sample Type: Cell Culture Supernates

Pilot study of rosiglitazone therapy in women with breast cancer: effects of short-term therapy on tumor tissue and serum markers.
Authors: Yee LD, Williams N, Wen P, Young DC, Lester J, Johnson MV, Farrar WB, Walker MJ, Povoski SP, Suster S, Eng C
Clin. Cancer Res., 2007;13(1):246-52.
Species: Human
Sample Type: Serum

Pleiotrophic and anti-inflammatory effects of pioglitazone precede the metabolic activity in type 2 diabetic patients with coronary artery disease.
Authors: Forst T, Karagiannis E, Lubben G, Hohberg C, Schondorf T, Dikta G, Drexler M, Morcos M, Danschel W, Borchert M, Pfutzner A
Atherosclerosis, 2007;197(1):311-7.
Species: Human
Sample Type: Plasma

Urinary biomarkers in the early diagnosis of acute kidney injury.
Authors: Han WK, Waikar SS, Johnson A, Betensky RA, Dent CL, Devarajan P, Bonventre JV
Kidney Int., 2007;73(7):863-9.
Species: Human
Sample Type: Urine

Plasma matrix metalloproteinase-9 level is better than serum matrix metalloproteinase-9 level to predict gastric cancer evolution.
Authors: Wu CY, Wu MS, Chiang EP, Chen YJ, Chen CJ, Chi NH, Shih YT, Chen GH, Lin JT
Clin. Cancer Res., 2007;13(7):2054-60.
Species: Human
Sample Type: Plasma

Multiple biomarker use for detection of adverse events in patients presenting with symptoms suggestive of acute coronary syndrome.
Authors: Apple FS, Pearce LA, Chung A, Ler R, Murakami MM
Clin. Chem., 2007;53(5):874-81.
Species: Human
Sample Type: Plasma

Airway remodeling and lack of bronchodilator response in steroid-resistant asthma.
Authors: Goleva E, Hauk PJ, Boguniewicz J, Martin RJ, Leung DY
J. Allergy Clin. Immunol., 2007;120(5):1065-72.
Species: Human
Sample Type: BALF

Is metalloproteinase-7 specific for idiopathic pulmonary fibrosis?
Authors: Huh JW, Kim DS, Oh YM, Shim TS, Lim CM, Lee SD, Koh Y, Kim WS, Kim WD, Kim KR
Chest, 2007;133(5):1101-6.
Species: Human
Sample Type: BALF

Matrix metalloprotease-9 dysregulation in lower airway secretions of cystic fibrosis patients.
Authors: Gaggar A, Li Y, Weathington N, Winkler M, Kong M, Jackson P, Blalock JE, Clancy JP
Am. J. Physiol. Lung Cell Mol. Physiol., 2007;293(1):L96-L104.
Species: Human
Sample Type: Sputum

C-reactive protein induces endothelial cell apoptosis and matrix metalloproteinase-9 production in human mononuclear cells: Implications for the destabilization of atherosclerotic plaque.
Authors: Nabata A, Kuroki M, Ueba H, Hashimoto S, Umemoto T, Wada H, Yasu T, Saito M, Momomura S, Kawakami M
Atherosclerosis, 2007;196(1):129-35.
Species: Human
Sample Type: Cell Culture Supernates

Clarithromycin targets neutrophilic airway inflammation in refractory asthma.
Authors: Simpson JL, Powell H, Boyle MJ, Scott RJ, Gibson PG
Am. J. Respir. Crit. Care Med., 2007;177(2):148-55.
Species: Human
Sample Type: Sputum

Selective functional exhaustion of hematopoietic progenitor cells in the bone marrow of patients with postinfarction heart failure.
Authors: Kissel CK, Lehmann R, Assmus B, Aicher A, Honold J, Fischer-Rasokat U, Heeschen C, Spyridopoulos I, Dimmeler S, Zeiher AM
J. Am. Coll. Cardiol., 2007;49(24):2341-9.
Species: Human
Sample Type: Bone Marrow Plasma

Actinobacillus actinomycetemcomitans lipopolysaccharide regulates matrix metalloproteinase, tissue inhibitors of matrix metalloproteinase, and plasminogen activator production by human gingival fibroblasts: a potential role in connective tissue destruction.
Authors: Bodet C, Andrian E, Tanabe S, Grenier D
J. Cell. Physiol., 2007;212(1):189-94.
Species: Human
Sample Type: Cell Culture Supernates

Generation of endostatin by matrix metalloproteinase and cathepsin from human limbocorneal epithelial cells cultivated on amniotic membrane.
Authors: Ma DH, Yao JY, Kuo MT, See LC, Lin KY, Chen SC, Chen JK, Chao AS, Wang SF, Lin KK
Invest. Ophthalmol. Vis. Sci., 2007;48(2):644-51.
Species: Human
Sample Type: Cell Culture Supernates

Phase I clinical and pharmacodynamic evaluation of oral CI-1033 in patients with refractory cancer.
Authors: Zinner RG, Nemunaitis J, Eiseman I, Shin HJ, Olson SC, Christensen J, Huang X, Lenehan PF, Donato NJ, Shin DM
Clin. Cancer Res., 2007;13(10):3006-14.
Species: Human
Sample Type: Plasma

Humoral and cellular factors responsible for coronary collateral formation.
Authors: Sherman JA, Hall A, Malenka DJ, De Muinck ED, Simons M
Am. J. Cardiol., 2006;98(9):1194-7.
Species: Human
Sample Type: Plasma

Vascular endothelial growth factor modulates matrix metalloproteinase-9 expression in asthma.
Authors: Lee KS, Min KH, Kim SR, Park SJ, Park HS, Jin GY, Lee YC
Am. J. Respir. Crit. Care Med., 2006;174(2):161-70.
Species: Human
Sample Type: BALF

Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice.
Authors: Rofstad EK, Mathiesen B, Kindem K, Galappathi K
Cancer Res., 2006;66(13):6699-707.
Species: Human
Sample Type: Cell Culture Supernates

Effects of rosiglitazone alone and in combination with atorvastatin on nontraditional markers of cardiovascular disease in patients with type 2 diabetes mellitus.
Authors: Chu CS, Lee KT, Lee MY, Su HM, Voon WC, Sheu SH, Lai WT
Am. J. Cardiol., 2006;97(5):646-50.
Species: Human
Sample Type: Serum

Airway inflammation in iron ore miners exposed to dust and diesel exhaust.
Authors: Adelroth E, Hedlund U, Blomberg A, Helleday R, Ledin MC, Levin JO, Pourazar J, Sandstrom T, Jarvholm B
Eur. Respir. J., 2006;27(4):714-9.
Species: Human
Sample Type: Sputum

Dental plaque, gingival inflammation, and elevated levels of interleukin-6 and cortisol in gingival crevicular fluid from women with stress-related depression and exhaustion.
Authors: Johannsen A, Rylander G, Soder B, Asberg M
J. Periodontol., 2006;77(8):1403-9.
Species: Human
Sample Type: Gingival Crevicular Fluid (GCF)

Ligation of the FcR gamma chain-associated human osteoclast-associated receptor enhances the proinflammatory responses of human monocytes and neutrophils.
Authors: Merck E, Gaillard C, Scuiller M, Scapini P, Cassatella MA, Trinchieri G, Bates EE
J. Immunol., 2006;176(5):3149-56.
Species: Human
Sample Type: Cell Culture Supernates

Serum levels of syndecan-1 in B-cell chronic lymphocytic leukemia: correlation with the extent of angiogenesis and disease-progression risk in early disease.
Authors: Molica S, Vitelli G, Mirabelli R, Digiesu G, Giannarelli D, Cuneo A, Ribatti D, Vacca A
Leuk. Lymphoma, 2006;47(6):1034-40.
Species: Human
Sample Type: Serum

Role of platelet-derived growth factor and transforming growth factor beta1 the in the regulation of metalloproteinase expressions.
Authors: Borrelli V, di Marzo L, Sapienza P, Colasanti M, Moroni E, Cavallaro A
Surgery, 2006;140(3):454-63.
Species: Human
Sample Type: Cell Culture Supernates

Neutrophil-derived metalloproteinase-9 predicts healing quality after sinus surgery.
Authors: Watelet JB, Demetter P, Claeys C, Van Cauwenberge P, Cuvelier C, Bachert C
Laryngoscope, 2005;115(1):56-61.
Species: Human
Sample Type: Nasal Fluid

A comparison of airway and serum matrix metalloproteinase-9 activity among normal subjects, asthmatic patients, and patients with asthmatic mucus hypersecretion.
Authors: Ko FW, Diba C, Roth M, McKay K, Johnson PR, Salome C, King GG
Chest, 2005;127(6):1919-27.
Species: Human
Sample Type: Serum

Endurance training reduces circulating inflammatory markers in persons at risk of coronary events: impact on plaque stabilization?
Authors: Niessner A, Richter B, Penka M, Steiner S, Strasser B, Ziegler S, Heeb-Elze E, Zorn G, Leitner-Heinschink A, Niessner C, Wojta J, Huber K
Atherosclerosis, 2005;186(1):160-5.
Species: Human
Sample Type: Plasma

Plasma storage at -80 degrees C does not protect matrix metalloproteinase-9 from degradation.
Authors: Rouy D, Ernens I, Jeanty C, Wagner DR
Anal. Biochem., 2005;338(2):294-8.
Species: Human
Sample Type: Plasma

Induced sputum matrix metalloproteinase-9 correlates with lung function and airway inflammation in children with cystic fibrosis.
Authors: Sagel SD, Kapsner RK, Osberg I
Pediatr. Pulmonol., 2005;39(3):224-32.
Species: Human
Sample Type: Sputum

Differential proteolytic enzyme activity in eosinophilic and neutrophilic asthma.
Authors: Simpson JL, Scott RJ, Boyle MJ, Gibson PG
Am. J. Respir. Crit. Care Med., 2005;172(5):559-65.
Species: Human
Sample Type: Sputum

Aberrant neutrophil reactions in periodontitis.
Authors: Figueredo CM, Fischer RG, Gustafsson A
J. Periodontol., 2005;76(6):951-5.
Species: Human
Sample Type: Gingival Crevicular Fluid (GCF)

CXCL12-CXCR4 interactions modulate prostate cancer cell migration, metalloproteinase expression and invasion.
Authors: Singh S, Singh UP, Grizzle WE, Lillard JW
Lab. Invest., 2004;84(12):1666-76.
Species: Human
Sample Type: Cell Culture Supernates

Intrafollicular expression of matrix metalloproteinases and their inhibitors in normally ovulating women compared with patients undergoing in vitro fertilization treatment.
Authors: D'Ascenzo S, Giusti I, Millimaggi D, Marci R, Tatone C, Cardigno Colonna R, Moscarini M, Pavan A, Dolo V, Caserta D
Eur. J. Endocrinol., 2004;151(1):87-91.
Species: Human
Sample Type: Follicular Fluid

Stimulation of matrix metalloproteinases by hyperosmolarity via a JNK pathway in human corneal epithelial cells.
Authors: Li DQ, Chen Z, Song XJ, Luo L, Pflugfelder SC
Invest. Ophthalmol. Vis. Sci., 2004;45(12):4302-11.
Species: Human
Sample Type: Cell Culture Supernates

Matrix metalloprotenase-9 in acute pyelonephritis.
Authors: Laudanski P, Reduta T
Pediatr. Res., 2004;55(2):357; author r.
Species: Human
Sample Type: Urine

Determination of the serum matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in patients with either advanced small-cell lung cancer or non-small-cell lung cancer prior to treatment.
Authors: Jumper C, Cobos E, Lox C
Respir Med, 2004;98(2):173-7.
Species: Human
Sample Type: Serum

Matrix metalloproteinases production in malignant pleural effusions after talc pleurodesis.
Authors: D'Agostino P
Clin. Exp. Immunol., 2003;134(1):138-42.
Species: Human
Sample Type: Pleural Effusion

Gonadotropin and steroid regulation of matrix metalloproteinases and their endogenous tissue inhibitors in the developed corpus luteum of the rhesus monkey during the menstrual cycle.
Authors: Young KA, Stouffer RL
Biol. Reprod., 2003;70(1):244-52.
Species: Primate
Sample Type: Tissue Homogenates

Anti-inflammatory cytokine profile in acute coronary syndromes: behavior of interleukin-10 in association with serum metalloproteinases and proinflammatory cytokines.
Authors: Tziakas DN, Chalikias GK, Hatzinikolaou HI, Parissis JT, Papadopoulos ED, Trypsianis GA, Papadopoulou E, Tentes IK, Karas SM, Hatseras DI
Int. J. Cardiol., 2003;92(2):169-75.
Species: Human
Sample Type: Serum

Antidiabetic PPAR gamma-activator rosiglitazone reduces MMP-9 serum levels in type 2 diabetic patients with coronary artery disease.
Authors: Marx N, Froehlich J, Siam L, Ittner J, Wierse G, Schmidt A, Scharnagl H, Hombach V, Koenig W
Arterioscler. Thromb. Vasc. Biol., 2003;23(2):283-8.
Species: Human
Sample Type: Serum

Evasion from NK cell immunity by MHC class I chain-related molecules expressing colon adenocarcinoma.
Authors: Doubrovina ES, Doubrovin MM, Vider E, Sisson RB, O'Reilly RJ, Dupont B, Vyas YM
J. Immunol., 2003;171(12):6891-9.
Species: Human
Sample Type: Serum

Matrix metalloproteinases and tissue inhibitors of metalloproteinases in sera and tissue of patients with Dupuytrens disease.
Authors: Ulrich D, Hrynyschyn K, Pallua N
Plast. Reconstr. Surg., 2003;112(5):1279-86.
Species: Human
Sample Type: Serum

Matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1: a possible role in the pathogenesis of endometriosis.
Authors: Szamatowicz J, Laudanski P, Tomaszewska I
Hum. Reprod., 2002;17(2):284-8.
Species: Human
Sample Type: Peritoneal Fluid

Induced sputum-retrieved matrix metalloproteinase 9 and tissue metalloproteinase inhibitor 1 in granulomatous diseases.
Authors: Fireman E, Kraiem Z, Sade O, Greif J, Fireman Z
Clin. Exp. Immunol., 2002;130(2):331-7.
Species: Human
Sample Type: Saliva

Matrix metalloproteinase-9, but not tissue inhibitor of matrix metalloproteinase-1, increases in the sputum from allergic asthmatic patients after allergen challenge.
Authors: Cataldo DD, Bettiol J, Noel A, Bartsch P, Foidart JM, Louis R
Chest, 2002;122(5):1553-9.
Species: Human
Sample Type: Sputum

生物活性< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景

The matrix metalloproteinases (MMPs) consist of 24 known human zinc proteases with essential roles in breaking down components of the extracellular matrix (ECM). Additional MMP substrates include cytokines, chemokines, growth factors and binding proteins, cell/cell adhesion molecules, and other proteinases. With a few exceptions, MMPs share common structural motifs including a pro-peptide domain, a catalytic domain, a hinge region, and a hemopexin-like domain. Synthesized as pro-enzymes, most MMPs are secreted before conversion to their active form. MMP activities are modulated on several levels including transcription, pro-enzyme activation, or by their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs). A subset of MMPs are associated with membranes and designated as membrane-type metalloproteinases (MT-MMP).

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参考文献
  • Airway Inflammation and Remodeling
  • APP Cleavage and Amyloid-beta Degradation
  • Cancer Biomarkers
  • Cell to Cell Adhesion Disassembly During EMT
  • Collagen Modifying Enzymes
  • Enzymes Secreted by Endothelial Cells
  • Extracellular Matrix Remodeling and Cell Migration During EMT
  • Gametes and Fertilization
  • Inflammatory Mediators
  • Mesenchymal Cells and EMT
  • Metalloproteases and Regulators
  • MMPs, TIMPs and Related Molecules
  • Molecules Secreted by VSMC
  • Preeclampsia