一抗

克隆类型
多抗单抗
产品类型
标签抗体磷酸化抗体内参抗体甲基化抗体乙酰化抗体药物与化合物抗体植物抗体
研究领域
肿瘤心血管细胞生物免疫学发育生物学染色质和核信号微生物学细胞凋亡信号转导干细胞神经生物学生长因子和激素糖尿病内分泌病转运蛋白植物细菌及病毒转录调节因子海洋生物上皮细胞趋化因子结合蛋白细胞表面分子G蛋白偶联受体胶原蛋白糖蛋白交换蛋白细胞分化血管内皮细胞细胞类型标志物内皮细胞淋巴细胞T-淋巴细胞B-淋巴细胞细胞粘附分子肿瘤细胞生物标志物骨髓细胞细胞骨架跨膜蛋白细胞因子自然杀伤细胞树突状细胞标志物脂蛋白新陈代谢锌指蛋白通道蛋白细胞周期蛋白激酶和磷酸酶昆虫线粒体环指蛋白细胞自噬细胞膜受体药物及化合物泛素干扰素G蛋白信号细胞膜蛋白Alzheimers表观遗传学细胞外基质合成与降解

标记一抗

标记类型
HRPBiotinGoldRBITCAPFITCCy3Cy5Cy5.5Cy7PEPE-Cy3PE-Cy5PE-Cy5.5PE-Cy7APCAlexa Fluor 350Alexa Fluor 488Alexa Fluor 555Alexa Fluor 594Alexa Fluor 647

二抗

克隆类型
多抗单抗
产品分类
二抗二抗血清

标记二抗

标记类型
HRPBiotinGoldRBITCAPFITCCy3Cy5Cy5.5Cy7PEPE-Cy3PE-Cy5PE-Cy5.5PE-Cy7APCAlexa Fluor 350Alexa Fluor 488Alexa Fluor 555Alexa Fluor 594Alexa Fluor 647

蛋白质与多肽

产品分类
蛋白质多肽

标记蛋白质与多肽

所有产品
全部标记蛋白质与多肽

正常动物血清及免疫球蛋白

产品分类
正常动物血清免疫球蛋白

试剂盒

产品分类
ELISA试剂盒

常用试剂

产品分类
免疫组化常用试剂免疫印迹常用试剂常用显色试剂细胞生物学试剂分子生物学生化试剂

亲和层析柱

所有产品
亲和层析柱

配套试剂

所有产品
常用配套试剂

ELISA试剂盒

人ELISA试剂盒 大鼠ELISA试剂盒 小鼠ELISA试剂盒 牛ELISA试剂盒 鸡ELISA试剂盒 植物ELISA试剂盒 猴ELISA试剂盒 猪ELISA试剂盒 山羊ELISA试剂盒 马ELISA试剂盒 仓鼠ELISA试剂盒 绵羊ELISA试剂盒 兔子ELISA试剂盒 犬ELISA试剂盒 豚鼠ELISA试剂盒 其他ELISA试剂盒

生化试剂

色素类 分离材料及耗材 维生素 染色剂 碳水化合物 植物激素及核酸 抗生素 蛋白质 氨基酸 测试盒 其他生物试剂 缓冲剂 表面活性剂

血浆

血浆

血清

Sigma胎牛血清 gibco胎牛血清 Hyclone血清 人血清 国产新生牛血清 国产胎牛血清 其他血清

细胞

其它细胞 仓鼠细胞 猴细胞 大鼠细胞 人细胞 狗细胞 小鼠细胞 猫细胞 鸡细胞

标准品

对照品 农药标准品 标准物质 食品 无机溶液标准物质 有机溶液标准物质

抗体

兔抗 鼠抗 IgY抗体 IgA抗体 IgG抗体 二抗 一抗

裂解血

裂解血

培养基

美国药典培养基 化妆品检验培养基 大肠杆菌、大肠菌群 金黄色葡萄球菌检验 消毒灭菌效果评价 临床检验用培养基 中华人民共和国药典 欧洲药典(EP) 饮用天然矿泉水检验方法 微生物检验 霉菌、酵母菌 肠球菌、链球菌 沙门氏菌、志贺氏菌 弧菌 弯曲杆菌 李斯特氏菌 产气荚膜梭菌 阪崎肠杆菌 乳酸菌、双歧杆菌 小肠结肠炎耶尔森氏菌 蜡样芽孢杆菌检验 小肠结肠炎耶尔森氏菌检验 一次性试管、液体培养基 乳酸菌检验 菌落总数测定、无菌检验 显色培养基 植物组培

产品中心

当前位置:首页>产品中心

Human IL-2 Quantikine SixPak (6 Plates) (1 PK)

货号: S2050 基本售价: 29971.6 元 规格: 1 PACK

产品信息

概述
货号S2050
描述The Quantikine Human IL-2 Immunoassay is a 4.5 hour solid phase ELISA designed to measure IL-2 levels in cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant human IL-2 and antibodies raised against recombinant human IL-2. This immunoassay has been shown to accurately quantitate the recombinant factor. Results obtained using natural human IL-2 showed dose response curves that were parallel to the standard curves obtained using the recombinant Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural human IL-2
别名aldesleukin; IL2; IL-2; IL-2lymphokine; interleukin 2; interleukin-2; involved in regulation of T-cell clonal expansion; T cell growth factor; T-cell growth factor; TCGF;
全称
Interleukin 2
反应种属Human
目标/特异性Natural and recombinant human IL-2
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs
3558 (Human); 16183 (Mouse); 116562 (Rat); 396868 (Porcine); 280822 (Bovine); 403989 (Canine); 100034204 (Equine); 751114 (Feline); 100302458 (Rabbit)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

T Cell Subset and Stimulation Strength-Dependent Modulation of T Cell Activation by Kv1.3 Blockers
Authors: WP Fung-Leung, W Edwards, Y Liu, K Ngo, J Angsana, G Castro, N Wu, X Liu, RV Swanson, AD Wickenden
PLoS ONE, 2017;12(1):e0170102.
Species: Human
Sample Type: Cell Culture Supernates

Involvement of NK Cells and NKp30 Pathway in Antisynthetase Syndrome
J Immunol, 2016;197(5):1621-30.
Species: Human
Sample Type: Serum

The Suppressed Induction of Human Mature Cytotoxic T Lymphocytes Caused by Asbestos Is Not due to Interleukin-2 Insufficiency
J Immunol Res, 2016;2016(0):7484872.
Species: Human
Sample Type: Cell Culture Supernates

Impact of Exogenous Galectin-9 on Human T Cells: CONTRIBUTION OF THE T CELL RECEPTOR COMPLEX TO ANTIGEN-INDEPENDENT ACTIVATION BUT NOT TO APOPTOSIS INDUCTION.
Authors: Lhuillier C, Barjon C, Niki T, Gelin A, Praz F, Morales O, Souquere S, Hirashima M, Wei M, Dellis O, Busson P
J Biol Chem, 2015;290(27):16797-811.
Species: Human
Sample Type: Cell Culture Supernates

Inhibition of G-protein betagamma signaling enhances T cell receptor-stimulated interleukin 2 transcription in CD4+ T helper cells.
Authors: Yost E, Hynes T, Hartle C, Ott B, Berlot C
PLoS ONE, 2015;10(1):e0116575.
Species: Human
Sample Type: Cell Culture Supernates

The Association between Serum Cytokines and Damage to Large and Small Nerve Fibers in Diabetic Peripheral Neuropathy.
Authors: Magrinelli F, Briani C, Romano M, Ruggero S, Toffanin E, Triolo G, Peter G, Praitano M, Lauriola M, Zanette G, Tamburin S
J Diabetes Res, 2015;2015(0):547834.
Species: Human
Sample Type: Serum

The injury-induced myokine insulin-like 6 is protective in experimental autoimmune myositis.
Authors: Zeng L, Maruyama S, Nakamura K, Parker-Duffen J, Adham I, Zhong X, Lee H, Querfurth H, Walsh K
Skelet Muscle, 2015;4(0):16.
Species: Human
Sample Type: Cell Culture Supernates

Role of programmed death ligands in effective T-cell interactions in extranodal natural killer/T-cell lymphoma.
Authors: Han L, Liu F, Li R, Li Z, Chen X, Zhou Z, Zhang X, Hu T, Zhang Y, Young K, Sun S, Wen J, Zhang M
Oncol Lett, 2014;8(4):1461-1469.
Species: Human
Sample Type: Serum

Targeting the ion channel Kv1.3 with scorpion venom peptides engineered for potency, selectivity, and half-life.
Authors: Edwards W, Fung-Leung W, Huang C, Chi E, Wu N, Liu Y, Maher M, Bonesteel R, Connor J, Fellows R, Garcia E, Lee J, Lu L, Ngo K, Scott B, Zhou H, Swanson R, Wickenden A
J Biol Chem, 2014;289(33):22704-14.
Species: Human
Sample Type: Cell Culture Supernates

Activation of silenced cytokine gene promoters by the synergistic effect of TBP-TALE and VP64-TALE activators.
Authors: Anthony, Kim, More, Abhijit, Zhang, Xiaoliu
PLoS ONE, 2014;9(4):e95790.
Species: Human
Sample Type: Cell Culture Supernates

Sos1 regulates sustained TCR-mediated Erk activation.
Authors: Poltorak M, Meinert I, Stone J, Schraven B, Simeoni L
Eur J Immunol, 2014;44(5):1535-40.
Species: Human
Sample Type: Cell Culture Supernates

Immunogenicity of a vaccine regimen composed of simian immunodeficiency virus DNA, rMVA, and viral particles administered to female rhesus macaques via four different mucosal routes.
Authors: Manrique M, Kozlowski P, Cobo-Molinos A, Wang S, Wilson R, Montefiori D, Carville A, Aldovini A
J Virol, 2013;87(8):4738-50.
Species: Human
Sample Type: Cell Culture Supernates

Multiplexing immunoassays for cytokine detection in the serum of patients with rheumatoid arthritis: lack of sensitivity and interference by rheumatoid factor.
Authors: Churchman SM, Geiler J, Parmar R, Horner EA, Church LD, Emery P, Buch MH, McDermott MF, Ponchel F
Clin. Exp. Rheumatol., 2012;30(4):534-42.
Species: Human
Sample Type: Serum

Antigen presentation and MHC class II expression by human esophageal epithelial cells: role in eosinophilic esophagitis.
Authors: Mulder DJ, Pooni A, Mak N, Hurlbut DJ, Basta S, Justinich CJ
Am. J. Pathol., 2011;178(2):744-53.
Species: Human
Sample Type: Cell Culture Supernates

HDAC inhibition by LBH589 affects the phenotype and function of human myeloid dendritic cells.
Authors: Song W, Tai YT, Tian Z, Hideshima T, Chauhan D, Nanjappa P, Exley MA, Anderson KC, Munshi NC
Leukemia, 2011;25(1):161-8.
Species: Human
Sample Type: Cell Culture Supernates

Origination of new immunological functions in the costimulatory molecule B7-H3: the role of exon duplication in evolution of the immune system.
Authors: Sun J, Fu F, Gu W, Yan R, Zhang G, Shen Z, Zhou Y, Wang H, Shen B, Zhang X
PLoS ONE, 2011;6(9):e24751.
Species: Human
Sample Type: Cell Culture Supernates

Urinary proinflammatory cytokine response in renal transplant recipients with polyomavirus BK viruria.
Authors: Sadeghi M, Daniel V, Schnitzler P, Lahdou I, Naujokat C, Zeier M, Opelz G
Transplantation, 2009;88(9):1109-16.
Species: Human
Sample Type: Urine

Immunologic markers as predictors of tuberculosis-associated immune reconstitution inflammatory syndrome in HIV and tuberculosis coinfected persons in Thailand.
Authors: Tieu HV, Ananworanich J, Avihingsanon A, Apateerapong W, Sirivichayakul S, Siangphoe U, Klongugkara S, Boonchokchai B, Hammer SM, Manosuthi W
AIDS Res. Hum. Retroviruses, 2009;25(11):1083-9.
Species: Human
Sample Type: Serum

Short communication: decreasing soluble CD30 and increasing IFN-gamma plasma levels are indicators of effective highly active antiretroviral therapy.
Authors: Sadeghi M, Susal C, Daniel V, Naujokat C, Zimmermann R, Huth-Kuhne A, Opelz G
AIDS Res. Hum. Retroviruses, 2007;23(7):886-90.
Species: Human
Sample Type: Plasma

Co-occurrence of IgA antibodies against ethanol metabolites and tissue transglutaminase in alcohol consumers: correlation with proinflammatory cytokines and markers of fibrogenesis.
Authors: Koivisto H, Hietala J, Anttila P, Niemela O
Dig. Dis. Sci., 2007;53(2):500-5.
Species: Human
Sample Type: Serum

Functional polymorphisms in FAS and FASL contribute to increased apoptosis of tumor infiltration lymphocytes and risk of breast cancer.
Authors: Zhang B, Sun T, Xue L, Han X, Zhang B, Lu N, Shi Y, Tan W, Zhou Y, Zhao D, Zhang X, Guo Y, Lin D
Carcinogenesis, 2007;28(5):1067-73.
Species: Human
Sample Type: Cell Culture Supernates

1, 25 Dihydroxyvitamin D3 modulated cytokine response in pulmonary tuberculosis.
Authors: Vidyarani M, Selvaraj P, Jawahar MS, Narayanan PR
Cytokine, 2007;40(2):128-34.
Species: Human
Sample Type: Cell Culture Supernates

CD200 is induced by ERK and is a potential therapeutic target in melanoma.
Authors: Petermann KB, Rozenberg GI, Zedek D, Groben P, McKinnon K, Buehler C, Kim WY, Shields JM, Penland S, Bear JE, Thomas NE, Serody JS, Sharpless NE
J. Clin. Invest., 2007;117(12):3922-3929.
Species: Human
Sample Type: Cell Culture Supernates

Expression of B7-H1 on gastric epithelial cells: its potential role in regulating T cells during Helicobacter pylori infection.
Authors: Das S, Suarez G, Beswick EJ, Sierra JC, Graham DY, Reyes VE
J. Immunol., 2006;176(5):3000-9.
Species: Human
Sample Type: Cell Culture Supernates

Interleukin-2 in human milk: a potential modulator of lymphocyte development in the breastfed infant.
Authors: Bryan DL, Forsyth KD, Gibson RA, Hawkes JS
Cytokine, 2006;33(5):289-93.
Species: Human
Sample Type: Milk

Decreased plasma CXCL16/SR-PSOX concentration is associated with coronary artery disease.
Authors: Sheikine Y, Bang CS, Nilsson L, Samnegard A, Hamsten A, Jonasson L, Eriksson P, Sirsjo A
Atherosclerosis, 2006;188(2):462-6.
Species: Human
Sample Type: Serum

Human liver sinusoidal endothelial cells induce apoptosis in activated T cells: a role in tolerance induction.
Authors: Karrar A, Broome U, Uzunel M, Qureshi AR, Sumitran-Holgersson S
Gut, 2006;56(2):243-52.
Species: Human
Sample Type: Cell Culture Supernates

C-reactive protein and vascular cell adhesion molecule-1 as markers of severity in sickle cell disease.
Authors: Makis AC, Hatzimichael EC, Stebbing J, Bourantas KL
Arch. Intern. Med., 2006;166(3):366-8.
Species: Human
Sample Type: Plasma

Influence of eotaxin 67G>A polymorphism on plasma eotaxin concentrations in myocardial infarction survivors and healthy controls.
Authors: Sheikine Y, Olsen B, Gharizadeh B, Jatta K, Tornvall P, Ghaderi M
Atherosclerosis, 2006;189(2):458-63.
Species: Human
Sample Type: Serum

Strong inflammatory cytokine response in male and strong anti-inflammatory response in female kidney transplant recipients with urinary tract infection.
Authors: Sadeghi M, Daniel V, Naujokat C, Wiesel M, Hergesell O, Opelz G
Transpl. Int., 2005;18(2):177-85.
Species: Human
Sample Type: Plasma

Cytokines and adhesion molecules in multiple sclerosis patients treated with interferon-beta1b.
Authors: Jensen J, Krakauer M, Sellebjerg F
Cytokine, 2005;29(1):24-30.
Species: Human
Sample Type: Plasma

Th2 predominance and CD8+ memory T cell depletion in patients with severe acute respiratory syndrome.
Authors: Huang JL, Huang J, Duan ZH, Wei J, Min J, Luo XH, Li JG, Tan WP, Wu LZ, Liu RY, Li Y, Shao J, Huang BJ, Zeng YX, Huang W
Microbes Infect., 2005;7(3):427-36.
Species: Human
Sample Type: Serum

Th2 predominance and CD8+ memory T cell depletion in patients with severe acute respiratory syndrome.
Authors: Huang JL, Huang J, Duan ZH, Wei J, Min J, Luo XH, Li JG, Tan WP, Wu LZ, Liu RY, Li Y, Shao J, Huang BJ, Zeng YX, Huang W
Microbes Infect., 2005;7(3):427-36.
Species: Human
Sample Type: Serum

Primary cutaneous T-cell lymphomas show a deletion or translocation affecting NAV3, the human UNC-53 homologue.
Authors: Karenko L, Hahtola S, Paivinen S, Karhu R, Syrja S, Kahkonen M, Nedoszytko B, Kytölä S, Zhou Y, Blazevic V, Pesonen M, Nevala H, Nupponen N, Sihto H, Krebs I, Poustka A, Roszkiewicz J, Saksela K, Peterson P, Visakorpi T, Ranki A
Cancer Res., 2005;65(18):8101-10.
Species: Human
Sample Type: Cell Culture Supernates

Inflammatory cytokine concentrations are elevated in seminal plasma of men with spinal cord injuries.
Authors: Basu S, Aballa TC, Ferrell SM, Lynne CM, Brackett NL
J. Androl., 2004;25(2):250-4.
Species: Human
Sample Type: seminal plasma

Urinary IL-2 assay for monitoring intravesical bacillus Calmette-Guerin response of superficial bladder cancer during induction course and maintenance therapy.
Authors: Saint F, Kurth N, Maille P, Vordos D, Hoznek A, Soyeux P, Patard JJ, Abbou CC, Chopin DK
Int. J. Cancer, 2003;107(3):434-40.
Species: Human
Sample Type: Urine

Fibroblasts from human spleen regulate NK cell differentiation from blood CD34(+) progenitors via cell surface IL-15.
Authors: Briard D, Brouty-Boye D, Azzarone B, Jasmin C
J. Immunol., 2002;168(9):4326-32.
Species: Human
Sample Type: Cell Culture Supernates

Local immunostimulation induced by intravesical administration of autologous interferon-gamma-activated macrophages in patients with superficial bladder cancer.
Authors: Pages F, Lebel-Binay S, Vieillefond A, Deneux L, Cambillau M, Soubrane O, Debre B, Tardy D, Lemonne JL, Abastado JP, Fridman WH, Thiounn N
Clin. Exp. Immunol., 2002;127(2):303-9.
Species: Human
Sample Type: Urine

Intraperitoneal bispecific antibody (HEA125xOKT3) therapy inhibits malignant ascites production in advanced ovarian carcinoma.
Authors: Marme A, Strauss G, Bastert G, Grischke EM, Moldenhauer G
Int. J. Cancer, 2002;101(2):183-9.
Species: Human
Sample Type: Ascites

Embryotoxicity of peritoneal fluid in women with endometriosis. Its relation with cytokines and lymphocyte populations.
Authors: Gomez-Torres MJ, Acien P, Campos A, Velasco I
Hum. Reprod., 2002;17(3):777-81.
Species: Human
Sample Type: Peritoneal Fluid

Human T-cell leukemia virus type 2 induces survival and proliferation of CD34(+) TF-1 cells through activation of STAT1 and STAT5 by secretion of interferon-gamma and granulocyte macrophage-colony-stimulating factor.
Authors: Bovolenta C, Pilotti E, Mauri M, Turci M, Ciancianaini P, Fisicaro P, Bertazzoni U, Poli G, Casoli C
Blood, 2002;99(1):224-31.
Species: Human
Sample Type: Cell Culture Supernates

An analysis of acute changes in interleukin-6 levels after treatment of hepatitis C with consensus interferon.
Authors: Cotler SJ, Reddy KR, McCone J, Wolfe DL, Liu A, Craft TR, Ferris MW, Conrad AJ, Albrecht J, Morrissey M, Ganger DR, Rosenblate H, Blatt LM, Jensen DM, Taylor MW
J. Interferon Cytokine Res., 2001;21(12):1011-9.
Species: Human
Sample Type: Serum

Effects of UVB radiation on cytokine generation, cell adhesion molecules, and cell activation markers in T-lymphocytes and peripheral blood HPCs.
Authors: Lankford KV, Mosunjac M, Hillyer CD
Transfusion, 2000;40(3):361-7.
Species: Human
Sample Type: Cell Culture Supernates

Human amniotic fluid lacks interleukin-2 and interleukin-15 but can interact with the beta-chain of the interleukin-2 receptor.
Authors: Searle RF, Bromage SJ, Palmer J, Curry JE, Lang AK
Immunology, 2000;99(3):411-7.
Species: Human
Sample Type: Amniotic Fluid

Natural interferon alpha/beta-producing cells link innate and adaptive immunity.
Authors: Kadowaki N, Antonenko S, Lau JY, Liu YJ
J. Exp. Med., 2000;192(2):219-26.
Species: Human
Sample Type: Cell Culture Supernates

Cytokine profiles in parotid saliva from HIV-1-infected individuals: changes associated with opportunistic infections in the oral cavity.
Authors: Black, K P, Merrill, K W, Jackson, S, Katz, J
Oral Microbiol Immunol, 2000;15(2):74-81.
Species: Human
Sample Type: Saliva

High versus low basal cortisol secretion in asymptomatic, medication-free HIV-infected men: differential effects of severe life stress on parameters of immune status.
Authors: Petitto JM, Leserman J, Perkins DO, Stern RA, Silva SG, Gettes D, Zheng B, Folds JD, Golden RN, Evans DL
Behav Med, 2000;25(4):143-51.
Species: Human
Sample Type: Cell Culture Supernates

生物活性< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景IL-2 (Interleukin 2) is a critical cytokine in T cell biology. It promotes T cell activation and expansion, the development, maintenance and function of regulatory T cells (Treg), and the differentiation of CD8+ T cells into terminal effector cells and memory cells. IL-2 signals through a receptor complex composed of CD25/IL-2 R alpha, IL-2 R beta, and the Common gamma Chain (gamma c). IL-2 R beta is also a component of the IL-15 receptor complex. Gamma c is also a signaling subunit in the receptors for IL-4, -7, -9, -15, and -21.
运输条件Blue Ice
存放说明4℃
参考文献
  • Cancer Biomarkers
  • Common gamma Chain Receptor Family
  • Conventional/Classical Dendritic Cells
  • Cytokines and Receptors in Allergy and Asthma
  • Cytokines and Receptors in Tfh Cell Differentiation and Function
  • gamma delta T Cells
  • Group 1 ILCs
  • Infectious Diseases
  • Inflammatory Mediators
  • Isolation, Culture, and Identification of Natural Killer Cells
  • Multiple Sclerosis and Myelin Related Molecules
  • NCR+ILC3
  • Neuroinflammation
  • Preeclampsia
  • Regulatory T Cells (Tregs)
  • T Cell Cytokine Signaling
  • Th1 Cells
  • Th2 Cells
  • Th9 Cells