Galectin-3 Induces a Pro-degradative/inflammatory Gene Signature in Human Chondrocytes, Teaming Up with Galectin-1 in Osteoarthritis Pathogenesis
Sci Rep, 2016;6(0):39112.
Species: Human
Sample Type: cell culture supernatants

Metallothionein-3 Increases Triple-Negative Breast Cancer Cell Invasiveness via Induction of Metalloproteinase Expression.
Authors: Kmiecik A, Pula B, Suchanski J, Olbromski M, Gomulkiewicz A, Owczarek T, Kruczak A, Ambicka A, Rys J, Ugorski M, Podhorska-Okolow M, Dziegiel P
PLoS ONE, 2015;10(5):e0124865.
Species: Human
Sample Type: Cell Culture Supernates

Matrix metalloproteinase (MMP)-1 induces lung alveolar epithelial cell migration and proliferation, protects from apoptosis, and represses mitochondrial oxygen consumption.
Authors: Herrera I, Cisneros J, Maldonado M, Ramirez R, Ortiz-Quintero B, Anso E, Chandel N, Selman M, Pardo A
J Biol Chem, 2013;288(36):25964-75.
Species: Human
Sample Type: BAL

Anti-arthritic effects of magnolol in human interleukin 1β-stimulated fibroblast-like synoviocytes and in a rat arthritis model.
Authors: Wang JH, Shih KS, Liou JP, Wu YW, Chang AS, Wang KL, Tsai CL, Yang CR
PLoS ONE, 2012;7(2):e31368.
Species: Human
Sample Type: Cell Culture Supernates

Myoferlin depletion in breast cancer cells promotes mesenchymal to epithelial shape change and stalls invasion.
Authors: Li R, Ackerman WE, Mihai C
PLoS ONE, 2012;7(6):e39766.
Species: Human
Sample Type: Cell Culture Supernates

Interleukin-6 and matrix metalloproteinase expression in the subretinal fluid during proliferative vitreoretinopathy: correlation with extent, duration of RRD and PVR grade.
Authors: Symeonidis C, Papakonstantinou E, Androudi S, Tsaousis KT, Tsinopoulos I, Brazitikos P, Karakiulakis G, Diza E, Dimitrakos SA
Cytokine, 2012;59(1):184-90.
Species: Human
Sample Type: Subretinal fluid

High molecular weight hyaluronic acid inhibits IL-6-induced MMP production from human chondrocytes by up-regulating the ERK inhibitor, MKP-1.
Authors: Hashizume M, Mihara M
Biochem. Biophys. Res. Commun., 2010;403(2):184-9.
Species: Human
Sample Type: Cell Culture Supernates

Primary human acute myelogenous leukemia cells release matrix metalloproteases and their inhibitors: release profile and pharmacological modulation.
Authors: Reikvam H, Hatfield KJ, Oyan AM, Kalland KH, Kittang AO, Bruserud O
Eur. J. Haematol., 2010;84(3):239-51.
Species: Human
Sample Type: Cell Culture Supernates

PI3Kgamma regulates cartilage damage in chronic inflammatory arthritis.
Authors: Hayer S, Pundt N, Peters MA, Wunrau C, Kuhnel I, Neugebauer K, Strietholt S, Zwerina J, Korb A, Penninger J, Joosten LA, Gay S, Ruckle T, Schett G, Pap T
FASEB J., 2009;23(12):4288-98.
Species: Human
Sample Type: Cell Culture Supernates

Serum matrix metalloproteinases in adult CF patients: Relation to pulmonary exacerbation.
Authors: Roderfeld M, Rath T, Schulz R, Seeger W, Tschuschner A, Graf J, Roeb E
J. Cyst. Fibros., 2009;8(5):338-47.
Species: Human
Sample Type: Serum

Establishment of a matrix-associated transepithelial resistance invasion assay to precisely measure the invasive potential of synovial fibroblasts.
Authors: Wunrau C, Schnaeker EM, Freyth K, Pundt N, Wendholt D, Neugebauer K, Hansen U, Pap T, Dankbar B
Arthritis Rheum., 2009;60(9):2606-11.
Species: Human
Sample Type: Cell Culture Supernates

Proteinase-activated receptor (PAR)-2 activation impacts bone resorptive properties of human osteoarthritic subchondral bone osteoblasts.
Authors: Amiable N, Tat SK, Lajeunesse D, Duval N, Pelletier JP, Martel-Pelletier J, Boileau C
Bone, 2009;44(6):1143-50.
Species: Human
Sample Type: Cell Culture Supernates

Serum levels of matrix metalloproteinases -1,-2,-3 and -9 in thoracic aortic diseases and acute myocardial ischemia.
Authors: Karapanagiotidis GT, Antonitsis P, Charokopos N, Foroulis CN, Anastasiadis K, Rouska E, Argiriadou H, Rammos K, Papakonstantinou C
J Cardiothorac Surg, 2009;4(0):59.
Species: Human
Sample Type: Serum

MMP1 and MMP7 as potential peripheral blood biomarkers in idiopathic pulmonary fibrosis.
Authors: Rosas IO, Richards TJ, Konishi K, Zhang Y, Gibson K, Lokshin AE, Lindell KO, Cisneros J, Macdonald SD, Pardo A, Sciurba F, Dauber J, Selman M, Gochuico BR, Kaminski N
PLoS Med., 2008;5(4):e93.
Species: Human
Sample Type: Serum

Prostaglandin E2 exerts catabolic effects in osteoarthritis cartilage: evidence for signaling via the EP4 receptor.
Authors: Attur M, Al-Mussawir HE, Patel J, Kitay A, Dave M, Palmer G, Pillinger MH, Abramson SB
J. Immunol., 2008;181(7):5082-8.
Species: Human
Sample Type: Cell Culture Supernates

Amidic alginate hydrogel for nucleus pulposus replacement.
Authors: Leone G, Torricelli P, Chiumiento A, Facchini A, Barbucci R
J Biomed Mater Res A, 2008;84(2):391-401.
Species: Human
Sample Type: Cell Culture Supernates

Targeting a metalloprotease-PAR1 signaling system with cell-penetrating pepducins inhibits angiogenesis, ascites, and progression of ovarian cancer.
Authors: Agarwal A, Covic L, Sevigny LM, Kaneider NC, Lazarides K, Azabdaftari G, Sharifi S, Kuliopulos A
Mol. Cancer Ther., 2008;7(9):2746-57.
Species: Human
Sample Type: ovarian ascites

Inhibition of interleukin-1beta-induced matrix metalloproteinases 1 and 13 production in human osteoarthritic chondrocytes by prostaglandin D2.
Authors: Zayed N, Afif H, Chabane N, Mfuna-Endam L, Benderdour M, Martel-Pelletier J, Pelletier JP, Motiani RK, Trebak M, Duval N, Fahmi H
Arthritis Rheum., 2008;58(11):3530-40.
Species: Human
Sample Type: Cell Culture Supernates

Borrelia burgdorferi-induced monocyte chemoattractant protein-1 production in vivo and in vitro.
Authors: Zhao Z, McCloud B, Fleming R, Klempner MS
Biochem. Biophys. Res. Commun., 2007;358(2):528-33.
Species: Human
Sample Type: Tissue Homogenates

Advanced glycation end products increases matrix metalloproteinase-1, -3, and -13, and TNF-alpha in human osteoarthritic chondrocytes.
Authors: Nah SS, Choi IY, Yoo B, Kim YG, Moon HB, Lee CK
FEBS Lett., 2007;581(9):1928-32.
Species: Human
Sample Type: Cell Culture Supernates

Gingival fibroblasts inhibit MMP-1 and MMP-3 activities in an ex-vivo artery model.
Authors: Naveau A, Reinald N, Fournier B
Connect. Tissue Res., 2007;48(6):300-8.
Species: Human
Sample Type: Cell Culture Supernates

The potential of adiponectin in driving arthritis.
Authors: Ehling A, Schaffler A, Herfarth H, Tarner IH, Anders S, Distler O, Paul G, Distler J, Gay S, Scholmerich J, Neumann E, Muller-Ladner U
J. Immunol., 2006;176(7):4468-78.
Species: Human
Sample Type: Cell Culture Supernates

Humoral and cellular factors responsible for coronary collateral formation.
Authors: Sherman JA, Hall A, Malenka DJ, De Muinck ED, Simons M
Am. J. Cardiol., 2006;98(9):1194-7.
Species: Human
Sample Type: Plasma

Oncostatin M induces angiogenesis and cartilage degradation in rheumatoid arthritis synovial tissue and human cartilage cocultures.
Authors: Fearon U, Mullan R, Markham T, Connolly M, Sullivan S, Poole AR, FitzGerald O, Bresnihan B, Veale DJ
Arthritis Rheum., 2006;54(10):3152-62.
Species: Human
Sample Type: Cell Culture Supernates

IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis.
Authors: Wolk K, Witte E, Wallace E, Docke WD, Kunz S, Asadullah K, Volk HD, Sterry W, Sabat R
Eur. J. Immunol., 2006;36(5):1309-23.

Cell expression of MMP-1 and TIMP-1 in co-cultures of human gingival fibroblasts and monocytes: the involvement of ICAM-1.
Authors: Domeij H, Modeer T, Quezada HC, Yucel-Lindberg T
Biochem. Biophys. Res. Commun., 2005;338(4):1825-33.
Species: Human
Sample Type: Cell Culture Supernates

Stimulation of matrix metalloproteinases by hyperosmolarity via a JNK pathway in human corneal epithelial cells.
Authors: Li DQ, Chen Z, Song XJ, Luo L, Pflugfelder SC
Invest. Ophthalmol. Vis. Sci., 2004;45(12):4302-11.
Species: Human
Sample Type: Cell Culture Supernates

Matrix metalloproteinases production in malignant pleural effusions after talc pleurodesis.
Authors: D'Agostino P
Clin. Exp. Immunol., 2003;134(1):138-42.
Species: Human
Sample Type: Pleural Effusion

Matrix metalloproteinases and tissue inhibitors of metalloproteinases in sera and tissue of patients with Dupuytrens disease.
Authors: Ulrich D, Hrynyschyn K, Pallua N
Plast. Reconstr. Surg., 2003;112(5):1279-86.
Species: Human
Sample Type: Serum

The matrix metalloproteinases (MMPs) consist of 24 known human zinc proteases with essential roles in breaking down components of the extracellular matrix (ECM). Additional MMP substrates include cytokines, chemokines, growth factors and binding proteins, cell/cell adhesion molecules, and other proteinases. With a few exceptions, MMPs share common structural motifs including a pro-peptide domain, a catalytic domain, a hinge region, and a hemopexin-like domain. Synthesized as pro-enzymes, most MMPs are secreted before conversion to their active form. MMP activities are modulated on several levels including transcription, pro-enzyme activation, or by their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs). A subset of MMPs are associated with membranes and designated as membrane-type metalloproteinases (MT-MMP).

• Cancer Biomarkers
• Collagen Modifying Enzymes
• Enzymes Secreted by Endothelial Cells
• Extracellular Matrix Remodeling and Cell Migration During EMT
• HIF Transcription Factors
• Metalloproteases and Regulators
• MMPs, TIMPs and Related Molecules
• Molecules Secreted by VSMC
• Platelets