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Human IL-13 Quantikine SixPak (6 Plates) (1 PK)

货号: S1300B 基本售价: 29971.6 元 规格: 1 PACK

产品信息

概述
货号S1300B
描述The Quantikine Human IL-13 Immunoassay is a 4.5 hour solid phase ELISA designed to measure IL-13 levels in cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant human IL-13 and antibodies raised against the recombinant factor. This immunoassay has been shown to quantitate recombinant human IL-13 accurately. Results obtained using natural human IL-13 showed dose response curves that were parallel to the standard curves obtained using the recombinant kit standards. These results indicate that this kit can be used to determine relative mass values for natural human IL-13.
别名ALRHMGC116789; BHR1interleukin-13; IL13; IL-13; IL-13MGC116788; interleukin 13; MGC116786; NC30; P600;
全称
Interleukin 13
反应种属Human
目标/特异性Natural and recombinant human IL-13
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs
3596 (Human); 16163 (Mouse); 116553 (Rat); 574325 (Primate)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

IL-33 reflects dynamics of disease activity in patients with autoimmune hemolytic anemia by regulating autoantibody production.
Authors: Bu X, Zhang T, Wang C, Ren T, Wen Z
J Transl Med, 2015;13(0):381.
Species: Human
Sample Type: Cell Culture Supernates

Soluble interleukin-18 receptor complex is a novel biomarker in rheumatoid arthritis.
Authors: Takei S, Hoshino T, Matsunaga K, Sakazaki Y, Sawada M, Oda H, Takenaka S, Imaoka H, Kinoshita T, Honda S, Ida H, Fukuda TA, Aizawa H
Arthritis Res. Ther., 2011;13(2):R52.
Species: Human
Sample Type: Serum

Thymic stromal lymphopoietin-induced human asthmatic airway epithelial cell proliferation through an IL-13-dependent pathway.
Authors: Semlali A, Jacques E, Koussih L, Gounni AS, Chakir J
J. Allergy Clin. Immunol., 2010;125(4):844-50.
Species: Human
Sample Type: Cell Culture Supernates

IL-17 in atopic eczema: linking allergen-specific adaptive and microbial-triggered innate immune response.
Authors: Eyerich K, Pennino D, Scarponi C, Foerster S, Nasorri F, Behrendt H, Ring J, Traidl-Hoffmann C, Albanesi C, Cavani A
J. Allergy Clin. Immunol., 2009;123(1):59-66.e4.
Species: Human
Sample Type: Cell Culture Supernates

Mast cell-dependent contraction of human airway smooth muscle cell-containing collagen gels: influence of cytokines, matrix metalloproteases, and serine proteases.
Authors: Margulis A, Nocka KH, Brennan AM, Deng B, Fleming M, Goldman SJ, Kasaian MT
J. Immunol., 2009;183(3):1739-50.
Species: Human
Sample Type: Cell Culture Supernates

Distinct subsets of human invariant NKT cells differentially regulate T helper responses via dendritic cells.
Authors: Liu TY, Uemura Y, Suzuki M, Narita Y, Hirata S, Ohyama H, Ishihara O, Matsushita S
Eur. J. Immunol., 2008;38(4):1012-23.
Species: Human
Sample Type: Cell Culture Supernates

Mycobacterium bovis Bacillus Calmette-Guerin suppresses inflammatory Th2 responses by inducing functional alteration of TSLP-activated dendritic cells.
Authors: Yokoi T, Amakawa R, Tanijiri T, Sugimoto H, Torii Y, Amuro H, Son Y, Tajima K, Liu YJ, Ito T, Fukuhara S
Int. Immunol., 2008;20(10):1321-9.
Species: Human
Sample Type: Cell Culture Supernates

Detection of pancreatic cancer using antibody microarray-based serum protein profiling.
Authors: Ingvarsson J, Wingren C, Carlsson A, Ellmark P, Wahren B, Engstrom G, Harmenberg U, Krogh M, Peterson C, Borrebaeck CA
Proteomics, 2008;8(11):2211-9.
Species: Human
Sample Type: Serum

Development of an in vitro potency bioassay for therapeutic IL-13 antagonists: the A-549 cell bioassay.
Authors: Miller R, Sadhukhan R, Wu C
J. Immunol. Methods, 2008;334(1):134-41.
Species: Human
Sample Type: Cell Culture Supernates

IL-13 involvement in eosinophilic esophagitis: transcriptome analysis and reversibility with glucocorticoids.
Authors: Blanchard C, Mingler MK, Vicario M, Abonia JP, Wu YY, Lu TX, Collins MH, Putnam PE, Wells SI, Rothenberg ME
J. Allergy Clin. Immunol., 2007;120(6):1292-300.
Species: Human
Sample Type: Cell Culture Supernates

Placental growth factor down-regulates type 1 T helper immune response by modulating the function of dendritic cells.
Authors: Lin YL, Liang YC, Chiang BL
J. Leukoc. Biol., 2007;82(6):1473-80.
Species: Human
Sample Type: Cell Culture Supernates

Expression of interleukin-18 and caspase-1 in cutaneous T-cell lymphoma.
Authors: Yamanaka K, Clark R, Dowgiert R, Hurwitz D, Shibata M, Rich BE, Hirahara K, Jones DA, Eapen S, Mizutani H, Kupper TS
Clin. Cancer Res., 2006;12(2):376-82.
Species: Human
Sample Type: Plasma

Chemokines indicate allergic bronchopulmonary aspergillosis in patients with cystic fibrosis.
Authors: Hartl D, Latzin P, Zissel G, Krane M, Krauss-Etschmann S, Griese M
Am. J. Respir. Crit. Care Med., 2006;173(12):1370-6.
Species: Human
Sample Type: Serum

A network-based analysis of the late-phase reaction of the skin.
Authors: Benson M, Langston MA, Adner M, Andersson B, Torinssson-Naluai A, Cardell LO
J. Allergy Clin. Immunol., 2006;118(1):220-5.
Species: Human
Sample Type: Cell Culture Supernates

Relationship between cytokines and the embryotoxicity of hydrosalpingeal fluid.
Authors: Bedaiwy MA, Falcone T, Goldberg JM, Attaran M, Sharma R, Miller K, Nelson DR, Agarwal A
J. Assist. Reprod. Genet., 2005;22(4):161-5.
Species: Human
Sample Type: Hypersalpingeal fluid (HSF)

Differential expression of interleukins IL-13 and IL-15 in normal ovarian tissue and ovarian carcinomas.
Authors: Ripley D, Shoup B, Majewski A
Gynecol. Oncol., 2004;92(3):761-8.
Species: Human
Sample Type: Tissue Homogenates

Differential expression of interleukins IL-13 and IL-15 in normal ovarian tissue and ovarian carcinomas.
Authors: Ripley D, Shoup B, Majewski A
Gynecol. Oncol., 2004;92(3):761-8.
Species: Human
Sample Type: Tissue Homogenates

Implications of serum TNF-beta and IL-13 in the treatment response of childhood nephrotic syndrome.
Authors: Tain YL, Chen TY, Yang KD
Cytokine, 2003;21(3):155-9.
Species: Human
Sample Type: Serum

Modulation of human immune response by Echinococcus granulosus antigen B and its possible role in evading host defenses.
Authors: Rigano R, Profumo E, Bruschi F, Carulli G, Azzara A, Ioppolo S, Buttari B, Ortona E, Margutti P, Teggi A, Siracusano A
Infect. Immun., 2001;69(1):288-96.
Species: Human
Sample Type: Cell Culture Supernates

生物活性< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景IL-13 (Interleukin-13) plays a key role in the pathogenesis of allergy, cancer, and tissue fibrosis. It is secreted by several helper T cell subsets, NK cells, mast cells, eosinophils, basophils, and visceral smooth muscle cells. IL-13 suppresses the production of proinflammatory cytokines and other cytotoxic substances by macrophages, fibroblasts, and endothelial cells. It promotes B cell activation, immunoglobulin class switching to IgE, and the upregulation of CD23/Fc epsilon RII. IL-13 signals through a receptor complex containing IL-13 R alpha 1 and IL-4 R alpha. This complex also functions as the type 2 IL-4 receptor. IL-13 R alpha 2 binds IL-13 and prevents IL-13 from signaling through the IL-13 R alpha 1/IL-4 R alpha complex. IL-13-bound IL-13 R alpha 2 can directly promote tumor cell invasiveness and the development of tissue fibrosis.
运输条件Blue Ice
存放说明4℃
参考文献
  • Cytokines and Receptors in Allergy and Asthma
  • Cytokines and Receptors in Angiogenesis
  • Cytokines and Receptors in Tfh Cell Differentiation and Function
  • gamma delta T Cells
  • Group 2 ILCs
  • Myeloid-derived Suppressor Cells (MDSC)
  • Natural Killer T (NKT) Cells
  • T Cell Cytokine Signaling
  • Th2 Cells
  • Th22 Cells