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Human IGF-I Quantikine SixPak (6 Plates) (1 PK)

货号: SG100 基本售价: 29971.6 元 规格: 1 PACK

产品信息

概述
货号SG100
描述The Quantikine Human IGF-I Immunoassay is a 3.5 hour solid-phase ELISA designed to measure human IGF-I in cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant human IGF-I and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human IGF-I showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally expressed IGF-I.
别名IBP1; IGF1; IGF-1; IGF1A; IGFI; IGF-I; IGF-IA; IGF-IB; insulin-like growth factor 1 (somatomedin C); insulin-like growth factor 1; insulin-like growth factor I; insulin-like growth factor IA; insulin-like growth factor IB; Mechano growth factor; MGF; Somatomedin A; Somatomedin C; somatomedin-C;
全称
Insulin-like Growth Factor I
反应种属Human
目标/特异性Natural and recombinant human IGF-I
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs
3479 (Human); 16000 (Mouse); 24482 (Rat)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Evaluation of Not-Activated and Activated PRP in Hair Loss Treatment: Role of Growth Factor and Cytokine Concentrations Obtained by Different Collection Systems
Authors: P Gentile, JP Cole, MA Cole, S Garcovich, A Bielli, MG Scioli, A Orlandi, C Insalaco, V Cervelli
Int J Mol Sci, 2017;18(2):.
Species: Human
Sample Type: Plasma

Metformin inhibits the proliferation of benign prostatic epithelial cells
Authors: Z Wang, X Xiao, R Ge, J Li, CW Johnson, C Rassoulian, AF Olumi
PLoS ONE, 2017;12(3):e0173335.
Species: Human
Sample Type: Cell Culture Supernates

IGF1R as a Key Target in High Risk, Metastatic Medulloblastoma
Authors: Matthew N Svalina
Sci Rep, 2016;6(0):27012.
Species: Human
Sample Type: CSF

The tobacco-specific carcinogen-operated calcium channel promotes lung tumorigenesis via IGF2 exocytosis in lung epithelial cells
Nat Commun, 2016;7(0):12961.
Species: Human
Sample Type: Cell Culture Supernates

Neovascularization Potential of Blood Outgrowth Endothelial Cells From Patients With Stable Ischemic Heart Failure Is Preserved
Authors: D Dauwe, B Pelacho, A Wibowo, AS Walravens, K Verdonck, H Gillijns, E Caluwe, P Pokreisz, N van Gastel, G Carmeliet, M Depypere, F Maes, N Vanden Dri, W Droogne, J Van Cleemp, J Vanhaecke, F Prosper, C Verfaillie, A Luttun, S Janssens
J Am Heart Assoc, 2016;5(4):.
Species: Human
Sample Type: Cell Culture Supernates

Impact of Hyperglycemia and Low Oxygen Tension on Adipose-Derived Stem Cells Compared with Dermal Fibroblasts and Keratinocytes: Importance for Wound Healing in Type 2 Diabetes
PLoS ONE, 2016;11(12):e0168058.
Species: Human
Sample Type: Cell Culture Supernates

A preliminary study of pamidronic acid downregulation of angiogenic factors IGF-1/PECAM-1 expression in circulating level in bone metastatic breast cancer patients
Authors: Zeng Wang
Onco Targets Ther, 2016;9(0):3147-52.
Species: Human
Sample Type: Serum

Adipose-derived mesenchymal stem cells from patients with atherosclerotic renovascular disease have increased DNA damage and reduced angiogenesis that can be modified by hypoxia
Stem Cell Res Ther, 2016;7(1):128.
Species: Human
Sample Type: Cell Culture Supernates

Genetic variation in IGF1 predicts renal cell carcinoma susceptibility and prognosis in Chinese population
Sci Rep, 2016;6(0):39014.
Species: Human
Sample Type: Serum

LMP1 promotes expression of insulin-like growth factor 1 (IGF1) to selectively activate IGF1 receptor and drive cell proliferation.
Authors: Tworkoski K, Raab-Traub N
J Virol, 2015;89(5):2590-602.
Species: Human
Sample Type: Cell Culture Supernates

Effects of exercise and milk fat globule membrane (MFGM) supplementation on body composition, physical function, and hematological parameters in community-dwelling frail Japanese women: a randomized double blind, placebo-controlled, follow-up trial.
Authors: Kim H, Suzuki T, Kim M, Kojima N, Ota N, Shimotoyodome A, Hase T, Hosoi E, Yoshida H
PLoS ONE, 2015;10(2):e0116256.
Species: Human
Sample Type: Serum

Implantation of rAAV5-IGF-I transduced autologous chondrocytes improves cartilage repair in full-thickness defects in the equine model.
Authors: Ortved K, Begum L, Mohammed H, Nixon A
Mol Ther, 2015;23(2):363-73.
Species: Equine
Sample Type: Synovial Fluid

A randomized phase II presurgical trial of transdermal 4-hydroxytamoxifen gel versus oral tamoxifen in women with ductal carcinoma in situ of the breast.
Authors: Lee O, Page K, Ivancic D, Helenowski I, Parini V, Sullivan M, Margenthaler J, Chatterton R, Jovanovic B, Dunn B, Heckman-Stoddard B, Foster K, Muzzio M, Shklovskaya J, Skripkauskas S, Kulesza P, Green D, Hansen N, Bethke K, Jeruss J, Bergan R, Khan S
Clin Cancer Res, 2014;20(14):3672-82.
Species: Human
Sample Type: Plasma

Overexpression of human IGF-I via direct rAAV-mediated gene transfer improves the early repair of articular cartilage defects in vivo.
Authors: Cucchiarini M, Madry H
Gene Ther, 2014;21(9):811-9.
Species: Human
Sample Type: Cell Culture Supernates

Functional and differential proteomic analyses to identify platelet derived factors affecting ex vivo expansion of mesenchymal stromal cells.
Authors: Kinzebach S, Dietz L, Kluter H, Thierse H, Bieback K
BMC Cell Biol, 2013;14(0):48.
Species: Human
Sample Type: Cell Culture Supernates

Arsenic exposure affects plasma insulin-like growth factor 1 (IGF-1) in children in rural Bangladesh.
Authors: Ahmed S, Rekha R, Ahsan K, Doi M, Grander M, Roy A, Ekstrom E, Wagatsuma Y, Vahter M, Raqib R
PLoS ONE, 2013;8(11):e81530.
Species: Human
Sample Type: Plasma

Human bone marrow-derived mesenchymal stem cells suppress human glioma growth through inhibition of angiogenesis.
Authors: Ho I, Toh H, Ng W, Teo Y, Guo C, Hui K, Lam P
Stem Cells, 2013;31(1):146-55.
Species: Human
Sample Type: Tissue Lysate

Role of serum concentration of VEGFR1 and TIMP2 on clinical outcome in primary cervical cancer: results of a companion protocol of the randomized, NOGGO-AGO phase III adjuvant trial of simultaneous cisplatin-based radiochemotherapy vs. carboplatin and paclitaxel containing sequential radiotherapy.
Authors: Braicu E, Fotopoulou C, Chekerov R, Richter R, Blohmer J, Kummel S, Stamatian F, Yalcinkaya I, Mentze M, Lichtenegger W, Sehouli J
Cytokine, 2013;61(3):755-8.
Species: Human
Sample Type: Serum

Maternal and fetal placental growth hormone and IGF axis in type 1 diabetic pregnancy.
Authors: Higgins MF, Russell NE, Crossey PA, Nyhan KC, Brazil DP, McAuliffe FM
PLoS ONE, 2012;7(2):e29164.
Species: Human
Sample Type: Plasma

Benefits of recombinant adeno-associated virus (rAAV)-mediated insulinlike growth factor I (IGF-I) overexpression for the long-term reconstruction of human osteoarthritic cartilage by modulation of the IGF-I axis.
Authors: Weimer A, Madry H, Venkatesan JK
Mol. Med., 2012;18(1):346-58.
Species: Human
Sample Type: Cell Culture Supernates

Inflammation associated with obesity: relationship with blood and bone marrow endothelial cells.
Authors: McGuire TR, Brusnahan SK, Bilek LD, Jackson JD, Kessinger MA, Berger AM, Garvin KL, OKane BJ, Tuljapurkar SR, Sharp JG
Obesity (Silver Spring), 2011;19(11):2130-6.
Species: Human
Sample Type: Plasma

Association of angiopoietin-2, C-reactive protein and markers of obesity and insulin resistance with survival outcome in colorectal cancer.
Authors: Volkova E, Willis JA, Wells JE, Robinson BA, Dachs GU, Currie MJ
Br. J. Cancer, 2011;104(1):51-9.
Species: Human
Sample Type: Serum

The stature of boys is inversely correlated to the levels of their sertoli cell hormones: do the testes restrain the maturation of boys?
Authors: Morgan K, Dennis NA, Ruffman T, Bilkey DK, McLennan IS
PLoS ONE, 2011;6(6):e20533.
Species: Human
Sample Type: Serum

Expansion of human cardiac stem cells in physiological oxygen improves cell production efficiency and potency for myocardial repair.
Authors: Li TS, Cheng K, Malliaras K, Matsushita N, Sun B, Marban L, Zhang Y, Marban E
Cardiovasc. Res., 2011;89(1):157-65.
Species: Human
Sample Type: Cell Culture Supernates

Prognostic significance of angiogenic factors in uterine cervical cancer.
Authors: Landt S, Wehling M, Heidecke H, Jeschke S, Korlach S, Stoblen F, Schmid P, Blohmer JU, Lichtenegger W, Sehouli J, Kummel S
Anticancer Res., 2011;31(8):2589-95.
Species: Human
Sample Type: Serum

Alternatives to the use of fetal bovine serum: human platelet lysates as a serum substitute in cell culture media.
Authors: Rauch C, Feifel E, Amann EM, Spotl HP, Schennach H, Pfaller W, Gstraunthaler G
ALTEX, 2011;28(4):305-16.
Species: Human
Sample Type: Cell Lysates

Abnormalities in metalloproteinase pathways and IGF-I axis: a link between birth weight, hypertension, and vascular damage in childhood.
Authors: Sesso R, Franco MC
Am. J. Hypertens., 2010;23(1):6-11.
Species: Human
Sample Type: Plasma

Hyperactivation of the insulin-like growth factor receptor I signaling pathway is an essential event for cisplatin resistance of ovarian cancer cells.
Authors: Eckstein N, Servan K, Hildebrandt B, Politz A, von Jonquieres G, Wolf-Kummeth S, Napierski I, Hamacher A, Kassack MU, Budczies J, Beier M, Dietel M, Royer-Pokora B, Denkert C, Royer HD
Cancer Res., 2009;69(7):2996-3003.
Species: Human
Sample Type: Cell Culture Supernates

Insulin-like growth factor-1 and neurotrophin-3 gene therapy prevents motor decline in an X-linked adrenoleukodystrophy mouse model.
Authors: Mastroeni R, Bensadoun JC, Charvin D, Aebischer P, Pujol A, Raoul C
Ann. Neurol., 2009;66(1):117-22.
Species: Human
Sample Type: CSF

Isolation and characterization of CD146+ multipotent mesenchymal stromal cells.
Authors: Sorrentino A, Ferracin M, Castelli G, Biffoni M, Tomaselli G, Baiocchi M, Fatica A, Negrini M, Peschle C, Valtieri M
Exp. Hematol., 2008;36(8):1035-46.
Species: Human
Sample Type: Cell Culture Supernates

Identification of transforming growth factor beta1-driven genetic programs of acute lung fibrosis.
Authors: Pulichino AM, Wang IM, Caron A, Mortimer J, Auger A, Boie Y, Elias JA, Kartono A, Xu L, Menetski J, Sayegh CE
Am. J. Respir. Cell Mol. Biol., 2008;39(3):324-36.
Species: Human
Sample Type: BALF

cAMP/PKA pathway activation in human mesenchymal stem cells in vitro results in robust bone formation in vivo.
Authors: Siddappa R, Martens A, Doorn J, Leusink A, Olivo C, Licht R, van Rijn L, Gaspar C, Fodde R, Janssen F, van Blitterswijk C, de Boer J
Proc. Natl. Acad. Sci. U.S.A., 2008;105(20):7281-6.
Species: Human
Sample Type: Cell Culture Supernates

Insulin-like growth factor-1 improves survival in sepsis via enhanced hepatic bacterial clearance.
Authors: Ashare A, Nymon AB, Doerschug KC, Morrison JM, Monick MM, Hunninghake GW
Am. J. Respir. Crit. Care Med., 2008;178(2):149-57.
Species: Human
Sample Type: Serum

Serum concentrations of insulin-like growth factor-I (igf-I) as a marker of liver fibrosis in patients with chronic hepatitis C.
Authors: Lorenzo-Zuniga V, Bartoli R, Masnou H, Montoliu S, Morillas RM, Planas R
Dig. Dis. Sci., 2007;52(11):3245-50.
Species: Human
Sample Type: Serum

Peripheral elevation of IGF-1 fails to alter Abeta clearance in multiple in vivo models.
Authors: Lanz TA, Salatto CT, Semproni AR, Marconi M, Brown TM, Richter KE, Schmidt K, Nelson FR, Schachter JB
Biochem. Pharmacol., 2007;75(5):1093-103.
Species: Canine
Sample Type: Plasma

Clinical pharmacodynamic effects of the growth hormone receptor antagonist pegvisomant: implications for cancer therapy.
Authors: Yin D, Vreeland F, Schaaf LJ, Millham R, Duncan BA, Sharma A
Clin. Cancer Res., 2007;13(3):1000-9.
Species: Human
Sample Type: Plasma

Serum insulin-like growth factor I (IGF-I) and IGF-binding protein 3 (IGFBP-3) in IVF patients with polycystic ovary syndrome: correlations with outcome.
Authors: Schoyer KD, Liu HC, Witkin S, Rosenwaks Z, Spandorfer SD
Fertil. Steril., 2007;88(1):139-44.
Species: Human
Sample Type: Serum

The levels of steroid hormones and cytokines in individual follicles are not associated with the fertilization outcome after intracytoplasmic sperm injection.
Authors: Asimakopoulos B, Abu-Hassan D, Metzen E, Al-Hasani S, Diedrich K, Nikolettos N
Fertil. Steril., 2007;90(1):60-4.
Species: Human
Sample Type: Follicular Fluid

Muscle atrophy and hypertrophy signaling in patients with chronic obstructive pulmonary disease.
Authors: Doucet M, Russell AP, Leger B, Debigare R, Joanisse DR, Caron MA, LeBlanc P, Maltais F
Am. J. Respir. Crit. Care Med., 2007;176(3):261-9.
Species: Human
Sample Type: Plasma

Insulin-like growth factor-II (IGF-II), IGF-binding protein-3 (IGFBP-3), and IGFBP-4 in follicular fluid are associated with oocyte maturation and embryo development.
Authors: Wang TH, Chang CL, Wu HM, Chiu YM, Chen CK, Wang HS
Fertil. Steril., 2006;86(5):1392-401.
Species: Human
Sample Type: Follicular Fluid

Insulin-like growth factor binding protein-4 (IGFBP-4) is a novel anti-angiogenic and anti-tumorigenic mediator secreted by dibutyryl cyclic AMP (dB-cAMP)-differentiated glioblastoma cells.
Authors: Moreno MJ, Ball M, Andrade MF, McDermid A, Stanimirovic DB
Glia, 2006;53(8):845-57.
Species: Human
Sample Type: Cell Culture Supernates

Quantitative assessment of growth factors in reaming aspirate, iliac crest, and platelet preparation.
Authors: Herrmann S, Green J, Weber T, Scharfenberger A
Bone, 2006;39(5):1156-63.
Species: Human
Sample Type: Tissue Homogenates

Growth hormone-induced stimulation of multilineage human hematopoiesis.
Authors: Hanley MB, Napolitano LA, McCune JM
Stem Cells, 2005;23(8):1170-9.
Species: Human
Sample Type: Cell Culture Supernates

Measurement of bone morphogenetic proteins and other growth factors in demineralized bone matrix.
Authors: Blum B, Moseley J, Miller L, Richelsoph K, Haggard W
Orthopedics, 2004;27(1):161-5.

Dose response of bone mass to dietary arachidonic acid in piglets fed cow milk-based formula.
Authors: Blanaru JL, Kohut JR, Fitzpatrick-Wong SC, Weiler HA
Am. J. Clin. Nutr., 2004;79(1):139-47.
Species: Porcine
Sample Type: Plasma

Insulin growth factor-1 protects against excitotoxicity in the rat striatum.
Authors: Escartin C, Boyer F, Bemelmans AP, Hantraye P, Brouillet E
Neuroreport, 2004;15(14):2251-4.
Species: Human
Sample Type: recombinant IGF-I

生物活性< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景

Insulin-like growth factor (IGF)-I (also known as somatomedin C and somatomedin A) and IGF-II (multiplication stimulating activity or MSA) belong to the family of insulin-like growth factors that are structurally homologous to proinsulin. Mature IGF-I and IGF-II share approximately 70% sequence identity. Both IGF-I and IGF-II are expressed in many tissues and cell types and may have autocrine, paracrine and endocrine functions. Mature IGF-I and IGF-II are highly conserved between the human, bovine and porcine proteins (100% identity), and exhibit cross-species activity.

The IGFL (insulin-like growth factor-like) family includes four small (~11 kDa), probably secreted family members in humans and one in mouse. This family shares A and B chain cysteine motifs with the IGF superfamily, and has an additional cysteine motif within an uncleaved region corresponding to the C peptide of the IGF family.

运输条件Blue Ice
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参考文献
  • ALS Related Molecules
  • Cancer Biomarkers
  • Cytokines in Lipid/Cholesterol Metabolism
  • Diabetes and Obesity Research
  • Endocrine Regulation of Lipid Metabolism
  • gamma delta T Cells
  • Glucose Homeostasis
  • IGF Family
  • IGF Ligands
  • Insulin-like Growth Factor (IGF) and Receptors
  • Metabolic Peptide Hormones and Regulators
  • Preeclampsia
  • Protein/Peptide Hormones and Regulators
  • Reproduction