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Human P-Selectin/CD62P SixPak (6 Plates) (1 PK)

货号: SBBE6 基本售价: 29971.6 元 规格: 1 PACK

产品信息

概述
货号SBBE6
描述The Human sP-Selectin Immunoassay is a 1.25 hour solid phase ELISA that measures sP-Selectin in cell culture supernates, serum, and plasma. It contains recombinant human sP-Selectin and antibodies raised against the recombinant factor. It has been shown to accurately quantitate the recombinant sP-Selectin. Results obtained using natural human sP-Selectin showed linear curves that were parallel to the standard curves obtained using the recombinant kit standards. These results indicate that this kit can be used to determine relative mass values for natural human sP-Selectin.
别名CD62P antigen; CD62P; FLJ45155; GMP140; GRMP; PADGEM; PADGEMantigen CD62); PSEL; P-Selectin; selectin P (granule membrane protein 140kDa, antigen CD62); SELP;
反应种属Human
目标/特异性Natural and recombinant human sP-Selectin
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs
6403 (Human); 20344 (Mouse)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Association between obstructive sleep apnea severity and endothelial dysfunction in patients with type 2 diabetes
Authors: V Bironneau, F Goupil, PH Ducluzeau, M Le Vaillan, P Abraham, S Henni, S Dubois, A Paris, P Priou, N Meslier, C Sanguin, W Trzépizur, R Andriantsi, MC Martinez, F Gagnadoux
Cardiovasc Diabetol, 2017;16(1):39.
Species: Human
Sample Type: Serum

Neutrophil-derived microparticles are released into the coronary circulation following percutaneous coronary intervention in acute coronary syndromes
Biosci. Rep, 2016;0(0):.
Species: Human
Sample Type: Plasma

Immune-inflammatory markers and arterial stiffness indexes in subjects with acute ischemic stroke with and without metabolic syndrome.
Authors: Tuttolomondo A, Pecoraro R, Di Raimondo D, Di Sciacca R, Canino B, Arnao V, Butta C, Della Corte V, Maida C, Licata G, Pinto A
Diabetol Metab Syndr, 2014;6(1):28.
Species: Human
Sample Type: Plasma

Persistently raised plasma levels of platelet-derived inflammatory mediators in HIV-infected patients during highly active anti-retroviral therapy.
Authors: Landro L, Ueland T, Otterdal K, Froland SS, Aukrust P
J. Thromb. Haemost., 2011;9(5):1075-7.
Species: Human
Sample Type: Platelet-Poor Plasma

Thrombospondin-1: a unique marker to identify in vitro platelet activation when monitoring in vivo processes.
Authors: Starlinger P, Moll HP
J. Thromb. Haemost., 2010;0(0):.
Species: Human
Sample Type: Serum

Endothelial activation, inflammation and premature atherosclerosis in children with familial dyslipidemia.
Authors: Guardamagna O, Abello F, Saracco P
Atherosclerosis, 2009;207(2):471-5.
Species: Human
Sample Type: Serum

Immuno-inflammatory predictors of stroke at follow-up in patients with chronic non-valvular atrial fibrillation (NVAF).
Authors: Pinto A, Tuttolomondo A, Casuccio A, Di Raimondo D, Di Sciacca R, Arnao V, Licata G
Clin. Sci., 2009;116(10):781-9.
Species: Human
Sample Type: Plasma

HIV increases markers of cardiovascular risk: results from a randomized, treatment interruption trial.
Authors: Calmy A, Gayet-Ageron A, Montecucco F, Nguyen A, Mach F, Burger F, Ubolyam S, Carr A, Ruxungtham K, Hirschel B, Ananworanich J,
AIDS, 2009;23(8):929-39.
Species: Human
Sample Type: Plasma

Cross-sectional relations of multiple inflammatory biomarkers to peripheral arterial disease: The Framingham Offspring Study.
Authors: Murabito JM, Keyes MJ, Guo CY, Keaney JF, Vasan RS, DAgostino RB, Benjamin EJ
Atherosclerosis, 2009;203(2):509-14.
Species: Human
Sample Type: Plasma

Immuno-inflammatory and thrombotic/fibrinolytic variables associated with acute ischemic stroke diagnosis.
Authors: Tuttolomondo A, Pinto A, Corrao S, Di Raimondo D, Fernandez P, Di Sciacca R, Arnao V, Licata G
Atherosclerosis, 2009;203(2):503-8.
Species: Human
Sample Type: Plasma

Pulmonary arterial hypertension and left-sided heart disease in sickle cell disease: clinical characteristics and association with soluble adhesion molecule expression.
Authors: Klings ES, Anton Bland D, Rosenman D, Princeton S, Odhiambo A, Li G, Bernard SA, Steinberg MH, Farber HW
Am. J. Hematol., 2008;83(7):547-53.
Species: Human
Sample Type: Plasma

Pharmacodynamics and Pharmacokinetics of the Novel Thrombopoietin Mimetic Peptide RWJ-800088 in Humans.
Authors: Liem-Moolenaar M, Cerneus D, Molloy C, End D, Brown K, de Kam M, Cohen A, van Hensbergen Y, Burggraaf J
2008;84(0):481.
Species: Human
Sample Type: Plasma

Soluble P-selectin, SELP polymorphisms, and atherosclerotic risk in European-American and African-AFrican young adults: the Coronary Artery Risk Development in Young Adults (CARDIA) Study.
Authors: Reiner AP, Carlson CS, Thyagarajan B, Rieder MJ, Polak JF, Siscovick DS, Nickerson DA, Jacobs DR, Gross MD
Arterioscler. Thromb. Vasc. Biol., 2008;28(8):1549-55.
Species: Human
Sample Type: Plasma

Fish oil in combination with high or low intakes of linoleic acid lowers plasma triacylglycerols but does not affect other cardiovascular risk markers in healthy men.
Authors: Damsgaard CT, Frokiaer H, Andersen AD, Lauritzen L
J. Nutr., 2008;138(6):1061-6.
Species: Human
Sample Type: Plasma

Changes in plasma vascular endothelial growth factor, angiopoietins, and their receptors following surgery for breast cancer.
Authors: Caine GJ, Stonelake PS, Lip GY, Blann AD
Cancer Lett., 2007;248(1):131-6.
Species: Human
Sample Type: Plasma

Pleiotrophic and anti-inflammatory effects of pioglitazone precede the metabolic activity in type 2 diabetic patients with coronary artery disease.
Authors: Forst T, Karagiannis E, Lubben G, Hohberg C, Schondorf T, Dikta G, Drexler M, Morcos M, Danschel W, Borchert M, Pfutzner A
Atherosclerosis, 2007;197(1):311-7.
Species: Human
Sample Type: Serum

Elevated urinary VCAM-1, P-selectin, soluble TNF receptor-1, and CXC chemokine ligand 16 in multiple murine lupus strains and human lupus nephritis.
Authors: Wu T, Xie C, Wang HW, Zhou XJ, Schwartz N, Calixto S, Mackay M, Aranow C, Putterman C, Mohan C
J. Immunol., 2007;179(10):7166-75.
Species: Human
Sample Type: Urine

Interferon-beta and adhesion molecules (E-selectin and s-intracellular adhesion molecule-1) are detected in sera from patients with retinal vasculitis and are induced in retinal vascular endothelial cells by Toll-like receptor 3 signalling.
Authors: Lee MT, Hooper LC, Kump L, Hayashi K, Nussenblatt R, Hooks JJ, Detrick B
Clin. Exp. Immunol., 2007;147(1):71-80.
Species: Human
Sample Type: Serum

Significant decrease in angiopoietin-1 and angiopoietin-2 after radical prostatectomy in prostate cancer patients.
Authors: Caine GJ, Ryan P, Lip GY, Blann AD
Cancer Lett., 2007;251(2):296-301.
Species: Human
Sample Type: Plasma

No difference in the effects of clopidogrel and aspirin on inflammatory markers in patients with coronary heart disease.
Authors: Solheim S, Pettersen AA, Arnesen H, Seljeflot I
Thromb. Haemost., 2006;96(5):660-4.
Species: Human
Sample Type: Plasma

Association between enhanced soluble CD40 ligand and prothrombotic state in inflammatory bowel disease.
Authors: Koutroubakis IE, Theodoropoulou A, Xidakis C, Sfiridaki A, Notas G, Kolios G, Kouroumalis EA
Eur J Gastroenterol Hepatol, 2004;16(11):1147-52.
Species: Human
Sample Type: Platelet-Poor Plasma

生物活性< 0.5% cross-reactivity observed with available related molecules.Cross-species reactivity not tested.
背景The Selectin family is comprised of three members, E-Selectin, L-Selectin, and P-Selectin. E-Selectin [endothelial leukocyte adhesion molecule-1 (ELAM-1), CD62E] is transiently expressed on vascular endothelial cells in response to IL-1 beta and TNF-alpha. The human and rat proteins share approximately 67% amino acid sequence identity. The mouse and rat proteins share approximately 78% amino acid sequence identity. L-Selectin (Leukocyte Selectin, LAM-1, LECAM-1, LECCAM-1, TQ1, Leu-8, MEL-14 antigen, DREG, lymph node homing receptor, CD62L) is expressed constitutively on a wide variety of leukocytes. Two forms of L-Selectin have been reported, apparently arising as a result of post-translational modifications. Human and mouse L-Selectin share 76% amino acid sequence identity. Human P-Selectin (GMP-140, LECAM-3, PADGEM, CD62P) is expressed by activated platelets and endothelial cells. The extracellular domains of human and mouse P-Selectin share approximately 73% amino acid sequence identity.
运输条件Blue Ice
存放说明4℃
参考文献
  • Adhesion Molecules in Angiogenesis
  • Adhesion Molecules on Endothelial Cells
  • Adhesion Molecules on VSMC
  • Endothelial Cell Markers
  • Lectins
  • Platelets
  • Regulatory T Cells (Tregs)
  • Selectins