Galectin-3 Induces a Pro-degradative/inflammatory Gene Signature in Human Chondrocytes, Teaming Up with Galectin-1 in Osteoarthritis Pathogenesis
Sci Rep, 2016;6(0):39112.
Species: Human
Sample Type: Cell Culture Supernates

Central role of SREBP-2 in the pathogenesis of osteoarthritis.
Authors: Kostopoulou F, Gkretsi V, Malizos KN, Iliopoulos D, Oikonomou P, Poultsides L, Tsezou A
PLoS ONE, 2012;7(5):e35753.
Species: Human
Sample Type: Cell Culture Supernates

Anti-arthritic effects of magnolol in human interleukin 1β-stimulated fibroblast-like synoviocytes and in a rat arthritis model.
Authors: Wang JH, Shih KS, Liou JP, Wu YW, Chang AS, Wang KL, Tsai CL, Yang CR
PLoS ONE, 2012;7(2):e31368.
Species: Human
Sample Type: Cell Culture Supernates

Proteolytic release of the receptor for advanced glycation end products from in vitro and in situ alveolar epithelial cells.
Authors: Yamakawa N, Uchida T, Matthay MA, Makita K
Am. J. Physiol. Lung Cell Mol. Physiol., 2011;300(4):L516-25.
Species: Human
Sample Type: pulmonary edema fluid

Primary human acute myelogenous leukemia cells release matrix metalloproteases and their inhibitors: release profile and pharmacological modulation.
Authors: Reikvam H, Hatfield KJ, Oyan AM, Kalland KH, Kittang AO, Bruserud O
Eur. J. Haematol., 2010;84(3):239-51.
Species: Human
Sample Type: Cell Culture Supernates

High molecular weight hyaluronic acid inhibits IL-6-induced MMP production from human chondrocytes by up-regulating the ERK inhibitor, MKP-1.
Authors: Hashizume M, Mihara M
Biochem. Biophys. Res. Commun., 2010;403(2):184-9.
Species: Human
Sample Type: Cell Culture Supernates

Establishment of a matrix-associated transepithelial resistance invasion assay to precisely measure the invasive potential of synovial fibroblasts.
Authors: Wunrau C, Schnaeker EM, Freyth K, Pundt N, Wendholt D, Neugebauer K, Hansen U, Pap T, Dankbar B
Arthritis Rheum., 2009;60(9):2606-11.
Species: Human
Sample Type: Cell Culture Supernates

Interleukin-7 stimulates secretion of S100A4 by activating the JAK/STAT signaling pathway in human articular chondrocytes.
Authors: Yammani RR, Long D, Loeser RF
Arthritis Rheum., 2009;60(3):792-800.
Species: Human
Sample Type: Cell Culture Supernates

Targeting a metalloprotease-PAR1 signaling system with cell-penetrating pepducins inhibits angiogenesis, ascites, and progression of ovarian cancer.
Authors: Agarwal A, Covic L, Sevigny LM, Kaneider NC, Lazarides K, Azabdaftari G, Sharifi S, Kuliopulos A
Mol. Cancer Ther., 2008;7(9):2746-57.
Species: Human
Sample Type: ovarian ascites

Amidic alginate hydrogel for nucleus pulposus replacement.
Authors: Leone G, Torricelli P, Chiumiento A, Facchini A, Barbucci R
J Biomed Mater Res A, 2008;84(2):391-401.
Species: Human
Sample Type: Cell Culture Supernates

Inhibition of interleukin-1beta-induced matrix metalloproteinases 1 and 13 production in human osteoarthritic chondrocytes by prostaglandin D2.
Authors: Zayed N, Afif H, Chabane N, Mfuna-Endam L, Benderdour M, Martel-Pelletier J, Pelletier JP, Motiani RK, Trebak M, Duval N, Fahmi H
Arthritis Rheum., 2008;58(11):3530-40.
Species: Human
Sample Type: Cell Culture Supernates

Prostaglandin E2 exerts catabolic effects in osteoarthritis cartilage: evidence for signaling via the EP4 receptor.
Authors: Attur M, Al-Mussawir HE, Patel J, Kitay A, Dave M, Palmer G, Pillinger MH, Abramson SB
J. Immunol., 2008;181(7):5082-8.
Species: Human
Sample Type: Cell Culture Supernates

ROCK-II mediates colon cancer invasion via regulation of MMP-2 and MMP-13 at the site of invadopodia as revealed by multiphoton imaging.
Authors: Vishnubhotla R, Sun S, Huq J, Bulic M, Ramesh A, Guzman G, Cho M, Glover SC
Lab. Invest., 2007;87(11):1149-58.
Species: Human
Sample Type: Cell Culture Supernates

Advanced glycation end products increases matrix metalloproteinase-1, -3, and -13, and TNF-alpha in human osteoarthritic chondrocytes.
Authors: Nah SS, Choi IY, Yoo B, Kim YG, Moon HB, Lee CK
FEBS Lett., 2007;581(9):1928-32.
Species: Human
Sample Type: Cell Culture Supernates

Calcineurin modulates the catabolic and anabolic activity of chondrocytes and participates in the progression of experimental osteoarthritis.
Authors: Yoo SA, Park BH, Yoon HJ, Lee JY, Song JH, Kim HA, Cho CS, Kim WU
Arthritis Rheum., 2007;56(7):2299-311.
Species: Human
Sample Type: Cell Culture Supernates

Basic fibroblast growth factor stimulates matrix metalloproteinase-13 via the molecular cross-talk between the mitogen-activated protein kinases and protein kinase Cdelta pathways in human adult articular chondrocytes.
Authors: Im HJ, Muddasani P, Natarajan V, Schmid TM, Block JA, Davis F, van Wijnen AJ, Loeser RF
J. Biol. Chem., 2007;282(15):11110-21.
Species: Human
Sample Type: Synovial Fluid

Alendronate-hydroxyapatite nanocomposites and their interaction with osteoclasts and osteoblast-like cells.
Authors: Boanini E, Torricelli P, Gazzano M, Giardino R, Bigi A
Biomaterials, 2007;29(7):790-6.
Species: Human
Sample Type: Cell Culture Supernates

The potential of adiponectin in driving arthritis.
Authors: Ehling A, Schaffler A, Herfarth H, Tarner IH, Anders S, Distler O, Paul G, Distler J, Gay S, Scholmerich J, Neumann E, Muller-Ladner U
J. Immunol., 2006;176(7):4468-78.
Species: Human
Sample Type: Cell Culture Supernates

Oncostatin M induces angiogenesis and cartilage degradation in rheumatoid arthritis synovial tissue and human cartilage cocultures.
Authors: Fearon U, Mullan R, Markham T, Connolly M, Sullivan S, Poole AR, FitzGerald O, Bresnihan B, Veale DJ
Arthritis Rheum., 2006;54(10):3152-62.
Species: Human
Sample Type: Cell Culture Supernates

Increase in production of matrix metalloproteinase 13 by human articular chondrocytes due to stimulation with S100A4: Role of the receptor for advanced glycation end products.
Authors: Yammani RR, Carlson CS, Bresnick AR, Loeser RF
Arthritis Rheum., 2006;54(9):2901-11.
Species: Human
Sample Type: Cell Culture Supernates

Induction of host matrix metalloproteinases by Borrelia burgdorferi differs in human and murine lyme arthritis.
Authors: Behera AK, Hildebrand E, Scagliotti J, Steere AC, Hu LT
Infect. Immun., 2005;73(1):126-34.
Species: Human
Sample Type: Synovial Fluid

The role of human HtrA1 in arthritic disease.
Authors: Grau S, Richards PJ, Kerr B, Hughes C, Caterson B, Williams AS, Junker U, Jones SA, Clausen T, Ehrmann M
J. Biol. Chem., 2005;281(10):6124-9.
Species: Human
Sample Type: Cell Culture Supernates

Differential modulation of human melanoma cell metalloproteinase expression by alpha2beta1 integrin and CD44 triple-helical ligands derived from type IV collagen.
Authors: Baronas-Lowell D, Lauer-Fields JL, Borgia JA, Sferrazza GF, Al-Ghoul M, Minond D, Fields GB
J. Biol. Chem., 2004;279(42):43503-13.
Species: Human
Sample Type: Cell Culture Supernates

Stimulation of matrix metalloproteinases by hyperosmolarity via a JNK pathway in human corneal epithelial cells.
Authors: Li DQ, Chen Z, Song XJ, Luo L, Pflugfelder SC
Invest. Ophthalmol. Vis. Sci., 2004;45(12):4302-11.
Species: Human
Sample Type: Cell Culture Supernates

The matrix metalloproteinases (MMPs) consist of 24 known human zinc proteases with essential roles in breaking down components of the extracellular matrix (ECM). Additional MMP substrates include cytokines, chemokines, growth factors and binding proteins, cell/cell adhesion molecules, and other proteinases. With a few exceptions, MMPs share common structural motifs including a pro-peptide domain, a catalytic domain, a hinge region, and a hemopexin-like domain. Synthesized as pro-enzymes, most MMPs are secreted before conversion to their active form. MMP activities are modulated on several levels including transcription, pro-enzyme activation, or by their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs). A subset of MMPs are associated with membranes and designated as membrane-type metalloproteinases (MT-MMP).

• Cancer Biomarkers
• Collagen Modifying Enzymes
• Extracellular Matrix Remodeling and Cell Migration During EMT
• Metalloproteases and Regulators
• MMPs, TIMPs and Related Molecules