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Human CCL2/MCP-1 Quantikine SixPak (6 Plates) (1 PK)

货号: SCP00 基本售价: 29971.6 元 规格: 1 PACK

产品信息

概述
货号SCP00
描述The Quantikine Human MCP-1 Immunoassay is a 3.5 or 4.5 hour solid phase ELISA designed to measure MCP-1 in cell culture supernates, serum, plasma, and urine. It contains E. coli-expressed recombinant human MCP-1 and antibodies raised against the recombinant factor. This immunoassay has been shown to accurately quantitate recombinant human MCP-1. Results obtained using natural human MCP-1 showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural human MCP-1.
别名CCL2; MCAF; MCP-1;
反应种属Human
目标/特异性Natural and recombinant human MCP-1
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs
6347 (Human); 20296 (Mouse); 24770 (Rat); 403981 (Canine)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Visceral fat area is a strong predictor of leukocyte cell-derived chemotaxin 2, a potential biomarker of dyslipidemia
Authors: K Tanisawa, H Taniguchi, X Sun, T Ito, R Kawakami, S Sakamoto, M Higuchi
PLoS ONE, 2017;12(3):e0173310.
Species: Human
Sample Type: Serum

Sterile inflammation as a factor in human male infertility: Involvement of Toll like receptor 2, biglycan and peritubular cells
Sci Rep, 2016;6(0):37128.
Species: Human
Sample Type: Whole Cells

Activation of the vitamin D receptor selectively interferes with calcineurin-mediated inflammation: a clinical evaluation in the abdominal aortic aneurysm
Authors: Arend Jan Nieuwland
Lab Invest, 2016;0(0):.
Species: Human
Sample Type: Tissue Homogenates

Plasma Levels of Monocyte Chemoattractant Protein-1, n-Terminal Fragment of Brain Natriuretic Peptide and Calcidiol Are Independently Associated with the Complexity of Coronary Artery Disease
PLoS ONE, 2016;11(5):e0152816.
Species: Human
Sample Type: Plasma

Microbial Translocation and Inflammation Occur in Hyperacute Immunodeficiency Virus Infection and Compromise Host Control of Virus Replication
PLoS Pathog, 2016;12(12):e1006048.
Species: Primate - cynomolgus macaques
Sample Type: Plasma

Secreted ectodomain of sialic acid-binding Ig-like lectin-9 and monocyte chemoattractant protein-1 promote recovery after rat spinal cord injury by altering macrophage polarity.
Authors: Matsubara K, Matsushita Y, Sakai K, Kano F, Kondo M, Noda M, Hashimoto N, Imagama S, Ishiguro N, Suzumura A, Ueda M, Furukawa K, Yamamoto A
J Neurosci, 2015;35(6):2452-64.
Species: Rat
Sample Type: Cell Culture Supernates

Transfer of intracellular HIV Nef to endothelium causes endothelial dysfunction.
Authors: Wang T, Green L, Gupta S, Kim C, Wang L, Almodovar S, Flores S, Prudovsky I, Jolicoeur P, Liu Z, Clauss M
PLoS ONE, 2014;9(3):e91063.
Species: Human
Sample Type: Cell Culture Supernates

Effect of Sfrp5 on cytokine release and insulin action in primary human adipocytes and skeletal muscle cells.
Authors: Carstensen M, Wiza C, Rohrig K, Fahlbusch P, Roden M, Herder C, Ouwens D
PLoS ONE, 2014;9(1):e85906.
Species: Human
Sample Type: Cell Culture Supernates

Nuclear NF-kappaB p65 in peripheral blood mononuclear cells correlates with urinary MCP-1, RANTES and the severity of type 2 diabetic nephropathy.
Authors: Yi B, Hu X, Zhang H, Huang J, Liu J, Hu J, Li W, Huang L
PLoS ONE, 2014;9(6):e99633.
Species: Human
Sample Type: Urine

Expression and functional characterization of NOD2 in decidual stromal cells isolated during the first trimester of pregnancy.
Authors: Zhang Y, Chen H, Sun C, Wang H, Liu M, Li Y, Nie X, Du M, Li D, Zhang J
PLoS ONE, 2014;9(6):e99612.
Species: Human
Sample Type: Cell Culture Supernates

ACE inhibitors potently reduce vascular inflammation, results of an open proof-of-concept study in the abdominal aortic aneurysm.
Authors: Kortekaas K, Meijer C, Hinnen J, Dalman R, Xu B, Hamming J, Lindeman J
PLoS ONE, 2014;9(12):e111952.
Species: Human
Sample Type: Tissue Homogenates

Sulfur compounds block MCP-1 production by Mycoplasma fermentans-infected macrophages through NF-kappaB inhibition.
Authors: Benedetti F, Davinelli S, Krishnan S, Gallo R, Scapagnini G, Zella D, Curreli S
J Transl Med, 2014;12(0):145.
Species: Human
Sample Type: Cell Culture Supernates

The impact of concomitant pulmonary infection on immune dysregulation in Pneumocystis jirovecii pneumonia.
Authors: Chou C, Lin F, Tsai H, Chang S
BMC Pulm Med, 2014;14(0):182.
Species: Human
Sample Type: BALF

Autophagy facilitates TLR4- and TLR3-triggered migration and invasion of lung cancer cells through the promotion of TRAF6 ubiquitination.
Authors: Zhan Z, Xie X, Cao H, Zhou X, Zhang X, Fan H, Liu Z
Autophagy, 2014;10(2):257-68.
Species: Human
Sample Type: Cell Culture Supernates

PPM1A is a RelA phosphatase with tumor suppressor-like activity.
Authors: Lu X, An H, Jin R, Zou M, Guo Y, Su P, Liu D, Shyr Y, Yarbrough W
Oncogene, 2014;33(22):2918-27.
Species: Human
Sample Type: Conditioned media

The expression of cytokines and chemokines in the blood of patients with severe weight loss from anorexia nervosa: an exploratory study.
Authors: Pisetsky D, Trace S, Brownley K, Hamer R, Zucker N, Roux-Lombard P, Dayer J, Bulik C
Cytokine, 2014;69(1):110-5.
Species: Human
Sample Type: Cell Culture Supernates

Bisphosphonates inhibit osteosarcoma-mediated osteolysis via attenuation of tumor expression of MCP-1 and RANKL.
Authors: Ohba T, Cole H, Cates J, Slosky D, Haro H, Ando T, Schwartz H, Schoenecker J
J Bone Miner Res, 2014;29(6):1431-45.
Species: Human
Sample Type: Cell Culture Supernates

Effects of high-dose cholecalciferol on serum markers of inflammation and immunity in patients with early chronic kidney disease.
Authors: Alvarez J, Zughaier S, Law J, Hao L, Wasse H, Ziegler T, Tangpricha V
Eur J Clin Nutr, 2013;67(3):264-9.
Species: Human
Sample Type: Cell Culture Supernates

Leukemia cells induce changes in human bone marrow stromal cells.
Authors: Civini S, Jin P, Ren J, Sabatino M, Castiello L, Jin J, Wang H, Zhao Y, Marincola F, Stroncek D
J Transl Med, 2013;11(0):298.
Species: Human
Sample Type: Cell Culture Supernates

Prevention of F-actin assembly switches the response to SCF from chemotaxis to degranulation in human mast cells.
Authors: Smrz D, Bandara G, Beaven M, Metcalfe D, Gilfillan A
Eur J Immunol, 2013;43(7):1873-82.
Species: Human
Sample Type: Cell Culture Supernates

Increased Eotaxin and MCP-1 Levels in Serum from Individuals with Periodontitis and in Human Gingival Fibroblasts Exposed to Pro-Inflammatory Cytokines.
Authors: Bostrom E, Kindstedt E, Sulniute R, Palmqvist P, Majster M, Holm C, Zwicker S, Clark R, Onell S, Johansson I, Lerner U, Lundberg P
PLoS ONE, 2013;10(8):e0134608.

Monocyte chemotactic protein-1 (MCP-1) in patients with chronic schistosomiasis mansoni: evidences of subclinical renal inflammation.
Authors: Hanemann A, Liborio A, Daher E, Martins A, Pinheiro M, Sousa M, Bezerra F
PLoS ONE, 2013;8(11):e80421.
Species: Human
Sample Type: Urine

Mycobacterium bovis bacilli Calmette-Guerin regulates leukocyte recruitment by modulating alveolar inflammatory responses.
Authors: Andersson M, Lutay N, Hallgren O, Westergren-Thorsson G, Svensson M, Godaly G
Innate Immun, 2012;18(3):531-40.
Species: Human
Sample Type: Cell Culture Supernates

Intermediate monocytes but not TIE2-expressing monocytes are a sensitive diagnostic indicator for colorectal cancer.
Authors: Schauer D, Starlinger P, Reiter C, Jahn N, Zajc P, Buchberger E, Bachleitner-Hofmann T, Bergmann M, Stift A, Gruenberger T, Brostjan C
PLoS ONE, 2012;7(9):e44450.
Species: Human
Sample Type: Plasma

Exenatide as a weight-loss therapy in extreme pediatric obesity: a randomized, controlled pilot study.
Authors: Kelly AS, Metzig AM, Rudser KD, Fitch AK, Fox CK, Nathan BM, Deering MM, Schwartz BL, Abuzzahab MJ, Gandrud LM, Moran A, Billington CJ, Schwarzenberg SJ
Obesity (Silver Spring), 2012;20(2):364-70.
Species: Human
Sample Type: Plasma

Anti-inflammatory effects of methoxyphenolic compounds on human airway cells.
Authors: Houser KR, Johnson DK, Ishmael FT
J Inflamm (Lond), 2012;9(0):6.
Species: Human
Sample Type: Cell Culture Supernates

Prevalence of Chronic Kidney Disease and Progression of Disease Over Time among Patients Enrolled in the Houston West Nile Virus Cohort.
Authors: Nolan MS, Podoll AS, Hause AM
PLoS ONE, 2012;7(7):e40374.
Species: Human
Sample Type: Urine

Increased levels of inflammatory cytokines and endothelin-1 in alveolar macrophages from patients with chronic heart failure.
Authors: Sikkeland LI, Dahl CP, Ueland T, Andreassen AK, Gude E, Edvardsen T, Holm T, Yndestad A, Gullestad L, Kongerud J, Aukrust P, ØIe E
PLoS ONE, 2012;7(5):e36815.

Alveolar fibrocyte percentage is an independent predictor of poor outcome in patients with acute lung injury.
Authors: Quesnel C, Piednoir P, Gelly J, Nardelli L, Garnier M, Lecon V, Lasocki S, Bouadma L, Philip I, Elbim C, Mentre F, Soler P, Crestani B, Dehoux M
Crit. Care Med., 2012;40(1):21-8.
Species: Human
Sample Type: BALF

Attenuated, oncolytic, but not wild-type measles virus infection has pleiotropic effects on human neutrophil function.
Authors: Zhang Y, Patel B, Dey A, Ghorani E, Rai L, Elham M, Castleton AZ, Fielding AK
J. Immunol., 2012;188(3):1002-10.
Species: Human
Sample Type: Cell Culture Supernates

Hypoxia potentiates glioma-mediated immunosuppression.
Authors: Wei J, Wu A, Kong LY, Wang Y, Fuller G, Fokt I, Melillo G, Priebe W, Heimberger AB
PLoS ONE, 2012;6(1):e16195.
Species: Human
Sample Type: Cell Culture Supernates

Regulation of inflammatory chemokine receptors on blood T cells associated to the circulating versus liver chemokines in dengue Fever.
Authors: de-Oliveira-Pinto LM, Marinho CF, Povoa TF, de Azeredo EL, de Souza LA, Barbosa LD, Motta-Castro AR, Alves AM, Avila CA, de Souza LJ, da Cunha RV, Damasco PV, Paes MV, Kubelka CF
PLoS ONE, 2012;7(7):e38527.
Species: Human
Sample Type: Plasma

A composite urine biomarker reflects interstitial inflammation in lupus nephritis kidney biopsies.
Authors: Zhang X, Nagaraja HN, Nadasdy T
Kidney Int., 2012;81(4):401-6.
Species: Human
Sample Type: Urine

Vascular endothelial growth factor-A (VEGF-A) and chemokine ligand-2 (CCL2) in Amyotrophic Lateral Sclerosis (ALS) patients.
Authors: Gupta PK, Prabhakar S
J Neuroinflammation, 2011;8(1):47.
Species: Human
Sample Type: Serum

Preclinical Evaluation of Local JAK1 and JAK2 Inhibition in Cutaneous Inflammation.
Authors: Fridman JS, Scherle PA, Collins R, Burn T, Neilan CL, Hertel D, Contel N, Haley P, Thomas B, Shi J, Collier P, Rodgers JD, Shepard S, Metcalf B, Hollis G, Newton RC, Yeleswaram S, Friedman SM, Vaddi K
J. Invest. Dermatol., 2011;131(9):1838-44.
Species: Human
Sample Type: Cell Culture Supernates

Oral cholecalciferol decreases albuminuria and urinary TGF-beta1 in patients with type 2 diabetic nephropathy on established renin-angiotensin-aldosterone system inhibition.
Authors: Kim MJ, Frankel AH, Donaldson M, Darch SJ, Pusey CD, Hill PD, Mayr M, Tam FW
Kidney Int., 2011;80(8):851-60.
Species: Human
Sample Type: Urine

Distraction osteogenesis induces endothelial progenitor cell mobilization without inflammatory response in man.
Authors: Lee DY, Cho TJ, Lee HR, Park MS, Yoo WJ, Chung CY, Choi IH
Bone, 2010;46(3):673-9.
Species: Human
Sample Type: Plasma

Cerebrospinal fluid in HIV-1 systemic viral controllers: absence of HIV-1 RNA and intrathecal inflammation.
Authors: Probasco JC, Deeks SG, Lee E, Hoh R, Hunt PW, Liegler T, Price RW, Spudich SS
AIDS, 2010;24(7):1001-5.
Species: Human
Sample Type: CSF

Rickettsia rickettsii infection of human macrovascular and microvascular endothelial cells reveals activation of both common and cell type-specific host response mechanisms.
Authors: Rydkina E, Turpin LC, Sahni SK
Infect. Immun., 2010;78(6):2599-606.
Species: Human
Sample Type: Cell Culture Supernates

IL-33 mediates inflammatory responses in human lung tissue cells.
Authors: Yagami A, Orihara K, Morita H
J. Immunol., 2010;185(10):5743-50.
Species: Human
Sample Type: Cell Culture Supernates

Monocyte chemoattractant protein-1 (MCP-1)/CCL2 secreted by hepatic myofibroblasts promotes migration and invasion of human hepatoma cells.
Authors: Dagouassat M, Suffee N, Hlawaty H, Haddad O, Charni F, Laguillier C, Vassy R, Martin L, Schischmanoff PO, Gattegno L, Oudar O, Sutton A, Charnaux N
Int. J. Cancer, 2010;126(5):1095-108.
Species: Human
Sample Type: Cell Culture Supernates

Phagocytosis of apoptotic cells modulates mesenchymal stem cells osteogenic differentiation to enhance IL-17 and RANKL expression on CD4+ T cells.
Authors: Tso GH, Law HK, Tu W
Stem Cells, 2010;28(5):939-54.
Species: Human
Sample Type: Cell Culture Supernates

Exenatide affects circulating cardiovascular risk biomarkers independently of changes in body composition.
Authors: Bunck MC, Diamant M, Eliasson B, Corner A, Shaginian RM, Heine RJ, Taskinen MR, Yki-Jarvinen H, Smith U
Diabetes Care, 2010;33(8):1734-7.
Species: Human
Sample Type: Serum

Tumour necrosis factor alpha stimulates the production of monocyte chemoattractants by extravillous trophoblast cells via differential activation of MAPK pathways.
Authors: Renaud SJ, Sullivan R, Graham CH
Placenta, 2009;30(4):313-9.
Species: Human
Sample Type: Cell Culture Supernates

A plant stanol yogurt drink alone or combined with a low-dose statin lowers serum triacylglycerol and non-HDL cholesterol in metabolic syndrome patients.
Authors: Plat J, Brufau G, Dallinga-Thie GM, Dasselaar M, Mensink RP
J. Nutr., 2009;139(6):1143-9.
Species: Human
Sample Type: Plasma

Smoking, inflammatory patterns and postprandial hypertriglyceridemia.
Authors: Kabagambe EK, Ordovas JM, Tsai MY, Borecki IB, Hopkins PN, Glasser SP, Arnett DK
Atherosclerosis, 2009;203(2):633-9.
Species: Human
Sample Type: Serum

HIV increases markers of cardiovascular risk: results from a randomized, treatment interruption trial.
Authors: Calmy A, Gayet-Ageron A, Montecucco F, Nguyen A, Mach F, Burger F, Ubolyam S, Carr A, Ruxungtham K, Hirschel B, Ananworanich J,
AIDS, 2009;23(8):929-39.
Species: Human
Sample Type: Plasma

HLA-DR+ leukocytes acquire CD1 antigens in embryonic and fetal human skin and contain functional antigen-presenting cells.
Authors: Schuster C, Vaculik C, Fiala C, Meindl S, Brandt O, Imhof M, Stingl G, Eppel W, Elbe-Burger A
J. Exp. Med., 2009;206(1):169-81.
Species: Human
Sample Type: Cell Culture Supernates

CXCL10 and CCL2 chemokine serum levels in patients with hepatitis C associated with autoimmune thyroiditis.
Authors: Antonelli A, Ferri C, Fallahi P, Ferrari SM, Frascerra S, Pampana A, Panicucci E, Carpi A, Nicolini A, Ferrannini E
J. Interferon Cytokine Res., 2009;29(6):345-51.
Species: Human
Sample Type: Serum

Prostate cancer promotes CD11b positive cells to differentiate into osteoclasts.
Authors: Mizutani K, Sud S, Pienta KJ
J. Cell. Biochem., 2009;106(4):563-9.
Species: Human
Sample Type: Cell Culture Supernates

Inflammatory interaction between LIGHT and proteinase-activated receptor-2 in endothelial cells: potential role in atherogenesis.
Authors: Sandberg WJ, Halvorsen B, Yndestad A, Smith C, Otterdal K, Brosstad FR, Froland SS, Olofsson PS, Damas JK, Gullestad L, Hansson GK, Oie E, Aukrust P
Circ. Res., 2009;104(1):60-8.
Species: Human
Sample Type: Cell Culture Supernates

Cross-sectional relations of multiple inflammatory biomarkers to peripheral arterial disease: The Framingham Offspring Study.
Authors: Murabito JM, Keyes MJ, Guo CY, Keaney JF, Vasan RS, DAgostino RB, Benjamin EJ
Atherosclerosis, 2009;203(2):509-14.
Species: Human
Sample Type: Plasma

Serum levels of monocyte chemoattractant protein-1 in periodontal health and disease.
Authors: Pradeep AR, Daisy H, Hadge P
Cytokine, 2009;47(2):77-81.
Species: Human
Sample Type: Serum

Interleukin-18 is a strong predictor of cardiovascular events in elderly men with the metabolic syndrome: synergistic effect of inflammation and hyperglycemia.
Authors: Troseid M, Seljeflot I, Hjerkinn EM, Arnesen H
Diabetes Care, 2009;32(3):486-92.
Species: Human
Sample Type: Plasma

Effect of protein kinase Cbeta inhibition on renal hemodynamic function and urinary biomarkers in humans with type 1 diabetes: a pilot study.
Authors: Cherney DZ, Konvalinka A, Zinman B, Diamandis EP, Soosaipillai A, Reich H, Lorraine J, Lai V, Scholey JW, Miller JA
Diabetes Care, 2009;32(1):91-3.
Species: Human
Sample Type: Urine

Intensive insulin therapy decreases urinary MCP-1 and ICAM-1 excretions in incipient diabetic nephropathy.
Authors: Ye SD, Zheng M, Zhao LL, Qian Y, Yao XM, Ren A, Li SM, Jing CY
Eur. J. Clin. Invest., 2009;39(11):980-5.
Species: Human
Sample Type: Urine

High levels and inflammatory effects of soluble CXC ligand 16 (CXCL16) in coronary artery disease: down-regulatory effects of statins.
Authors: Smith C, Halvorsen B, Otterdal K, Waehre T, Yndestad A, Fevang B, Sandberg WJ, Breland UM, Froland SS, Oie E, Gullestad L, Damas JK, Aukrust P
Cardiovasc. Res., 2008;79(1):195-203.
Species: Human
Sample Type: Cell Culture Supernates

A polymorphism in the CCL2 chemokine gene is associated with asthma risk: a case-control and a family study in Tunisia.
Authors: Chelbi H, Ghadiri A, Lacheb J, Ghandil P, Hamzaoui K, Hamzaoui A, Combadiere C
Genes Immun., 2008;9(7):575-81.
Species: Human
Sample Type: Plasma

Exploring human testicular peritubular cells: identification of secretory products and regulation by tumor necrosis factor-alpha.
Authors: Schell C, Albrecht M, Mayer C, Schwarzer JU, Frungieri MB, Mayerhofer A
Endocrinology, 2008;149(4):1678-86.
Species: Human
Sample Type: Cell Culture Supernates

The role of capillary density, macrophage infiltration and interstitial scarring in the pathogenesis of human chronic kidney disease.
Authors: Eardley KS, Kubal C, Zehnder D, Quinkler M, Lepenies J, Savage CO, Howie AJ, Kaur K, Cooper MS, Adu D, Cockwell P
Kidney Int., 2008;74(4):495-504.
Species: Human
Sample Type: Urine

Reduction of the vitamin D hormonal system in kidney disease is associated with increased renal inflammation.
Authors: Zehnder D, Quinkler M, Eardley KS, Bland R, Lepenies J, Hughes SV, Raymond NT, Howie AJ, Cockwell P, Stewart PM, Hewison M
Kidney Int., 2008;74(10):1343-53.
Species: Human
Sample Type: Urine

Chemokine production and chemokine receptor expression by human glioma cells: role of CXCL10 in tumour cell proliferation.
Authors: Maru SV, Holloway KA, Flynn G, Lancashire CL, Loughlin AJ, Male DK, Romero IA
J. Neuroimmunol., 2008;199(1):35-45.
Species: Human
Sample Type: Cell Culture Supernates

An oil mixture with trans-10, cis-12 conjugated linoleic acid increases markers of inflammation and in vivo lipid peroxidation compared with cis-9, trans-11 conjugated linoleic acid in postmenopausal women.
Authors: Tholstrup T, Raff M, Straarup EM, Lund P, Basu S, Bruun JM
J. Nutr., 2008;138(8):1445-51.
Species: Human
Sample Type: Serum

Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseases.
Authors: Hartl D, Krauss-Etschmann S, Koller B, Hordijk PL, Kuijpers TW, Hoffmann F, Hector A, Eber E, Marcos V, Bittmann I, Eickelberg O, Griese M, Roos D
J. Immunol., 2008;181(11):8053-67.
Species: Human
Sample Type: BALF

In vitro induction of a dendritic cell phenotype in primary human acute myelogenous leukemia (AML) blasts alters the chemokine release profile and increases the levels of T cell chemotactic CCL17 and CCL22.
Authors: Olsnes AM, Ryningen A, Ersvaer E, Bruserud Ø
J. Interferon Cytokine Res., 2008;28(5):297-310.
Species: Human
Sample Type: Cell Culture Supernates

Thrombin-induced expression of endothelial CX3CL1 potentiates monocyte CCL2 production and transendothelial migration.
Authors: Popovic M, Laumonnier Y, Burysek L, Syrovets T, Simmet T
J. Leukoc. Biol., 2008;84(1):215-23.
Species: Human
Sample Type: Cell Culture Supernates

MMP-12 induces IL-8/CXCL8 secretion through EGFR and ERK1/2 activation in epithelial cells.
Authors: Le Quement C, Guenon I, Gillon JY, Lagente V, Boichot E
Am. J. Physiol. Lung Cell Mol. Physiol., 2008;294(6):L1076-84.
Species: Human
Sample Type: Cell Culture Supernates

Proliferation, differentiation, and cytokine secretion of human umbilical cord blood-derived mononuclear cells in vitro.
Authors: Neuhoff S, Moers J, Rieks M, Grunwald T, Jensen A, Dermietzel R, Meier C
Exp. Hematol., 2007;35(7):1119-31.
Species: Human
Sample Type: Cell Culture Supernates

Tumor necrosis factor alpha as a new target for renal cell carcinoma: two sequential phase II trials of infliximab at standard and high dose.
Authors: Harrison ML, Obermueller E, Maisey NR, Hoare S, Edmonds K, Li NF, Chao D, Hall K, Lee C, Timotheadou E, Charles K, Ahern R, King DM, Eisen T, Corringham R, DeWitte M, Balkwill F, Gore M
J. Clin. Oncol., 2007;25(29):4542-9.
Species: Human
Sample Type: Plasma

L5, the most electronegative subfraction of plasma LDL, induces endothelial vascular cell adhesion molecule 1 and CXC chemokines, which mediate mononuclear leukocyte adhesion.
Authors: Abe Y, Fornage M, Yang CY, Bui-Thanh NA, Wise V, Chen HH, Rangaraj G, Ballantyne CM
Atherosclerosis, 2007;192(1):56-66.
Species: Human
Sample Type: Cell Culture Supernates

Specificity of immunomodulator secretion in urinary samples in response to infection by alpha-hemolysin and CNF1 bearing uropathogenic Escherichia coli.
Authors: Real JM, Munro P, Buisson-Touati C, Lemichez E, Boquet P, Landraud L
Cytokine, 2007;37(1):22-5.
Species: Human
Sample Type: Urine

Neuroinvasion of fluorescein-positive monocytes in acute simian immunodeficiency virus infection.
Authors: Clay CC, Rodrigues DS, Ho YS, Fallert BA, Janatpour K, Reinhart TA, Esser U
J. Virol., 2007;81(21):12040-8.
Species: Primate - Macaca mulatta (Rhesus monkey)
Sample Type: Plasma

Protection against inflammation- and autoantibody-caused fetal loss by the chemokine decoy receptor D6.
Authors: Martinez de la Torre Y, Buracchi C, Borroni EM, Dupor J, Bonecchi R, Nebuloni M, Pasqualini F, Doni A, Lauri E, Agostinis C, Bulla R, Cook DN, Haribabu B, Meroni P, Rukavina D, Vago L, Tedesco F, Vecchi A, Lira SA, Locati M, Mantovani A
Proc. Natl. Acad. Sci. U.S.A., 2007;104(7):2319-24.
Species: Human
Sample Type: Cell Culture Supernates

Panel of markers can accurately predict endometriosis in a subset of patients.
Authors: Seeber B, Sammel MD, Fan X, Gerton GL, Shaunik A, Chittams J, Barnhart KT
Fertil. Steril., 2007;89(5):1073-81.
Species: Human
Sample Type: Serum

Pleiotrophic and anti-inflammatory effects of pioglitazone precede the metabolic activity in type 2 diabetic patients with coronary artery disease.
Authors: Forst T, Karagiannis E, Lubben G, Hohberg C, Schondorf T, Dikta G, Drexler M, Morcos M, Danschel W, Borchert M, Pfutzner A
Atherosclerosis, 2007;197(1):311-7.
Species: Human
Sample Type: Plasma

Newly recruited human monocytes have a preserved responsiveness towards bacterial peptides in terms of CD11b up-regulation and intracellular hydrogen peroxide production.
Authors: Dadfar E, Jacobson SH, Lundahl J
Clin. Exp. Immunol., 2007;148(3):573-82.
Species: Human
Sample Type: Serum

The monocyte chemoattractant protein-1/cognate CC chemokine receptor 2 system affects cell motility in cultured human podocytes.
Authors: Burt D, Salvidio G, Tarabra E, Barutta F, Pinach S, Dentelli P, Camussi G, Perin PC, Gruden G
Am. J. Pathol., 2007;171(6):1789-99.
Species: Human
Sample Type: Cell Culture Supernates

Crucial role of the protein C pathway in governing microvascular inflammation in inflammatory bowel disease.
Authors: Scaldaferri F, Sans M, Vetrano S, Graziani C, De Cristofaro R, Gerlitz B, Repici A, Arena V, Malesci A, Panes J, Grinnell BW, Danese S
J. Clin. Invest., 2007;117(7):1951-60.
Species: Human
Sample Type: Whole Cells

Glucocorticoid-induced tumour necrosis factor receptor-related protein-mediated macrophage stimulation may induce cellular adhesion and cytokine expression in rheumatoid arthritis.
Authors: Bae E, Kim WJ, Kang YM, Suk K, Koh EM, Cha HS, Ahn KS, Huh TL, Lee WH
Clin. Exp. Immunol., 2007;148(3):410-8.
Species: Human
Sample Type: Cell Culture Supernates

IL-18 is induced and IL-18 receptor alpha plays a critical role in the pathogenesis of cigarette smoke-induced pulmonary emphysema and inflammation.
Authors: Kang MJ, Homer RJ, Gallo A, Lee CG, Crothers KA, Cho SJ, Rochester C, Cain H, Chupp G, Yoon HJ, Elias JA
J. Immunol., 2007;178(3):1948-59.
Species: Human
Sample Type: BALF

Borrelia burgdorferi-induced monocyte chemoattractant protein-1 production in vivo and in vitro.
Authors: Zhao Z, McCloud B, Fleming R, Klempner MS
Biochem. Biophys. Res. Commun., 2007;358(2):528-33.
Species: Human
Sample Type: Tissue Homogenates

Microparticles of human atherosclerotic plaques enhance the shedding of the tumor necrosis factor-alpha converting enzyme/ADAM17 substrates, tumor necrosis factor and tumor necrosis factor receptor-1.
Authors: Canault M, Leroyer AS, Peiretti F, Leseche G, Tedgui A, Bonardo B, Alessi MC, Boulanger CM, Nalbone G
Am. J. Pathol., 2007;171(5):1713-23.
Species: Human
Sample Type: Cell Culture Supernates

Comparison of serum levels of inflammatory markers in patients with coronary vasospasm without significant fixed coronary artery disease versus patients with stable angina pectoris and acute coronary syndromes with significant fixed coronary artery disease.
Authors: Hung MJ, Cherng WJ, Cheng CW, Li LF
Am. J. Cardiol., 2006;97(10):1429-34.
Species: Human
Sample Type: Serum

Relationship of CSF leukocytosis to compartmentalized changes in MCP-1/CCL2 in the CSF of HIV-infected patients undergoing interruption of antiretroviral therapy.
Authors: Monteiro de Almeida S, Letendre S, Zimmerman J, Kolakowski S, Lazzaretto D, McCutchan JA, Ellis R
J. Neuroimmunol., 2006;179(1):180-5.
Species: Human
Sample Type: CSF

CD16+ monocyte-derived macrophages activate resting T cells for HIV infection by producing CCR3 and CCR4 ligands.
Authors: Ancuta P, Autissier P, Wurcel A, Zaman T, Stone D, Gabuzda D
J. Immunol., 2006;176(10):5760-71.
Species: Human
Sample Type: Cell Culture Supernates

Increased levels of neutrophil-activating peptide-2 in acute coronary syndromes: possible role of platelet-mediated vascular inflammation.
Authors: Smith C, Damas JK, Otterdal K, ØIe E, Sandberg WJ, Yndestad A, Waehre T, Scholz H, Endresen K, Olofsson PS, Halvorsen B, Gullestad L, Froland SS, Hansson GK, Aukrust P
J. Am. Coll. Cardiol., 2006;48(8):1591-9.
Species: Human
Sample Type: Cell Culture Supernates

No difference in the effects of clopidogrel and aspirin on inflammatory markers in patients with coronary heart disease.
Authors: Solheim S, Pettersen AA, Arnesen H, Seljeflot I
Thromb. Haemost., 2006;96(5):660-4.
Species: Human
Sample Type: Plasma

An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium.
Authors: Johnson LA, Clasper S, Holt AP, Lalor PF, Baban D, Jackson DG
J. Exp. Med., 2006;203(12):2763-77.
Species: Human
Sample Type: Cell Culture Supernates

Function of interleukin-20 as a proinflammatory molecule in rheumatoid and experimental arthritis.
Authors: Hsu YH, Li HH, Hsieh MY, Liu MF, Huang KY, Chin LS, Chen PC, Cheng HH, Chang MS
Arthritis Rheum., 2006;54(9):2722-33.
Species: Human
Sample Type: Cell Culture Supernates

Regulated upon activation, normal T cell expressed and secreted (RANTES) and monocyte chemotactic protein 1 in follicular fluid accumulate differentially in patients with and without endometriosis undergoing in vitro fertilization.
Authors: Schultze-Mosgau A, Agic A, Diedrich K, Hornung D
Fertil. Steril., 2006;86(6):1616-20.
Species: Human
Sample Type: Serum

Exhaled breath condensate levels of 8-isoprostane, growth related oncogene alpha and monocyte chemoattractant protein-1 in patients with chronic obstructive pulmonary disease.
Authors: Ko FW, Lau CY, Leung TF, Wong GW, Lam CW, Hui DS
Respir Med, 2006;100(4):630-8.
Species: Human
Sample Type: Exhaled Breath Condensate (EBC)

Changes in immune and glial markers in the CSF of patients with Complex Regional Pain Syndrome.
Authors: Alexander GM, Perreault MJ, Reichenberger ER, Schwartzman RJ
Brain Behav. Immun., 2006;21(5):668-76.
Species: Human
Sample Type: CSF

RANTES and monocyte chemoattractant protein 1 as sensitive markers of disease activity in patients with juvenile rheumatoid arthritis: a six-year longitudinal study.
Authors: Yao TC, Kuo ML, See LC, Ou LS, Lee WI, Chan CK, Huang JL
Arthritis Rheum., 2006;54(8):2585-93.
Species: Human
Sample Type: Serum

Systemic inflammation in nonalcoholic fatty liver disease is characterized by elevated levels of CCL2.
Authors: Haukeland JW, Damas JK, Konopski Z, Loberg EM, Haaland T, Goverud I, Torjesen PA, Birkeland K, Bjoro K, Aukrust P
J. Hepatol., 2006;44(6):1167-74.
Species: Human
Sample Type: Serum

Mast cell beta-tryptase selectively cleaves eotaxin and RANTES and abrogates their eosinophil chemotactic activities.
Authors: Pang L, Nie M, Corbett L, Sutcliffe A, Knox AJ
J. Immunol., 2006;176(6):3788-95.
Species: Human
Sample Type: Cell Culture Supernates

Messenger RNA expression of target genes in the urinary sediment of patients with chronic kidney diseases.
Authors: Szeto CC, Chan RW, Lai KB, Szeto CY, Chow KM, Li PK, Lai FM
Nephrol. Dial. Transplant., 2005;20(1):105-13.
Species: Human
Sample Type: Urine

Markers of immune activation and viral load in HIV-associated sensory neuropathy.
Authors: Schifitto G, McDermott MP, McArthur JC, Marder K, Sacktor N, McClernon DR, Conant K, Cohen B, Epstein LG, Kieburtz K, Kieburtz K
Neurology, 2005;64(5):842-8.
Species: Human
Sample Type: CSF

Correlations between IL-4, IL-12 levels and CCL2, CCL5 levels in serum and cerebrospinal fluid of multiple sclerosis patients.
Authors: Bartosik-Psujek H, Stelmasiak Z
J Neural Transm, 2005;112(6):797-803.
Species: Human
Sample Type: Serum

Interleukin-8, monocyte chemoattractant protein-1 and IL-10 in the vitreous fluid of patients with proliferative diabetic retinopathy.
Authors: Hernandez C, Segura RM, Fonollosa A, Carrasco E, Francisco G, Simo R
Diabet. Med., 2005;22(6):719-22.
Species: Human
Sample Type: Vitreous Humor

Th2 predominance and CD8+ memory T cell depletion in patients with severe acute respiratory syndrome.
Authors: Huang JL, Huang J, Duan ZH, Wei J, Min J, Luo XH, Li JG, Tan WP, Wu LZ, Liu RY, Li Y, Shao J, Huang BJ, Zeng YX, Huang W
Microbes Infect., 2005;7(3):427-36.
Species: Human
Sample Type: Serum

Th2 predominance and CD8+ memory T cell depletion in patients with severe acute respiratory syndrome.
Authors: Huang JL, Huang J, Duan ZH, Wei J, Min J, Luo XH, Li JG, Tan WP, Wu LZ, Liu RY, Li Y, Shao J, Huang BJ, Zeng YX, Huang W
Microbes Infect., 2005;7(3):427-36.
Species: Human
Sample Type: Serum

Simian human immunodeficiency virus-associated pneumonia correlates with increased expression of MCP-1, CXCL10, and viral RNA in the lungs of rhesus macaques.
Authors: Sui Y, Li S, Pinson D, Adany I, Li Z, Villinger F, Narayan O, Buch S
Am. J. Pathol., 2005;166(2):355-65.
Species: Primate - Macaca mulatta (Rhesus monkey)
Sample Type: Tissue Homogenates

CCR5 expression and CC chemokine levels in idiopathic pulmonary fibrosis.
Authors: Capelli A, Di Stefano A, Gnemmi I, Donner CF
Eur. Respir. J., 2005;25(4):701-7.
Species: Human
Sample Type: BALF

Endurance training reduces circulating inflammatory markers in persons at risk of coronary events: impact on plaque stabilization?
Authors: Niessner A, Richter B, Penka M, Steiner S, Strasser B, Ziegler S, Heeb-Elze E, Zorn G, Leitner-Heinschink A, Niessner C, Wojta J, Huber K
Atherosclerosis, 2005;186(1):160-5.
Species: Human
Sample Type: Plasma

The effect of inflammatory cytokines on secretion of macrophage colony-stimulating factor and monocyte chemoattractant protein-1 in human granulosa cells.
Authors: Kawano Y, Fukuda J, Itoh H, Takai N, Nasu K, Miyakawa I
Am. J. Reprod. Immunol., 2004;52(2):124-8.
Species: Human
Sample Type: Follicular Fluid

Oxidative stress and renal injury with intravenous iron in patients with chronic kidney disease.
Authors: Vasavada N, Sachs NG, Chase S
Kidney Int., 2004;65(6):2279-89.
Species: Human
Sample Type: Urine

Monocyte chemoattractant protein-1 and interleukin-8 levels in children with acute poststreptococcal glomerulonephritis.
Authors: Besbas N, Ozaltin F, Catal F, Ozen S, Topaloglu R, Bakkaloglu A
Pediatr. Nephrol., 2004;19(8):864-8.
Species: Human
Sample Type: Urine

Natural killer T cells infiltrate neuroblastomas expressing the chemokine CCL2.
Authors: Metelitsa LS, Wu HW, Wang H, Yang Y, Warsi Z, Asgharzadeh S, Groshen S, Wilson SB, Seeger RC
J. Exp. Med., 2004;199(9):1213-21.
Species: Human
Sample Type: Cell Culture Supernates

Alterations in expression of monocyte chemotactic protein-1 in the simian immunodeficiency virus model of disseminated Mycobacterium avium complex.
Authors: Hendricks EE, Lin KC, Boisvert K, Pauley D, Mansfield KG
J. Infect. Dis., 2004;189(9):1714-20.
Species: Primate - Macaca mulatta (Rhesus monkey)
Sample Type: Cell Culture Supernates

The monocyte chemotactic protein-1 -2578G allele is associated with elevated MCP-1 concentrations in cerebrospinal fluid.
Authors: Letendre S, Marquie-Beck J, Singh KK, de Almeida S, Zimmerman J, Spector SA, Grant I, Ellis R
J. Neuroimmunol., 2004;157(1):193-6.
Species: Human
Sample Type: Plasma

CXCR3 and CCR5 positive T-cell recruitment in acute human renal allograft rejection.
Authors: Panzer U, Reinking RR, Steinmetz OM, Zahner G, Sudbeck U, Fehr S, Pfalzer B, Schneider A, Thaiss F, Mack M, Conrad S, Huland H, Helmchen U, Stahl RA
Transplantation, 2004;78(9):1341-50.
Species: Human
Sample Type: Urine

CXC-chemokine stimulation of neutrophils correlates with plasma levels of myeloperoxidase and lactoferrin and contributes to clinical outcome after pediatric cardiac surgery.
Authors: Gessler P, Pretre R, Hohl V, Rousson V, Fischer J, Dahinden C
Shock, 2004;22(6):513-20.
Species: Human
Sample Type: Plasma

Cerebrospinal fluid markers that predict SIV CNS disease.
Authors: Mankowski JL, Queen SE, Clements JE, Zink MC
J. Neuroimmunol., 2004;157(1):66-70.
Species: Primate - Macaca mulatta (Rhesus monkey)
Sample Type: Plasma

Effects of contrast media on porcine bone marrow-derived mononuclear cells and calf myoblast viability and secretion of VEGF and MCP-1.
Authors: Baffour R, Pakala R, Hellinga D, Seabron R, Fournadjiev J, Wolfram R, Okubagzi P, Epstein SE, Waksman R
Catheter Cardiovasc Interv, 2004;62(4):476-81.
Species: Porcine
Sample Type: Cell Culture Supernates

CD8+ cell depletion amplifies the acute retroviral syndrome.
Authors: Madden LJ, Zandonatti MA, Flynn CT, Taffe MA, Marcondes MC, Schmitz JE, Reimann KA, Henriksen SJ, Fox HS
J. Neurovirol., 2004;10(0):58-66.
Species: Primate - Macaca mulatta (Rhesus monkey)
Sample Type: CSF

Differential macrophage infiltration in early and advanced endometriosis and adjacent peritoneum.
Authors: Khan KN, Masuzaki H, Fujishita A, Kitajima M, Sekine I, Ishimaru T
Fertil. Steril., 2004;81(3):652-61.
Species: Human
Sample Type: Peritoneal Fluid

Pathogenesis of Ebola hemorrhagic fever in cynomolgus macaques: evidence that dendritic cells are early and sustained targets of infection.
Authors: Geisbert TW, Hensley LE, Larsen T, Young HA, Reed DS, Geisbert JB, Scott DP, Kagan E, Jahrling PB, Davis KJ
Am. J. Pathol., 2003;163(6):2347-70.
Species: Primate - Macaca fascicularis (Crab-eating or Cynomolgus macaque)
Sample Type: Serum

Helper T-lymphocyte-related chemokines in healthy newborns.
Authors: Leung TF, Ng PC, Tam WH, Li CY, Wong E, Ma TP, Lam CW, Fok TF
Pediatr. Res., 2003;55(2):334-8.
Species: Human
Sample Type: Serum

Proinflammatory effects of oxidative stress in chronic kidney disease: role of additional angiotensin II blockade.
Authors: Agarwal R
Am. J. Physiol. Renal Physiol., 2003;284(4):F863-9.
Species: Human
Sample Type: Urine

CCR5-binding chemokines modulate CXCL12 (SDF-1)-induced responses of progenitor B cells in human bone marrow through heterologous desensitization of the CXCR4 chemokine receptor.
Authors: Honczarenko M, Le Y, Glodek AM, Silberstein LE
Blood, 2002;100(7):2321-9.
Species: Human
Sample Type: Cell Culture Supernates

Fibrinogen induces chemotactic activity in endothelial cells.
Authors: Seeger FH, Blessing E, Gu L, Bornhold R, Denger S, Kreuzer J
Acta Physiol. Scand., 2002;176(2):109-15.
Species: Porcine
Sample Type: Cell Culture Supernates

Neuropathogenesis of lentiviral infection in macaques: roles of CXCR4 and CCR5 viruses and interleukin-4 in enhancing monocyte chemoattractant protein-1 production in macrophages.
Authors: Hicks A, Potula R, Sui YJ, Villinger F, Pinson D, Adany I, Li Z, Long C, Cheney P, Marcario J, Novembre F, Mueller N, Kumar A, Major E, Narayan O, Buch S
Am. J. Pathol., 2002;161(3):813-22.
Species: Primate - Macaca mulatta (Rhesus monkey)
Sample Type: Cell Culture Supernates

Impact of NNRTI compared to PI-based highly active antiretroviral therapy on CCR5 receptor expression, beta-chemokines and IL-16 secretion in HIV-1 infection.
Authors: Burton CT, Hardy GA, Sullivan AK, Nelson MR, Gazzard B, Gotch FM, Imami N
Clin. Exp. Immunol., 2002;130(2):286-92.
Species: Human
Sample Type: Plasma

Correlates of independent HIV-1 replication in the CNS and of its control by antiretrovirals.
Authors: De Luca A, Ciancio BC, Larussa D, Murri R, Cingolani A, Rizzo MG, Giancola ML, Ammassari A, Ortona L
Neurology, 2002;59(3):342-7.
Species: Human
Sample Type: CSF

Analysis of chemokines and chemokine receptor expression in ovarian cancer ascites.
Authors: Milliken D, Scotton C, Raju S, Balkwill F, Wilson J
Clin. Cancer Res., 2002;8(4):1108-14.
Species: Human
Sample Type: Plasma

TNFalpha-induced macrophage chemokine secretion is more dependent on NF-kappaB expression than lipopolysaccharides-induced macrophage chemokine secretion.
Authors: Ciesielski CJ, Andreakos E, Foxwell BM, Feldmann M
Eur. J. Immunol., 2002;32(7):2037-45.
Species: Human
Sample Type: Cell Culture Supernates

Transendocardial delivery of autologous bone marrow enhances collateral perfusion and regional function in pigs with chronic experimental myocardial ischemia.
Authors: Fuchs S, Baffour R, Zhou YF, Shou M, Pierre A, Tio FO, Weissman NJ, Leon MB, Epstein SE, Kornowski R
J. Am. Coll. Cardiol., 2001;37(6):1726-32.
Species: Porcine
Sample Type: Cell Culture Supernates

Increased macrophage chemoattractant protein-1 in cerebrospinal fluid precedes and predicts simian immunodeficiency virus encephalitis.
Authors: Zink MC, Coleman GD, Mankowski JL, Adams RJ, Tarwater PM, Fox K, Clements JE
J. Infect. Dis., 2001;184(8):1015-21.
Species: Primate - Macaca mulatta (Rhesus monkey)
Sample Type: CSF

Up-regulation of beta-chemokines and down-modulation of CCR5 co-receptors inhibit simian immunodeficiency virus transmission in non-human primates.
Authors: Lehner T, Wang Y, Cranage M, Tao L, Mitchell E, Bravery C, Doyle C, Pratt K, Hall G, Dennis M, Villinger L, Bergmeier L
Immunology, 2000;99(4):569-77.
Species: Primate - Macaca mulatta (Rhesus monkey)
Sample Type: Cell Culture Supernates

生物活性< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景CCL2/JE/MCP-1, is a chemokine that binds the receptor CCR2 and induces the chemoattraction of mononuclear cells. It induces the activation of monocytes, NK cells, lymphocytes, and basophils. Additionally, CCL2 promotes Th2 polarization in CD4+ T cells, and CCL2-mediated recruitment of monocytes to sites of inflammation contributes to disease severity in atherosclerosis, multiple sclerosis, and allergic asthma. Endogenous proteolytic trimming of CCL2 at the N-terminus, including the N-terminal pyrrolidone carboxylic acid-modified glutamine, downregulates activity but not receptor binding.
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参考文献
  • CC Chemokines and Receptors
  • Chemokines and Receptors
  • Chemokines and Receptors in Allergy and Asthma
  • Chemokines and Receptors in Angiogenesis
  • gamma delta T Cells
  • HIF Transcription Factors
  • Inflammatory Mediators
  • Macrophage Activation Markers
  • Molecules Secreted by VSMC
  • Neuroinflammation