一抗

克隆类型
多抗单抗
产品类型
标签抗体磷酸化抗体内参抗体甲基化抗体乙酰化抗体药物与化合物抗体植物抗体
研究领域
肿瘤心血管细胞生物免疫学发育生物学染色质和核信号微生物学细胞凋亡信号转导干细胞神经生物学生长因子和激素糖尿病内分泌病转运蛋白植物细菌及病毒转录调节因子海洋生物上皮细胞趋化因子结合蛋白细胞表面分子G蛋白偶联受体胶原蛋白糖蛋白交换蛋白细胞分化血管内皮细胞细胞类型标志物内皮细胞淋巴细胞T-淋巴细胞B-淋巴细胞细胞粘附分子肿瘤细胞生物标志物骨髓细胞细胞骨架跨膜蛋白细胞因子自然杀伤细胞树突状细胞标志物脂蛋白新陈代谢锌指蛋白通道蛋白细胞周期蛋白激酶和磷酸酶昆虫线粒体环指蛋白细胞自噬细胞膜受体药物及化合物泛素干扰素G蛋白信号细胞膜蛋白Alzheimers表观遗传学细胞外基质合成与降解

标记一抗

标记类型
HRPBiotinGoldRBITCAPFITCCy3Cy5Cy5.5Cy7PEPE-Cy3PE-Cy5PE-Cy5.5PE-Cy7APCAlexa Fluor 350Alexa Fluor 488Alexa Fluor 555Alexa Fluor 594Alexa Fluor 647

二抗

克隆类型
多抗单抗
产品分类
二抗二抗血清

标记二抗

标记类型
HRPBiotinGoldRBITCAPFITCCy3Cy5Cy5.5Cy7PEPE-Cy3PE-Cy5PE-Cy5.5PE-Cy7APCAlexa Fluor 350Alexa Fluor 488Alexa Fluor 555Alexa Fluor 594Alexa Fluor 647

蛋白质与多肽

产品分类
蛋白质多肽

标记蛋白质与多肽

所有产品
全部标记蛋白质与多肽

正常动物血清及免疫球蛋白

产品分类
正常动物血清免疫球蛋白

试剂盒

产品分类
ELISA试剂盒

常用试剂

产品分类
免疫组化常用试剂免疫印迹常用试剂常用显色试剂细胞生物学试剂分子生物学生化试剂

亲和层析柱

所有产品
亲和层析柱

配套试剂

所有产品
常用配套试剂

ELISA试剂盒

人ELISA试剂盒 大鼠ELISA试剂盒 小鼠ELISA试剂盒 牛ELISA试剂盒 鸡ELISA试剂盒 植物ELISA试剂盒 猴ELISA试剂盒 猪ELISA试剂盒 山羊ELISA试剂盒 马ELISA试剂盒 仓鼠ELISA试剂盒 绵羊ELISA试剂盒 兔子ELISA试剂盒 犬ELISA试剂盒 豚鼠ELISA试剂盒 其他ELISA试剂盒

生化试剂

色素类 分离材料及耗材 维生素 染色剂 碳水化合物 植物激素及核酸 抗生素 蛋白质 氨基酸 测试盒 其他生物试剂 缓冲剂 表面活性剂

血浆

血浆

血清

Sigma胎牛血清 gibco胎牛血清 Hyclone血清 人血清 国产新生牛血清 国产胎牛血清 其他血清

细胞

其它细胞 仓鼠细胞 猴细胞 大鼠细胞 人细胞 狗细胞 小鼠细胞 猫细胞 鸡细胞

标准品

对照品 农药标准品 标准物质 食品 无机溶液标准物质 有机溶液标准物质

抗体

兔抗 鼠抗 IgY抗体 IgA抗体 IgG抗体 二抗 一抗

裂解血

裂解血

培养基

美国药典培养基 化妆品检验培养基 大肠杆菌、大肠菌群 金黄色葡萄球菌检验 消毒灭菌效果评价 临床检验用培养基 中华人民共和国药典 欧洲药典(EP) 饮用天然矿泉水检验方法 微生物检验 霉菌、酵母菌 肠球菌、链球菌 沙门氏菌、志贺氏菌 弧菌 弯曲杆菌 李斯特氏菌 产气荚膜梭菌 阪崎肠杆菌 乳酸菌、双歧杆菌 小肠结肠炎耶尔森氏菌 蜡样芽孢杆菌检验 小肠结肠炎耶尔森氏菌检验 一次性试管、液体培养基 乳酸菌检验 菌落总数测定、无菌检验 显色培养基 植物组培

产品中心

当前位置:首页>产品中心

Human IL-15 Quantikine SixPak (6 Plates) (1 PK)

货号: S1500 基本售价: 29971.6 元 规格: 1 PACK

产品信息

概述
货号S1500
描述The Quantikine Human IL-15 Immunoassay is a 4.25 or 4.5 hour solid phase ELISA designed to measure human IL-15 in cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant human IL-15 and antibodies raised against the recombinant factor. This immunoassay has been shown to accurately quantitate the recombinant factor. Results obtained using natural human IL-15 expressed by HuT-102 cells showed linear curves that were parallel to the standard curves obtained using the recombinant Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural human IL-15.
别名IL15; IL-15; IL-15MGC9721; interleukin 15; interleukin-15;
全称
Interleukin 15
反应种属Human
目标/特异性Natural and recombinant human IL-15
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs
3600 (Human); 16168 (Mouse); 25670 (Rat); 493682 (Feline)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Involvement of NK Cells and NKp30 Pathway in Antisynthetase Syndrome
J Immunol, 2016;197(5):1621-30.
Species: Human
Sample Type: Serum

Intramuscular delivery of heterodimeric IL-15 DNA in macaques produces systemic levels of bioactive cytokine inducing proliferation of NK and T cells.
Authors: Bergamaschi C, Kulkarni V, Rosati M, Alicea C, Jalah R, Chen S, Bear J, Sardesai N, Valentin A, Felber B, Pavlakis G
Gene Ther, 2015;22(1):76-86.
Species: Human
Sample Type: Cell Culture Supernates

Immune Recovery after Allogeneic Hematopoietic Stem Cell Transplantation Following Flu-TBI versus TLI-ATG Conditioning.
Authors: Hannon M, Beguin Y, Ehx G, Servais S, Seidel L, Graux C, Maertens J, Kerre T, Daulne C, De Bock M, Fillet M, Ory A, Willems E, Gothot A, Humblet-Baron S, Baron F
Clin Cancer Res, 2015;21(14):3131-9.
Species: Human
Sample Type: Plasma

Decreased IL-7 responsiveness is related to oxidative stress in HIV disease.
Authors: Kalinowska M, Bazdar D, Lederman M, Funderburg N, Sieg S
PLoS ONE, 2013;8(3):e58764.
Species: Human
Sample Type: Serum

IL-15 Expression on RA Synovial Fibroblasts Promotes B Cell Survival.
Authors: Benito-Miguel M, Garcia-Carmona Y, Balsa A, Bautista-Caro MB, Arroyo-Villa I, Cobo-Ibanez T, Bonilla-Hernan MG, De Ayala CP, Sanchez-Mateos P, Martin-Mola E, Miranda-Carus ME
PLoS ONE, 2012;7(7):e40620.
Species: Human
Sample Type: Cell Culture Supernates

Adoptive transfer of autologous natural killer cells leads to high levels of circulating natural killer cells but does not mediate tumor regression.
Authors: Parkhurst MR, Riley JP, Dudley ME, Rosenberg SA
Clin. Cancer Res., 2011;17(19):6287-97.
Species: Human
Sample Type: Serum

Development of an IL-15-autocrine CD8 T-cell leukemia in IL-15-transgenic mice requires the cis expression of IL-15R alpha.
Authors: Sato N, Sabzevari H, Fu S, Ju W, Petrus MN, Bamford RN, Waldmann TA, Tagaya Y
Blood, 2011;117(15):4032-40.
Species: Human
Sample Type: Serum

Long-lasting inhibitory effects of fetal liver mesenchymal stem cells on T-lymphocyte proliferation.
Authors: Giuliani M, Fleury M, Vernochet A, Ketroussi F, Clay D, Azzarone B, Lataillade JJ, Durrbach A
2011;6(5):e19988.
Species: Human
Sample Type: Cell Culture Supernates

Plasma levels of IL-7 and IL-15 after reduced intensity conditioned allo-SCT and relationship to acute GVHD.
Authors: Thiant S, Labalette M, Trauet J, Coiteux V, de Berranger E, Dessaint JP, Yakoub-Agha I
Bone Marrow Transplant., 2010;46(10):1374-81.
Species: Human
Sample Type: Plasma

Phenotype markers and cytokine intracellular production by CD8+ gammadelta T lymphocytes do not support a regulatory T profile in Behcet's disease patients and healthy controls.
Authors: Clemente A, Cambra A, Munoz-Saa I, Crespi C, Pallares L, Juan A, Matamoros N, Julia MR
Immunol. Lett., 2010;129(2):57-63.
Species: Human
Sample Type: Serum

Lack of anti-tumour reactivity despite enhanced numbers of circulating natural killer T cells in two patients with metastatic renal cell carcinoma.
Authors: Vyth-Dreese FA, Sein J, van de Kasteele W, Dellemijn TA, van den Bogaard C, Nooijen WJ, de Gast GC, Haanen JB, Bex A
Clin. Exp. Immunol., 2010;162(3):447-59.
Species: Human
Sample Type: Plasma

Plasma levels of IL-7 and IL-15 in the first month after myeloablative BMT are predictive biomarkers of both acute GVHD and relapse.
Authors: Thiant S, Yakoub-Agha I, Magro L, Trauet J, Coiteux V, Jouet JP, Dessaint JP, Labalette M
Bone Marrow Transplant., 2010;45(10):1546-52.
Species: Human
Sample Type: Plasma

Enhancing the in vivo expansion of adoptively transferred EBV-specific CTL with lymphodepleting CD45 monoclonal antibodies in NPC patients.
Authors: Louis CU, Straathof K, Bollard CM, Gerken C, Huls MH, Gresik MV, Wu MF, Weiss HL, Gee AP, Brenner MK, Rooney CM, Heslop HE, Gottschalk S
Blood, 2009;113(11):2442-50.
Species: Human
Sample Type: Plasma

Single-dose nevirapine exposure affects T cell response and cytokine levels in HIV type 1-infected women.
Authors: Shalekoff S, Meddows-Taylor S, Schramm DB, Gray G, Sherman G, Coovadia A, Kuhn L, Tiemessen CT
AIDS Res. Hum. Retroviruses, 2009;25(10):1049-53.
Species: Human
Sample Type: Plasma

Safety and immunologic effects of IL-15 administration in nonhuman primates.
Authors: Berger C, Berger M, Hackman RC, Gough M, Elliott C, Jensen MC, Riddell SR
Blood, 2009;114(12):2417-26.
Species: Primate- Macaca nemestrina (Pigtailed Macaque)
Sample Type: Plasma

Isolation and characterization of CD8+ regulatory T cells in multiple sclerosis.
Authors: Correale J, Villa A
J. Neuroimmunol., 2008;195(1):121-34.
Species: Human
Sample Type: Serum

An unusual CD56(bright) CD16(low) NK cell subset dominates the early posttransplant period following HLA-matched hematopoietic stem cell transplantation.
Authors: Dulphy N, Haas P, Busson M, Belhadj S, Peffault de Latour R, Robin M, Carmagnat M, Loiseau P, Tamouza R, Scieux C, Rabian C, Di Santo JP, Charron D, Janin A, Socie G, Toubert A
J. Immunol., 2008;181(3):2227-37.
Species: Human
Sample Type: Serum

Chemokines CXCL10 and CXCL11 in the cerebrospinal fluid of patients with tick-borne encephalitis.
Authors: Lepej SZ, Misic-Majerus L, Jeren T, Rode OD, Remenar A, Sporec V, Vince A
Acta Neurol. Scand., 2007;115(2):109-14.
Species: Human
Sample Type: CSF

Circulating interleukin-15 and RANTES chemokine in Parkinsons disease.
Authors: Rentzos M, Nikolaou C, Andreadou E, Paraskevas GP, Rombos A, Zoga M, Tsoutsou A, Boufidou F, Kapaki E, Vassilopoulos D
Acta Neurol. Scand., 2007;116(6):374-9.
Species: Human
Sample Type: Serum

Serum interleukin-15 level is a useful predictor of the complications and mortality in severe acute pancreatitis.
Authors: Ueda T, Takeyama Y, Yasuda T, Shinzeki M, Sawa H, Nakajima T, Takase K, Matsumoto I, Fujita T, Ajiki T, Fujino Y, Kuroda Y
Surgery, 2007;142(3):319-26.
Species: Human
Sample Type: Serum

Increased ENA-78 in the follicular fluid of patients with endometriosis.
Authors: Wunder DM, Mueller MD, Birkhauser MH, Bersinger NA
Acta Obstet Gynecol Scand, 2006;85(3):336-42.
Species: Human
Sample Type: Follicular Fluid

Levels of IL-15 in serum and cerebrospinal fluid of patients with Behçet's disease.
Authors: Hamzaoui K, Hamzaoui A, Ghorbel I, Khanfir M, Houman H
Scand. J. Immunol., 2006;64(6):655-60.
Species: Human
Sample Type: Serum

Juxtacrine function of interleukin-15/interleukin-15 receptor system in tumour derived human B-cell lines.
Authors: Tsukamoto K, Huang YC, Dorsey WC, Carns B, Sharma V
Clin. Exp. Immunol., 2006;146(3):559-66.
Species: Human
Sample Type: Cell Culture Supernates

Differential expression of interleukins IL-13 and IL-15 in normal ovarian tissue and ovarian carcinomas.
Authors: Ripley D, Shoup B, Majewski A
Gynecol. Oncol., 2004;92(3):761-8.
Species: Human
Sample Type: Tissue Homogenates

NK cells regulate CD8+ T cell effector function in response to an intracellular pathogen.
Authors: Vankayalapati R, Klucar P, Wizel B, Weis SE, Samten B, Safi H, Shams H, Barnes PF
J. Immunol., 2004;172(1):130-7.
Species: Human
Sample Type: Cell Culture Supernates

Differential expression of interleukins IL-13 and IL-15 in normal ovarian tissue and ovarian carcinomas.
Authors: Ripley D, Shoup B, Majewski A
Gynecol. Oncol., 2004;92(3):761-8.
Species: Human
Sample Type: Tissue Homogenates

Growth and apoptosis of human natural killer cell neoplasms: role of interleukin-2/15 signaling.
Authors: Yamasaki S, Maeda M, Ohshima K, Kikuchi M, Otsuka T, Harada M
Leuk. Res., 2004;28(10):1023-31.
Species: Human
Sample Type: Serum

Fibroblasts from human spleen regulate NK cell differentiation from blood CD34(+) progenitors via cell surface IL-15.
Authors: Briard D, Brouty-Boye D, Azzarone B, Jasmin C
J. Immunol., 2002;168(9):4326-32.
Species: Human
Sample Type: Cell Culture Supernates

Human T-cell leukemia virus type 2 induces survival and proliferation of CD34(+) TF-1 cells through activation of STAT1 and STAT5 by secretion of interferon-gamma and granulocyte macrophage-colony-stimulating factor.
Authors: Bovolenta C, Pilotti E, Mauri M, Turci M, Ciancianaini P, Fisicaro P, Bertazzoni U, Poli G, Casoli C
Blood, 2002;99(1):224-31.
Species: Human
Sample Type: Cell Culture Supernates

Decreased IL-15 may contribute to elevated IgE and acute inflammation in atopic dermatitis.
Authors: Ong PY, Hamid QA, Travers JB, Strickland I, Al Kerithy M, Boguniewicz M, Leung DY
J. Immunol., 2002;168(1):505-10.
Species: Human
Sample Type: Cell Culture Supernates

Natural interferon alpha/beta-producing cells link innate and adaptive immunity.
Authors: Kadowaki N, Antonenko S, Lau JY, Liu YJ
J. Exp. Med., 2000;192(2):219-26.
Species: Human
Sample Type: Cell Culture Supernates

Interleukin-12 induces sustained activation of multiple host inflammatory mediator systems in chimpanzees.
Authors: Lauw FN, Dekkers PE, te Velde AA, Speelman P, Levi M, Kurimoto M, Hack CE, Van Deventer SJ, van der Poll T
J. Infect. Dis., 1999;179(3):646-52.
Species: Primate - Pan troglodytes (Chimpanzee)
Sample Type: Plasma

生物活性< 0.5% cross-reactivity observed with available related molecules.Cross-species reactivity not tested.
背景IL-15 (Interleukin 15) is a cytokine that induces or enhances the differentiation, maintenance, or activation of multiple T cell subsets including NK, NKT, Th17, Treg, and CD8+ memory cells. It also induces dendritic cell differentiation and inflammatory activation, exhibits anti-tumor activity, and inhibits the deposition of lipid in adipocytes. Complexes of IL-15 with cell surface IL-15 R alpha interact with complexes of IL-2 R beta and the Common gamma Chain on adjacent cells. This transpresentation mechanism enables cells to respond to IL-15 even if they do not express IL-15 R alpha. Ligation of membrane-associated IL-15/IL-15 R alpha complexes also induces reverse signaling that promotes activation of the IL-15/IL-15 R alpha expressing cells. The activity of circulating IL-15 is limited by its association with soluble IL-15 R alpha.
运输条件Blue Ice
存放说明4℃
参考文献
  • Common gamma Chain Receptor Family
  • Group 1 ILCs
  • Isolation, Culture, and Identification of Natural Killer Cells
  • Macrophage Activation Markers
  • Molecules Secreted by VSMC
  • Natural Killer T (NKT) Cells