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Human IFN-gamma Quantikine SixPak (6 Plates) (1 PK)

货号: SIF50 基本售价: 29971.6 元 规格: 1 PACK

产品信息

概述
货号SIF50
描述The Quantikine Human IFN-gamma Immunoassay is a 4.5 hour solid phase ELISA designed to measure IFN-gamma levels in cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant human IFN-gamma and antibodies raised against the recombinant factor. Results obtained for naturally occurring human IFN-gamma samples showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural human IFN-gamma.
别名IFG; IFI; IFNG; IFNgamma; IFN-gamma; Immune interferon; interferon gamma; interferon, gamma;
全称
Interferon gamma
反应种属Human
目标/特异性Natural and recombinant human IFN-gamma
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs
3458 (Human); 15978 (Mouse); 25712 (Rat); 396991 (Porcine); 281237 (Bovine); 403801 (Canine); 493965 (Feline)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Frequency and role of NKp46 and NKG2A in hepatitis B virus infection
Authors: T Yoshioka, T Tatsumi, T Miyagi, K Mukai, K Nishio, A Nishio, Y Yokoyama, T Suda, T Kegasawa, M Shigekawa, H Hikita, R Sakamori, T Takehara
PLoS ONE, 2017;12(3):e0174103.
Species: Human
Sample Type: Cell Culture Supernates

Alterations in the Fecal Microbiota of Patients with HIV-1 Infection: An Observational Study in A Chinese Population
Sci Rep, 2016;6(0):30673.
Species: Human
Sample Type: Serum

Involvement of NK Cells and NKp30 Pathway in Antisynthetase Syndrome
J Immunol, 2016;197(5):1621-30.
Species: Human
Sample Type: Serum

A randomized, placebo controlled trial of omega-3 fatty acids in the treatment of young children with autism.
Authors: Mankad D, Dupuis A, Smile S, Roberts W, Brian J, Lui T, Genore L, Zaghloul D, Iaboni A, Marcon P, Anagnostou E
Mol Autism, 2015;6(0):18.
Species: Human
Sample Type: Plasma

WNT5A transforms intestinal CD8alphaalpha(+) IELs into an unconventional phenotype with pro-inflammatory features.
Authors: Zhao D, Xu A, Dai Z, Peng J, Zhu M, Shen J, Zheng Q, Ran Z
BMC Gastroenterol, 2015;15(0):173.
Species: Mouse
Sample Type: Cell Culture Supernates

Comparative Multi-Donor Study of IFNgamma Secretion and Expression by Human PBMCs Using ELISPOT Side-by-Side with ELISA and Flow Cytometry Assays.
Authors: Hagen J, Zimmerman R, Goetz C, Bonnevier J, Houchins J, Reagan K, Kalyuzhny A
Cells, 2015;4(1):84-95.
Species: Human
Sample Type: Whole Cells

CCL20-CCR6 Cytokine Network Facilitate Treg Activity in Advanced Grades and Metastatic Variants of Hepatocellular Carcinoma.
Authors: Li W, Liu H
Scand J Immunol, 2015;83(1):33-7.
Species: Human
Sample Type: Tissue Homgenates

A Multidrug-resistant Engineered CAR T Cell for Allogeneic Combination Immunotherapy.
Authors: Valton J, Guyot V, Marechal A, Filhol J, Juillerat A, Duclert A, Duchateau P, Poirot L
Mol Ther, 2015;23(9):1507-18.
Species: Human
Sample Type: Cell Culture Supernates

Role of programmed death ligands in effective T-cell interactions in extranodal natural killer/T-cell lymphoma.
Authors: Han L, Liu F, Li R, Li Z, Chen X, Zhou Z, Zhang X, Hu T, Zhang Y, Young K, Sun S, Wen J, Zhang M
Oncol Lett, 2014;8(4):1461-1469.
Species: Human
Sample Type: Serum

Expression and functional characterization of NOD2 in decidual stromal cells isolated during the first trimester of pregnancy.
Authors: Zhang Y, Chen H, Sun C, Wang H, Liu M, Li Y, Nie X, Du M, Li D, Zhang J
PLoS ONE, 2014;9(6):e99612.
Species: Human
Sample Type: Cell Culture Supernates

Mycobacteria bypass mucosal NF-kB signalling to induce an epithelial anti-inflammatory IL-22 and IL-10 response.
Authors: Lutay N, Hakansson G, Alaridah N, Hallgren O, Westergren-Thorsson G, Godaly G
PLoS ONE, 2014;9(1):e86466.
Species: Human
Sample Type: Cell Culture Supernates

EBV-encoded miR-BART20-5p and miR-BART8 inhibit the IFN-gamma-STAT1 pathway associated with disease progression in nasal NK-cell lymphoma.
Authors: Huang W, Lin C
Am J Pathol, 2014;184(4):1185-97.
Species: Human
Sample Type: Cell culture supernatant

Exogenous IFN-beta regulates the RANKL-c-Fos-IFN-beta signaling pathway in the collagen antibody-induced arthritis model.
Authors: Zhao R, Chen N, Zhou X, Miao P, Hu C, Qian L, Yu Q, Zhang J, Nie H, Chen X, Li P, Xu R, Xiao L, Zhang X, Liu J, Zhang D
J Transl Med, 2014;12(1):330.
Species: Human
Sample Type: Serum

Neutrophil microparticles modulate cytokine production by natural killer cells.
Authors: Pliyev B, Kalintseva M, Abdulaeva S, Yarygin K, Savchenko V
Cytokine, 2013;65(2):126-9.
Species: Human
Sample Type: Cell Culture Supernates

Cleaved/associated TLR3 represents the primary form of the signaling receptor.
Authors: Toscano F, Estornes Y, Virard F, Garcia-Cattaneo A, Pierrot A, Vanbervliet B, Bonnin M, Ciancanelli M, Zhang S, Funami K, Seya T, Matsumoto M, Pin J, Casanova J, Renno T, Lebecque S
J Immunol, 2013;190(2):764-73.
Species: Human
Sample Type: cell culture supernate

Effects of interval and continuous exercise training on CD4 lymphocyte apoptotic and autophagic responses to hypoxic stress in sedentary men.
Authors: Weng T, Huang S, Chuang Y, Wang J
PLoS ONE, 2013;8(11):e80248.
Species: Human
Sample Type: Plasma

N6-isopentenyladenosine, an endogenous isoprenoid end product, directly affects cytotoxic and regulatory functions of human NK cells through FDPS modulation.
Authors: Ciaglia E, Pisanti S, Picardi P, Laezza C, Malfitano A, DAlessandro A, Gazzerro P, Vitale M, Carbone E, Bifulco M
J Leukoc Biol, 2013;94(6):1207-19.
Species: Human
Sample Type: Cell Culture Supernates

Susceptibility-associated genetic variation at IL12B enhances Th1 polarization in psoriasis.
Authors: Johnston A, Xing X, Swindell W, Kochkodan J, Riblett M, Nair R, Stuart P, Ding J, Voorhees J, Elder J, Gudjonsson J
Hum Mol Genet, 2013;22(9):1807-15.
Species: Human
Sample Type: Serum

Multiplexing immunoassays for cytokine detection in the serum of patients with rheumatoid arthritis: lack of sensitivity and interference by rheumatoid factor.
Authors: Churchman SM, Geiler J, Parmar R, Horner EA, Church LD, Emery P, Buch MH, McDermott MF, Ponchel F
Clin. Exp. Rheumatol., 2012;30(4):534-42.
Species: Human
Sample Type: Serum

Engulfment of hematopoietic stem cells caused by down-regulation of CD47 is critical in the pathogenesis of hemophagocytic lymphohistiocytosis.
Authors: Kuriyama T, Takenaka K, Kohno K, Yamauchi T, Daitoku S, Yoshimoto G, Kikushige Y, Kishimoto J, Abe Y, Harada N, Miyamoto T, Iwasaki H, Teshima T, Akashi K
Blood, 2012;120(19):4058-67.
Species: Human
Sample Type: Serum

Analysis of the Interferon Gamma (rs2430561, +874T/A) Functional Gene Variant in Relation to the Presence of Cardiovascular Events in Rheumatoid Arthritis.
Authors: Garcia-Bermudez M, Lopez-Mejias R, Gonzalez-Juanatey C, Corrales A, Robledo G, Castaneda S, Miranda-Filloy J, Blanco R, Fernandez-Gutierrez B, Balsa A, Gonzalez-Alvaro I, Gomez-Vaquero C, Llorca J, Martin J, Gonzalez-Gay M
PLoS ONE, 2012;7(10):e47166.
Species: Human
Sample Type: Serum

Potent adjuvanticity of a pure TLR7-agonistic imidazoquinoline dendrimer.
Authors: Shukla N, Salunke D, Balakrishna R, Mutz C, Malladi S, David S
PLoS ONE, 2012;7(8):e43612.
Species: Human
Sample Type: Cell Culture Supernates

Evidence for a pathophysiological role of keratinocyte-derived type III interferon (IFN-lambda) in cutaneous lupus erythematosus.
Authors: Zahn S, Rehkamper C, Kummerer BM, Ferring-Schmidt S, Bieber T, Tuting T, Wenzel J
J. Invest. Dermatol., 2011;131(1):133-40.
Species: Human
Sample Type: Cell Culture Supernates

Cytokine Response Patterns in Severe Pandemic 2009 H1N1 and Seasonal Influenza among Hospitalized Adults.
Authors: Lee N, Wong CK, Chan PK, Chan MC, Wong RY, Lun SW, Ngai KL, Lui GC, Wong BC, Lee SK, Choi KW, Hui DS
PLoS ONE, 2011;6(10):e26050.
Species: Human
Sample Type: Plasma

Subnormal cytokine profile in the tear fluid of keratoconus patients.
Authors: Jun AS, Cope L, Speck C, Feng X, Lee S, Meng H, Hamad A, Chakravarti S
PLoS ONE, 2011;6(1):e16437.
Species: Human
Sample Type: Tears

Origination of new immunological functions in the costimulatory molecule B7-H3: the role of exon duplication in evolution of the immune system.
Authors: Sun J, Fu F, Gu W, Yan R, Zhang G, Shen Z, Zhou Y, Wang H, Shen B, Zhang X
PLoS ONE, 2011;6(9):e24751.
Species: Human
Sample Type: Cell Culture Supernates

HDAC inhibition by LBH589 affects the phenotype and function of human myeloid dendritic cells.
Authors: Song W, Tai YT, Tian Z, Hideshima T, Chauhan D, Nanjappa P, Exley MA, Anderson KC, Munshi NC
Leukemia, 2011;25(1):161-8.
Species: Human
Sample Type: Cell Culture Supernates

Identification of human NK17/NK1 cells.
Authors: Pandya AD, Al-Jaderi Z, Hoglund RA, Holmoy T, Harbo HF, Norgauer J, Maghazachi AA
PLoS ONE, 2011;6(10):e26780.
Species: Human
Sample Type: Cell Culture Supernates

Myeloid-derived suppressor cells in the peripheral blood of cancer patients contain a subset of immature neutrophils with impaired migratory properties.
Authors: Brandau S, Trellakis S, Bruderek K, Schmaltz D, Steller G, Elian M, Suttmann H, Schenck M, Welling J, Zabel P, Lang S
J. Leukoc. Biol., 2011;89(2):311-7.
Species: Human
Sample Type: Cell Culture Supernates

Soluble interleukin-18 receptor complex is a novel biomarker in rheumatoid arthritis.
Authors: Takei S, Hoshino T, Matsunaga K, Sakazaki Y, Sawada M, Oda H, Takenaka S, Imaoka H, Kinoshita T, Honda S, Ida H, Fukuda TA, Aizawa H
Arthritis Res. Ther., 2011;13(2):R52.
Species: Human
Sample Type: Serum

Antigen presentation and MHC class II expression by human esophageal epithelial cells: role in eosinophilic esophagitis.
Authors: Mulder DJ, Pooni A, Mak N, Hurlbut DJ, Basta S, Justinich CJ
Am. J. Pathol., 2011;178(2):744-53.
Species: Human
Sample Type: Whole Tissue

B7-h3 augments the inflammatory response and is associated with human sepsis.
Authors: Zhang G, Wang J, Kelly J
J. Immunol., 2010;185(6):3677-84.
Species: Human
Sample Type: Plasma

SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity.
Authors: Rutanen J, Yaluri N, Modi S, Pihlajamaki J, Vanttinen M, Itkonen P, Kainulainen S, Yamamoto H, Lagouge M, Sinclair DA, Elliott P, Westphal C, Auwerx J, Laakso M
Diabetes, 2010;59(4):829-35.
Species: Human
Sample Type: Plasma

Presence of IL-5 protein and IgE antibodies to staphylococcal enterotoxins in nasal polyps is associated with comorbid asthma.
Authors: Bachert C, Zhang N, Holtappels G, De Lobel L, Van Cauwenberge P, Liu S, Lin P, Bousquet J, Van Steen K
J. Allergy Clin. Immunol., 2010;126(5):962.
Species: Human
Sample Type: Tissue Homogenates

A novel immunomodulatory mechanism of ribavirin in suppressing natural killer cell function.
Authors: Ogbomo H, Michaelis M, Altenbrandt B, Doerr HW, Cinatl J
Biochem. Pharmacol., 2010;79(2):188-97.
Species: Human
Sample Type: Cell Culture Supernates

IL-8 dictates glycosaminoglycan binding and stability of IL-18 in cystic fibrosis.
Authors: Reeves EP, Williamson M, Byrne B, Bergin DA, Smith SG, Greally P, OKennedy R, ONeill SJ, McElvaney NG
J. Immunol., 2010;184(3):1642-52.
Species: Human
Sample Type: Serum

Interleukin-1beta, C-x-C motif ligand 10, and interferon-gamma serum levels in mixed cryoglobulinemia with or without autoimmune thyroiditis.
Authors: Antonelli A, Ferri C, Ferrari SM, De Marco S, Di Domenicantonio A, Centanni M, Pupilli C, Villa E, Menichetti F, Fallahi P
J. Interferon Cytokine Res., 2010;30(11):835-42.
Species: Human
Sample Type: Serum

Shaping of iNKT cell repertoire after unrelated cord blood transplantation.
Authors: Beziat V, Nguyen S, Exley M, Achour A, Simon T, Chevallier P, Sirvent A, Vigouroux S, Debre P, Rio B, Vieillard V, Lubrano-Berthelier C, Alatrakchi N
Clin. Immunol., 2010;135(3):364-73.
Species: Human
Sample Type: Cell Culture Supernates

Cytokine secretion by human mesenchymal stem cells cocultured with damaged corneal epithelial cells.
Authors: Oh JY, Kim MK, Shin MS, Wee WR, Lee JH
Cytokine, 2009;46(1):100-3.
Species: Human
Sample Type: Cell Culture Supernates

IL-17 in atopic eczema: linking allergen-specific adaptive and microbial-triggered innate immune response.
Authors: Eyerich K, Pennino D, Scarponi C, Foerster S, Nasorri F, Behrendt H, Ring J, Traidl-Hoffmann C, Albanesi C, Cavani A
J. Allergy Clin. Immunol., 2009;123(1):59-66.e4.
Species: Human
Sample Type: Cell Culture Supernates

Interleukin-32 promotes osteoclast differentiation but not osteoclast activation.
Authors: Mabilleau G, Sabokbar A
PLoS ONE, 2009;4(1):e4173.
Species: Human
Sample Type: Cell Culture Supernates

Arginase I-producing myeloid-derived suppressor cells in renal cell carcinoma are a subpopulation of activated granulocytes.
Authors: Rodriguez PC, Ernstoff MS, Hernandez C, Atkins M, Zabaleta J, Sierra R, Ochoa AC
Cancer Res., 2009;69(4):1553-60.
Species: Human
Sample Type: Plasma

Distinct subsets of human invariant NKT cells differentially regulate T helper responses via dendritic cells.
Authors: Liu TY, Uemura Y, Suzuki M, Narita Y, Hirata S, Ohyama H, Ishihara O, Matsushita S
Eur. J. Immunol., 2008;38(4):1012-23.
Species: Human
Sample Type: Cell Culture Supernates

Synergistic interactions between interferon-gamma and TRAIL modulate c-FLIP in endothelial cells, mediating their lineage-specific sensitivity to thrombotic thrombocytopenic purpura plasma-associated apoptosis.
Authors: Stefanescu R, Bassett D, Modarresi R, Santiago F, Fakruddin M, Laurence J
Blood, 2008;112(2):340-9.
Species: Human
Sample Type: Plasma

Mycobacterium bovis Bacillus Calmette-Guerin suppresses inflammatory Th2 responses by inducing functional alteration of TSLP-activated dendritic cells.
Authors: Yokoi T, Amakawa R, Tanijiri T, Sugimoto H, Torii Y, Amuro H, Son Y, Tajima K, Liu YJ, Ito T, Fukuhara S
Int. Immunol., 2008;20(10):1321-9.
Species: Human
Sample Type: Cell Culture Supernates

Staphylococcus aureus in nasal lavage and biopsy of patients with chronic rhinosinusitis.
Authors: Niederfuhr A, Kirsche H, Deutschle T, Poppert S, Riechelmann H, Wellinghausen N
Allergy, 2008;63(10):1359-67.
Species: Human
Sample Type: nasal lavage

An evaluation of commercial fluorescent bead-based luminex cytokine assays.
Authors: Djoba Siawaya JF, Roberts T, Babb C, Black G, Golakai HJ, Stanley K, Bapela NB, Hoal E, Parida S, van Helden P, Walzl G
PLoS ONE, 2008;3(7):e2535.
Species: Human
Sample Type: Cell Culture Supernates

Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseases.
Authors: Hartl D, Krauss-Etschmann S, Koller B, Hordijk PL, Kuijpers TW, Hoffmann F, Hector A, Eber E, Marcos V, Bittmann I, Eickelberg O, Griese M, Roos D
J. Immunol., 2008;181(11):8053-67.
Species: Human
Sample Type: BALF

CD200 is induced by ERK and is a potential therapeutic target in melanoma.
Authors: Petermann KB, Rozenberg GI, Zedek D, Groben P, McKinnon K, Buehler C, Kim WY, Shields JM, Penland S, Bear JE, Thomas NE, Serody JS, Sharpless NE
J. Clin. Invest., 2007;117(12):3922-3929.
Species: Human
Sample Type: Cell Culture Supernates

Placental growth factor down-regulates type 1 T helper immune response by modulating the function of dendritic cells.
Authors: Lin YL, Liang YC, Chiang BL
J. Leukoc. Biol., 2007;82(6):1473-80.
Species: Human
Sample Type: Cell Culture Supernates

Fucoidan ingestion increases the expression of CXCR4 on human CD34+ cells.
Authors: Irhimeh MR, Fitton JH, Lowenthal RM
Exp. Hematol., 2007;35(6):989-94.
Species: Human
Sample Type: Plasma

Impairment of human NK cell cytotoxic activity and cytokine release by cigarette smoke.
Authors: Mian MF, Lauzon NM, Stampfli MR, Mossman KL, Ashkar AA
J. Leukoc. Biol., 2007;83(3):774-84.
Species: Human
Sample Type: Cell Culture Supernates

Neuroinvasion of fluorescein-positive monocytes in acute simian immunodeficiency virus infection.
Authors: Clay CC, Rodrigues DS, Ho YS, Fallert BA, Janatpour K, Reinhart TA, Esser U
J. Virol., 2007;81(21):12040-8.
Species: Primate - Macaca mulatta (Rhesus monkey)
Sample Type: Plasma

IL-22 induces lipopolysaccharide-binding protein in hepatocytes: a potential systemic role of IL-22 in Crohn's disease.
Authors: Wolk K, Witte E, Hoffmann U, Doecke WD, Endesfelder S, Asadullah K, Sterry W, Volk HD, Wittig BM, Sabat R
J. Immunol., 2007;178(9):5973-81.
Species: Human
Sample Type: Cell Culture Supernates

1, 25 Dihydroxyvitamin D3 modulated cytokine response in pulmonary tuberculosis.
Authors: Vidyarani M, Selvaraj P, Jawahar MS, Narayanan PR
Cytokine, 2007;40(2):128-34.
Species: Human
Sample Type: Cell Culture Supernates

Translocation of bacterial DNA from Gram-positive microorganisms is associated with a species-specific inflammatory response in serum and ascitic fluid of patients with cirrhosis.
Authors: Frances R, Gonzalez-Navajas JM, Zapater P, Munoz C, Cano R, Pascual S, Santana F, Marquez D, Perez-Mateo M, Such J
Clin. Exp. Immunol., 2007;150(2):230-7.
Species: Human
Sample Type: Serum

Panel of markers can accurately predict endometriosis in a subset of patients.
Authors: Seeber B, Sammel MD, Fan X, Gerton GL, Shaunik A, Chittams J, Barnhart KT
Fertil. Steril., 2007;89(5):1073-81.
Species: Human
Sample Type: Serum

Interferon-beta and adhesion molecules (E-selectin and s-intracellular adhesion molecule-1) are detected in sera from patients with retinal vasculitis and are induced in retinal vascular endothelial cells by Toll-like receptor 3 signalling.
Authors: Lee MT, Hooper LC, Kump L, Hayashi K, Nussenblatt R, Hooks JJ, Detrick B
Clin. Exp. Immunol., 2007;147(1):71-80.
Species: Human
Sample Type: Serum

Phase 2 study of pegylated liposomal doxorubicin in combination with interleukin-12 for AIDS-related Kaposi sarcoma.
Authors: Little RF, Aleman K, Kumar P, Wyvill KM, Pluda JM, Read-Connole E, Wang V, Pittaluga S, Catanzaro AT, Steinberg SM, Yarchoan R
Blood, 2007;110(13):4165-71.
Species: Human
Sample Type: Serum

Human plasmacytoid predendritic cells activate NK cells through glucocorticoid-induced tumor necrosis factor receptor-ligand (GITRL).
Authors: Hanabuchi S, Watanabe N, Wang YH, Ito T, Shaw J, Cao W, Qin FX, Liu YJ
Blood, 2006;107(9):3617-23.
Species: Human
Sample Type: Cell Culture Supernates

The apoptotic-cell receptor CR3, but not alphavbeta5, is a regulator of human dendritic-cell immunostimulatory function.
Authors: Skoberne M, Somersan S, Almodovar W, Truong T, Petrova K, Henson PM, Bhardwaj N
Blood, 2006;108(3):947-55.
Species: Human
Sample Type: Cell Culture Supernates

Th2 cytokine response in Major Depressive Disorder patients before treatment.
Authors: Pavon L, Kiryushko D, Novitskaya V, Sandoval-Lopez G, Eugenia Hernandez M, Soroka V, Klingelhofer J, Loria F, Estrada I, Lukanidin E, Berezin V, Perez M, Moreno J, Bock E, Avila U, Leff P, Anton B, Heinze G
J. Neuroimmunol., 2006;172(1):156-65.
Species: Human
Sample Type: Serum

Human liver sinusoidal endothelial cells induce apoptosis in activated T cells: a role in tolerance induction.
Authors: Karrar A, Broome U, Uzunel M, Qureshi AR, Sumitran-Holgersson S
Gut, 2006;56(2):243-52.
Species: Human
Sample Type: Cell Culture Supernates

Human intestinal intraepithelial lymphocytes keep TNF alpha levels low by cell uptake and feedback inhibition of transcription.
Authors: Ebert EC, Mehta V
Cell. Immunol., 2006;241(1):7-13.
Species: Human
Sample Type: Cell Culture Supernates

Expression of interleukin-18 and caspase-1 in cutaneous T-cell lymphoma.
Authors: Yamanaka K, Clark R, Dowgiert R, Hurwitz D, Shibata M, Rich BE, Hirahara K, Jones DA, Eapen S, Mizutani H, Kupper TS
Clin. Cancer Res., 2006;12(2):376-82.
Species: Human
Sample Type: Plasma

Elevation of IL-12 p40 and its antibody in myasthenia gravis with thymoma.
Authors: Yoshikawa H, Sato K, Edahiro S, Furukawa Y, Maruta T, Iwasa K, Watanabe H, Takaoka S, Suzuki Y, Takamori M, Yamada M
J. Neuroimmunol., 2006;175(1):169-75.
Species: Human
Sample Type: Serum

A novel bispecific protein (ULBP2-BB4) targeting the NKG2D receptor on natural killer (NK) cells and CD138 activates NK cells and has potent antitumor activity against human multiple myeloma in vitro and in vivo.
Authors: von Strandmann EP, Hansen HP, Reiners KS, Schnell R, Borchmann P, Merkert S, Simhadri VR, Draube A, Reiser M, Purr I, Hallek M, Engert A
Blood, 2006;107(5):1955-62.
Species: Human
Sample Type: Cell Culture Supernates

Chemokines indicate allergic bronchopulmonary aspergillosis in patients with cystic fibrosis.
Authors: Hartl D, Latzin P, Zissel G, Krane M, Krauss-Etschmann S, Griese M
Am. J. Respir. Crit. Care Med., 2006;173(12):1370-6.
Species: Human
Sample Type: Serum

Over-expression of p53 mutants in LNCaP cells alters tumor growth and angiogenesis in vivo.
Authors: Perryman LA, Blair JM, Kingsley EA, Szymanska B, Ow KT, Wen VW, MacKenzie KL, Vermeulen PB, Jackson P, Russell PJ
Biochem. Biophys. Res. Commun., 2006;345(3):1207-14.
Species: Human
Sample Type: Cell Culture Supernates

IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis.
Authors: Wolk K, Witte E, Wallace E, Docke WD, Kunz S, Asadullah K, Volk HD, Sterry W, Sabat R
Eur. J. Immunol., 2006;36(5):1309-23.
Species: Human
Sample Type: Plasma

Erythropoiesis abnormalities contribute to early-onset anemia in patients with septic shock.
Authors: Claessens YE, Fontenay M, Pene F, Chiche JD, Guesnu M, Hababou C, Casadevall N, Dhainaut JF, Mira JP, Cariou A
Am. J. Respir. Crit. Care Med., 2006;174(1):51-7.
Species: Human
Sample Type: Plasma

Respiratory syncytial virus and other respiratory viruses during the first 3 months of life promote a local TH2-like response.
Authors: Kristjansson S, Bjarnarson SP, Wennergren G, Palsdottir AH, Arnadottir T, Haraldsson A, Jonsdottir I
J. Allergy Clin. Immunol., 2005;116(4):805-11.
Species: Human
Sample Type: Nasopharyngeal Secretions

Detection of interleukin 10 in cerebrospinal fluid of patients with subacute sclerosing panencephalitis.
Authors: Mistchenko AS, Fornari MC, Viegas M, Barrero PR, Diez RA
J. Neurovirol., 2005;11(1):66-9.
Species: Human
Sample Type: CSF

Cytokines and adhesion molecules in multiple sclerosis patients treated with interferon-beta1b.
Authors: Jensen J, Krakauer M, Sellebjerg F
Cytokine, 2005;29(1):24-30.
Species: Human
Sample Type: Plasma

Th2 predominance and CD8+ memory T cell depletion in patients with severe acute respiratory syndrome.
Authors: Huang JL, Huang J, Duan ZH, Wei J, Min J, Luo XH, Li JG, Tan WP, Wu LZ, Liu RY, Li Y, Shao J, Huang BJ, Zeng YX, Huang W
Microbes Infect., 2005;7(3):427-36.
Species: Human
Sample Type: Serum

Effect of piceatannol in human monocyte-derived dendritic cells in vitro.
Authors: Takei M, Umeyama A, Arihara S, Matsumoto H
J Pharm Sci, 2005;94(5):974-82.
Species: Human
Sample Type: Cell Culture Supernates

Th2 predominance and CD8+ memory T cell depletion in patients with severe acute respiratory syndrome.
Authors: Huang JL, Huang J, Duan ZH, Wei J, Min J, Luo XH, Li JG, Tan WP, Wu LZ, Liu RY, Li Y, Shao J, Huang BJ, Zeng YX, Huang W
Microbes Infect., 2005;7(3):427-36.
Species: Human
Sample Type: Serum

Specific recognition and killing of glioblastoma multiforme by interleukin 13-zetakine redirected cytolytic T cells.
Authors: Kahlon KS, Brown C, Cooper LJ, Raubitschek A, Forman SJ, Jensen MC
Cancer Res., 2004;64(24):9160-6.
Species: Human
Sample Type: Cell Culture Supernates

IL-22 increases the innate immunity of tissues.
Authors: Wolk K, Kunz S, Witte E, Friedrich M, Asadullah K, Sabat R
Immunity, 2004;21(2):241-54.
Species: Human
Sample Type: Cell Culture Supernates

A novel form of complete IL-12/IL-23 receptor beta1 deficiency with cell surface-expressed nonfunctional receptors.
Authors: Fieschi C, Bosticardo M, de Beaucoudrey L, Boisson-Dupuis S, Feinberg J, Santos OF, Bustamante J, Levy J, Candotti F, Casanova JL
Blood, 2004;104(7):2095-101.
Species: Human
Sample Type: Cell Culture Supernates

Production of interferon gamma in respiratory syncytial virus infection of humans is not associated with interleukins 12 and 18.
Authors: Garofalo RP, Hintz KH, Hill V, Ogra PL, Welliver RC
J. Med. Virol., 2004;73(2):289-94.
Species: Human
Sample Type: Nasopharyngeal Secretions

Effects of antiasthmatic agents on the functions of peripheral blood monocyte-derived dendritic cells from atopic patients.
Authors: Saeki S, Matsuse H, Kondo Y, Machida I, Kawano T, Tomari S, Obase Y, Fukushima C, Kohno S
J. Allergy Clin. Immunol., 2004;114(3):538-44.
Species: Human
Sample Type: Cell Culture Supernates

Inflammatory cytokine concentrations are elevated in seminal plasma of men with spinal cord injuries.
Authors: Basu S, Aballa TC, Ferrell SM, Lynne CM, Brackett NL
J. Androl., 2004;25(2):250-4.
Species: Human
Sample Type: seminal plasma

Cytokines evaluation in nasal lavage of allergic children after Bacillus clausii administration: a pilot study.
Authors: Ciprandi G, Tosca MA, Milanese M, Caligo G, Ricca V
Pediatr Allergy Immunol, 2004;15(2):148-51.
Species: Human
Sample Type: nasal lavage

Escape from cardiomyocyte apoptosis by enterovirus persistence due to elevated soluble Fas-receptors.
Authors: Alter P, Maisch B
Z Kardiol, 2004;93(7):524-32.
Species: Human
Sample Type: Serum

Phenotypic and functional analysis of T cells homing into the CSF of subjects with inflammatory diseases of the CNS.
Authors: Giunti D, Borsellino G, Benelli R, Marchese M, Capello E, Valle MT, Pedemonte E, Noonan D, Albini A, Bernardi G, Mancardi GL, Battistini L, Uccelli A
J. Leukoc. Biol., 2003;73(5):584-90.
Species: Human
Sample Type: Cell Culture Supernates

IL-18 receptor beta-induced changes in the presentation of IL-18 binding sites affect ligand binding and signal transduction.
Authors: Wu C, Sakorafas P, Miller R, McCarthy D, Scesney S, Dixon R, Ghayur T
J. Immunol., 2003;170(11):5571-7.
Species: Human
Sample Type: Cell Culture Supernates

In human B cells, IL-12 triggers a cascade of molecular events similar to Th1 commitment.
Authors: Durali D, de Goer de Herve MG, Giron-Michel J, Azzarone B, Delfraissy JF, Taoufik Y
Blood, 2003;102(12):4084-9.
Species: Human
Sample Type: Cell Culture Supernates

Cytokine profile in Behcet's disease patients. Relationship with disease activity.
Authors: Hamzaoui K, Hamzaoui A, Guemira F, Bessioud M, Hamza M, Ayed K
Scand. J. Rheumatol., 2002;31(4):205-10.
Species: Human
Sample Type: Serum

The significance of cytokines, chemical composition, and murine embryo development in hydrosalpinx fluid for predicting the IVF outcome in women with hydrosalpinx.
Authors: Chen CD, Yang JH, Lin KC, Chao KH, Ho HN, Yang YS
Hum. Reprod., 2002;17(1):128-33.
Species: Human
Sample Type: Hydrosalpinx Fluid

Skewing of cytotoxic activity and chemokine production, but not of chemokine receptor expression, in human type-1/-2 gamma delta T lymphocytes.
Authors: D'Ambrosio D
Eur. J. Immunol., 2002;32(10):2934-43.
Species: Human
Sample Type: Cell Culture Supernates

A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R.
Authors: Parham C, Chirica M, Timans J, Vaisberg E, Travis M, Cheung J, Pflanz S, Zhang R, Singh KP, Vega F, To W, Wagner J, O'Farrell AM, McClanahan T, Zurawski S, Hannum C, Gorman D, Rennick DM, Kastelein RA, de Waal Malefyt R, Moore KW
J. Immunol., 2002;168(11):5699-708.
Species: Human
Sample Type: Cell Culture Supernates

Fibroblasts from human spleen regulate NK cell differentiation from blood CD34(+) progenitors via cell surface IL-15.
Authors: Briard D, Brouty-Boye D, Azzarone B, Jasmin C
J. Immunol., 2002;168(9):4326-32.
Species: Human
Sample Type: Cell Culture Supernates

Intraperitoneal bispecific antibody (HEA125xOKT3) therapy inhibits malignant ascites production in advanced ovarian carcinoma.
Authors: Marme A, Strauss G, Bastert G, Grischke EM, Moldenhauer G
Int. J. Cancer, 2002;101(2):183-9.
Species: Human
Sample Type: Ascites

Chimeric co-stimulatory molecules that selectively act through CD28 or CTLA-4 on human T cells.
Authors: Lazetic S, Leong SR, Chang JC, Ong R, Dawes G, Punnonen J
J. Biol. Chem., 2002;277(41):38660-8.
Species: Human
Sample Type: Cell Culture Supernates

Cytokine pattern in blister fluid and sera of patients with pemphigus.
Authors: Baroni A, Perfetto B, Ruocco E, Greco R, Criscuolo D, Ruocco V
Dermatology (Basel), 2002;205(2):116-21.
Species: Human
Sample Type: blister fluid

An analysis of acute changes in interleukin-6 levels after treatment of hepatitis C with consensus interferon.
Authors: Cotler SJ, Reddy KR, McCone J, Wolfe DL, Liu A, Craft TR, Ferris MW, Conrad AJ, Albrecht J, Morrissey M, Ganger DR, Rosenblate H, Blatt LM, Jensen DM, Taylor MW
J. Interferon Cytokine Res., 2001;21(12):1011-9.
Species: Human
Sample Type: Serum

Modulation of human immune response by Echinococcus granulosus antigen B and its possible role in evading host defenses.
Authors: Rigano R, Profumo E, Bruschi F, Carulli G, Azzara A, Ioppolo S, Buttari B, Ortona E, Margutti P, Teggi A, Siracusano A
Infect. Immun., 2001;69(1):288-96.
Species: Human
Sample Type: Cell Culture Supernates

A cytokine-to-chemokine axis between T lymphocytes and keratinocytes can favor Th1 cell accumulation in chronic inflammatory skin diseases.
Authors: Albanesi C, Scarponi C, Sebastiani S, Cavani A, Federici M, Sozzani S, Girolomoni G
J. Leukoc. Biol., 2001;70(4):617-23.
Species: Human
Sample Type: Cell Culture Supernates

Mature dendritic cells infiltrate the T cell-rich region of oral mucosa in chronic periodontitis: in situ, in vivo, and in vitro studies.
Authors: Jotwani R, Palucka AK, Al-Quotub M, Nouri-Shirazi M, Kim J, Bell D, Banchereau J, Cutler CW
J. Immunol., 2001;167(8):4693-700.
Species: Human
Sample Type: Gingival Crevicular Fluid (GCF)

Restoration of cytotoxic T lymphocyte function in malignant pleural effusion: interleukin-15 vs. interleukin-2.
Authors: Chen YM, Ting CC, Peng JW, Yang WK, Yang KY, Tsai CM, Perng RP
J. Interferon Cytokine Res., 2000;20(1):31-9.
Species: Human
Sample Type: Pleural Effusion

Low levels of interferon-gamma in nasal fluid accompany raised levels of T-helper 2 cytokines in children with ongoing allergic rhinitis.
Authors: Benson M, Strannegard IL, Wennergren G, Strannegard O
Pediatr Allergy Immunol, 2000;11(1):20-8.
Species: Human
Sample Type: nasal lavage

Natural interferon alpha/beta-producing cells link innate and adaptive immunity.
Authors: Kadowaki N, Antonenko S, Lau JY, Liu YJ
J. Exp. Med., 2000;192(2):219-26.
Species: Human
Sample Type: Cell Culture Supernates

Cytokine profiles in parotid saliva from HIV-1-infected individuals: changes associated with opportunistic infections in the oral cavity.
Authors: Black, K P, Merrill, K W, Jackson, S, Katz, J
Oral Microbiol Immunol, 2000;15(2):74-81.
Species: Human
Sample Type: Saliva

Cytokine production in rhesus monkeys infected with Plasmodium coatneyi.
Authors: Yang C, Xiao L, Tongren JE, Sullivan J, Lal AA, Collins WE
Am. J. Trop. Med. Hyg., 1999;61(2):226-9.
Species: Primate
Sample Type: Serum

生物活性< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景IFN-gamma (Interferon-gamma) is the prototype proinflammatory cytokine and is produced by a variety of immune cells under inflammatory conditions, notably by T cells and NK cells. It plays a key role in host defense by promoting the development and activation of Th1 cells, chemoattraction and activation of monocytes and macrophages, upregulation of antigen presentation molecules, and immunoglobulin class switching in B cells. It also exhibits antiviral, antiproliferative, and apoptotic effects. In addition, IFN-gamma functions as an anti-inflammatory mediator by promoting the development of regulatory T cells and inhibiting Th17 cell differentiation. IFN-gamma dimers signal through a receptor complex of two IFN-gamma R1 and two IFN-gamma R2 subunits.
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参考文献
  • Conventional/Classical Dendritic Cells
  • Cytokines and Receptors in Allergy and Asthma
  • Cytokines and Receptors in Angiogenesis
  • Cytokines and Receptors in Tfh Cell Differentiation and Function
  • gamma delta T Cells
  • Group 1 ILCs
  • IL-10/Interferon Family
  • Infectious Diseases
  • Inflammatory Mediators
  • Isolation, Culture, and Identification of Natural Killer Cells
  • Macrophage Activation Markers
  • Molecules Secreted by VSMC
  • Multiple Sclerosis and Myelin Related Molecules
  • Myeloid-derived Suppressor Cells (MDSC)
  • Natural Killer T (NKT) Cells
  • NCR+ILC3
  • NCR-ILC3
  • Neuroinflammation
  • Regulatory T Cells (Tregs)
  • T Cell Cytokine Signaling
  • Th1 Cells