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Human Lipocalin-2/NGAL Quantikine SixPak (6 Plates) (1 PK)

货号: SLCN20 基本售价: 29971.6 元 规格: 1 PACK

产品信息

概述
货号SLCN20
描述The Quantikine Human Lipocalin-2 Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human Lipocalin-2 in cell culture supernates, serum, plasma, urine, and saliva. It contains NS0-expressed recombinant human Lipocalin-2 and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human Lipocalin-2 showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring human Lipocalin-2.
别名24p3; 25 kDa alpha-2-microglobulin-related subunit of MMP-9; HNL; LCN2; lipocalin 2 (oncogene 24p3); lipocalin 2; Lipocalin2; Lipocalin-2; migration-stimulating factor inhibitor; MSFI; neutrophil gelatinase-associated lipocalin; NGAL; NGALlipocalin-2; Oncogene 24p3; p25; Siderocalin;
全称
Neutrophil Gelatinase-associated Lipocalin
反应种属Human
目标/特异性Natural and recombinant human Lipocalin-2
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs
3934 (Human); 16819 (Mouse); 170496 (Rat)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Ascorbic acid ameliorates renal injury in a murine model of contrast-induced nephropathy
Authors: K Rollins, A Noorani, L Janeckova, T Jones, M Griffiths, MP Baker, JR Boyle
BMC Nephrol, 2017;18(1):101.
Species: Human
Sample Type: Tissue Homogenates

Acute Stress Responses Are Early Molecular Events of Retinal Degeneration in Abca4-/-Rdh8-/- Mice After Light Exposure
Authors: Tanu Parmar
Invest Ophthalmol Vis Sci, 2016;57(7):3257-67.
Species: Human
Sample Type: Whole Cells

Urinary Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Patients with Obstructive Sleep Apnea
PLoS ONE, 2016;11(5):e0154503.
Species: Human
Sample Type: Urine

Combined Biomarker Analysis for Risk of Acute Kidney Injury in Patients with ST-Segment Elevation Myocardial Infarction.
Authors: Tung Y, Chang C, Chen Y, Chu P
PLoS ONE, 2015;10(4):e0125282.
Species: Human
Sample Type: Serum

Lipocalin 2: a new mechanoresponding gene regulating bone homeostasis.
Authors: Rucci N, Capulli M, Piperni S, Cappariello A, Lau P, Frings-Meuthen P, Heer M, Teti A
J Bone Miner Res, 2015;30(2):357-68.
Species: Human
Sample Type: Serum

Growth differentiation factor-15 (GDF-15) levels are associated with cardiac and renal injury in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass.
Authors: Kahli A, Guenancia C, Zeller M, Grosjean S, Stamboul K, Rochette L, Girard C, Vergely C
PLoS ONE, 2014;9(8):e105759.
Species: Human
Sample Type: Plasma

Autophagy activation reduces renal tubular injury induced by urinary proteins.
Authors: Liu, Wei Jing, Luo, Mian-Na, Tan, Jin, Chen, Wei, Huang, Lei-zhao, Yang, Chen, Pan, Qingjun, Li, Benyi, Liu, Hua-feng
Autophagy, 2014;10(2):243-56.
Species: Human
Sample Type: Cell Culture Supernates

A case-control study of pre-operative levels of serum neutrophil gelatinase-associated lipocalin and other potential inflammatory markers in colorectal cancer.
Authors: Duvillard L, Ortega-Deballon P, Bourredjem A, Scherrer M, Mantion G, Delhorme J, Deguelte-Lardiere S, Petit J, Bonithon-Kopp C
BMC Cancer, 2014;14(0):912.
Species: Human
Sample Type: Serum

Urinary L-FABP and its combination with urinary NGAL in early diagnosis of acute kidney injury after cardiac surgery in adult patients.
Biomarkers, 2013;18(1):95-101.
Species: Human
Sample Type: Urine

Lipocalin 2, the TNF-like receptor TWEAKR and its ligand TWEAK act downstream of NFAT1 to regulate breast cancer cell invasion.
Authors: Gaudineau B, Fougere M, Guaddachi F, Lemoine F, de la Grange P, Jauliac S
J Cell Sci, 2012;125(0):4475-86.
Species: Human
Sample Type: Cell Culture Supernates

Urinary neutrophil gelatinase-associated lipocalin is a potential biomarker for renal damage in patients with systemic lupus erythematosus.
Authors: Yang CC, Hsieh SC, Li KJ, Wu CH, Lu MC, Tsai CY, Yu CL
J. Biomed. Biotechnol., 2012;2012(0):759313.
Species: Human
Sample Type: Urine

Prevalence of Chronic Kidney Disease and Progression of Disease Over Time among Patients Enrolled in the Houston West Nile Virus Cohort.
Authors: Nolan MS, Podoll AS, Hause AM
PLoS ONE, 2012;7(7):e40374.
Species: Human
Sample Type: Urine

The association between the preoperative serum levels of lipocalin-2 and matrix metalloproteinase-9 (MMP-9) and prognosis of breast cancer.
BMC Cancer, 2012;12(0):193.
Species: Human
Sample Type: Serum

Urinary neutrophil gelatinase-associated lipocalin and L-type fatty acid binding protein as diagnostic markers of early acute kidney injury after liver transplantation.
Authors: Li Y, Zhu M, Xia Q
Biomarkers, 2012;17(4):336-42.
Species: Human
Sample Type: Urine

Acute kidney injury biomarkers for patients in a coronary care unit: a prospective cohort study.
Authors: Chen TH, Chang CH, Lin CY, Jenq CC, Chang MY, Tian YC, Hung CC, Fang JT, Yang CW, Wen MS, Lin FC, Chen YC
PLoS ONE, 2012;7(2):e32328.
Species: Human
Sample Type: Serum

Indomethacin reduces glomerular and tubular damage markers but not renal inflammation in chronic kidney disease patients: a post-hoc analysis.
Authors: de Borst MH, Nauta FL, Vogt L, Laverman GD, Gansevoort RT, Navis G
PLoS ONE, 2012;7(5):e37957.
Species: Human
Sample Type: Urine

Elevated Levels of Neutrophil Gelatinase-Associated Lipocalin in Bile From Patients With Malignant Pancreatobiliary Disease.
Authors: Zabron AA, Horneffer-van der Sluis VM, Wadsworth CA, Laird F, Gierula M, Thillainayagam AV, Vlavianos P, Westaby D, Taylor-Robinson SD, Edwards RJ, Khan SA
Am. J. Gastroenterol., 2011;106(0):1711-7.
Species: Human
Sample Type: Bile

Isotretinoin increases skin-surface levels of neutrophil gelatinase-associated lipocalin in patients treated for severe acne.
Authors: Lumsden KR, Nelson AM, Dispenza MC, Gilliland KL, Cong Z, Zaenglein AL, Thiboutot DM
Br. J. Dermatol., 2011;165(2):302-10.
Species: Human
Sample Type: tape-strip extract

Upregulation of lipocalin 2 in adipose tissues of severely obese women: positive relationship with proinflammatory cytokines.
Authors: Auguet T, Quintero Y, Terra X, Martinez S, Lucas A, Pellitero S, Aguilar C, Hernandez M, Del Castillo D, Richart C
Obesity (Silver Spring), 2011;19(12):2295-300.
Species: Human
Sample Type: Serum

Urinary excretion of twenty peptides forms an early and accurate diagnostic pattern of acute kidney injury.
Authors: Metzger J, Kirsch T, Schiffer E, Ulger P, Mentes E, Brand K, Weissinger EM, Haubitz M, Mischak H, Herget-Rosenthal S
Kidney Int., 2010;78(12):1252-62.
Species: Human
Sample Type: Urine

Ex vivo and in vivo regulation of lipocalin-2, a novel adipokine, by insulin.
Authors: Tan BK, Adya R, Shan X, Syed F, Lewandowski KC, OHare JP, Randeva HS
Diabetes Care, 2009;32(1):129-31.
Species: Human
Sample Type: Cell Culture Supernates

Lipocalin 2 promotes breast cancer progression.
Authors: Yang J, Bielenberg DR, Rodig SJ, Doiron R, Clifton MC, Kung AL, Strong RK, Zurakowski D, Moses MA
Proc. Natl. Acad. Sci. U.S.A., 2009;106(10):3913-8.
Species: Human
Sample Type: Urine

Lipocalin 2 regulation by thermal stresses: protective role of Lcn2/NGAL against cold and heat stresses.
Authors: Roudkenar MH, Halabian R, Roushandeh AM, Nourani MR, Masroori N, Ebrahimi M, Nikogoftar M, Rouhbakhsh M, Bahmani P, Najafabadi AJ, Shokrgozar MA
Exp. Cell Res., 2009;315(18):3140-51.
Species: Human
Sample Type: Cell Culture Supernates

Circulating levels of matrix metalloproteinase-9 (MMP-9), neutrophil gelatinase-associated lipocalin (NGAL) and their complex MMP-9/NGAL in breast cancer disease.
Authors: Provatopoulou X, Gounaris A, Kalogera E
BMC Cancer, 2009;9(0):390.
Species: Human
Sample Type: Serum

Retinol-binding protein 4 and lipocalin-2 in childhood and adolescent obesity: when children are not just "small adults".
Authors: Kanaka-Gantenbein C, Margeli A, Pervanidou P, Sakka S, Mastorakos G, Chrousos GP, Papassotiriou I
Clin. Chem., 2008;54(7):1176-82.
Species: Human
Sample Type: Serum

Serum concentrations of atherogenic proteins neutrophil gelatinase-associated lipocalin and its complex with matrix metalloproteinase-9 are significantly lower in women with polycystic ovary syndrome: hint of a protective mechanism?
Authors: Diamanti-Kandarakis E, Livadas S, Kandarakis SA, Margeli A, Papassotiriou I
Eur. J. Endocrinol., 2008;158(4):525-31.
Species: Human
Sample Type: Serum

生物活性< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景The Lipocalin family comprises a diverse group of mostly secreted soluble proteins that bind hydrophobic ligands and act as transporters, carrying small molecules to specific cells. Lipocalins are related by possessing an 8-stranded beta-barrel structure. Lipocalin-1, also named tear lipocalin (TL), von Ebners gland protein (VEG) and tear pre-albumin, binds a large number of hydrophobic molecules and exhibits cysteine proteinase inhibitor and endonuclear activities. Lipocalin-2, also known as neutrophil gelatinase-associated lipocalin (NGAL), is a component of granules in neutrophils from tissues that are normally exposed to microorganisms and is upregulated during inflammation. Lipocalin-2 can form homodimers and can heterodimerize with the neutrophil gelatinase MMP-9.
运输条件Blue Ice
存放说明4℃
参考文献
  • Cancer Biomarkers
  • Metalloproteases and Regulators
  • MMPs, TIMPs and Related Molecules
  • Renal Markers