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Human IL-1 beta/IL-1F2 Quantikine SixPak (6 Plates) (1 PK)

货号: SLB50 基本售价: 29971.6 元 规格: 1 PACK

产品信息

概述
货号SLB50
描述The Quantikine Human IL-1 beta Immunoassay is a 3.5 or 4.5 hour solid phase ELISA designed to measure IL-1 beta in cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant human IL-1 beta and antibodies raised against the recombinant factor. It has been shown to quantitate recombinant human IL-1 beta accurately. Results obtained using natural IL-1 beta showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural IL-1 beta. Reports indicate that this and other ELISA kits calibrated using mature IL-1 beta as a standard will detect, but considerably underestimate, the unprocessed IL-1 beta precursor present in samples. In biological samples other than cell lysates, the precursor form of IL-1 beta is usually not the predominant form of IL-1 beta present and, additionally, is not biologically active. Therefore, results obtained using this kit should provide a useful measure of the levels of active IL-1 beta present in biological fluids.
别名catabolin; IL1 beta; IL-1 beta; IL-1; IL1B; IL-1B; IL1-BETA; IL-1F2; IL1F2IL-1 beta; interleukin 1, beta; interleukin-1 beta; preinterleukin 1 beta; pro-interleukin-1-beta;
全称
Interleukin 1 beta
反应种属Human
目标/特异性Natural and recombinant human IL-1 beta
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs
3553 (Human); 16176 (Mouse); 24494 (Rat); 397122 (Porcine); 403974 (Canine); 100034237 (Equine); 100135556 (Guinea Pig)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Impaired Surface Expression of HLA-DR, TLR2, TLR4, and TLR9 in Ex Vivo-In Vitro Stimulated Monocytes from Severely Injured Trauma Patients
Authors: D Heftrig, R Sturm, E Oppermann, K Kontradowi, K Jurida, L Schimunek, M Woschek, I Marzi, B Relja
Mediators Inflamm, 2017;2017(0):2608349.
Species: Human
Sample Type: Other

High serum resistin associates with intrahepatic inflammation and necrosis: an index of disease severity for patients with chronic HBV infection
Authors: Z Meng, Y Zhang, Z Wei, P Liu, J Kang, Y Zhang, D Ma, C Ke, Y Chen, J Luo, Z Gong
BMC Gastroenterol, 2017;17(1):6.
Species: Human
Sample Type: Serum

A point mutation in AgrC determines cytotoxic or colonizing properties associated with phenotypic variants of ST22 MRSA strains
Authors: S Mairpady S, N Siemens, IR Monk, DB Mohan, S Mukundan, KC Krishnan, S Prabhakara, J Snäll, A Kearns, F Vandenesch, M Svensson, M Kotb, B Gopal, G Arakere, A Norrby-Teg
Sci Rep, 2016;6(0):31360.
Species: Human
Sample Type: Tissue Culture Supernates

Association between mannose-binding lectin variants, haplotypes and risk of hepatocellular carcinoma: A case-control study
Sci Rep, 2016;6(0):32147.
Species: Human
Sample Type: Plasma

Identification of Gingival Crevicular Fluid Sampling, Analytical Methods, and Oral Biomarkers for the Diagnosis and Monitoring of Periodontal Diseases: A Systematic Review
Authors: Z Nazar Maje, K Philip, AM Alabsi, S Pushparaja, D Swaminatha
Dis. Markers, 2016;2016(0):1804727.
Species: Human
Sample Type: Saliva

Cell surface-anchored syndecan-1 ameliorates intestinal inflammation and neutrophil transmigration in ulcerative colitis
J Cell Mol Med, 2016;0(0):.
Species: Human
Sample Type: Serum

Activation and IL-1? secretion of human peripheral phagocytes infected with Actinomadura madurae, Nocardia asteroides and Candida albicans
Asian Pac J Trop Med, 2016;9(10):962-967.
Species: Human
Sample Type: Cell Culture Supernates

Circulating Fibrocytes Are Increased in Neonates with Bronchopulmonary Dysplasia
Authors: Chun Li
PLoS ONE, 2016;11(6):e0157181.
Species: Human
Sample Type: Plasma

NLRP3 Inflammasome Activation in THP-1 Target Cells Triggered by Pathogenic Naegleria fowleri
Authors: JH Kim, HJ Sohn, JK Yoo, H Kang, GS Seong, YJ Chwae, K Kim, S Park, HJ Shin
Infect. Immun, 2016;84(9):2422-8.
Species: Human
Sample Type: Cell Culture Supernates

Innovative Flow Cytometry Allows Accurate Identification of Rare Circulating Cells Involved in Endothelial Dysfunction
PLoS ONE, 2016;11(8):e0160153.
Species: Human
Sample Type: Plasma

Novel high throughput pooled shRNA screening identifies NQO1 as a potential drug target for host directed therapy for tuberculosis
Authors: Qing Li
Sci Rep, 2016;6(0):27566.
Species: Human
Sample Type: Cell Culture Supernates

Nuclear DNA damage-triggered NLRP3 inflammasome activation promotes UVB-induced inflammatory responses in human keratinocytes
Authors: Tatsuya Hasegawa
Biochem Biophys Res Commun, 2016;0(0):.
Species: Human
Sample Type: Cell Culture Supernates

Simple Plex() : A Novel Multi-Analyte, Automated Microfluidic Immunoassay Platform for the Detection of Human and Mouse Cytokines and Chemokines.
Authors: Aldo P, Marusov G, Svancara D, David J, Mor G
Am J Reprod Immunol, 2016;75(6):678-93.
Species: Human
Sample Type: Plasma

Cross-talk between intestinal epithelial cells and immune cells in inflammatory bowel disease
Sci Rep, 2016;6(0):29783.
Species: Human
Sample Type: Cell Culture Supernates

Identification of tumour-reactive lymphatic endothelial cells capable of inducing progression of gastric cancer.
Authors: Tokumoto M, Tanaka H, Tauchi Y, Kasashima H, Kurata K, Yashiro M, Sakurai K, Toyokawa T, Kubo N, Amano R, Kimura K, Muguruma K, Maeda K, Ohira M, Hirakawa K
Br J Cancer, 2015;113(7):1046-54.
Species: Human
Sample Type: Cell Culture Supernates

MyD88-Dependent Signaling Decreases the Antitumor Efficacy of Epidermal Growth Factor Receptor Inhibition in Head and Neck Cancer Cells.
Authors: Koch A, Love-Homan L, Espinosa-Cotton M, Stanam A, Simons A
Cancer Res, 2015;75(8):1657-67.
Species: Human
Sample Type: Cell Culture Supernates

A novel carboline derivative inhibits nitric oxide formation in macrophages independent of effects on tumor necrosis factor alpha and interleukin-1beta expression.
Authors: Grodzki A, Poola B, Pasupuleti N, Nantz M, Lein P, Gorin F
J Pharmacol Exp Ther, 2015;352(3):438-47.
Species: Human
Sample Type: Cell Culture Supernates

An Allergic Lung Microenvironment Suppresses Carbon Nanotube-Induced Inflammasome Activation via STAT6-Dependent Inhibition of Caspase-1.
Authors: Shipkowski K, Taylor A, Thompson E, Glista-Baker E, Sayers B, Messenger Z, Bauer R, Jaspers I, Bonner J
PLoS ONE, 2015;10(6):e0128888.
Species: Human
Sample Type: Cell Culture Supernates

Prostaglandin E2 Inhibits NLRP3 Inflammasome Activation through EP4 Receptor and Intracellular Cyclic AMP in Human Macrophages.
Authors: Sokolowska M, Chen L, Liu Y, Martinez-Anton A, Qi H, Logun C, Alsaaty S, Park Y, Kastner D, Chae J, Shelhamer J
J Immunol, 2015;194(11):5472-87.
Species: Human
Sample Type: Cell Culture Supernates

Cross talk between neuroregulatory molecule and monocyte: nerve growth factor activates the inflammasome.
Authors: Datta-Mitra A, Kundu-Raychaudhuri S, Mitra A, Raychaudhuri S
PLoS ONE, 2015;10(4):e0121626.
Species: Human
Sample Type: Cell Culture Supernates

Neutrophil elastase promotes interleukin-1beta secretion from human coronary endothelium.
Authors: Alfaidi M, Wilson H, Daigneault M, Burnett A, Ridger V, Chamberlain J, Francis S
J Biol Chem, 2015;290(40):24067-78.
Species: Human
Sample Type: Cell Culture Supernates

Phosphocholine-Modified Macromolecules and Canonical Nicotinic Agonists Inhibit ATP-Induced IL-1beta Release.
Authors: Hecker A, Kullmar M, Wilker S, Richter K, Zakrzewicz A, Atanasova S, Mathes V, Timm T, Lerner S, Klein J, Kaufmann A, Bauer S, Padberg W, Kummer W, Janciauskiene S, Fronius M, Schweda E, Lochnit G, Grau V
J Immunol, 2015;195(5):2325-34.
Species: Human
Sample Type: Cell Culture Supernates

Aggregatibacter actinomycetemcomitans cytolethal distending toxin activates the NLRP3 inflammasome in human macrophages, leading to the release of proinflammatory cytokines.
Authors: Shenker B, Ojcius D, Walker L, Zekavat A, Scuron M, Boesze-Battaglia K
Infect Immun, 2015;83(4):1487-96.
Species: Human
Sample Type: Cell Culture Supernates

Preventive effect of Daiokanzoto (TJ-84) on 5-fluorouracil-induced human gingival cell death through the inhibition of reactive oxygen species production.
Authors: Yoshida K, Yoshioka M, Okamura H, Moriyama S, Kawazoe K, Grenier D, Hinode D
PLoS ONE, 2014;9(11):e112689.
Species: Human
Sample Type: Cell Culture Supernates

Early mucosal sensing of SIV infection by paneth cells induces IL-1beta production and initiates gut epithelial disruption.
Authors: Hirao L, Grishina I, Bourry O, Hu W, Somrit M, Sankaran-Walters S, Gaulke C, Fenton A, Li J, Crawford R, Chuang F, Tarara R, Marco M, Baumler A, Cheng H, Dandekar S
PLoS Pathog, 2014;10(8):e1004311.
Species: Primate - Macaca mulatta (Rhesus monkey)
Sample Type: Homogenized Tissue

Early efficacy trial of anakinra in corticosteroid-resistant autoimmune inner ear disease.
Authors: Vambutas A, Lesser M, Mullooly V, Pathak S, Zahtz G, Rosen L, Goldofsky E
J Clin Invest, 2014;124(9):4115-22.
Species: Human
Sample Type: Plasma

The impact of concomitant pulmonary infection on immune dysregulation in Pneumocystis jirovecii pneumonia.
Authors: Chou C, Lin F, Tsai H, Chang S
BMC Pulm Med, 2014;14(0):182.
Species: Human
Sample Type: BALF

Improving membrane based multiplex immunoassays for semi-quantitative detection of multiple cytokines in a single sample.
Authors: Altara, Raffaele, Manca, Marco, Hessel, Marleen, Janssen, Ben J, Struijker-Boudier, Harry H, Hermans, Rob J J, Blankesteijn, W Matthi
BMC Biotechnol, 2014;14(0):63.
Species: Human
Sample Type: Serum

Looking beyond endotoxin: a comparative study of pyrogen retention by ultrafilters used for the preparation of sterile dialyis fluid.
Authors: Glorieux, Griet, Hulko, Michael, Speidel, Rose, Brodbeck, Katrin, Krause, Bernd, Vanholder, Raymond
Sci Rep, 2014;4(0):6390.
Species: Human
Sample Type: Cell Culture Supernates

Immune-inflammatory markers and arterial stiffness indexes in subjects with acute ischemic stroke with and without metabolic syndrome.
Authors: Tuttolomondo A, Pecoraro R, Di Raimondo D, Di Sciacca R, Canino B, Arnao V, Butta C, Della Corte V, Maida C, Licata G, Pinto A
Diabetol Metab Syndr, 2014;6(1):28.
Species: Human
Sample Type: Plasma

CREB-induced inflammation is important for malignant mesothelioma growth.
Authors: Westbom C, Shukla A, MacPherson M, Yasewicz E, Miller J, Beuschel S, Steele C, Pass H, Vacek P, Shukla A
Am J Pathol, 2014;184(10):2816-27.
Species: Human
Sample Type: cell culture supernate

Differences in PGE2 production between primary human monocytes and differentiated macrophages: role of IL-1beta and TRIF/IRF3.
Authors: Endo Y, Blinova K, Romantseva T, Golding H, Zaitseva M
PLoS ONE, 2014;9(5):e98517.
Species: Human
Sample Type: cell culture supernatants

Expression and functional characterization of NOD2 in decidual stromal cells isolated during the first trimester of pregnancy.
Authors: Zhang Y, Chen H, Sun C, Wang H, Liu M, Li Y, Nie X, Du M, Li D, Zhang J
PLoS ONE, 2014;9(6):e99612.
Species: Human
Sample Type: Cell Culture Supernates

CLEC5A is critical for dengue virus-induced inflammasome activation in human macrophages.
Authors: Wu M, Chen S, Yang A, Lin W, Lin Y, Chen N, Tsai I, Li L, Hsieh S
Blood, 2013;121(1):95-106.
Species: Human
Sample Type: Cell Culture Supernates

Human bone marrow-derived mesenchymal stem cells suppress human glioma growth through inhibition of angiogenesis.
Authors: Ho I, Toh H, Ng W, Teo Y, Guo C, Hui K, Lam P
Stem Cells, 2013;31(1):146-55.
Species: Human
Sample Type: Tissue Lysate

The anti-tumorigenic mushroom Agaricus blazei Murill enhances IL-1beta production and activates the NLRP3 inflammasome in human macrophages.
Authors: Huang T, Ojcius D, Young J, Wu Y, Ko Y, Wong T, Wu C, Lu C, Lai H
PLoS ONE, 2012;7(7):e41383.
Species: Human
Sample Type: Cell Culture Supernates

Validation and quality control of ELISAs for the use with human saliva samples.
Authors: Jaedicke KM, Taylor JJ, Preshaw PM
J. Immunol. Methods, 2012;377(1):62-5.
Species: Human
Sample Type: Saliva

A novel small molecule, HK-156, inhibits lipopolysaccharide-induced activation of NF-kappaB signaling and improves survival in mouse models of sepsis.
Acta Pharmacol. Sin., 2012;33(9):1204-16.
Species: Human
Sample Type: Cell Culture Supernates

Role of IL-1alpha and the Nlrp3/caspase-1/IL-1beta axis in cigarette smoke-induced pulmonary inflammation and COPD.
Authors: Pauwels NS, Bracke KR, Dupont LL, Van Pottelberge GR, Provoost S, Vanden Berghe T, Vandenabeele P, Lambrecht BN, Joos GF, Brusselle GG
Eur. Respir. J., 2011;38(5):1019-28.
Species: Human
Sample Type: Sputum

IL-1beta is overexpressed and aberrantly regulated in corticosteroid nonresponders with autoimmune inner ear disease.
Authors: Pathak S, Goldofsky E, Vivas EX, Bonagura VR, Vambutas A
J. Immunol., 2011;186(3):1870-9.
Species: Human
Sample Type: Plasma

High levels of beta-catenin signaling reduce osteogenic differentiation of stem cells in inflammatory microenvironments through inhibition of the noncanonical Wnt pathway.
Authors: Liu N, Shi S, Deng M, Tang L, Zhang G, Liu N, Ding B, Liu W, Liu Y, Shi H, Liu L, Jin Y
J. Bone Miner. Res., 2011;26(9):2082-95.
Species: Human
Sample Type: Cell Culture Supernates

The detrimental effects of IFN-alpha on vasculogenesis in lupus are mediated by repression of IL-1 pathways: potential role in atherogenesis and renal vascular rarefaction.
Authors: Thacker SG, Berthier CC, Mattinzoli D, Rastaldi MP, Kretzler M, Kaplan MJ
J. Immunol., 2010;185(7):4457-69.
Species: Human
Sample Type: Serum

Bacillus anthracis capsule activates caspase-1 and induces interleukin-1beta release from differentiated THP-1 and human monocyte-derived dendritic cells.
Authors: Cho MH, Ahn HJ, Ha HJ, Park J, Chun JH, Kim BS, Oh HB, Rhie GE
Infect. Immun., 2010;78(1):387-92.
Species: Human
Sample Type: Cell Culture Supernates

Presence of IL-5 protein and IgE antibodies to staphylococcal enterotoxins in nasal polyps is associated with comorbid asthma.
Authors: Bachert C, Zhang N, Holtappels G, De Lobel L, Van Cauwenberge P, Liu S, Lin P, Bousquet J, Van Steen K
J. Allergy Clin. Immunol., 2010;126(5):962.
Species: Human
Sample Type: Tissue Homogenates

Immuno-inflammatory and thrombotic/fibrinolytic variables associated with acute ischemic stroke diagnosis.
Authors: Tuttolomondo A, Pinto A, Corrao S, Di Raimondo D, Fernandez P, Di Sciacca R, Arnao V, Licata G
Atherosclerosis, 2009;203(2):503-8.
Species: Human
Sample Type: Plasma

Escherichia coli type 1 pili trigger late IL-8 production by neutrophil-like differentiated PLB-985 cells through a Src family kinase- and MAPK-dependent mechanism.
Authors: Semiramoth N, Gleizes A, Turbica I, Sandre C, Gorges R, Kansau I, Servin A, Chollet-Martin S
J. Leukoc. Biol., 2009;85(2):310-21.
Species: Human
Sample Type: Cell Culture Supernates

Toll-like receptor-mediated production of IL-1Ra is negatively regulated by GSK3 via the MAPK ERK1/2.
Authors: Rehani K, Wang H, Garcia CA, Kinane DF, Martin M
J. Immunol., 2009;182(1):547-53.
Species: Human
Sample Type: Cell Culture Supernates

Immuno-inflammatory predictors of stroke at follow-up in patients with chronic non-valvular atrial fibrillation (NVAF).
Authors: Pinto A, Tuttolomondo A, Casuccio A, Di Raimondo D, Di Sciacca R, Arnao V, Licata G
Clin. Sci., 2009;116(10):781-9.
Species: Human
Sample Type: Plasma

Characteristics of dengue virus-infected peripheral blood mononuclear cell death that correlates with the severity of illness.
Authors: Jaiyen Y, Masrinoul P, Kalayanarooj S, Pulmanausahakul R, Ubol S
Microbiol. Immunol., 2009;53(8):442-50.
Species: Human
Sample Type: Plasma

Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling.
Authors: Boniface K, Bak-Jensen KS, Li Y, Blumenschein WM, McGeachy MJ, McClanahan TK, McKenzie BS, Kastelein RA, Cua DJ, de Waal Malefyt R
J. Exp. Med., 2009;206(3):535-48.
Species: Human
Sample Type: Cell Culture Supernates

Neisseria gonorrhoeae activates the proteinase cathepsin B to mediate the signaling activities of the NLRP3 and ASC-containing inflammasome.
Authors: Duncan JA, Gao X, Huang MT, OConnor BP, Thomas CE, Willingham SB, Bergstralh DT, Jarvis GA, Sparling PF, Ting JP
J. Immunol., 2009;182(10):6460-9.
Species: Human
Sample Type: Cell Culture Supernates

RAS mutations affect tumor necrosis factor-induced apoptosis in colon carcinoma cells via ERK-modulatory negative and positive feedback circuits along with non-ERK pathway effects.
Authors: Kreeger PK, Mandhana R, Alford SK, Haigis KM, Lauffenburger DA
Cancer Res., 2009;69(20):8191-9.

Direct and indirect impairment of human dendritic cell function by virulent Francisella tularensis Schu S4.
Authors: Chase JC, Celli J, Bosio CM
Infect. Immun., 2009;77(1):180-95.
Species: Human
Sample Type: Cell Culture Supernates

Identification of interleukin-7 as a candidate disease mediator in spondylarthritis.
Authors: Rihl M, Kellner H, Kellner W, Barthel C, Yu DT, Tak PP, Zeidler H, Baeten D
Arthritis Rheum., 2008;58(11):3430-5.
Species: Human
Sample Type: Synovial Fluid

Biological and technical variables affecting immunoassay recovery of cytokines from human serum and simulated vaginal fluid: a multicenter study.
Authors: Fichorova RN, Richardson-Harman N, Alfano M, Belec L, Carbonneil C, Chen S, Cosentino L, Curtis K, Dezzutti CS, Donoval B, Doncel GF, Donaghay M, Grivel JC, Guzman E, Hayes M, Herold B, Hillier S, Lackman-Smith C, Landay A, Margolis L, Mayer KH, Pasicznyk JM, Pallansch-Cokonis M, Poli G, Reichelderfer P, Roberts P, Rodriguez I, Saidi H, Sassi RR, Shattock R, Cummins JE
Anal. Chem., 2008;80(12):4741-51.
Species: Human
Sample Type: WHO 86/680 reference standard

Decreased lubricin concentrations and markers of joint inflammation in the synovial fluid of patients with anterior cruciate ligament injury.
Authors: Elsaid KA, Fleming BC, Oksendahl HL, Machan JT, Fadale PD, Hulstyn MJ, Shalvoy R, Jay GD
Arthritis Rheum., 2008;58(6):1707-15.
Species: Human
Sample Type: Synovial Fluid

In vitro induction of a dendritic cell phenotype in primary human acute myelogenous leukemia (AML) blasts alters the chemokine release profile and increases the levels of T cell chemotactic CCL17 and CCL22.
Authors: Olsnes AM, Ryningen A, Ersvaer E, Bruserud Ø
J. Interferon Cytokine Res., 2008;28(5):297-310.
Species: Human
Sample Type: Cell Culture Supernates

The role of nerve growth factor in hyperosmolar stress induced apoptosis.
Authors: Chang EJ, Im YS, Kay EP
J. Cell. Physiol., 2008;216(1):69-77.
Species: Human
Sample Type: Cell Culture Supernates

Regulation of hepatocyte growth factor secretion by fibroblasts in patients with acute lung injury.
Authors: Quesnel C, Marchand-Adam S, Fabre A, Marchal-Somme J, Philip I, Lasocki S, Lecon V, Crestani B, Dehoux M
Am. J. Physiol. Lung Cell Mol. Physiol., 2007;294(2):L334-43.
Species: Human
Sample Type: BALF

C-reactive protein induces endothelial cell apoptosis and matrix metalloproteinase-9 production in human mononuclear cells: Implications for the destabilization of atherosclerotic plaque.
Authors: Nabata A, Kuroki M, Ueba H, Hashimoto S, Umemoto T, Wada H, Yasu T, Saito M, Momomura S, Kawakami M
Atherosclerosis, 2007;196(1):129-35.
Species: Human
Sample Type: Cell Culture Supernates

Expression and gene polymorphisms of the chemokine CXCL5 in colorectal cancer patients.
Authors: Dimberg J, Dienus O, Lofgren S, Hugander A, Wagsater D
Int. J. Oncol., 2007;31(1):97-102.
Species: Human
Sample Type:

IL-1alpha and IL-1beta are endogenous mediators linking cell injury to the adaptive alloimmune response.
Authors: Rao DA, Tracey KJ, Pober JS
J. Immunol., 2007;179(10):6536-46.
Species: Human
Sample Type: Cell Culture Supernates

Advanced glycation end products increases matrix metalloproteinase-1, -3, and -13, and TNF-alpha in human osteoarthritic chondrocytes.
Authors: Nah SS, Choi IY, Yoo B, Kim YG, Moon HB, Lee CK
FEBS Lett., 2007;581(9):1928-32.
Species: Human
Sample Type: Cell Culture Supernates

TREM-1 expression in tumor-associated macrophages and clinical outcome in lung cancer.
Authors: Ho CC, Liao WY, Wang CY, Lu YH, Huang HY, Chen HY, Chan WK, Chen HW, Yang PC
Am. J. Respir. Crit. Care Med., 2007;177(7):763-70.
Species: Human
Sample Type: Whole Cells

Toll-like receptors 3 and 4 are expressed by human bone marrow-derived mesenchymal stem cells and can inhibit their T-cell modulatory activity by impairing Notch signaling.
Authors: Liotta F, Angeli R, Cosmi L, Fili L, Manuelli C, Frosali F, Mazzinghi B, Maggi L, Pasini A, Lisi V, Santarlasci V, Consoloni L, Angelotti ML, Romagnani P, Parronchi P, Krampera M, Maggi E, Romagnani S, Annunziato F
Stem Cells, 2007;26(1):279-89.
Species: Human
Sample Type: Cell Culture Supernates

The levels of steroid hormones and cytokines in individual follicles are not associated with the fertilization outcome after intracytoplasmic sperm injection.
Authors: Asimakopoulos B, Abu-Hassan D, Metzen E, Al-Hasani S, Diedrich K, Nikolettos N
Fertil. Steril., 2007;90(1):60-4.
Species: Human
Sample Type: Follicular Fluid

Statin-induced proinflammatory response in mitogen-activated peripheral blood mononuclear cells through the activation of caspase-1 and IL-18 secretion in monocytes.
Authors: Coward WR, Marei A, Yang A, Vasa-Nicotera MM, Chow SC
J. Immunol., 2006;176(9):5284-92.
Species: Human
Sample Type: Cell Culture Supernates

Non-esterified fatty acid concentrations are independently associated with hepatic steatosis in obese subjects.
Authors: Holt HB, Wild SH, Wood PJ, Zhang J, Darekar AA, Dewbury K, Poole RB, Holt RI, Phillips DI, Byrne CD
Diabetologia, 2006;49(1):141-8.
Species: Human
Sample Type: Serum

Humoral and cellular factors responsible for coronary collateral formation.
Authors: Sherman JA, Hall A, Malenka DJ, De Muinck ED, Simons M
Am. J. Cardiol., 2006;98(9):1194-7.
Species: Human
Sample Type: Plasma

C-reactive protein and vascular cell adhesion molecule-1 as markers of severity in sickle cell disease.
Authors: Makis AC, Hatzimichael EC, Stebbing J, Bourantas KL
Arch. Intern. Med., 2006;166(3):366-8.
Species: Human
Sample Type: Plasma

Microvascular endothelial cells increase proliferation and inhibit apoptosis of native human acute myelogenous leukemia blasts.
Authors: Hatfield K, Ryningen A, Corbascio M, Bruserud O
Int. J. Cancer, 2006;119(10):2313-21.
Species: Human
Sample Type: Cell Culture Supernates

Modulation of cytokine secretion by pentacyclic triterpenes from olive pomace oil in human mononuclear cells.
Authors: Marquez-Martin A, De La Puerta R, Fernandez-Arche A, Ruiz-Gutierrez V, Yaqoob P
Cytokine, 2006;36(5):211-7.
Species: Human
Sample Type: Cell Culture Supernates

Dental plaque, gingival inflammation, and elevated levels of interleukin-6 and cortisol in gingival crevicular fluid from women with stress-related depression and exhaustion.
Authors: Johannsen A, Rylander G, Soder B, Asberg M
J. Periodontol., 2006;77(8):1403-9.
Species: Human
Sample Type: Gingival Crevicular Fluid (GCF)

The potential of adiponectin in driving arthritis.
Authors: Ehling A, Schaffler A, Herfarth H, Tarner IH, Anders S, Distler O, Paul G, Distler J, Gay S, Scholmerich J, Neumann E, Muller-Ladner U
J. Immunol., 2006;176(7):4468-78.
Species: Human
Sample Type: Cell Culture Supernates

The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production.
Authors: Chae JJ, Wood G, Masters SL, Richard K, Park G, Smith BJ, Kastner DL
Proc. Natl. Acad. Sci. U.S.A., 2006;103(26):9982-7.
Species: Human
Sample Type: Cell Culture Supernates

Celecoxib up-regulates the expression of the zeta chain of T cell receptor complex in tumor-infiltrating lymphocytes in human cervical cancer.
Authors: Ferrandina G, Ranelletti FO, Legge F, Salutari V, Martinelli E, Fattorossi A, Lorusso D, Zannoni G, Vellone V, Paglia A, Scambia G
Clin. Cancer Res., 2006;12(7):2055-60.
Species: Human
Sample Type: Plasma

Glycerol monolaurate inhibits the effects of Gram-positive select agents on eukaryotic cells.
Authors: Peterson ML, Schlievert PM
Biochemistry, 2006;45(7):2387-97.
Species: Human
Sample Type: Cell Culture Supernates

The response of human epithelial cells to TNF involves an inducible autocrine cascade.
Authors: Janes KA, Gaudet S, Albeck JG, Nielsen UB, Lauffenburger DA, Sorger PK
Cell, 2006;124(6):1225-39.
Species: Human
Sample Type: Cell Culture Supernates

The apoptotic-cell receptor CR3, but not alphavbeta5, is a regulator of human dendritic-cell immunostimulatory function.
Authors: Skoberne M, Somersan S, Almodovar W, Truong T, Petrova K, Henson PM, Bhardwaj N
Blood, 2006;108(3):947-55.
Species: Human
Sample Type: Cell Culture Supernates

Kinin receptor expression during Staphylococcus aureus infection.
Authors: Bengtson SH, Phagoo SB, Norrby-Teglund A, Pahlman L, Morgelin M, Zuraw BL, Leeb-Lundberg LM, Herwald H
Blood, 2006;108(6):2055-63.
Species: Human
Sample Type: Cell Culture Supernates

Keratinocyte-fibroblast paracrine interaction: the effects of substrate and culture condition.
Authors: Witte RP, Kao WJ
Biomaterials, 2005;26(17):3673-82.
Species: Human
Sample Type: Whole Cells

Interleukin-1beta tear concentration in glaucomatous and ocular hypertensive patients treated with preservative-free nonselective beta-blockers.
Authors: Manni G, Centofanti M, Oddone F, Parravano M, Bucci MG
Am. J. Ophthalmol., 2005;139(1):72-7.
Species: Human
Sample Type: Tears

Relationship between cytokines and the embryotoxicity of hydrosalpingeal fluid.
Authors: Bedaiwy MA, Falcone T, Goldberg JM, Attaran M, Sharma R, Miller K, Nelson DR, Agarwal A
J. Assist. Reprod. Genet., 2005;22(4):161-5.
Species: Human
Sample Type: Hypersalpingeal fluid (HSF)

Aseptic peritonitis due to peptidoglycan contamination of pharmacopoeia standard dialysis solution.
Authors: Martis L, Patel M, Giertych J, Mongoven J, Taminne M, Perrier MA, Mendoza O, Goud N, Costigan A, Denjoy N, Verger C, Owen WF
Lancet, 2005;365(9459):588-94.
Species: Human
Sample Type: dialysate effluent

Secretory IgA induces antigen-independent eosinophil survival and cytokine production without inducing effector functions.
Authors: Bartemes KR, Cooper KM, Drain KL, Kita H
J. Allergy Clin. Immunol., 2005;116(4):827-35.
Species: Human
Sample Type: Cell Culture Supernates

Mucosal wound healing in a rabbit model of subglottic stenosis: biochemical analysis of secretions.
Authors: Branski RC, Sandulache VC, Dohar JE, Hebda PA
Arch. Otolaryngol. Head Neck Surg., 2005;131(2):153-7.
Species: Rabbit
Sample Type: Wound Secretion

Circulating and synovial levels of IGF-I, cytokines, physical function and anthropometry differ in women awaiting total knee arthroplasty when compared to men.
Authors: Pagura SM, Thomas SG, Woodhouse LJ, Ezzat S, Marks P
J. Orthop. Res., 2005;23(2):397-405.
Species: Human
Sample Type: Synovial Fluid

Analysis of tumor necrosis factor-alpha, interleukin-6, interleukin-1beta, soluble tumor necrosis factor receptors I and II, interleukin-6 soluble receptor, interleukin-1 soluble receptor type II, interleukin-1 receptor antagonist, and protein in the synovial fluid of patients with temporomandibular joint disorders.
Authors: Kaneyama K, Segami N, Sun W, Sato J, Fujimura K
Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2005;99(3):276-84.
Species: Human
Sample Type: Synovial Fluid

Inflammatory cytokine concentrations are elevated in seminal plasma of men with spinal cord injuries.
Authors: Basu S, Aballa TC, Ferrell SM, Lynne CM, Brackett NL
J. Androl., 2004;25(2):250-4.
Species: Human
Sample Type: seminal plasma

Markers of wound healing in vocal fold secretions from patients with laryngeal pathology.
Authors: Branski RC, Rosen CA, Verdolini K, Hebda PA
Ann. Otol. Rhinol. Laryngol., 2004;113(1):23-9.
Species: Human
Sample Type: laryngeal secretion

Determinants of plasma leptin concentration in postmenopausal women.
Authors: Brooks-Asplund EM, Tupper CE, Daun JM, Kenney WL, Cannon JG
Mech. Ageing Dev., 2004;125(2):117-9.
Species: Human
Sample Type: Whole Cells

Effects of scaling and root planing on the amounts of interleukin-1 and interleukin-1 receptor antagonist and the mRNA expression of interleukin-1beta in gingival crevicular fluid and gingival tissues.
Authors: Yoshinari N, Kawase H, Mitani A, Ito M, Sugiishi S, Matsuoka M, Shirozu N, Ishihara Y, Bito B, Hiraga M, Arakawa K, Noguchi T
J. Periodont. Res., 2004;39(3):158-67.
Species: Human
Sample Type: Gingival Crevicular Fluid (GCF)

Guiding the vaginal microbicide trials with biomarkers of inflammation.
Authors: Fichorova RN
J. Acquir. Immune Defic. Syndr., 2004;37(0):S184-93.
Species: Human
Sample Type: cervicovaginal lavage

Changes in CSF S100B and cytokine concentrations in early-phase severe traumatic brain injury.
Authors: Hayakata T, Shiozaki T, Tasaki O, Ikegawa H, Inoue Y, Toshiyuki F, Hosotubo H, Kieko F, Yamashita T, Tanaka H, Shimazu T, Sugimoto H
Shock, 2004;22(2):102-7.
Species: Human
Sample Type: Serum

The investigation of glutathione peroxidase, lactoferrin, myeloperoxidase and interleukin-1beta in gingival crevicular fluid: implications for oxidative stress in human periodontal diseases.
Authors: Wei PF, Ho KY, Ho YP, Wu YM, Yang YH, Tsai CC
J. Periodont. Res., 2004;39(5):287-93.
Species: Human
Sample Type: Gingival Crevicular Fluid (GCF)

Tissue adhesiveness and host response of in situ photopolymerizable interpenetrating networks containing methylprednisolone acetate.
Authors: Zilinski JL, Kao WJ
J Biomed Mater Res A, 2004;68(2):392-400.
Species: Human
Sample Type: Intestinal Perfusion Fluid

Shifts in biochemical markers associated with wound healing in laryngeal secretions following phonotrauma: a preliminary study.
Authors: Verdolini K, Rosen CA, Branski RC, Hebda PA
Ann. Otol. Rhinol. Laryngol., 2003;112(12):1021-5.
Species: Human
Sample Type: laryngeal secretion

T lymphocyte-mediated changes in airway smooth muscle responsiveness are attributed to induced autocrine release and actions of IL-5 and IL-1beta.
Authors: Hakonarson H, Whelan R, Leiter J, Kim C, Chen M, Campbell D, Grunstein MM
J. Allergy Clin. Immunol., 2002;110(4):624-33.
Species: Human
Sample Type: Cell Culture Supernates

Intraperitoneal bispecific antibody (HEA125xOKT3) therapy inhibits malignant ascites production in advanced ovarian carcinoma.
Authors: Marme A, Strauss G, Bastert G, Grischke EM, Moldenhauer G
Int. J. Cancer, 2002;101(2):183-9.
Species: Human
Sample Type: Ascites

Cytotoxicity and interleukin-1beta processing following Shigella flexneri infection of human monocyte-derived dendritic cells.
Authors: Edgeworth JD, Spencer J, Phalipon A, Griffin GE, Sansonetti PJ
Eur. J. Immunol., 2002;32(5):1464-71.
Species: Human
Sample Type: Cell Culture Supernates

Mature dendritic cells infiltrate the T cell-rich region of oral mucosa in chronic periodontitis: in situ, in vivo, and in vitro studies.
Authors: Jotwani R, Palucka AK, Al-Quotub M, Nouri-Shirazi M, Kim J, Bell D, Banchereau J, Cutler CW
J. Immunol., 2001;167(8):4693-700.
Species: Human
Sample Type: Gingival Crevicular Fluid (GCF)

Interleukin-6 is a major effector molecule of short-term G-CSF treatment inducing bone metabolism and an acute-phase response.
Authors: Carstanjen D, Regenfus M, Muller C, Salama A
Exp. Hematol., 2001;29(7):812-21.
Species: Human
Sample Type: Plasma

Interleukin-11 induces Th2 polarization of human CD4(+) T cells.
Authors: Curti A, Ratta M, Corinti S, Girolomoni G, Ricci F, Tazzari P, Siena M, Grande A, Fogli M, Tura S, Lemoli RM
Blood, 2001;97(9):2758-63.
Species: Human
Sample Type: Cell Culture Supernates

Characterization of bone resorbing activity in gingival crevicular fluid from patients with periodontitis.
Authors: Rasmussen L, Hanstrom L, Lerner UH
J. Clin. Periodontol., 2000;27(1):41-52.
Species: Human
Sample Type: Gingival Crevicular Fluid (GCF)

Luminal neutrophil migration in ileoanal pouches studied by whole gut lavage.
Authors: Evgenikos NL, Bartolo DC, Hamer-Hodges DW, Ghosh S
Eur J Gastroenterol Hepatol, 2000;12(5):553-7.
Species: Human
Sample Type: gut lavage fluid

Proinflammatory cytokines increase in sepsis after anti-adhesion molecule therapy.
Authors: Welty-Wolf KE, Carraway MS, Ghio A, Kantrow SP, Huang YC, Piantadosi CA
Shock, 2000;13(5):404-9.
Species: Primate- Papio cynocephalus (Baboon)
Sample Type: Serum

Natural interferon alpha/beta-producing cells link innate and adaptive immunity.
Authors: Kadowaki N, Antonenko S, Lau JY, Liu YJ
J. Exp. Med., 2000;192(2):219-26.
Species: Human
Sample Type: Cell Culture Supernates

Functional genomic analysis in arthritis-affected cartilage: yin-yang regulation of inflammatory mediators by alpha 5 beta 1 and alpha V beta 3 integrins.
Authors: Attur MG, Dave MN, Clancy RM, Patel IR, Abramson SB, Amin AR
J. Immunol., 2000;164(5):2684-91.
Species: Human
Sample Type: Cell Culture Supernates

Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.
Authors: Fadok, V A, Bratton, D L, Konowal, A, Freed, P W, Westcott, J Y, Henson, P M
J Clin Invest, 1998;101(4):890-8.
Species: Human
Sample Type: Cell Culture Supernates

Gingival crevicular fluid from patients with periodontitis contains bone resorbing activity.
Authors: Lerner UH, Modeer T, Krekmanova L, Claesson R, Rasmussen L
Eur. J. Oral Sci., 1998;106(3):778-87.
Species: Human
Sample Type: Gingival Crevicular Fluid (GCF)

生物活性< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景IL-1 beta (Interleukin-1 beta) is produced in response to inflammatory agents, infections, or microbial endotoxins. It plays a central role in immune and inflammatory responses, bone remodeling, fever, carbohydrate metabolism, and GH/IGF-I physiology. IL-1 beta dysregulation is implicated in many pathological conditions including sepsis, rheumatoid arthritis, inflammatory bowel disease, acute and chronic myelogenous leukemia, insulin-dependent diabetes mellitus, atherosclerosis, neuronal injury, and aging-related diseases. Intracellular cleavage of the IL-1 beta precursor by Caspase-1/ICE is a key step in the inflammatory response. IL-1 beta binds to IL-1 RI and IL-1 RII. The IL-1 receptor accessory protein (IL-1 RAcP) associates with IL-1 RI and is required for IL-1 RI signal transduction, and IL-1ra is a secreted molecule that functions as a competitive inhibitor of IL-1 bioactivity.
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参考文献
  • Cancer Biomarkers
  • Conventional/Classical Dendritic Cells
  • Cytokines and Receptors in Allergy and Asthma
  • Cytokines and Receptors in Angiogenesis
  • IL-1 Family
  • Infectious Diseases
  • Inflammatory Mediators
  • Isolation, Culture, and Identification of Natural Killer Cells
  • LTi Cells
  • Macrophage Activation Markers
  • Multiple Sclerosis and Myelin Related Molecules
  • Myeloid-derived Suppressor Cells (MDSC)
  • NCR-ILC3
  • Neuroinflammation
  • NOD-like Receptors and the Inflammasome
  • Platelets
  • Regulatory T Cells (Tregs)
  • T Cell Cytokine Signaling
  • Th17 Cells
  • Th9 Cells