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Human IL-1 alpha/IL-1F1 Quantikine SixPak (6 Plates) (1 PK)

货号: SLA50 基本售价: 29971.6 元 规格: 1 PACK

产品信息

概述
货号SLA50
描述The Quantikine Human IL-1 alpha Immunoassay is a 3.5 or 4.5 hour solid phase ELISA designed to measure IL-1 alpha in cell culture supernates, serum, and plasma. It contains recombinant human IL-1 alpha and antibodies raised against recombinant human IL-1 alpha and has been shown to accurately quantitate the recombinant factor. Results obtained using natural IL-1 alpha showed linear curves that were parallel to the standard curves obtained using the E. coli-expressed Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural human IL-1 alpha.
别名Hematopoietin-1; IL1 alpha; IL-1 alpha; IL1; IL1A; IL-1A; IL1-ALPHA; IL-1F1; IL1F1hematopoietin-1; interleukin 1, alpha; interleukin-1 alpha; preinterleukin 1 alpha; pro-interleukin-1-alpha;
全称
Interleukin 1 alpha
反应种属Human
目标/特异性Natural and recombinant human IL-1 alpha
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs
3552 (Human); 16175 (Mouse); 24493 (Rat); 397094 (Porcine)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Antibody Array Revealed PRL-3 Affects Protein Phosphorylation and Cytokine Secretion
Authors: Y Yang, S Lian, L Meng, L Qu, C Shou
PLoS ONE, 2017;12(1):e0169665.
Species: Human
Sample Type: Cell Culture Supernates

Nuclear DNA damage-triggered NLRP3 inflammasome activation promotes UVB-induced inflammatory responses in human keratinocytes
Authors: Tatsuya Hasegawa
Biochem Biophys Res Commun, 2016;0(0):.
Species: Human
Sample Type: Cell Culture Supernates

MyD88-Dependent Signaling Decreases the Antitumor Efficacy of Epidermal Growth Factor Receptor Inhibition in Head and Neck Cancer Cells.
Authors: Koch A, Love-Homan L, Espinosa-Cotton M, Stanam A, Simons A
Cancer Res, 2015;75(8):1657-67.
Species: Human
Sample Type: Cell Culture Supernates

Early efficacy trial of anakinra in corticosteroid-resistant autoimmune inner ear disease.
Authors: Vambutas A, Lesser M, Mullooly V, Pathak S, Zahtz G, Rosen L, Goldofsky E
J Clin Invest, 2014;124(9):4115-22.
Species: Human
Sample Type: Plasma

Role of IL-1alpha and the Nlrp3/caspase-1/IL-1beta axis in cigarette smoke-induced pulmonary inflammation and COPD.
Authors: Pauwels NS, Bracke KR, Dupont LL, Van Pottelberge GR, Provoost S, Vanden Berghe T, Vandenabeele P, Lambrecht BN, Joos GF, Brusselle GG
Eur. Respir. J., 2011;38(5):1019-28.
Species: Human
Sample Type: Sputum

In vivo regulation of interleukin 1beta in patients with cryopyrin-associated periodic syndromes.
Authors: Lachmann HJ, Lowe P, Felix SD, Rordorf C, Leslie K, Madhoo S, Wittkowski H, Bek S, Hartmann N, Bosset S, Hawkins PN, Jung T
J. Exp. Med., 2009;206(5):1029-36.
Species: Human
Sample Type: Plasma

HLA-DR+ leukocytes acquire CD1 antigens in embryonic and fetal human skin and contain functional antigen-presenting cells.
Authors: Schuster C, Vaculik C, Fiala C, Meindl S, Brandt O, Imhof M, Stingl G, Eppel W, Elbe-Burger A
J. Exp. Med., 2009;206(1):169-81.
Species: Human
Sample Type: Cell Culture Supernates

RAS mutations affect tumor necrosis factor-induced apoptosis in colon carcinoma cells via ERK-modulatory negative and positive feedback circuits along with non-ERK pathway effects.
Authors: Kreeger PK, Mandhana R, Alford SK, Haigis KM, Lauffenburger DA
Cancer Res., 2009;69(20):8191-9.
Species: Human
Sample Type: Cell Culture Supernates

Selective inhibition of proprotein convertases represses the metastatic potential of human colorectal tumor cells.
Authors: Scamuffa N, Siegfried G, Bontemps Y, Ma L, Basak A, Cherel G, Calvo F, Seidah NG, Khatib AM
J. Clin. Invest., 2008;118(1):352-63.
Species: Human
Sample Type: Cell Culture Supernates

Administration of cyclooxygenase-2 inhibitor reduces joint inflammation but exacerbates osteopenia in IL-1 alpha transgenic mice due to GM-CSF overproduction.
Authors: Niki Y, Takaishi H, Takito J, Miyamoto T, Kosaki N, Matsumoto H, Toyama Y, Tada N
J. Immunol., 2007;179(1):639-46.
Species: Human
Sample Type: Cell Culture Supernates

Protection of human keratinocytes from UVB-induced inflammation using root extract of Lithospermum erythrorhizon.
Authors: Ishida T, Sakaguchi I,
Biol. Pharm. Bull., 2007;30(5):928-34.
Species: Human
Sample Type: Cell Culture Supernates

The influence of anger expression on wound healing.
Authors: Gouin JP, Kiecolt-Glaser JK, Malarkey WB, Glaser R
Brain Behav. Immun., 2007;22(5):699-708.
Species: Human
Sample Type: Wound Secretion

Peroxisome proliferator-activated receptor-gamma agonists inhibit respiratory syncytial virus-induced expression of intercellular adhesion molecule-1 in human lung epithelial cells.
Authors: Arnold R, Neumann M, Konig W
Immunology, 2007;121(1):71-81.
Species: Human
Sample Type: Cell Culture Supernates

Inhibitory effects of micronized fenofibrate on carotid atherosclerosis in patients with essential hypertension.
Authors: Zhu S, Su G, Meng QH
Clin. Chem., 2006;52(11):2036-42.
Species: Human
Sample Type: Serum

The response of human epithelial cells to TNF involves an inducible autocrine cascade.
Authors: Janes KA, Gaudet S, Albeck JG, Nielsen UB, Lauffenburger DA, Sorger PK
Cell, 2006;124(6):1225-39.
Species: Human
Sample Type: Cell Culture Supernates

Circulating and synovial levels of IGF-I, cytokines, physical function and anthropometry differ in women awaiting total knee arthroplasty when compared to men.
Authors: Pagura SM, Thomas SG, Woodhouse LJ, Ezzat S, Marks P
J. Orthop. Res., 2005;23(2):397-405.
Species: Human
Sample Type: Synovial Fluid

Effects of scaling and root planing on the amounts of interleukin-1 and interleukin-1 receptor antagonist and the mRNA expression of interleukin-1beta in gingival crevicular fluid and gingival tissues.
Authors: Yoshinari N, Kawase H, Mitani A, Ito M, Sugiishi S, Matsuoka M, Shirozu N, Ishihara Y, Bito B, Hiraga M, Arakawa K, Noguchi T
J. Periodont. Res., 2004;39(3):158-67.
Species: Human
Sample Type: Gingival Crevicular Fluid (GCF)

Guiding the vaginal microbicide trials with biomarkers of inflammation.
Authors: Fichorova RN
J. Acquir. Immune Defic. Syndr., 2004;37(0):S184-93.
Species: Human
Sample Type: cervicovaginal lavage

The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 action.
Authors: Smith DE, Hanna R, Della Friend, Moore H, Chen H, Farese AM, MacVittie TJ, Virca GD, Sims JE
Immunity, 2003;18(1):87-96.
Species: Human
Sample Type: Serum

Retroviral interleukin 1alpha gene transfer in bone marrow stromal cells in a primate model: induction of myelopoiesis stimulation.
Authors: de Revel T, Becard N, Sorg T, Rousseau S, Spano JP, Thiebot H, Methali M, Gras G, Le Grand R, Dormont D
Br. J. Haematol., 2002;118(3):875-84.
Species: Primate- Macaca fascicularis (Cynomolgus/Crab-eating Monkey)
Sample Type: Cell Culture Supernates

Characterization of bone resorbing activity in gingival crevicular fluid from patients with periodontitis.
Authors: Rasmussen L, Hanstrom L, Lerner UH
J. Clin. Periodontol., 2000;27(1):41-52.
Species: Human
Sample Type: Gingival Crevicular Fluid (GCF)

High versus low basal cortisol secretion in asymptomatic, medication-free HIV-infected men: differential effects of severe life stress on parameters of immune status.
Authors: Petitto JM, Leserman J, Perkins DO, Stern RA, Silva SG, Gettes D, Zheng B, Folds JD, Golden RN, Evans DL
Behav Med, 2000;25(4):143-51.
Species: Human
Sample Type: Cell Culture Supernates

Natural interferon alpha/beta-producing cells link innate and adaptive immunity.
Authors: Kadowaki N, Antonenko S, Lau JY, Liu YJ
J. Exp. Med., 2000;192(2):219-26.
Species: Human
Sample Type: Cell Culture Supernates

c-Jun and JunB antagonistically control cytokine-regulated mesenchymal-epidermal interaction in skin.
Authors: Szabowski A, Maas-Szabowski N, Andrecht S, Kolbus A, Schorpp-Kistner M, Fusenig NE, Angel P
Cell, 2000;103(5):745-55.
Species: Human
Sample Type: Cell Culture Supernates

Cytokine profiles in parotid saliva from HIV-1-infected individuals: changes associated with opportunistic infections in the oral cavity.
Authors: Black, K P, Merrill, K W, Jackson, S, Katz, J
Oral Microbiol Immunol, 2000;15(2):74-81.
Species: Human
Sample Type: Saliva

Gingival crevicular fluid from patients with periodontitis contains bone resorbing activity.
Authors: Lerner UH, Modeer T, Krekmanova L, Claesson R, Rasmussen L
Eur. J. Oral Sci., 1998;106(3):778-87.
Species: Human
Sample Type: Gingival Crevicular Fluid (GCF)

生物活性< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景IL-1 alpha (Interleukin-1 alpha) is a cytokine that is induced during microbial exposure and promotes the release of multiple inflammatory mediators and acute phase proteins. It also supports hematopoietic stem cell expansion, promotes neutrophil mobilization from the bone marrow, and promotes osteoclast formation. IL-1 alpha signals through a receptor complex composed of IL-1 RI and IL-1 RAcP. It also binds the decoy receptor IL-1 RII which associates with IL-1 RAcP but does not transduce signaling.
运输条件Blue Ice
存放说明4℃
参考文献
  • Cancer Stem Cell Markers
  • Cytokines and Receptors in Allergy and Asthma
  • Cytokines and Receptors in Angiogenesis
  • IL-1 Family
  • Megakaryocytes
  • Neuroinflammation
  • Regulatory T Cells (Tregs)
  • T Cell Cytokine Signaling