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Human CCL4/MIP-1 beta Quantikine SixPak (6 Plates) (1 PK)

货号: SMB00 基本售价: 29971.6 元 规格: 1 PACK

产品信息

概述
货号SMB00
描述The Quantikine Human MIP-1 beta Immunoassay is a 3.0 or 4.5 hour solid phase ELISA designed to measure MIP-1 beta in cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant human MIP-1 beta (Act-2 variant) and antibodies raised against the recombinant factor. This immunoassay has been shown to accurately quantitate the recombinant human MIP-1 beta. Results obtained using natural human MIP-1 beta showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural human MIP-1 beta.
别名ACT2; ACT-2; AT744.1; C-C motif chemokine 4; CCL4; chemokine (C-C motif) ligand 4; Exodus-3; G-26 T-lymphocyte-secreted protein; G-26; HC21; LAG1; LAG-1; Lymphocyte activation gene 1 protein; Macrophage inflammatory protein 1-beta; MIP1 beta; MIP-1 beta; MIP1B; MIP1B1; MIP-1-beta; MIP-1-beta(1-69); PAT 744; Protein H400; SCYA2; SCYA4; secreted protein G-26; SIS-gamma; small inducible cytokine A4 (homologous to mouse Mip-1b); Small-inducible cytokine A4; T-cell activation protein 2;
反应种属Human
目标/特异性Natural and recombinant human MIP-1 beta
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs
6351 (Human); 20303 (Mouse); 116637 (Rat); 448786 (Canine)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Functional Differences between IgM and IgD Signaling in Chronic Lymphocytic Leukemia
J Immunol, 2016;0(0):.
Species: Human
Sample Type: Cell Culture Supernates

Stability of cytokines, chemokines and soluble activation markers in unprocessed blood stored under different conditions
Cytokine, 2016;84(0):17-24.
Species: Human
Sample Type: Serum

The phosphoinositide-3-kinase (PI3K)-delta and gamma inhibitor, IPI-145 (Duvelisib), overcomes signals from the PI3K/AKT/S6 pathway and promotes apoptosis in CLL.
Authors: Balakrishnan K, Peluso M, Fu M, Rosin N, Burger J, Wierda W, Keating M, Faia K, OBrien S, Kutok J, Gandhi V
Leukemia, 2015;29(9):1811-22.
Species: Human
Sample Type: Cell Culture Supernates

Serum levels of chemokines CCL4 and CCL5 in cirrhotic patients indicate the presence of hepatocellular carcinoma.
Authors: Sadeghi M, Lahdou I, Oweira H, Daniel V, Terness P, Schmidt J, Weiss K, Longerich T, Schemmer P, Opelz G, Mehrabi A
Br J Cancer, 2015;113(5):756-62.
Species: Human
Sample Type: Serum

Pleurocidin, a novel antimicrobial peptide, induces human mast cell activation through the FPRL1 receptor.
Authors: Pundir P, Catalli A, Leggiadro C, Douglas S, Kulka M
Mucosal Immunol, 2014;7(1):177-87.
Species: Human
Sample Type: Cell Culture Supernates

The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo.
Authors: Ponader S, Chen SS, Buggy JJ
Blood, 2012;119(5):1182-9.
Species: Human
Sample Type: Plasma

Respiratory syncytial virus glycoprotein G interacts with DC-SIGN and L-SIGN to activate ERK1 and ERK2.
Authors: Johnson TR, McLellan JS, Graham BS
J. Virol., 2012;86(3):1339-47.
Species: Human
Sample Type: Cell Culture Supernates

Regulation of inflammatory chemokine receptors on blood T cells associated to the circulating versus liver chemokines in dengue Fever.
Authors: de-Oliveira-Pinto LM, Marinho CF, Povoa TF, de Azeredo EL, de Souza LA, Barbosa LD, Motta-Castro AR, Alves AM, Avila CA, de Souza LJ, da Cunha RV, Damasco PV, Paes MV, Kubelka CF
PLoS ONE, 2012;7(7):e38527.
Species: Human
Sample Type: Plasma

CCL3 (MIP-1alpha) plasma levels and the risk for disease progression in chronic lymphocytic leukemia.
Authors: Sivina M, Hartmann E, Kipps TJ, Rassenti L, Krupnik D, Lerner S, LaPushin R, Xiao L, Huang X, Werner L, Neuberg D, Kantarjian H, OBrien S, Wierda WG, Keating MJ, Rosenwald A, Burger JA
Blood, 2011;117(5):1662-9.
Species: Human
Sample Type: Plasma

Lenalidomide as initial therapy of elderly patients with chronic lymphocytic leukemia.
Authors: Badoux XC, Keating MJ, Wen S
Blood, 2011;118(13):3489-98.
Species: Human
Sample Type: Plasma

Macrophage inflammatory protein-1beta induced cell adhesion with increased intracellular reactive oxygen species.
Authors: Tatara Y, Ohishi M, Yamamoto K, Shiota A, Hayashi N, Iwamoto Y, Takeda M, Takagi T, Katsuya T, Ogihara T, Rakugi H
J. Mol. Cell. Cardiol., 2009;47(1):104-11.
Species: Human
Sample Type: Plasma

Duffy antigen modifies the chemokine response in human endotoxemia.
Authors: Mayr FB, Spiel AO, Leitner JM, Firbas C, Kliegel T, Jilma-Stohlawetz P, Derendorf H, Jilma B
Crit. Care Med., 2008;36(1):159-65.
Species: Human
Sample Type: Plasma

Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseases.
Authors: Hartl D, Krauss-Etschmann S, Koller B, Hordijk PL, Kuijpers TW, Hoffmann F, Hector A, Eber E, Marcos V, Bittmann I, Eickelberg O, Griese M, Roos D
J. Immunol., 2008;181(11):8053-67.
Species: Human
Sample Type: BALF

NF-kappaB modulates sensitivity to apoptosis, proinflammatory and migratory potential in short- versus long-term cultured human gammadelta lymphocytes.
Authors: Ferrarini M, Delfanti F, Gianolini M, Rizzi C, Alfano M, Lazzarin A, Biswas P
J. Immunol., 2008;181(9):5857-64.
Species: Human
Sample Type: Cell Culture Supernates

Expression of CCR5 receptors on Reed-Sternberg cells and Hodgkin lymphoma cell lines: involvement of CCL5/Rantes in tumor cell growth and microenvironmental interactions.
Authors: Aldinucci D, Lorenzon D, Cattaruzza L, Pinto A, Gloghini A, Carbone A, Colombatti A
Int. J. Cancer, 2008;122(4):769-76.
Species: Human
Sample Type: Cell Culture Supernates

In vitro induction of a dendritic cell phenotype in primary human acute myelogenous leukemia (AML) blasts alters the chemokine release profile and increases the levels of T cell chemotactic CCL17 and CCL22.
Authors: Olsnes AM, Ryningen A, Ersvaer E, Bruserud Ø
J. Interferon Cytokine Res., 2008;28(5):297-310.
Species: Human
Sample Type: Cell Culture Supernates

Endothelial damage from cytomegalovirus-specific host immune response can be prevented by targeted disruption of fractalkine-CX3CR1 interaction.
Authors: Bolovan-Fritts CA, Spector SA
Blood, 2007;111(1):175-82.
Species: Human
Sample Type: Cell Culture Supernates

High T-cell response to human cytomegalovirus induces chemokine-mediated endothelial cell damage.
Authors: Bolovan-Fritts CA, Trout RN, Spector SA
Blood, 2007;110(6):1857-63.
Species: Human
Sample Type: Cell Culture Supernates

Human Vgamma2Vdelta2 T cells contain cytoplasmic RANTES.
Authors: Tikhonov I, Deetz CO, Paca R, Berg S, Lukyanenko V, Lim JK, Pauza CD
Int. Immunol., 2006;18(8):1243-51.
Species: Human
Sample Type: Cell Culture Supernates

A network-based analysis of the late-phase reaction of the skin.
Authors: Benson M, Langston MA, Adner M, Andersson B, Torinssson-Naluai A, Cardell LO
J. Allergy Clin. Immunol., 2006;118(1):220-5.
Species: Human
Sample Type: Cell Culture Supernates

Respiratory syncytial virus and other respiratory viruses during the first 3 months of life promote a local TH2-like response.
Authors: Kristjansson S, Bjarnarson SP, Wennergren G, Palsdottir AH, Arnadottir T, Haraldsson A, Jonsdottir I
J. Allergy Clin. Immunol., 2005;116(4):805-11.
Species: Human
Sample Type: Nasopharyngeal Secretions

CCR5 expression and CC chemokine levels in idiopathic pulmonary fibrosis.
Authors: Capelli A, Di Stefano A, Gnemmi I, Donner CF
Eur. Respir. J., 2005;25(4):701-7.
Species: Human
Sample Type: BALF

Inhibition of human immunodeficiency virus type 1 replication by Z-100, an immunomodulator extracted from human-type tubercle bacilli, in macrophages.
Authors: Emori Y, Ikeda T, Ohashi T, Masuda T, Kurimoto T, Takei M, Kannagi M
J. Gen. Virol., 2004;85(0):2603-13.
Species: Human
Sample Type: Cell Culture Supernates

Concentrations of macrophage inflammatory proteins MIP-1alpha and MIP-1beta and interleukin 8 (il-8) in lyme borreliosis.
Authors: Grygorczuk S, Pancewicz S, Zajkowska J, Kondrusik M, Rwierzbinska R, Hermanowska-Szpakowicz T
Infection, 2004;32(6):350-5.
Species: Human
Sample Type: CSF

Virally stimulated plasmacytoid dendritic cells produce chemokines and induce migration of T and NK cells.
Authors: Megjugorac NJ, Young HA, Amrute SB, Olshalsky SL, Fitzgerald-Bocarsly P
J. Leukoc. Biol., 2004;75(3):504-14.
Species: Human
Sample Type: Cell Culture Supernates

Analysis of chemokines and chemokine receptor expression in ovarian cancer ascites.
Authors: Milliken D, Scotton C, Raju S, Balkwill F, Wilson J
Clin. Cancer Res., 2002;8(4):1108-14.
Species: Human
Sample Type: Plasma

Endogenously expressed nef uncouples cytokine and chemokine production from membrane phenotypic maturation in dendritic cells.
Authors: Messmer D, Jacque JM, Santisteban C, Bristow C, Han SY, Villamide-Herrera L, Mehlhop E, Marx PA, Steinman RM, Gettie A, Pope M
J. Immunol., 2002;169(8):4172-82.
Species: Human
Sample Type: Cell Culture Supernates

Impact of NNRTI compared to PI-based highly active antiretroviral therapy on CCR5 receptor expression, beta-chemokines and IL-16 secretion in HIV-1 infection.
Authors: Burton CT, Hardy GA, Sullivan AK, Nelson MR, Gazzard B, Gotch FM, Imami N
Clin. Exp. Immunol., 2002;130(2):286-92.
Species: Human
Sample Type: Plasma

TNFalpha-induced macrophage chemokine secretion is more dependent on NF-kappaB expression than lipopolysaccharides-induced macrophage chemokine secretion.
Authors: Ciesielski CJ, Andreakos E, Foxwell BM, Feldmann M
Eur. J. Immunol., 2002;32(7):2037-45.
Species: Human
Sample Type: Cell Culture Supernates

Simian immunodeficiency viruses with defective nef genes show increased susceptibility to the noncytotoxic antiviral activity of CD8+ lymphocytes.
Authors: Binninger-Schinzel D, Norley S, Adler HS, Oberg HH, Kurth R
Virology, 2002;294(1):209-21.
Species: Human
Sample Type: Cell Culture Supernates

CCR5-binding chemokines modulate CXCL12 (SDF-1)-induced responses of progenitor B cells in human bone marrow through heterologous desensitization of the CXCR4 chemokine receptor.
Authors: Honczarenko M, Le Y, Glodek AM, Silberstein LE
Blood, 2002;100(7):2321-9.
Species: Human
Sample Type: Cell Culture Supernates

Skewing of cytotoxic activity and chemokine production, but not of chemokine receptor expression, in human type-1/-2 gamma delta T lymphocytes.
Authors: D'Ambrosio D
Eur. J. Immunol., 2002;32(10):2934-43.
Species: Human
Sample Type: Cell Culture Supernates

Amyloid beta and amylin fibrils induce increases in proinflammatory cytokine and chemokine production by THP-1 cells and murine microglia.
Authors: Yates SL, Burgess LH, Kocsis-Angle J, Antal JM, Dority MD, Embury PB, Piotrkowski AM, Brunden KR
J. Neurochem., 2000;74(3):1017-25.
Species: Human
Sample Type: Cell Culture Supernates

Up-regulation of beta-chemokines and down-modulation of CCR5 co-receptors inhibit simian immunodeficiency virus transmission in non-human primates.
Authors: Lehner T, Wang Y, Cranage M, Tao L, Mitchell E, Bravery C, Doyle C, Pratt K, Hall G, Dennis M, Villinger L, Bergmeier L
Immunology, 2000;99(4):569-77.
Species: Primate - Macaca mulatta (Rhesus monkey)
Sample Type: Cell Culture Supernates

Immunization with live attenuated simian immunodeficiency virus induces strong type 1 T helper responses and beta-chemokine production.
Authors: Gauduin MC, Glickman RL, Ahmad S, Yilma T, Johnson RP
Proc. Natl. Acad. Sci. U.S.A., 1999;96(24):14031-6.
Species: Primate
Sample Type: Cell Culture Supernates

Interleukin-12 induces sustained activation of multiple host inflammatory mediator systems in chimpanzees.
Authors: Lauw FN, Dekkers PE, te Velde AA, Speelman P, Levi M, Kurimoto M, Hack CE, Van Deventer SJ, van der Poll T
J. Infect. Dis., 1999;179(3):646-52.
Species: Primate - Pan troglodytes (Chimpanzee)
Sample Type: Plasma

Protective mucosal immunity elicited by targeted iliac lymph node immunization with a subunit SIV envelope and core vaccine in macaques.
Authors: Lehner T, Wang Y, Cranage M, Bergmeier LA, Mitchell E, Tao L, Hall G, Dennis M, Cook N, Brookes R, Klavinskis L, Jones I, Doyle C, Ward R
Nat. Med., 1996;2(7):767-75.
Species: Primate - Macaca mulatta (Rhesus monkey)
Sample Type: Cell Culture Supernates

生物活性< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景CCL4/MIP-1 beta is a beta chemokine that is secreted at sites of inflammation by activated leukocytes, lymphocytes, vascular endothelial cells, and pulmonary smooth muscle cells. It attracts a variety of immune cells to sites of microbial infection as well as to other pathologic inflammation such as allergic asthma and ischemic myocardium. CCL4 is secreted from activated monocytes as a heterodimer with CCL3/MIP-1 alpha. It signals through CCR5, and an N-terminally trimmed form additionally interacts with CCR1 and CCR2. In humans, the ability of CCL4 to bind CCR5 inhibits the cellular entry of M-tropic HIV-1 which utilizes CCR5 as a coreceptor.
运输条件Blue Ice
存放说明4℃
参考文献
  • CC Chemokines and Receptors
  • Chemokines and Receptors
  • Chemokines and Receptors in Allergy and Asthma
  • Chemokines and Receptors in Angiogenesis
  • Infectious Diseases
  • Inflammatory Mediators
  • Macrophage Activation Markers
  • Molecules Secreted by VSMC
  • Neuroinflammation
  • Regulatory T Cells (Tregs)