| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. The effect of type 2 diabetes mellitus and smoking on periodontal parameters and salivary matrix metalloproteinase-8 levels
Authors: N Gupta, ND Gupta, S Garg, L Goyal, A Gupta, S Khan, S Moin
J Oral Sci, 2016;58(1):1-6.
Species: Human
Sample Type: Saliva
Identification of Gingival Crevicular Fluid Sampling, Analytical Methods, and Oral Biomarkers for the Diagnosis and Monitoring of Periodontal Diseases: A Systematic Review
Authors: Z Nazar Maje, K Philip, AM Alabsi, S Pushparaja, D Swaminatha
Dis. Markers, 2016;2016(0):1804727.
Species: Human
Sample Type: Saliva
Relationship between Serum Levels of Metalloproteinase-8 and Tissue Inhibitor of Metalloproteinases-1 and Exercise Test Results in Postmenopausal Women
Authors: J Mieczkowsk, E Rutkowska, J Mosiewicz, B Mosiewicz
Dis. Markers, 2016;2016(0):7169531.
Species: Human
Sample Type: Serum
Interleukin-6 and matrix metalloproteinase expression in the subretinal fluid during proliferative vitreoretinopathy: correlation with extent, duration of RRD and PVR grade.
Authors: Symeonidis C, Papakonstantinou E, Androudi S, Tsaousis KT, Tsinopoulos I, Brazitikos P, Karakiulakis G, Diza E, Dimitrakos SA
Cytokine, 2012;59(1):184-90.
Species: Human
Sample Type: Subretinal fluid
Validation and quality control of ELISAs for the use with human saliva samples.
Authors: Jaedicke KM, Taylor JJ, Preshaw PM
J. Immunol. Methods, 2012;377(1):62-5.
Species: Human
Sample Type: Saliva
Early Elevation of Matrix Metalloproteinase-8 and -9 in Pediatric ARDS Is Associated with an Increased Risk of Prolonged Mechanical Ventilation.
Authors: Kong MY, Li Y, Oster R, Gaggar A, Clancy JP
PLoS ONE, 2011;6(8):e22596.
Species: Human
Sample Type: Tracheal Aspirates
Increased levels of leukocyte-derived MMP-9 in patients with stable angina pectoris.
Authors: Jonasson S, Lundberg A, Kalvegren H, Bergstrom I, Szymanowski A, Jonasson L
PLoS ONE, 2011;6(4):e19340.
Species: Human
Sample Type: Serum
Interleukin-6 and the matrix metalloproteinase response in the vitreous during proliferative vitreoretinopathy.
Authors: Symeonidis C, Papakonstantinou E, Androudi S, Rotsos T, Diza E, Brazitikos P, Karakiulakis G, Dimitrakos SA
Cytokine, 2011;54(2):212-7.
Species: Human
Sample Type: Vitreous Humor
Leptin administered in physiological or pharmacological doses does not regulate circulating angiogenesis factors in humans.
Authors: Aronis KN, Diakopoulos KN, Fiorenza CG
Diabetologia, 2011;54(9):2358-67.
Species: Human
Sample Type: Serum
Primary human acute myelogenous leukemia cells release matrix metalloproteases and their inhibitors: release profile and pharmacological modulation.
Authors: Reikvam H, Hatfield KJ, Oyan AM, Kalland KH, Kittang AO, Bruserud O
Eur. J. Haematol., 2010;84(3):239-51.
Species: Human
Sample Type: Cell Culture Supernates
Serum matrix metalloproteinases in adult CF patients: Relation to pulmonary exacerbation.
Authors: Roderfeld M, Rath T, Schulz R, Seeger W, Tschuschner A, Graf J, Roeb E
J. Cyst. Fibros., 2009;8(5):338-47.
Species: Human
Sample Type: Serum
Targeting a metalloprotease-PAR1 signaling system with cell-penetrating pepducins inhibits angiogenesis, ascites, and progression of ovarian cancer.
Authors: Agarwal A, Covic L, Sevigny LM, Kaneider NC, Lazarides K, Azabdaftari G, Sharifi S, Kuliopulos A
Mol. Cancer Ther., 2008;7(9):2746-57.
Species: Human
Sample Type: ovarian ascites
Matrix metalloprotease-9 dysregulation in lower airway secretions of cystic fibrosis patients.
Authors: Gaggar A, Li Y, Weathington N, Winkler M, Kong M, Jackson P, Blalock JE, Clancy JP
Am. J. Physiol. Lung Cell Mol. Physiol., 2007;293(1):L96-L104.
Species: Human
Sample Type: Sputum
Changes in periodontal and rheumatological conditions after 2 years in patients with juvenile idiopathic arthritis.
Authors: Miranda LA, Braga F, Fischer RG, Sztajnbok FR, Figueredo CM, Gustafsson A
J. Periodontol., 2006;77(10):1695-700.
Species: Human
Sample Type: Gingival Crevicular Fluid (GCF)
Aberrant neutrophil reactions in periodontitis.
Authors: Figueredo CM, Fischer RG, Gustafsson A
J. Periodontol., 2005;76(6):951-5.
Species: Human
Sample Type: Gingival Crevicular Fluid (GCF)
Midtrimester amniotic fluid matrix metalloproteinase-8 (MMP-8) levels above the 90th percentile are a marker for subsequent preterm premature rupture of membranes.
Authors: Biggio JR, Ramsey PS, Cliver SP, Lyon MD, Goldenberg RL, Wenstrom KD
Am. J. Obstet. Gynecol., 2005;192(1):109-13.
Species: Human
Sample Type: Amniotic Fluid
Differential modulation of human melanoma cell metalloproteinase expression by alpha2beta1 integrin and CD44 triple-helical ligands derived from type IV collagen.
Authors: Baronas-Lowell D, Lauer-Fields JL, Borgia JA, Sferrazza GF, Al-Ghoul M, Minond D, Fields GB
J. Biol. Chem., 2004;279(42):43503-13.
Species: Human
Sample Type: Cell Culture Supernates
Antidiabetic PPAR gamma-activator rosiglitazone reduces MMP-9 serum levels in type 2 diabetic patients with coronary artery disease.
Authors: Marx N, Froehlich J, Siam L, Ittner J, Wierse G, Schmidt A, Scharnagl H, Hombach V, Koenig W
Arterioscler. Thromb. Vasc. Biol., 2003;23(2):283-8.
Species: Human
Sample Type: Serum
Effect of tobacco smoking on neutrophil activity following periodontal surgery.
Authors: Persson L, Bergstrom J, Gustafsson A
J. Periodontol., 2003;74(10):1475-82.
Species: Human
Sample Type: Gingival Crevicular Fluid (GCF)
Shifts in biochemical markers associated with wound healing in laryngeal secretions following phonotrauma: a preliminary study.
Authors: Verdolini K, Rosen CA, Branski RC, Hebda PA
Ann. Otol. Rhinol. Laryngol., 2003;112(12):1021-5.
Species: Human
Sample Type: laryngeal secretion
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| 背景 | The matrix metalloproteinases (MMPs) consist of 24 known human zinc proteases with essential roles in breaking down components of the extracellular matrix (ECM). Additional MMP substrates include cytokines, chemokines, growth factors and binding proteins, cell/cell adhesion molecules, and other proteinases. With a few exceptions, MMPs share common structural motifs including a pro-peptide domain, a catalytic domain, a hinge region, and a hemopexin-like domain. Synthesized as pro-enzymes, most MMPs are secreted before conversion to their active form. MMP activities are modulated on several levels including transcription, pro-enzyme activation, or by their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs). A subset of MMPs are associated with membranes and designated as membrane-type metalloproteinases (MT-MMP). |
