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Mouse/Rat Leptin Quantikine SixPak (6 Plates) (1 PK)

货号: SMOB00 基本售价: 19749.7 元 规格: 1 PACK

产品信息

概述
货号SMOB00
描述The Quantikine Mouse Leptin Immunoassay is a 4.5 hour solid phase ELISA designed to measure soluble mouse leptin in cell culture supernates, serum*, and plasma. It contains recombinant mouse leptin expressed in E. coli and antibodies raised against the recombinant factor. This immunoassay has been shown to quantitate the recombinant mouse leptin accurately. Results obtained measuring natural mouse leptin showed dose-response curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural mouse leptin.

*Pregnant mouse serum from the second trimester of pregnancy through post-partum day 1 require acid/urea activation of mouse leptin.
别名FLJ94114; LEP; leptin (murine obesity homolog); leptin (obesity homolog, mouse); Leptin; OB; Obese protein; obese, mouse, homolog of; Obesity factor; OBOBS;
反应种属Mouse/Rat
目标/特异性Natural and recombinant mouse and rat Leptin.  This assay cross-reacts 0.24% with Human Leptin.
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs
3952 (Human); 16846 (Mouse); 25608 (Rat)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Weight Perturbation Alters Leptin Signal Transduction in a Region-Specific Manner throughout the Brain
Authors: MV Morabito, Y Ravussin, BR Mueller, AA Skowronski, K Watanabe, KS Foo, SX Lee, A Lehmann, S Hjorth, LM Zeltser, CA LeDuc, RL Leibel
PLoS ONE, 2017;12(1):e0168226.
Species: Mouse
Sample Type: Serum

Further investigation of phenotypes and confounding factors of progressive ratio performance and feeding behavior in the BACHD rat model of Huntington disease
Authors: EK Clemensson, LE Clemensson, B Fabry, O Riess, HP Nguyen
PLoS ONE, 2017;12(3):e0173232.
Species: Rat
Sample Type: Serum

Monocyte chemotactic protein-1 deficiency reduces spontaneous metastasis of Lewis lung carcinoma in mice fed a high-fat diet
Oncotarget, 2016;7(17):24792-9.
Species: Mouse
Sample Type: Plasma

Traditional medicine, Sobokchukeo?Tang, modulates the inflammatory response in adipocytes and macrophages
Mol Med Rep, 2016;0(0):.
Species: Mouse
Sample Type: Whole Cells

Anti-Inflammatory Effects of Rosiglitazone in Obesity-Impaired Wound Healing Depend on Adipocyte Differentiation
PLoS ONE, 2016;11(12):e0168562.
Species: Mouse
Sample Type: Cell Culture Supernates

Korean Curcuma longa L. induces lipolysis and regulates leptin in adipocyte cells and rats
Nutr Res Pract, 2016;10(5):487-493.

Reprogramming the body weight set point by a reciprocal interaction of hypothalamic leptin sensitivity and Pomc gene expression reverts extreme obesity
Mol Metab, 2016;5(10):869-81.
Species: Mouse
Sample Type: Plasma

Is Western Diet-Induced Nonalcoholic Steatohepatitis in Ldlr-/- Mice Reversible?
Authors: Lytle K, Jump D
PLoS ONE, 2016;11(1):e0146942.
Species: Mouse
Sample Type: Plasma

Leptin ameliorates ischemic necrosis of the femoral head in rats with obesity induced by a high-fat diet.
Authors: Zhou L, Jang K, Moon Y, Wagle S, Kim K, Lee K, Park B, Kim J
Sci Rep, 2015;5(0):9397.
Species: Rat
Sample Type: Plasma

Moderate calorie restriction during gestation programs offspring for lower BAT thermogenic capacity driven by thyroid and sympathetic signaling.
Authors: Palou M, Priego T, Romero M, Szostaczuk N, Konieczna J, Cabrer C, Remesar X, Palou A, Pico C
Int J Obes (Lond), 2015;39(2):339-45.
Species: Rat
Sample Type: Plasma

A spontaneous deletion within the desmoglein 3 extracellular domain of mice results in hypomorphic protein expression, immunodeficiency, and a wasting disease phenotype.
Authors: Kountikov E, Poe J, Maclver N, Rathmell J, Tedder T
Am J Pathol, 2015;185(3):617-30.
Species: Mouse
Sample Type: Serum

Modulation of the leptin receptor mediates tumor growth and migration of pancreatic cancer cells.
Authors: Mendonsa A, Chalfant M, Gorden L, VanSaun M
PLoS ONE, 2015;10(4):e0126686.
Species: Mouse
Sample Type: Plasma

Transgenic mice overexpressing amyloid precursor protein exhibit early metabolic deficits and a pathologically low leptin state associated with hypothalamic dysfunction in arcuate neuropeptide Y neurons.
Authors: Ishii M, Wang G, Racchumi G, Dyke J, Iadecola C
J Neurosci, 2014;34(27):9096-106.
Species: Mouse
Sample Type: Plasma

Rescue of cardiac leptin receptors in db/db mice prevents myocardial triglyceride accumulation.
Authors: Hall M, Maready M, Hall J, Stec D
Am J Physiol Endocrinol Metab, 2014;307(3):E316-25.
Species: Mouse
Sample Type: Plasma

Hypermethylation of Sp1 binding site suppresses hypothalamic POMC in neonates and may contribute to metabolic disorders in adults: impact of maternal dietary CLAs.
Authors: Zhang, Xiaomei, Yang, Ran, Jia, Yan, Cai, Demin, Zhou, Bo, Qu, Xiaoli, Han, Huihua, Xu, Liang, Wang, Linfeng, Yao, Yanan, Yang, Guoqing
Diabetes, 2014;63(5):1475-87.
Species: Mouse
Sample Type: Plasma

Lipid profiling and transcriptomic analysis reveals a functional interplay between estradiol and growth hormone in liver.
Authors: Fernandez-Perez L, Santana-Farre R, de Mirecki-Garrido M, Garcia I, Guerra B, Mateo-Diaz C, Iglesias-Gato D, Diaz-Chico J, Flores-Morales A, Diaz M
PLoS ONE, 2014;9(5):e96305.
Species: Rat
Sample Type: Serum

Obesity induced a leptin-Notch signaling axis in breast cancer.
Authors: Battle M, Gillespie C, Quarshie A, Lanier V, Harmon T, Wilson K, Torroella-Kouri M, Gonzalez-Perez R
Int J Cancer, 2014;134(7):1605-16.
Species: Mouse
Sample Type: Plasma

Beneficial metabolic effects of rapamycin are associated with enhanced regulatory cells in diet-induced obese mice.
Authors: Makki K, Taront S, Molendi-Coste O, Bouchaert E, Neve B, Eury E, Lobbens S, Labalette M, Duez H, Staels B, Dombrowicz D, Froguel P, Wolowczuk I
PLoS ONE, 2014;9(4):e92684.
Species: Mouse
Sample Type: Serum

Effect of intermittent cold exposure on brown fat activation, obesity, and energy homeostasis in mice.
Authors: Ravussin Y, Xiao C, Gavrilova O, Reitman M
PLoS ONE, 2014;9(1):e85876.
Species: Mouse
Sample Type: Serum

Temporal changes in nutritional state affect hypothalamic POMC peptide levels independently of leptin in adult male mice.
Authors: Mercer A, Stuart R, Attard C, Otero-Corchon V, Nillni E, Low M
Am J Physiol Endocrinol Metab, 2014;306(8):E904-15.
Species: Mouse
Sample Type: Plasma

Protopanaxatriol, a novel PPARgamma antagonist from Panax ginseng, alleviates steatosis in mice.
Authors: Zhang Y, Yu L, Cai W, Fan S, Feng L, Ji G, Huang C
Sci Rep, 2014;4(0):7375.
Species: Mouse
Sample Type: Serum

Ghrelin induces leptin resistance by activation of suppressor of cytokine signaling 3 expression in male rats: implications in satiety regulation.
Authors: Heldsinger A, Grabauskas G, Wu X, Zhou S, Lu Y, Song I, Owyang C
Endocrinology, 2014;155(10):3956-69.
Species: Rat
Sample Type: Plasma

PKClambda haploinsufficiency prevents diabetes by a mechanism involving alterations in hepatic enzymes.
Authors: Sajan M, Ivey R, Lee M, Mastorides S, Jurczak M, Samuels V, Shulman G, Braun U, Leitges M, Farese R
Mol Endocrinol, 2014;28(7):1097-107.
Species: Mouse
Sample Type: Serum

Butter naturally enriched in cis-9, trans-11 CLA prevents hyperinsulinemia and increases both serum HDL cholesterol and triacylglycerol levels in rats.
Authors: de Almeida M, Luquetti S, Sabarense C, do Amaral Correa J, dos Reis L, Santos da Conceicao E, Lisboa P, de Moura E, Gameiro J, da Gama M, Lopes F, Garcia R
Lipids Health Dis, 2014;13(0):200.
Species: Rat
Sample Type: Serum

A leptin-mediated central mechanism in analgesia-enhanced opioid reward in rats.
Authors: Lim G, Kim H, McCabe M, Chou C, Wang S, Chen L, Marota J, Blood A, Breiter H, Mao J
J Neurosci, 2014;34(29):9779-88.
Species: Rat
Sample Type: Serum

Leptin metabolically licenses T cells for activation to link nutrition and immunity.
Authors: Saucillo, Donte C, Gerriets, Valerie, Sheng, John, Rathmell, Jeffrey, Maciver, Nancie J
J Immunol, 2014;192(1):136-44.
Species: Mouse
Sample Type: Serum

Enhanced leptin sensitivity, reduced adiposity, and improved glucose homeostasis in mice lacking exchange protein directly activated by cyclic AMP isoform 1.
Authors: Yan J, Mei F, Cheng H, Lao D, Hu Y, Wei J, Patrikeev I, Hao D, Stutz S, Dineley K, Motamedi M, Hommel J, Cunningham K, Chen J, Cheng X
Mol Cell Biol, 2013;33(5):918-26.
Species: Mouse
Sample Type: Plasma

Euglycemic hyperinsulinemia increases blood pressure in pregnant rats independent of placental antiangiogenic and inflammatory factors.
Authors: Palei A, Spradley F, Granger J
Am J Hypertens, 2013;26(12):1445-51.
Species: Rat
Sample Type: Serum

Exercise protects against diet-induced insulin resistance through downregulation of protein kinase Cbeta in mice.
Authors: Rao X, Zhong J, Xu X, Jordan B, Maurya S, Braunstein Z, Wang T, Huang W, Aggarwal S, Periasamy M, Rajagopalan S, Mehta K, Sun Q
PLoS ONE, 2013;8(12):e81364.
Species: Mouse
Sample Type: Plasma

Obesity and IL-6 interact in modulating the response to endotoxemia in mice.
Cytokine, 2013;61(1):71-7.
Species: Mouse
Sample Type: Plasma

HDL and Glut1 inhibition reverse a hypermetabolic state in mouse models of myeloproliferative disorders.
Authors: Gautier E, Westerterp M, Bhagwat N, Cremers S, Shih A, Abdel-Wahab O, Lutjohann D, Randolph G, Levine R, Tall A, Yvan-Charvet L
J Exp Med, 2013;210(2):339-53.
Species: Mouse
Sample Type: Plasma

Oral leptin treatment in suckling rats ameliorates detrimental effects in hypothalamic structure and function caused by maternal caloric restriction during gestation.
Authors: Konieczna J, Garcia A, Sanchez J, Palou M, Palou A, Pico C
PLoS ONE, 2013;8(11):e81906.
Species: Rat
Sample Type: Plasma

HCV core-induced nonobese hepatic steatosis is associated with hypoadiponectinemia and is ameliorated by adiponectin administration.
Authors: Chang ML, Yeh HC, Tsou YK
Obesity (Silver Spring), 2012;20(7):1474-80.
Species: Mouse
Sample Type: Serum

Disruption of the chemokine-like receptor-1 (CMKLR1) gene is associated with reduced adiposity and glucose intolerance.
Authors: Ernst MC, Haidl ID, Zúñiga LA, Dranse HJ, Rourke JL, Zabel BA, Butcher EC, Sinal CJ
Endocrinology, 2012;153(2):672-82.
Species: Mouse
Sample Type: Serum

Obesity in mice with adipocyte-specific deletion of clock component Arntl.
Authors: Paschos, Georgios, Ibrahim, Salam, Song, Wen-Lian, Kunieda, Takeshig, Grant, Gregory, Reyes, Teresa M, Bradfield, Christop, Vaughan, Cheryl H, Eiden, Michael, Masoodi, Mojgan, Griffin, Julian L, Wang, Fenfen, Lawson, John A, Fitzgerald, Garret A
Nat Med, 2012;18(12):1768-77.
Species: Mouse
Sample Type: Plasma

Tangeretin stimulates glucose uptake via regulation of AMPK signaling pathways in C2C12 myotubes and improves glucose tolerance in high-fat diet-induced obese mice.
Mol. Cell. Endocrinol., 2012;358(1):127-34.
Species: Mouse
Sample Type: Serum

Physiological roles of group X-secreted phospholipase A2 in reproduction, gastrointestinal phospholipid digestion, and neuronal function.
Authors: Sato H, Isogai Y, Masuda S
J. Biol. Chem., 2011;286(13):11632-48.
Species: Mouse
Sample Type: Serum

Castration-induced changes in mouse epididymal white adipose tissue.
Authors: Floryk D, Kurosaka S, Tanimoto R, Yang G, Goltsov A, Park S, Thompson TC
Mol. Cell. Endocrinol., 2011;345(1):58-67.
Species: Mouse
Sample Type: Serum

Perinatal lack of maternal IL-6 promotes increased adiposity during adulthood in mice.
Authors: Lager S, Asterholm IW, Schele E, Jansson N, Nilsson S, Jansson JO, Lonn M, Holmang A
Endocrinology, 2011;152(4):1336-46.
Species: Mouse
Sample Type: Milk

Fasting induces an anti-inflammatory effect on the neuroimmune system which a high-fat diet prevents.
Authors: Lavin DN, Joesting JJ, Chiu GS, Moon ML, Meng J, Dilger RN, Freund GG
Obesity (Silver Spring), 2011;19(8):1586-94.
Species: Mouse
Sample Type: Serum

Varying susceptibility of pulmonary cytokine production to lipopolysaccharide in mice.
Authors: Alm AS, Li K, Yang D, Andersson R, Lu Y, Wang X
Cytokine, 2010;49(3):256-63.
Species: Mouse
Sample Type: BALF

Moderate caloric restriction in lactating rats protects offspring against obesity and insulin resistance in later life.
Authors: Palou M, Priego T, Sanchez J, Torrens JM, Palou A, Pico C
Endocrinology, 2010;151(3):1030-41.
Species: Rat
Sample Type: Milk

Leptin exacerbates sepsis-mediated morbidity and mortality.
Authors: Shapiro NI, Khankin EV, van Meurs M
J. Immunol., 2010;185(1):517-24.
Species: Mouse
Sample Type: Plasma

Neutralization of osteopontin inhibits obesity-induced inflammation and insulin resistance.
Authors: Kiefer FW, Zeyda M, Gollinger K, Pfau B, Neuhofer A, Weichhart T, Saemann MD, Geyeregger R, Schlederer M, Kenner L, Stulnig TM
Diabetes, 2010;59(4):935-46.
Species: Mouse
Sample Type: Plasma

Group X secretory phospholipase A2 negatively regulates adipogenesis in murine models.
Authors: Li X, Shridas P, Forrest K, Bailey W, Webb NR
FASEB J., 2010;24(11):4313-24.
Species: Mouse
Sample Type: Plasma

Deletion of Nhlh2 results in a defective torpor response and reduced Beta adrenergic receptor expression in adipose tissue.
Authors: Wankhade UD, Vella KR, Fox DL
PLoS ONE, 2010;5(8):e12324.
Species: Mouse
Sample Type: Serum

Differential effects of high MUFA with high or low P/S ratio (polyunsaturated to saturated fatty acids) on improving hepatic lipolytic enzymes and mediating PPARgamma related with lipoprotein lipase and hormone-sensitive lipase of white adipose tissue in diet-induced obese hamster.
Authors: Liao FH, Liou TH, Chiu WC, Shieh MJ, Chien YW
Int J Obes (Lond), 2010;34(11):1608-17.
Species: Hamster
Sample Type: Plasma

eNOS plays a major role in adiponectin synthesis in adipocytes.
Authors: Koh EH, Kim M, Ranjan KC, Kim HS, Park HS, Oh KS, Park IS, Lee WJ, Kim MS, Park JY, Youn JH, Lee KU
Am. J. Physiol. Endocrinol. Metab., 2010;298(4):E846-53.
Species: Mouse
Sample Type: Plasma

Enhanced production of IL-17A during zymosan-induced peritonitis in obese mice.
Authors: Pini M, Fantuzzi G
J. Leukoc. Biol., 2010;87(1):51-8.
Species: Mouse
Sample Type: Peritoneal Lavage

Early handling increases susceptibility to experimental autoimmune encephalomyelitis (EAE) in C57BL/6 male mice.
Authors: Columba-Cabezas S, Iaffaldano G, Chiarotti F, Alleva E, Cirulli F
J. Neuroimmunol., 2009;212(1):10-6.
Species: Mouse
Sample Type: Serum

Spinal leptin contributes to the pathogenesis of neuropathic pain in rodents.
Authors: Lim G, Wang S, Zhang Y, Tian Y, Mao J
J. Clin. Invest., 2009;119(2):295-304.
Species: Rat
Sample Type: Plasma

Development of obesity in the Otsuka Long-Evans Tokushima Fatty rat.
Authors: Schroeder M, Zagoory-Sharon O, Shbiro L, Marco A, Hyun J, Moran TH, Bi S, Weller A
Am. J. Physiol. Regul. Integr. Comp. Physiol., 2009;297(6):R1749-60.
Species: Rat
Sample Type: Plasma

Stearoyl-CoA desaturase 1 deficiency protects mice from immune-mediated liver injury.
Authors: Feng D, Wang Y, Mei Y, Xu Y, Xu H, Lu Y, Luo Q, Zhou S, Kong X, Xu L
Lab. Invest., 2009;89(2):222-30.
Species: Mouse
Sample Type: Plasma

Efficient method for obtaining Lep(ob)/Lep(ob)-derived animal models using adipose tissue transplantations.
Authors: Barros CC, Almeida SS, Mori MA, Valero VB, Haro AS, Batista EC, Rosa TS, Bacurau RF, Wurtele M, Araujo RC
Int J Obes (Lond), 2009;33(8):938-44.
Species: Mouse
Sample Type: Serum

Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice.
Authors: Osei-Hyiaman D, Liu J, Zhou L, Godlewski G, Harvey-White J, Jeong WI, Batkai S, Marsicano G, Lutz B, Buettner C, Kunos G
J. Clin. Invest., 2008;118(9):3160-9.
Species: Mouse
Sample Type: Plasma

Doubly truncated FosB isoform (Delta2DeltaFosB) induces osteosclerosis in transgenic mice and modulates expression and phosphorylation of Smads in osteoblasts independent of intrinsic AP-1 activity.
Authors: Sabatakos G, Rowe GC, Kveiborg M, Wu M, Neff L, Chiusaroli R, Philbrick WM, Baron R
J. Bone Miner. Res., 2008;23(5):584-95.
Species: Mouse
Sample Type: Serum

Identification of ALOX5 as a gene regulating adiposity and pancreatic function.
Authors: Mehrabian M, Schulthess FT, Nebohacova M, Castellani LW, Zhou Z, Hartiala J, Oberholzer J, Lusis AJ, Maedler K, Allayee H
Diabetologia, 2008;51(6):978-88.
Species: Mouse
Sample Type: Plasma

Adaptation to lactation in OLETF rats lacking CCK-1 receptors: body weight, fat tissues, leptin and oxytocin.
Authors: Zagoory-Sharon O, Schroeder M, Levine A, Moran TH, Weller A
Int J Obes (Lond), 2008;32(8):1211-21.
Species: Rat
Sample Type: Plasma

Novel black soy peptides with antiobesity effects: activation of leptin-like signaling and AMP-activated protein kinase.
Authors: Jang EH, Moon JS, Ko JH, Ahn CW, Lee HH, Shin JK, Park CS, Kang JH
Int J Obes (Lond), 2008;32(7):1161-70.
Species: Mouse
Sample Type: Plasma

Signal transducer and activator of transcription-3 is required in hypothalamic agouti-related protein/neuropeptide Y neurons for normal energy homeostasis.
Authors: Gong L, Yao F, Hockman K, Heng HH, Morton GJ, Takeda K, Akira S, Low MJ, Rubinstein M, MacKenzie RG
Endocrinology, 2008;149(7):3346-54.
Species: Mouse
Sample Type: Plasma

Octylphenol stimulates resistin gene expression in 3T3-L1 adipocytes via the estrogen receptor and extracellular signal-regulated kinase pathways.
Authors: Lee MJ, Lin H, Liu CW, Wu MH, Liao WJ, Chang HH, Ku HC, Chien YS, Ding WH, Kao YH
Am. J. Physiol., Cell Physiol., 2008;294(6):C1542-51.
Species: Mouse
Sample Type: Serum

Role and regulation of adipokines during zymosan-induced peritoneal inflammation in mice.
Authors: Pini M, Gove ME, Sennello JA, van Baal JW, Chan L, Fantuzzi G
Endocrinology, 2008;149(8):4080-5.
Species: Mouse
Sample Type: Serum

Leptin induces elongation of cardiac myocytes and causes eccentric left ventricular dilatation with compensation.
Authors: Abe Y, Ono K, Kawamura T, Wada H, Kita T, Shimatsu A, Hasegawa K
Am. J. Physiol. Heart Circ. Physiol., 2007;292(5):H2387-96.
Species: Mouse
Sample Type: Plasma

FXR-deficiency confers increased susceptibility to torpor.
Authors: Cariou B, Bouchaert E, Abdelkarim M, Dumont J, Caron S, Fruchart JC, Burcelin R, Kuipers F, Staels B
FEBS Lett., 2007;581(27):5191-8.
Species: Mouse
Sample Type: Plasma

High circulating leptin receptors with normal leptin sensitivity in liver-specific insulin receptor knock-out (LIRKO) mice.
Authors: Cohen SE, Kokkotou E, Biddinger SB, Kondo T, Gebhardt R, Kratzsch J, Mantzoros CS, Kahn CR
J. Biol. Chem., 2007;282(32):23672-8.
Species: Mouse
Sample Type: Serum

Integrating genetic and network analysis to characterize genes related to mouse weight.
Authors: Ghazalpour A, Doss S, Zhang B, Wang S, Plaisier C, Castellanos R, Brozell A, Schadt EE, Drake TA, Lusis AJ, Horvath S
PLoS Genet., 2006;2(8):e130.
Species: Mouse
Sample Type: Plasma

Impaired adipose tissue development in mice with inactivation of placental growth factor function.
Authors: Lijnen HR, Christiaens V, Scroyen I, Voros G, Tjwa M, Carmeliet P, Collen D
Diabetes, 2006;55(10):2698-704.
Species: Mouse
Sample Type: Tissue Homogenates

Long-term blockade of angiotensin AT1 receptors increases survival of obese Zucker rats.
Authors: O'Connor SE
Eur. J. Pharmacol., 2006;534(1):271-9.
Species: Mouse
Sample Type: Plasma

Metformin restores leptin sensitivity in high-fat-fed obese rats with leptin resistance.
Authors: Kim YW, Kim JY, Park YH, Park SY, Won KC, Choi KH, Huh JY, Moon KH
Diabetes, 2006;55(3):716-24.
Species: Rat
Sample Type: CSF

Leptin resistance protects mice from hyperoxia-induced acute lung injury.
Authors: Bellmeyer A, Martino JM, Chandel NS, Scott Budinger GR, Dean DA, Mutlu GM
Am. J. Respir. Crit. Care Med., 2006;175(6):587-94.
Species: Mouse
Sample Type: BALF

Role of leptin deficiency in early acute renal failure during endotoxemia in ob/ob mice.
Authors: Wang W, Poole B, Mitra A, Falk S, Fantuzzi G, Lucia S, Schrier R
J. Am. Soc. Nephrol., 2004;15(3):645-9.
Species: Mouse
Sample Type: Serum

Diurnal rhythms of leptin and ghrelin in the systemic circulation and in the gastric mucosa are related to food intake in rats.
Authors: Sanchez J, Oliver P, Pico C, Palou A
Pflugers Arch., 2004;448(5):500-6.
Species: Rat
Sample Type: Serum

Leptin accelerates autoimmune diabetes in female NOD mice.
Authors: Matarese G, Sanna V, Lechler RI, Sarvetnick N, Fontana S, Zappacosta S, La Cava A
Diabetes, 2002;51(5):1356-61.
Species: Mouse
Sample Type: Cell Culture Supernates

The increased bone mass in deltaFosB transgenic mice is independent of circulating leptin levels.
Authors: Kveiborg M, Chiusaroli R, Sims NA, Wu M, Sabatakos G, Horne WC, Baron R
Endocrinology, 2002;143(11):4304-9.
Species: Mouse
Sample Type: Serum

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity.
Authors: Yamauchi, T, Kamon, J, Waki, H, Terauchi, Y, Kubota, N, Hara, K, Mori, Y, Ide, T, Murakami, K, Tsuboyama-Kasaoka, N, Ezaki, O, Akanuma, Y, Gavrilova, O, Vinson, C, Reitman, M L, Kagechika, H, Shudo, K, Yoda, M, Nakano, Y, Tobe, K, Nagai, R, Kimura, S, Tomita, M, Froguel, P, Kadowaki, T
Nat Med, 2001;7(8):941-6.
Species: Mouse
Sample Type: Plasma

生物活性< 0.5% cross-reactivity observed with available related molecules.Cross-species reactivity observed with 1 or more species tested.
背景Leptin is a product of the mouse obese gene. Mice with mutations in the obese gene that block the synthesis of leptin are obese and diabetic, and have reduced activity, metabolism, and body temperature. Rat leptin shares approximately 96% and 82% sequence identity with the mouse and human protein, respectively. The expression of leptin mRNA is restricted to adipose tissue.
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参考文献
  • Adipocytokines
  • Adipogenesis Markers
  • Cancer Biomarkers
  • Cytokines and Receptors in Angiogenesis
  • Endocrine Regulation of Lipid Metabolism
  • Gametes and Fertilization
  • Glucose Homeostasis
  • IL-6 Family
  • Metabolic Peptide Hormones and Regulators
  • Metabolism
  • Neurotransmitters, Neuroactive Molecules and Associated Enzymes
  • Nutrition and Appetite
  • Obesity