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Human IGFBP-3 Quantikine SixPak (6 Plates) (1 PK)

货号: SGB300 基本售价: 29971.6 元 规格: 1 PACK

产品信息

概述
货号SGB300
描述The Quantikine Human IGFBP-3 Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human IGFBP-3 in cell culture supernates, serum, and plasma. It contains NS0-expressed recombinant human IGFBP-3 and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human IGFBP-3 showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring human IGFBP-3.
别名acid stable subunit of the 140 K IGF complex; binding protein 29; binding protein 53; growth hormone-dependent binding protein; IBP-3; IBP3BP-53; IGF-binding protein 3; IGFBP3; IGFBP-3; insulin-like growth factor binding protein 3; insulin-like growth factor-binding protein 3;
全称
Insulin-like Growth Factor Binding Protein 3
反应种属Human
目标/特异性Natural and recombinant human IGFBP-3
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs
3486 (Human); 16009 (Mouse)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

CD44 expression in endothelial colony-forming cells regulates neurovascular trophic effect
Authors: S Sakimoto, V Marchetti, E Aguilar, K Lee, Y Usui, S Murinello, F Bucher, JK Trombley, R Fallon, R Wagey, C Peters, EL Scheppke, PD Westenskow, M Friedlande
JCI Insight, 2017;2(2):e89906.
Species: Human
Sample Type: Cell Culture Supernates

IGF1R as a Key Target in High Risk, Metastatic Medulloblastoma
Authors: Matthew N Svalina
Sci Rep, 2016;6(0):27012.
Species: Human
Sample Type: CSF

Genetic variation in IGF1 predicts renal cell carcinoma susceptibility and prognosis in Chinese population
Sci Rep, 2016;6(0):39014.
Species: Human
Sample Type: Serum

The Differential Hormonal Milieu of Morning versus Evening May Have an Impact on Muscle Hypertrophic Potential
PLoS ONE, 2016;11(9):e0161500.
Species: Human
Sample Type: Serum

Effects of exercise and milk fat globule membrane (MFGM) supplementation on body composition, physical function, and hematological parameters in community-dwelling frail Japanese women: a randomized double blind, placebo-controlled, follow-up trial.
Authors: Kim H, Suzuki T, Kim M, Kojima N, Ota N, Shimotoyodome A, Hase T, Hosoi E, Yoshida H
PLoS ONE, 2015;10(2):e0116256.
Species: Human
Sample Type: Serum

Glucose intolerance in aging male IGFBP-3 transgenic mice: differential effects of human IGFBP-3 and its mutant IGFBP-3 devoid of IGF binding ability.
Authors: Nguyen K, Yao X, Erickson A, Mishra S, Nyomba B
Endocrinology, 2015;156(2):462-74.
Species: Human
Sample Type: Serum

Role of IGF-binding protein 3 in the resistance of EGFR mutant lung cancer cells to EGFR-tyrosine kinase inhibitors.
Authors: Choi Y, Park G, Rho J, Kim S, So G, Kim H, Choi C, Lee J
PLoS ONE, 2013;8(12):e81393.
Species: Human
Sample Type: Cell Culture Supernates

Role of serum concentration of VEGFR1 and TIMP2 on clinical outcome in primary cervical cancer: results of a companion protocol of the randomized, NOGGO-AGO phase III adjuvant trial of simultaneous cisplatin-based radiochemotherapy vs. carboplatin and paclitaxel containing sequential radiotherapy.
Authors: Braicu E, Fotopoulou C, Chekerov R, Richter R, Blohmer J, Kummel S, Stamatian F, Yalcinkaya I, Mentze M, Lichtenegger W, Sehouli J
Cytokine, 2013;61(3):755-8.
Species: Human
Sample Type: Serum

Maternal and fetal placental growth hormone and IGF axis in type 1 diabetic pregnancy.
Authors: Higgins MF, Russell NE, Crossey PA, Nyhan KC, Brazil DP, McAuliffe FM
PLoS ONE, 2012;7(2):e29164.
Species: Human
Sample Type: Plasma

Plasminogen activator inhibitor 1--insulin-like growth factor binding protein 3 cascade regulates stress-induced senescence.
Authors: Elzi, David J, Lai, Yanlai, Song, Meihua, Hakala, Kevin, Weintraub, Susan T, Shiio, Yuzuru
Proc Natl Acad Sci U S A, 2012;109(30):12052-7.
Species: Human
Sample Type: Cell Culture Supernates

FOXA1 promotes tumor progression in prostate cancer via the insulin-like growth factor binding protein 3 pathway.
Authors: Imamura, Yusuke, Sakamoto, Shinichi, Endo, Takumi, Utsumi, Takanobu, Fuse, Miki, Suyama, Takahito, Kawamura, Koji, Imamoto, Takashi, Yano, Kojiro, Uzawa, Katsuhir, Nihei, Naoki, Suzuki, Hiroyosh, Mizokami, Atsushi, Ueda, Takeshi, Seki, Naohiko, Tanzawa, Hideki, Ichikawa, Tomohiko
PLoS ONE, 2012;7(8):e42456.
Species: Human
Sample Type: Cell Culture Supernates

Administration of omega-3 fatty acids and Raloxifene to women at high risk of breast cancer: interim feasibility and biomarkers analysis from a clinical trial.
Eur J Clin Nutr, 2012;66(8):878-84.
Species: Human
Sample Type: Serum

Benefits of recombinant adeno-associated virus (rAAV)-mediated insulinlike growth factor I (IGF-I) overexpression for the long-term reconstruction of human osteoarthritic cartilage by modulation of the IGF-I axis.
Authors: Weimer A, Madry H, Venkatesan JK
Mol. Med., 2012;18(1):346-58.
Species: Human
Sample Type: Cell Culture Supernates

Prognostic significance of angiogenic factors in uterine cervical cancer.
Authors: Landt S, Wehling M, Heidecke H, Jeschke S, Korlach S, Stoblen F, Schmid P, Blohmer JU, Lichtenegger W, Sehouli J, Kummel S
Anticancer Res., 2011;31(8):2589-95.
Species: Human
Sample Type: Serum

The stature of boys is inversely correlated to the levels of their sertoli cell hormones: do the testes restrain the maturation of boys?
Authors: Morgan K, Dennis NA, Ruffman T, Bilkey DK, McLennan IS
PLoS ONE, 2011;6(6):e20533.
Species: Human
Sample Type: Serum

Biological effects induced by insulin-like growth factor binding protein 3 (IGFBP-3) in malignant melanoma.
Authors: Oy GF, Slipicevic A, Davidson B, Solberg Faye R, Maelandsmo GM, Florenes VA
Int. J. Cancer, 2010;126(2):350-61.
Species: Human
Sample Type: Plasma

Abnormalities in metalloproteinase pathways and IGF-I axis: a link between birth weight, hypertension, and vascular damage in childhood.
Authors: Sesso R, Franco MC
Am. J. Hypertens., 2010;23(1):6-11.
Species: Human
Sample Type: Plasma

Grape seed proanthocyanidins inhibit the growth of human non-small cell lung cancer xenografts by targeting insulin-like growth factor binding protein-3, tumor cell proliferation, and angiogenic factors.
Authors: Akhtar S, Meeran SM, Katiyar N, Katiyar SK
Clin. Cancer Res., 2009;15(3):821-31.
Species: Human
Sample Type: Plasma

Role of insulin-like growth factor binding protein-3 in allergic airway remodeling.
Authors: Veraldi KL, Gibson BT, Yasuoka H, Myerburg MM, Kelly EA, Balzar S, Jarjour NN, Pilewski JM, Wenzel SE, Feghali-Bostwick CA
Am. J. Respir. Crit. Care Med., 2009;180(7):611-7.
Species: Human
Sample Type: BALF

Clinical pharmacodynamic effects of the growth hormone receptor antagonist pegvisomant: implications for cancer therapy.
Authors: Yin D, Vreeland F, Schaaf LJ, Millham R, Duncan BA, Sharma A
Clin. Cancer Res., 2007;13(3):1000-9.
Species: Human
Sample Type: Plasma

Serum insulin-like growth factor I (IGF-I) and IGF-binding protein 3 (IGFBP-3) in IVF patients with polycystic ovary syndrome: correlations with outcome.
Authors: Schoyer KD, Liu HC, Witkin S, Rosenwaks Z, Spandorfer SD
Fertil. Steril., 2007;88(1):139-44.
Species: Human
Sample Type: Serum

Insulin-like growth factor-II (IGF-II), IGF-binding protein-3 (IGFBP-3), and IGFBP-4 in follicular fluid are associated with oocyte maturation and embryo development.
Authors: Wang TH, Chang CL, Wu HM, Chiu YM, Chen CK, Wang HS
Fertil. Steril., 2006;86(5):1392-401.
Species: Human
Sample Type: Follicular Fluid

生物活性< 0.5% cross-reactivity observed with available related molecules.Cross-species reactivity not tested.
背景The superfamily of insulin-like growth factor (IGF) binding proteins include the six high-affinity IGF binding proteins (IGFBP) and at least four additional low-affinity binding proteins referred to as IGFBP related proteins (IGFBP-rP). All IGFBP superfamily members are cysteine-rich proteins with conserved cysteine residues, which are clustered in the amino- and carboxy-terminal thirds of the molecule. IGFBPs modulate the biological activities of IGF proteins. Some IGFBPs may also have intrinsic bioactivity that is independent of their ability to bind IGF proteins. Post-translational modifications of IGFBP, including glycosylation, phosphorylation and proteolysis, have been shown to modify the affinities of the binding proteins to IGF. ALS (Acid Labile Subunit) is a liver-derived protein that exists in a ternary complex with Insulin-like Growth Factor (IGF)-binding Protein-3 (IGFBP-3) or IGFBP-5, and either IGF-I or IGF-II. ALS increases the half-life of IGF/IGFBP complexes in circulation.
运输条件Blue Ice
存放说明4℃
参考文献
  • Cancer Biomarkers
  • HIF Transcription Factors
  • IGF Family
  • Metabolic Peptide Hormones and Regulators
  • Osteoblast and Osteoclast Markers
  • Osteoblast Markers
  • Osteogenesis Markers