一抗

克隆类型
多抗单抗
产品类型
标签抗体磷酸化抗体内参抗体甲基化抗体乙酰化抗体药物与化合物抗体植物抗体
研究领域
肿瘤心血管细胞生物免疫学发育生物学染色质和核信号微生物学细胞凋亡信号转导干细胞神经生物学生长因子和激素糖尿病内分泌病转运蛋白植物细菌及病毒转录调节因子海洋生物上皮细胞趋化因子结合蛋白细胞表面分子G蛋白偶联受体胶原蛋白糖蛋白交换蛋白细胞分化血管内皮细胞细胞类型标志物内皮细胞淋巴细胞T-淋巴细胞B-淋巴细胞细胞粘附分子肿瘤细胞生物标志物骨髓细胞细胞骨架跨膜蛋白细胞因子自然杀伤细胞树突状细胞标志物脂蛋白新陈代谢锌指蛋白通道蛋白细胞周期蛋白激酶和磷酸酶昆虫线粒体环指蛋白细胞自噬细胞膜受体药物及化合物泛素干扰素G蛋白信号细胞膜蛋白Alzheimers表观遗传学细胞外基质合成与降解

标记一抗

标记类型
HRPBiotinGoldRBITCAPFITCCy3Cy5Cy5.5Cy7PEPE-Cy3PE-Cy5PE-Cy5.5PE-Cy7APCAlexa Fluor 350Alexa Fluor 488Alexa Fluor 555Alexa Fluor 594Alexa Fluor 647

二抗

克隆类型
多抗单抗
产品分类
二抗二抗血清

标记二抗

标记类型
HRPBiotinGoldRBITCAPFITCCy3Cy5Cy5.5Cy7PEPE-Cy3PE-Cy5PE-Cy5.5PE-Cy7APCAlexa Fluor 350Alexa Fluor 488Alexa Fluor 555Alexa Fluor 594Alexa Fluor 647

蛋白质与多肽

产品分类
蛋白质多肽

标记蛋白质与多肽

所有产品
全部标记蛋白质与多肽

正常动物血清及免疫球蛋白

产品分类
正常动物血清免疫球蛋白

试剂盒

产品分类
ELISA试剂盒

常用试剂

产品分类
免疫组化常用试剂免疫印迹常用试剂常用显色试剂细胞生物学试剂分子生物学生化试剂

亲和层析柱

所有产品
亲和层析柱

配套试剂

所有产品
常用配套试剂

ELISA试剂盒

人ELISA试剂盒 大鼠ELISA试剂盒 小鼠ELISA试剂盒 牛ELISA试剂盒 鸡ELISA试剂盒 植物ELISA试剂盒 猴ELISA试剂盒 猪ELISA试剂盒 山羊ELISA试剂盒 马ELISA试剂盒 仓鼠ELISA试剂盒 绵羊ELISA试剂盒 兔子ELISA试剂盒 犬ELISA试剂盒 豚鼠ELISA试剂盒 其他ELISA试剂盒

生化试剂

色素类 分离材料及耗材 维生素 染色剂 碳水化合物 植物激素及核酸 抗生素 蛋白质 氨基酸 测试盒 其他生物试剂 缓冲剂 表面活性剂

血浆

血浆

血清

Sigma胎牛血清 gibco胎牛血清 Hyclone血清 人血清 国产新生牛血清 国产胎牛血清 其他血清

细胞

其它细胞 仓鼠细胞 猴细胞 大鼠细胞 人细胞 狗细胞 小鼠细胞 猫细胞 鸡细胞

标准品

对照品 农药标准品 标准物质 食品 无机溶液标准物质 有机溶液标准物质

抗体

兔抗 鼠抗 IgY抗体 IgA抗体 IgG抗体 二抗 一抗

裂解血

裂解血

培养基

美国药典培养基 化妆品检验培养基 大肠杆菌、大肠菌群 金黄色葡萄球菌检验 消毒灭菌效果评价 临床检验用培养基 中华人民共和国药典 欧洲药典(EP) 饮用天然矿泉水检验方法 微生物检验 霉菌、酵母菌 肠球菌、链球菌 沙门氏菌、志贺氏菌 弧菌 弯曲杆菌 李斯特氏菌 产气荚膜梭菌 阪崎肠杆菌 乳酸菌、双歧杆菌 小肠结肠炎耶尔森氏菌 蜡样芽孢杆菌检验 小肠结肠炎耶尔森氏菌检验 一次性试管、液体培养基 乳酸菌检验 菌落总数测定、无菌检验 显色培养基 植物组培

产品中心

当前位置:首页>产品中心

Rat IL-1 beta/IL-1F2 Quantikine SixPak (6 Plates) (1 PK)

货号: SRLB00 基本售价: 19749.7 元 规格: 1 PACK

产品信息

概述
货号SRLB00
描述The Quantikine Rat IL-1 beta Immunoassay is a 4.5 hour solid phase ELISA designed to measure rat IL-1 beta in cell culture supernates, serum, and EDTA plasma. It contains recombinant rat IL-1 beta and antibodies raised against recombinant rat IL-1 beta. This immunoassay has been shown to quantitate the recombinant rat factor accurately.
别名catabolin; IL1 beta; IL-1 beta; IL-1; IL1B; IL-1B; IL1-BETA; IL-1F2; IL1F2IL-1 beta; interleukin 1, beta; interleukin-1 beta; preinterleukin 1 beta; pro-interleukin-1-beta;
全称
Interleukin 1 beta
反应种属Rat
目标/特异性Natural and recombinant rat IL-1 beta
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs
3553 (Human); 16176 (Mouse); 24494 (Rat); 397122 (Porcine); 403974 (Canine); 100034237 (Equine); 100135556 (Guinea Pig)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Physical versus psychological social stress in male rats reveals distinct cardiovascular, inflammatory and behavioral consequences
Authors: JE Finnell, CM Lombard, AR Padi, CM Moffitt, LB Wilson, CS Wood, SK Wood
PLoS ONE, 2017;12(2):e0172868.
Species: Rat
Sample Type: Tissue Homogenates

Chronic Cognitive Dysfunction after Traumatic Brain Injury Is Improved with a Phosphodiesterase 4B Inhibitor
J Neurosci, 2016;36(27):7095-108.
Species: Rat
Sample Type: Tissue Homgenates

Spatiotemporal Cadence of Macrophage Polarisation in a Model of Light-Induced Retinal Degeneration.
Authors: Jiao H, Natoli R, Valter K, Provis J, Rutar M
PLoS ONE, 2015;10(12):e0143952.
Species: Rat
Sample Type: Tissue Homogenates

Rhamnogalacturonan from Acmella oleracea (L.) R.K. Jansen: gastroprotective and ulcer healing properties in rats.
Authors: Maria-Ferreira D, da Silva L, Mendes D, Cabrini D, Nascimento A, Iacomini M, Cipriani T, Santos A, Werner M, Baggio C
PLoS ONE, 2014;9(1):e84762.
Species: Rat
Sample Type: Tissue Supernate

Perioperative aspirin improves neurological outcome after focal brain ischemia possibly via inhibition of Notch 1 in rat.
Authors: Wang Z, Huang W, Zuo Z
J Neuroinflammation, 2014;11(0):56.
Species: Rat
Sample Type: Whole Tissue

Epidermal growth factor receptor inhibitor ameliorates excessive astrogliosis and improves the regeneration microenvironment and functional recovery in adult rats following spinal cord injury.
Authors: Li Z, Li J, Wang L, Zhang J, Wu J, Mao X, Shi G, Wang Q, Wang F, Zou J
J Neuroinflammation, 2014;11(0):71.
Species: Rats
Sample Type: Cell Culture Supernates

Catalpol ameliorates sodium taurocholate-induced acute pancreatitis in rats via inhibiting activation of nuclear factor kappa B.
Authors: Xiao W, Yin G, Fan Y, Qiu L, Cang X, Yu G, Hu Y, Xing M, Wu D, Wang X, Hu G, Wan R
Int J Mol Sci, 2014;15(7):11957-72.
Species: Rat
Sample Type: Serum

Mechanical ventilation enhances HMGB1 expression in an LPS-induced lung injury model.
Authors: Ding N, Wang F, Xiao H, Xu L, She S
PLoS ONE, 2013;8(9):e74633.
Species: Rat
Sample Type: BALF

A short course of infusion of a hydrogen sulfide-donor attenuates endotoxemia induced organ injury via stimulation of anti-inflammatory pathways, with no additional protection from prolonged infusion.
Cytokine, 2013;61(2):614-21.
Species: Rat
Sample Type: BALF

Keratinocyte expression of inflammatory mediators plays a crucial role in substance P-induced acute and chronic pain.
J Neuroinflammation, 2012;9(0):181.
Species: Rat
Sample Type: Tissue Homogenates

House dust mite induces direct airway inflammation in vivo: implications for future disease therapy?
Authors: De Alba J, Raemdonck K, Dekkak A, Collins M, Wong S, Nials AT, Knowles RG, Belvisi MG, Birrell MA
Eur. Respir. J., 2010;35(6):1377-87.
Species: Rat
Sample Type: BALF

Identification of a serum-induced transcriptional signature associated with type 1 diabetes in the BioBreeding rat.
Authors: Kaldunski M, Jia S, Geoffrey R, Basken J, Prosser S, Kansra S, Mordes JP, Lernmark A, Wang X, Hessner MJ
Diabetes, 2010;59(10):2375-85.
Species: Rat
Sample Type: Cell Culture Supernates

Evidence that intrathecal morphine-3-glucuronide may cause pain enhancement via toll-like receptor 4/MD-2 and interleukin-1beta.
Authors: Lewis SS, Hutchinson MR, Rezvani N, Loram LC, Zhang Y, Maier SF, Rice KC, Watkins LR
Neuroscience, 2010;165(2):569-83.
Species: Rat
Sample Type: CSF

Neuregulin-ErbB signaling promotes microglial proliferation and chemotaxis contributing to microgliosis and pain after peripheral nerve injury.
Authors: Calvo M, Zhu N, Tsantoulas C, Ma Z, Grist J, Loeb JA, Bennett DL
J. Neurosci., 2010;30(15):5437-50.
Species: Rat
Sample Type: Cell Culture Supernates

Peripheral osmotic stimulation inhibits the brains innate immune response to microdialysis of acidic perfusion fluid adjacent to supraoptic nucleus.
Authors: Summy-Long JY, Hu S
Am. J. Physiol. Regul. Integr. Comp. Physiol., 2009;297(5):R1532-45.
Species: Rat
Sample Type: Plasma

In vivo Angiotensin II AT1 receptor blockade selectively inhibits LPS-induced innate immune response and ACTH release in rat pituitary gland.
Authors: Sanchez-Lemus E, Benicky J, Pavel J, Saavedra JM
Brain Behav. Immun., 2009;23(7):945-57.
Species: Rat
Sample Type: Tissue Homogenates

Spinal leptin contributes to the pathogenesis of neuropathic pain in rodents.
Authors: Lim G, Wang S, Zhang Y, Tian Y, Mao J
J. Clin. Invest., 2009;119(2):295-304.
Species: Rat
Sample Type: Cell Culture Supernates

Role of sensory innervation in the rat pulmonary neutrophil recruitment induced by staphylococcal enterotoxins type A and B.
Authors: Desouza IA, Camargo EA, Mariano NS, Optiz-Neto JB, Resende JS, Mello GC, Costa SK, De Nucci G, Antunes E
Eur. J. Pharmacol., 2009;613(1):128-34.
Species: Rat
Sample Type: BALF

Role of central beta-adrenergic receptors in regulating proinflammatory cytokine responses to a peripheral bacterial challenge.
Authors: Johnson JD, Cortez V, Kennedy SL, Foley TE, Hanson H, Fleshner M
Brain Behav. Immun., 2008;22(7):1078-86.
Species: Rat
Sample Type: Plasma

Human interleukin-10 gene transfer is protective in a rat model of Parkinson's disease.
Authors: Johnston LC, Su X, Maguire-Zeiss K, Horovitz K, Ankoudinova I, Guschin D, Hadaczek P, Federoff HJ, Bankiewicz K, Forsayeth J
Mol. Ther., 2008;16(8):1392-9.
Species: Rat
Sample Type: Tissue Homogenates

Substance P acts via the neurokinin receptor 1 to elicit bronchoconstriction, oxidative stress, and upregulated ICAM-1 expression after oil smoke exposure.
Authors: Li PC, Chen WC, Chang LC, Lin SC
Am. J. Physiol. Lung Cell Mol. Physiol., 2008;294(5):L912-20.
Species: Rat
Sample Type: BALF

Prothymosin alpha lacking the nuclear localization signal as an effective gene therapeutic strategy in collagen-induced arthritis.
Authors: Shiau AL, Chen SY, Chang MY
J. Immunol., 2007;178(7):4688-94.
Species: Rat
Sample Type: Tissue Homogenates

Interleukin-6 mediates low-threshold mechanical allodynia induced by intrathecal HIV-1 envelope glycoprotein gp120.
Authors: Schoeniger-Skinner DK, Ledeboer A, Frank MG, Milligan ED, Poole S, Martin D, Maier SF, Watkins LR
Brain Behav. Immun., 2007;21(5):660-7.
Species: Rat
Sample Type: Tissue Homogenates

Cellular recruitment and cytokine generation in a rat model of allergic lung inflammation are differentially modulated by progesterone and estradiol.
Authors: de Oliveira AP, Domingos HV, Cavriani G, Damazo AS, Dos Santos Franco AL, Oliani SM, Oliveira-Filho RM, Vargaftig BB, de Lima WT
Am. J. Physiol., Cell Physiol., 2007;293(3):C1120-8.
Species: Rat
Sample Type: BALF

IL-1beta promotes neurite outgrowth by deactivating RhoA via p38 MAPK pathway.
Authors: Temporin K, Tanaka H, Kuroda Y, Okada K, Yachi K, Moritomo H, Murase T, Yoshikawa H
Biochem. Biophys. Res. Commun., 2007;365(2):375-80.
Species: Rat
Sample Type: Tissue Homogenates

Cell-based angiopoietin-1 gene therapy for acute lung injury.
Authors: McCarter SD, Mei SH, Lai PF, Zhang QW, Parker CH, Suen RS, Hood RD, Zhao YD, Deng Y, Han RN, Dumont DJ, Stewart DJ
Am. J. Respir. Crit. Care Med., 2007;175(10):1014-26.
Species: Rat
Sample Type: BALF

Expression of the mu opioid receptor in the human immunodeficiency virus type 1 transgenic rat model.
Authors: Chang SL, Beltran JA, Swarup S
J. Virol., 2007;81(16):8406-11.
Species: Rat
Sample Type: Serum

Comprehensive gene expression profiling of rat lung reveals distinct acute and chronic responses to cigarette smoke inhalation.
Authors: Stevenson CS, Docx C, Webster R, Battram C, Hynx D, Giddings J, Cooper PR, Chakravarty P, Rahman I, Marwick JA, Kirkham PA, Charman C, Richardson DL, Nirmala NR, Whittaker P, Butler K
Am. J. Physiol. Lung Cell Mol. Physiol., 2007;293(5):L1183-93.
Species: Rat
Sample Type: BALF

Gene transfer to interfere with TNFalpha signaling in neuropathic pain.
Authors: Hao S, Mata M, Glorioso JC, Fink DJ
Gene Ther., 2007;14(13):1010-6.
Species: Rat
Sample Type: Tissue Homogenates

Changes of gene expression of iron regulatory proteins during turpentine oil-induced acute-phase response in the rat.
Authors: Sheikh N, Dudas J, Ramadori G
Lab. Invest., 2007;87(7):713-25.
Species: Rat
Sample Type: Serum

The age-related attenuation in long-term potentiation is associated with microglial activation.
Authors: Griffin R, Nally R, Nolan Y, McCartney Y, Linden J, Lynch MA
J. Neurochem., 2006;99(4):1263-72.
Species: Rat
Sample Type: Tissue Homogenates

Identification of astrocyte-expressed factors that modulate neural stem/progenitor cell differentiation.
Authors: Barkho BZ, Song H, Aimone JB
Stem Cells Dev., 2006;15(3):407-21.
Species: Rat
Sample Type: Cell Culture Supernates

Chlorpromazine and loxapine reduce interleukin-1beta and interleukin-2 release by rat mixed glial and microglial cell cultures.
Authors: Labuzek K, Kowalski J, Gabryel B, Herman ZS
Eur Neuropsychopharmacol, 2005;15(1):23-30.
Species: Rat
Sample Type: Cell Culture Supernates

Developmental changes induced by graded prenatal systemic hypoxic-ischemic insults in rats.
Authors: Robinson S, Petelenz K, Li Q, Cohen ML, Dechant A, Tabrizi N, Bucek M, Lust D, Miller RH
Neurobiol. Dis., 2005;18(3):568-81.
Species: Rat
Sample Type: Amniotic Fluid

Cytokine profiles in the testes of rats treated with lipopolysaccharide reveal localized suppression of inflammatory responses.
Authors: O'Bryan MK
Am. J. Physiol. Regul. Integr. Comp. Physiol., 2005;288(6):R1744-55.
Species: Rat
Sample Type: Tissue Homogenates

Prophylactic adenovirus-mediated human kallistatin gene therapy suppresses rat arthritis by inhibiting angiogenesis and inflammation.
Authors: Wang CR, Chen SY, Wu CL, Liu MF, Jin YT, Chao L, Chao J
Arthritis Rheum., 2005;52(4):1319-24.
Species: Rat
Sample Type: Tissue Homogenates

Interleukin-10 aerosol reduces proinflammatory mediators in bronchoalveolar fluid of endotoxemic rat.
Authors: Hofstetter C, Flondor M, Hoegl S, Muhl H, Zwissler B
Crit. Care Med., 2005;33(10):2317-22.
Species: Rat
Sample Type: BALF

HIV-1 gp120 stimulates proinflammatory cytokine-mediated pain facilitation via activation of nitric oxide synthase-I (nNOS).
Authors: Holguin A, O'Connor KA, Biedenkapp J, Campisi J, Wieseler-Frank J, Milligan ED, Hansen MK, Spataro L, Maksimova E, Bravmann C, Martin D, Fleshner M, Maier SF, Watkins LR
Pain, 2004;110(3):517-30.
Species: Rat
Sample Type: CSF

Oral (gavage), in utero and post-natal exposure of Sprague-Dawley rats to low doses of tributyltin chloride. Part II: effects on the immune system.
Authors: Tryphonas H, Cooke G, Caldwell D, Bondy G, Parenteau M, Hayward S, Pulido O
Food Chem. Toxicol., 2004;42(2):221-35.
Species: Rat
Sample Type: Serum

A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine.
Authors: Johnston IN, Milligan ED, Wieseler-Frank J, Frank MG, Zapata V, Campisi J, Langer S, Martin D, Green P, Fleshner M, Leinwand L, Maier SF, Watkins LR
J. Neurosci., 2004;24(33):7353-65.
Species: Rat
Sample Type: Tissue Homogenates

Insulin attenuates the systemic inflammatory response in endotoxemic rats.
Authors: Jeschke MG, Klein D, Bolder U, Einspanier R
Endocrinology, 2004;145(9):4084-93.
Species: Mouse
Sample Type: Tissue Homogenates

Insulin treatment improves hepatic morphology and function through modulation of hepatic signals after severe trauma.
Authors: Schubert T, Horch RE
Ann. Surg., 2004;240(2):340-9.
Species: Rat
Sample Type: Tissue Homogenates

Alveolar macrophage cytotoxicity for normal lung fibroblasts is mediated by nitric oxide release.
Authors: Morgan DL, Shines CJ
Toxicol In Vitro, 2004;18(1):139-46.
Species: Rat
Sample Type: Cell Culture Supernates

Gene transfer of tumor necrosis factor inhibitor improves the function of lung allografts.
Authors: Tagawa T, Kozower BD, Kanaan SA, Daddi N, Muraoka M, Oka T, Ritter JH, Patterson GA
J. Thorac. Cardiovasc. Surg., 2004;127(6):1558-63.
Species: Rat
Sample Type: Tissue Homogenates

A method for measuring multiple cytokines from small samples.
Authors: O'Connor KA
Brain Behav. Immun., 2004;18(3):274-80.
Species: Rat
Sample Type: CSF

Differential cytokine response in interstitial fluid in skin and serum during experimental inflammation in rats.
Authors: Nedrebo T, Reed RK, Jonsson R, Berg A, Wiig H
J. Physiol. (Lond.), 2004;556(0):193-202.
Species: Rat
Sample Type: Interstitial Fluid

Differential expression of cytokine genes and inducible nitric oxide synthase induced by opacity phenotype variants of Streptococcus pneumoniae during acute otitis media in the rat.
Authors: Long JP, Tong HH, Shannon PA, DeMaria TF
Infect. Immun., 2003;71(10):5531-40.
Species: Rat
Sample Type: middle ear effusion

Recipient intramuscular cotransfection of naked plasmid transforming growth factor beta1 and interleukin 10 ameliorates lung graft ischemia-reperfusion injury.
Authors: D'Ovidio F
J. Thorac. Cardiovasc. Surg., 2002;124(2):259-69.
Species: Rat
Sample Type: Lung Lavage

Role of IL-18 in acute lung inflammation.
Authors: Jordan JA, Guo RF, Yun EC, Sarma V, Warner RL, Crouch LD, Senaldi G, Ulich TR, Ward PA
J. Immunol., 2001;167(12):7060-8.
Species: Rat
Sample Type: BALF

生物活性< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景IL-1 beta (Interleukin-1 beta) is produced in response to inflammatory agents, infections, or microbial endotoxins. It plays a central role in immune and inflammatory responses, bone remodeling, fever, carbohydrate metabolism, and GH/IGF-I physiology. IL-1 beta dysregulation is implicated in many pathological conditions including sepsis, rheumatoid arthritis, inflammatory bowel disease, acute and chronic myelogenous leukemia, insulin-dependent diabetes mellitus, atherosclerosis, neuronal injury, and aging-related diseases. Intracellular cleavage of the IL-1 beta precursor by Caspase-1/ICE is a key step in the inflammatory response. IL-1 beta binds to IL-1 RI and IL-1 RII. The IL-1 receptor accessory protein (IL-1 RAcP) associates with IL-1 RI and is required for IL-1 RI signal transduction, and IL-1ra is a secreted molecule that functions as a competitive inhibitor of IL-1 bioactivity.
运输条件Blue Ice
存放说明4℃
参考文献
  • Cancer Biomarkers
  • Conventional/Classical Dendritic Cells
  • Cytokines and Receptors in Allergy and Asthma
  • Cytokines and Receptors in Angiogenesis
  • IL-1 Family
  • Infectious Diseases
  • Inflammatory Mediators
  • Isolation, Culture, and Identification of Natural Killer Cells
  • LTi Cells
  • Macrophage Activation Markers
  • Multiple Sclerosis and Myelin Related Molecules
  • Myeloid-derived Suppressor Cells (MDSC)
  • NCR-ILC3
  • Neuroinflammation
  • NOD-like Receptors and the Inflammasome
  • Platelets
  • Regulatory T Cells (Tregs)
  • T Cell Cytokine Signaling
  • Th17 Cells
  • Th9 Cells