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Human C-Reactive Protein/CRP Quantikine SixPak (6 Plates) (1 PK)

货号: SCRP00 基本售价: 29971.6 元 规格: 1 PACK

产品信息

概述
货号SCRP00
描述The Quantikine Human CRP Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human CRP in cell culture supernates, serum, and plasma. It contains NS0-expressed recombinant human CRP and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human CRP showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring human CRP.
别名C-Reactive Protein; C-reactive protein, pentraxin-related; CRP; MGC88244; pentraxin 1; PTX1MGC149895;
反应种属Human
目标/特异性Natural and recombinant human CRP
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs
1401 (Human); 12944 (Mouse); 25419 (Rat)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Link between plasminogen activator inhibitor-1 and cardiovascular risk in chronic hepatitis C after viral clearance
Authors: ML Chang, YS Lin, LH Pao, HC Huang, CT Chiu
Sci Rep, 2017;7(0):42503.
Species: Human
Sample Type: Serum

Circadian variations in clinical symptoms and concentrations of inflammatory cytokines, melatonin, and cortisol in polymyalgia rheumatica before and during prednisolone treatment: a controlled, observational, clinical experimental study
Arthritis Res Ther, 2016;18(1):174.
Species: Human
Sample Type: Plasma

Immunogenic FEAT protein circulates in the bloodstream of cancer patients
J Transl Med, 2016;14(1):275.
Species: Human
Sample Type: Plasma

Effects of nateglinide and rosiglitazone on pancreatic alpha- and beta-cells, GLP-1 secretion and inflammatory markers in patients with type 2 diabetes: randomized crossover clinical study.
Authors: Tostes G, Cunha M, Fukui R, Correia M, Rocha D, Dos Santos R, da Silva M
Diabetol Metab Syndr, 2016;8(0):1.
Species: Human
Sample Type: Serum

P2X7 Receptor Inhibition Improves CD34 T-Cell Differentiation in HIV-Infected Immunological Nonresponders on c-ART
Authors: I Menkova-Ga, H Hocini, E Foucat, P Tisserand, L Bourdery, C Delaugerre, C Benne, Y Lévy, JD Lelièvre
PLoS Pathog, 2016;12(4):e1005571.
Species: Human
Sample Type: Plasma

C-reactive protein (CRP), interferon gamma-inducible protein 10 (IP-10), and lipopolysaccharide (LPS) are associated with risk of tuberculosis after initiation of antiretroviral therapy in resource-limited settings.
Authors: Tenforde M, Gupte N, Dowdy D, Asmuth D, Balagopal A, Pollard R, Sugandhavesa P, Lama J, Pillay S, Cardoso S, Pawar J, Santos B, Riviere C, Mwelase N, Kanyama C, Kumwenda J, Hakim J, Kumarasamy N, Bollinger R, Semba R, Campbell T, Gupta A
PLoS ONE, 2015;10(2):e0117424.
Species: Human
Sample Type: Plasma

Serum levels of inflammatory markers in depressed elderly patients with diabetes and mild cognitive impairment.
Authors: Gorska-Ciebiada M, Saryusz-Wolska M, Borkowska A, Ciebiada M, Loba J
PLoS ONE, 2015;10(3):e0120433.
Species: Human
Sample Type: Serum

Number of sons contributes to ageing-associated inflammation.
Authors: Marttila S, Nevalainen T, Kananen L, Jylhava J, Jylha M, Hervonen A, Ilonen J, Hurme M
Sci Rep, 2015;5(0):8631.
Species: Human
Sample Type: Plasma

Plasma sCD14 as a biomarker to predict pulmonary exacerbations in cystic fibrosis.
Authors: Quon B, Ngan D, Wilcox P, Man S, Sin D
PLoS ONE, 2014;9(2):e89341.
Species: Human
Sample Type: Plasma

The expression of cytokines and chemokines in the blood of patients with severe weight loss from anorexia nervosa: an exploratory study.
Authors: Pisetsky D, Trace S, Brownley K, Hamer R, Zucker N, Roux-Lombard P, Dayer J, Bulik C
Cytokine, 2014;69(1):110-5.
Species: Human
Sample Type: Cell Culture Supernates

Prognostic value of a quantitative analysis of lipoarabinomannan in urine from patients with HIV-associated tuberculosis.
Authors: Kerkhoff A, Wood R, Vogt M, Lawn S
, 2014;0(0):.
Species: Human
Sample Type: Serum

Plasma level of cyclophilin A is increased in patients with type 2 diabetes mellitus and suggests presence of vascular disease.
Authors: Ramachandran S, Venugopal A, Kutty V, A V, G D, Chitrasree V, Mullassari A, Pratapchandran N, Santosh K, Pillai M, Kartha C
Cardiovasc Diabetol, 2014;13(0):38.
Species: Human
Sample Type: Plasma

HIV-associated tuberculosis: relationship between disease severity and the sensitivity of new sputum-based and urine-based diagnostic assays.
Authors: Lawn S, Kerkhoff A, Vogt M, Wood R
BMC Med, 2013;11(0):231.
Species: Human
Sample Type: Serum

Influence of interleukin-4 gene polymorphisms and interleukin-4 serum level on susceptibility and severity of rheumatoid arthritis in Egyptian population.
Authors: Hussein Y, El-Shal A, Rezk N, Abdel Galil S, Alzahrani S
Cytokine, 2013;61(3):849-55.
Species: Human
Sample Type: Serum

Characterization of the role of distinct plasma cell-free DNA species in age-associated inflammation and frailty.
Authors: Jylhava J, Nevalainen T, Marttila S, Jylha M, Hervonen A, Hurme M
Aging Cell, 2013;12(3):388-97.

Shared monocyte subset phenotypes in HIV-1 infection and in uninfected subjects with acute coronary syndrome.
Authors: Funderburg, Nicholas, Zidar, David A, Shive, Carey, Lioi, Anthony, Mudd, Joseph, Musselwhite, Laura W, Simon, Daniel I, Costa, Marco A, Rodriguez, Benigno, Sieg, Scott F, Lederman, Michael
Blood, 2012;120(23):4599-608.
Species: Human
Sample Type: Plasma

Prolonged neutrophil dysfunction after Plasmodium falciparum malaria is related to hemolysis and heme oxygenase-1 induction.
Authors: Cunnington, Aubrey J, Njie, Madi, Correa, Simon, Takem, Ebako N, Riley, Eleanor, Walther, Michael
J Immunol, 2012;189(11):5336-46.
Species: Human
Sample Type: Plasma

The relationship of systemic inflammation to prior hospitalization in adult patients with cystic fibrosis.
Authors: Ngan D, Wilcox P, Aldaabil M, Li Y, Leipsic J, Sin D, Man S
BMC Pulm Med, 2012;12(0):3.
Species: Human
Sample Type: Plasma

Elevated serum adipocyte fatty acid-binding protein concentrations are independently associated with renal dysfunction in patients with stable angina pectoris.
Authors: Iwamoto M, Miyoshi T, Doi M
Cardiovasc Diabetol, 2012;11(0):26.
Species: Human
Sample Type: Serum

Cortisol responses to mental stress and the progression of coronary artery calcification in healthy men and women.
Authors: Hamer M, Endrighi R, Venuraju SM, Lahiri A, Steptoe A
PLoS ONE, 2012;7(2):e31356.
Species: Human
Sample Type: Serum

Validation and quality control of ELISAs for the use with human saliva samples.
Authors: Jaedicke KM, Taylor JJ, Preshaw PM
J. Immunol. Methods, 2012;377(1):62-5.
Species: Human
Sample Type: Saliva

Plasma desmoplakin I biomarker of vascular recurrence after ischemic stroke.
Authors: Lopez-Farre AJ, Zamorano-Leon JJ, Segura A, Mateos-Caceres PJ, Modrego J, Rodriguez-Sierra P, Calatrava L, Tamargo J, Macaya C
J. Neurochem., 2012;121(2):314-25.
Species: Human
Sample Type: Plasma

Comparison of acute versus convalescent stage high-sensitivity C-Reactive protein level in predicting clinical outcome after acute ischemic stroke and impact of erythropoietin.
Authors: Yeh KH, Tsai TH, Chai HT, Leu S, Chung SY, Chua S, Chen YL, Lin HS, Yuen CM, Yip HK
J Transl Med, 2012;10(0):6.
Species: Human
Sample Type: Serum

Inflammation associated with obesity: relationship with blood and bone marrow endothelial cells.
Authors: McGuire TR, Brusnahan SK, Bilek LD, Jackson JD, Kessinger MA, Berger AM, Garvin KL, OKane BJ, Tuljapurkar SR, Sharp JG
Obesity (Silver Spring), 2011;19(11):2130-6.
Species: Human
Sample Type: Plasma

Association of angiopoietin-2, C-reactive protein and markers of obesity and insulin resistance with survival outcome in colorectal cancer.
Authors: Volkova E, Willis JA, Wells JE, Robinson BA, Dachs GU, Currie MJ
Br. J. Cancer, 2011;104(1):51-9.
Species: Human
Sample Type: Serum

Folic acid treatment normalizes NOS-dependence of vascular tone in the metabolic syndrome.
Authors: Schneider MP, Schlaich MP, Harazny JM, Raff U, Ritt M, Ott C, Schmieder RE
Obesity (Silver Spring), 2011;19(5):960-7.
Species: Human
Sample Type: Serum

Time-course of changes in inflammatory response after whole-body cryotherapy multi exposures following severe exercise.
Authors: Pournot H, Bieuzen F, Louis J, Fillard JR, Barbiche E, Hausswirth C
PLoS ONE, 2011;6(7):e22748.
Species: Human
Sample Type: Plasma

Increased prevalence of albuminuria in HIV-infected adults with diabetes.
Authors: Kim PS, Woods C, Dutcher L, Georgoff P, Rosenberg A, Mican JA, Kopp JB, Smith MA, Hadigan C
PLoS ONE, 2011;6(9):e24610.
Species: Human
Sample Type: Serum

C-reactive protein promotes acute renal inflammation and fibrosis in unilateral ureteral obstructive nephropathy in mice.
Authors: Li ZI, Chung AC, Zhou L, Huang XR, Liu F, Fu P, Fan JM, Szalai AJ, Lan HY
Lab. Invest., 2011;91(6):837-51.
Species: Human CRP transgenic mouse
Sample Type: Serum

C-reactive protein promotes diabetic kidney disease in a mouse model of type 1 diabetes.
Authors: Liu F, Chen HY, Huang XR, Chung AC, Zhou L, Fu P, Szalai AJ, Lan HY
Diabetologia, 2011;54(10):2713-23.
Species: Human
Sample Type: Cell Culture Supernates

Effect of intensive lifestyle changes on endothelial function and on inflammatory markers of atherosclerosis.
Authors: Dod HS, Bhardwaj R, Sajja V, Weidner G, Hobbs GR, Konat GW, Manivannan S, Gharib W, Warden BE, Nanda NC, Beto RJ, Ornish D, Jain AC
Am. J. Cardiol., 2010;105(3):362-7.
Species: Human
Sample Type: Serum

Reduction of elevated plasma osteopontin levels with resection of non-small-cell lung cancer.
Authors: Blasberg JD, Pass HI, Goparaju CM, Flores RM, Lee S, Donington JS
J. Clin. Oncol., 2010;28(6):936-41.
Species: Human
Sample Type: Plasma

Persistent cognitive depressive symptoms are associated with coronary artery calcification.
Authors: Hamer M, Kivimaki M, Lahiri A
Atherosclerosis, 2010;210(1):209-13.
Species: Human
Sample Type: Serum

Exenatide affects circulating cardiovascular risk biomarkers independently of changes in body composition.
Authors: Bunck MC, Diamant M, Eliasson B, Corner A, Shaginian RM, Heine RJ, Taskinen MR, Yki-Jarvinen H, Smith U
Diabetes Care, 2010;33(8):1734-7.
Species: Human
Sample Type: Serum

Salivary cortisol responses to mental stress are associated with coronary artery calcification in healthy men and women.
Authors: Hamer M, ODonnell K, Lahiri A, Steptoe A
Eur. Heart J., 2010;31(4):424-9.
Species: Human
Sample Type: Serum

Differential adaptation of human gut microbiota to bariatric surgery-induced weight loss: links with metabolic and low-grade inflammation markers.
Authors: Furet JP, Kong LC, Tap J, Poitou C, Basdevant A, Bouillot JL, Mariat D, Corthier G, Dore J, Henegar C, Rizkalla S, Clement K
Diabetes, 2010;59(12):3049-57.
Species: Human
Sample Type: Plasma

Improvements in coronary heart disease risk indicators by alternate-day fasting involve adipose tissue modulations.
Authors: Bhutani S, Klempel MC, Berger RA, Varady KA
Obesity (Silver Spring), 2010;18(11):2152-9.
Species: Human
Sample Type: Plasma

Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women.
Authors: Kars M, Yang L, Gregor MF, Mohammed BS, Pietka TA, Finck BN, Patterson BW, Horton JD, Mittendorfer B, Hotamisligil GS, Klein S
Diabetes, 2010;59(8):1899-905.
Species: Human
Sample Type: Plasma

Prospective study of physical fitness, adiposity, and inflammatory markers in healthy middle-aged men and women.
Authors: Hamer M, Steptoe A
Am. J. Clin. Nutr., 2009;89(1):85-9.
Species: Human
Sample Type: Plasma

Predictors of maintaining cognitive function in older adults: the Health ABC study.
Authors: Yaffe K, Fiocco AJ, Lindquist K, Vittinghoff E, Simonsick EM, Newman AB, Satterfield S, Rosano C, Rubin SM, Ayonayon HN, Harris TB,
Neurology, 2009;72(23):2029-35.
Species: Human
Sample Type: Plasma

C-reactive protein (CRP) induces chemokine secretion via CD11b/ICAM-1 interaction in human adherent monocytes.
Authors: Montecucco F, Steffens S, Burger F, Pelli G, Monaco C, Mach F
J. Leukoc. Biol., 2008;84(4):1109-19.
Species: Human
Sample Type: recombinant protein

Endothelial progenitor cell levels in obese men with the metabolic syndrome and the effect of simvastatin monotherapy vs. simvastatin/ezetimibe combination therapy.
Authors: Westerweel PE, Visseren FL, Hajer GR, Olijhoek JK, Hoefer IE, de Bree P, Rafii S, Doevendans PA, Verhaar MC
Eur. Heart J., 2008;29(22):2808-17.
Species: Human
Sample Type: Serum

Effects of atorvastatin added to inhaled corticosteroids on lung function and sputum cell counts in atopic asthma.
Authors: Hothersall EJ, Chaudhuri R, McSharry C, Donnelly I, Lafferty J, McMahon AD, Weir CJ, Meiklejohn J, Sattar N, McInnes I, Wood S, Thomson NC
Thorax, 2008;63(12):1070-5.
Species: Human
Sample Type: Serum

Effects of rehabilitative exercise on peripheral muscle TNFalpha, IL-6, IGF-I and MyoD expression in patients with COPD.
Authors: Vogiatzis I, Stratakos G, Simoes DC, Terzis G, Georgiadou O, Roussos C, Zakynthinos S
Thorax, 2007;62(11):950-6.
Species: Human
Sample Type: Plasma

Muscle atrophy and hypertrophy signaling in patients with chronic obstructive pulmonary disease.
Authors: Doucet M, Russell AP, Leger B, Debigare R, Joanisse DR, Caron MA, LeBlanc P, Maltais F
Am. J. Respir. Crit. Care Med., 2007;176(3):261-9.
Species: Human
Sample Type: Plasma

生物活性< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景C-Reactive Protein (CRP), also known as Pentraxin 1, is a secreted pentameric protein that functions as a sensor and activator for the innate immune response. In humans, it is a major acute-phase protein; its circulating concentration is dramatically elevated at the onset of inflammation. In mice, however, serum CRP levels increase only slightly during inflammation, and the analogous acute phase role is filled by Pentraxin 2. CRP binds, opsonizes, and induces the phagocytosis of bacteria and apoptotic cells. It regulates activation of the classical complement pathway by binding several proteins in the complement cascade as well as Fc gamma RI, Fc gamma RIIA, and Fc gamma RIIB on macrophages and dendritic cells. It also promotes dendritic cell maturation and humoral immunity. In cardiovascular disease, CRP binds to oxidized LDL, exacerbates tissue damage in myocardial infarction, and inhibits the repair of injured vascular endothelium.
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参考文献
  • Acute Phase Proteins
  • Airway Inflammation and Remodeling
  • Glucose Homeostasis
  • Inflammatory Mediators
  • Renal Markers