R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Weight Perturbation Alters Leptin Signal Transduction in a Region-Specific Manner throughout the Brain Authors: MV Morabito, Y Ravussin, BR Mueller, AA Skowronski, K Watanabe, KS Foo, SX Lee, A Lehmann, S Hjorth, LM Zeltser, CA LeDuc, RL Leibel PLoS ONE, 2017;12(1):e0168226. Species: Mouse Sample Type: Serum
Further investigation of phenotypes and confounding factors of progressive ratio performance and feeding behavior in the BACHD rat model of Huntington disease Authors: EK Clemensson, LE Clemensson, B Fabry, O Riess, HP Nguyen PLoS ONE, 2017;12(3):e0173232. Species: Rat Sample Type: Serum
Monocyte chemotactic protein-1 deficiency reduces spontaneous metastasis of Lewis lung carcinoma in mice fed a high-fat diet Oncotarget, 2016;7(17):24792-9. Species: Mouse Sample Type: Plasma
Traditional medicine, Sobokchukeo?Tang, modulates the inflammatory response in adipocytes and macrophages Mol Med Rep, 2016;0(0):. Species: Mouse Sample Type: Whole Cells
Anti-Inflammatory Effects of Rosiglitazone in Obesity-Impaired Wound Healing Depend on Adipocyte Differentiation PLoS ONE, 2016;11(12):e0168562. Species: Mouse Sample Type: Cell Culture Supernates
Korean Curcuma longa L. induces lipolysis and regulates leptin in adipocyte cells and rats Nutr Res Pract, 2016;10(5):487-493.
Reprogramming the body weight set point by a reciprocal interaction of hypothalamic leptin sensitivity and Pomc gene expression reverts extreme obesity Mol Metab, 2016;5(10):869-81. Species: Mouse Sample Type: Plasma
Is Western Diet-Induced Nonalcoholic Steatohepatitis in Ldlr-/- Mice Reversible? Authors: Lytle K, Jump D PLoS ONE, 2016;11(1):e0146942. Species: Mouse Sample Type: Plasma
Leptin ameliorates ischemic necrosis of the femoral head in rats with obesity induced by a high-fat diet. Authors: Zhou L, Jang K, Moon Y, Wagle S, Kim K, Lee K, Park B, Kim J Sci Rep, 2015;5(0):9397. Species: Rat Sample Type: Plasma
Moderate calorie restriction during gestation programs offspring for lower BAT thermogenic capacity driven by thyroid and sympathetic signaling. Authors: Palou M, Priego T, Romero M, Szostaczuk N, Konieczna J, Cabrer C, Remesar X, Palou A, Pico C Int J Obes (Lond), 2015;39(2):339-45. Species: Rat Sample Type: Plasma
A spontaneous deletion within the desmoglein 3 extracellular domain of mice results in hypomorphic protein expression, immunodeficiency, and a wasting disease phenotype. Authors: Kountikov E, Poe J, Maclver N, Rathmell J, Tedder T Am J Pathol, 2015;185(3):617-30. Species: Mouse Sample Type: Serum
Modulation of the leptin receptor mediates tumor growth and migration of pancreatic cancer cells. Authors: Mendonsa A, Chalfant M, Gorden L, VanSaun M PLoS ONE, 2015;10(4):e0126686. Species: Mouse Sample Type: Plasma
Transgenic mice overexpressing amyloid precursor protein exhibit early metabolic deficits and a pathologically low leptin state associated with hypothalamic dysfunction in arcuate neuropeptide Y neurons. Authors: Ishii M, Wang G, Racchumi G, Dyke J, Iadecola C J Neurosci, 2014;34(27):9096-106. Species: Mouse Sample Type: Plasma
Rescue of cardiac leptin receptors in db/db mice prevents myocardial triglyceride accumulation. Authors: Hall M, Maready M, Hall J, Stec D Am J Physiol Endocrinol Metab, 2014;307(3):E316-25. Species: Mouse Sample Type: Plasma
Hypermethylation of Sp1 binding site suppresses hypothalamic POMC in neonates and may contribute to metabolic disorders in adults: impact of maternal dietary CLAs. Authors: Zhang, Xiaomei, Yang, Ran, Jia, Yan, Cai, Demin, Zhou, Bo, Qu, Xiaoli, Han, Huihua, Xu, Liang, Wang, Linfeng, Yao, Yanan, Yang, Guoqing Diabetes, 2014;63(5):1475-87. Species: Mouse Sample Type: Plasma
Lipid profiling and transcriptomic analysis reveals a functional interplay between estradiol and growth hormone in liver. Authors: Fernandez-Perez L, Santana-Farre R, de Mirecki-Garrido M, Garcia I, Guerra B, Mateo-Diaz C, Iglesias-Gato D, Diaz-Chico J, Flores-Morales A, Diaz M PLoS ONE, 2014;9(5):e96305. Species: Rat Sample Type: Serum
Obesity induced a leptin-Notch signaling axis in breast cancer. Authors: Battle M, Gillespie C, Quarshie A, Lanier V, Harmon T, Wilson K, Torroella-Kouri M, Gonzalez-Perez R Int J Cancer, 2014;134(7):1605-16. Species: Mouse Sample Type: Plasma
Beneficial metabolic effects of rapamycin are associated with enhanced regulatory cells in diet-induced obese mice. Authors: Makki K, Taront S, Molendi-Coste O, Bouchaert E, Neve B, Eury E, Lobbens S, Labalette M, Duez H, Staels B, Dombrowicz D, Froguel P, Wolowczuk I PLoS ONE, 2014;9(4):e92684. Species: Mouse Sample Type: Serum
Effect of intermittent cold exposure on brown fat activation, obesity, and energy homeostasis in mice. Authors: Ravussin Y, Xiao C, Gavrilova O, Reitman M PLoS ONE, 2014;9(1):e85876. Species: Mouse Sample Type: Serum
Temporal changes in nutritional state affect hypothalamic POMC peptide levels independently of leptin in adult male mice. Authors: Mercer A, Stuart R, Attard C, Otero-Corchon V, Nillni E, Low M Am J Physiol Endocrinol Metab, 2014;306(8):E904-15. Species: Mouse Sample Type: Plasma
Protopanaxatriol, a novel PPARgamma antagonist from Panax ginseng, alleviates steatosis in mice. Authors: Zhang Y, Yu L, Cai W, Fan S, Feng L, Ji G, Huang C Sci Rep, 2014;4(0):7375. Species: Mouse Sample Type: Serum
Ghrelin induces leptin resistance by activation of suppressor of cytokine signaling 3 expression in male rats: implications in satiety regulation. Authors: Heldsinger A, Grabauskas G, Wu X, Zhou S, Lu Y, Song I, Owyang C Endocrinology, 2014;155(10):3956-69. Species: Rat Sample Type: Plasma
PKClambda haploinsufficiency prevents diabetes by a mechanism involving alterations in hepatic enzymes. Authors: Sajan M, Ivey R, Lee M, Mastorides S, Jurczak M, Samuels V, Shulman G, Braun U, Leitges M, Farese R Mol Endocrinol, 2014;28(7):1097-107. Species: Mouse Sample Type: Serum
Butter naturally enriched in cis-9, trans-11 CLA prevents hyperinsulinemia and increases both serum HDL cholesterol and triacylglycerol levels in rats. Authors: de Almeida M, Luquetti S, Sabarense C, do Amaral Correa J, dos Reis L, Santos da Conceicao E, Lisboa P, de Moura E, Gameiro J, da Gama M, Lopes F, Garcia R Lipids Health Dis, 2014;13(0):200. Species: Rat Sample Type: Serum
A leptin-mediated central mechanism in analgesia-enhanced opioid reward in rats. Authors: Lim G, Kim H, McCabe M, Chou C, Wang S, Chen L, Marota J, Blood A, Breiter H, Mao J J Neurosci, 2014;34(29):9779-88. Species: Rat Sample Type: Serum
Leptin metabolically licenses T cells for activation to link nutrition and immunity. Authors: Saucillo, Donte C, Gerriets, Valerie, Sheng, John, Rathmell, Jeffrey, Maciver, Nancie J J Immunol, 2014;192(1):136-44. Species: Mouse Sample Type: Serum
Enhanced leptin sensitivity, reduced adiposity, and improved glucose homeostasis in mice lacking exchange protein directly activated by cyclic AMP isoform 1. Authors: Yan J, Mei F, Cheng H, Lao D, Hu Y, Wei J, Patrikeev I, Hao D, Stutz S, Dineley K, Motamedi M, Hommel J, Cunningham K, Chen J, Cheng X Mol Cell Biol, 2013;33(5):918-26. Species: Mouse Sample Type: Plasma
Euglycemic hyperinsulinemia increases blood pressure in pregnant rats independent of placental antiangiogenic and inflammatory factors. Authors: Palei A, Spradley F, Granger J Am J Hypertens, 2013;26(12):1445-51. Species: Rat Sample Type: Serum
Exercise protects against diet-induced insulin resistance through downregulation of protein kinase Cbeta in mice. Authors: Rao X, Zhong J, Xu X, Jordan B, Maurya S, Braunstein Z, Wang T, Huang W, Aggarwal S, Periasamy M, Rajagopalan S, Mehta K, Sun Q PLoS ONE, 2013;8(12):e81364. Species: Mouse Sample Type: Plasma
Obesity and IL-6 interact in modulating the response to endotoxemia in mice. Cytokine, 2013;61(1):71-7. Species: Mouse Sample Type: Plasma
HDL and Glut1 inhibition reverse a hypermetabolic state in mouse models of myeloproliferative disorders. Authors: Gautier E, Westerterp M, Bhagwat N, Cremers S, Shih A, Abdel-Wahab O, Lutjohann D, Randolph G, Levine R, Tall A, Yvan-Charvet L J Exp Med, 2013;210(2):339-53. Species: Mouse Sample Type: Plasma
Oral leptin treatment in suckling rats ameliorates detrimental effects in hypothalamic structure and function caused by maternal caloric restriction during gestation. Authors: Konieczna J, Garcia A, Sanchez J, Palou M, Palou A, Pico C PLoS ONE, 2013;8(11):e81906. Species: Rat Sample Type: Plasma
HCV core-induced nonobese hepatic steatosis is associated with hypoadiponectinemia and is ameliorated by adiponectin administration. Authors: Chang ML, Yeh HC, Tsou YK Obesity (Silver Spring), 2012;20(7):1474-80. Species: Mouse Sample Type: Serum
Disruption of the chemokine-like receptor-1 (CMKLR1) gene is associated with reduced adiposity and glucose intolerance. Authors: Ernst MC, Haidl ID, Zúñiga LA, Dranse HJ, Rourke JL, Zabel BA, Butcher EC, Sinal CJ Endocrinology, 2012;153(2):672-82. Species: Mouse Sample Type: Serum
Obesity in mice with adipocyte-specific deletion of clock component Arntl. Authors: Paschos, Georgios, Ibrahim, Salam, Song, Wen-Lian, Kunieda, Takeshig, Grant, Gregory, Reyes, Teresa M, Bradfield, Christop, Vaughan, Cheryl H, Eiden, Michael, Masoodi, Mojgan, Griffin, Julian L, Wang, Fenfen, Lawson, John A, Fitzgerald, Garret A Nat Med, 2012;18(12):1768-77. Species: Mouse Sample Type: Plasma
Tangeretin stimulates glucose uptake via regulation of AMPK signaling pathways in C2C12 myotubes and improves glucose tolerance in high-fat diet-induced obese mice. Mol. Cell. Endocrinol., 2012;358(1):127-34. Species: Mouse Sample Type: Serum
Physiological roles of group X-secreted phospholipase A2 in reproduction, gastrointestinal phospholipid digestion, and neuronal function. Authors: Sato H, Isogai Y, Masuda S J. Biol. Chem., 2011;286(13):11632-48. Species: Mouse Sample Type: Serum
Castration-induced changes in mouse epididymal white adipose tissue. Authors: Floryk D, Kurosaka S, Tanimoto R, Yang G, Goltsov A, Park S, Thompson TC Mol. Cell. Endocrinol., 2011;345(1):58-67. Species: Mouse Sample Type: Serum
Perinatal lack of maternal IL-6 promotes increased adiposity during adulthood in mice. Authors: Lager S, Asterholm IW, Schele E, Jansson N, Nilsson S, Jansson JO, Lonn M, Holmang A Endocrinology, 2011;152(4):1336-46. Species: Mouse Sample Type: Milk
Fasting induces an anti-inflammatory effect on the neuroimmune system which a high-fat diet prevents. Authors: Lavin DN, Joesting JJ, Chiu GS, Moon ML, Meng J, Dilger RN, Freund GG Obesity (Silver Spring), 2011;19(8):1586-94. Species: Mouse Sample Type: Serum
Varying susceptibility of pulmonary cytokine production to lipopolysaccharide in mice. Authors: Alm AS, Li K, Yang D, Andersson R, Lu Y, Wang X Cytokine, 2010;49(3):256-63. Species: Mouse Sample Type: BALF
Moderate caloric restriction in lactating rats protects offspring against obesity and insulin resistance in later life. Authors: Palou M, Priego T, Sanchez J, Torrens JM, Palou A, Pico C Endocrinology, 2010;151(3):1030-41. Species: Rat Sample Type: Milk
Leptin exacerbates sepsis-mediated morbidity and mortality. Authors: Shapiro NI, Khankin EV, van Meurs M J. Immunol., 2010;185(1):517-24. Species: Mouse Sample Type: Plasma
Neutralization of osteopontin inhibits obesity-induced inflammation and insulin resistance. Authors: Kiefer FW, Zeyda M, Gollinger K, Pfau B, Neuhofer A, Weichhart T, Saemann MD, Geyeregger R, Schlederer M, Kenner L, Stulnig TM Diabetes, 2010;59(4):935-46. Species: Mouse Sample Type: Plasma
Group X secretory phospholipase A2 negatively regulates adipogenesis in murine models. Authors: Li X, Shridas P, Forrest K, Bailey W, Webb NR FASEB J., 2010;24(11):4313-24. Species: Mouse Sample Type: Plasma
Deletion of Nhlh2 results in a defective torpor response and reduced Beta adrenergic receptor expression in adipose tissue. Authors: Wankhade UD, Vella KR, Fox DL PLoS ONE, 2010;5(8):e12324. Species: Mouse Sample Type: Serum
Differential effects of high MUFA with high or low P/S ratio (polyunsaturated to saturated fatty acids) on improving hepatic lipolytic enzymes and mediating PPARgamma related with lipoprotein lipase and hormone-sensitive lipase of white adipose tissue in diet-induced obese hamster. Authors: Liao FH, Liou TH, Chiu WC, Shieh MJ, Chien YW Int J Obes (Lond), 2010;34(11):1608-17. Species: Hamster Sample Type: Plasma
eNOS plays a major role in adiponectin synthesis in adipocytes. Authors: Koh EH, Kim M, Ranjan KC, Kim HS, Park HS, Oh KS, Park IS, Lee WJ, Kim MS, Park JY, Youn JH, Lee KU Am. J. Physiol. Endocrinol. Metab., 2010;298(4):E846-53. Species: Mouse Sample Type: Plasma
Enhanced production of IL-17A during zymosan-induced peritonitis in obese mice. Authors: Pini M, Fantuzzi G J. Leukoc. Biol., 2010;87(1):51-8. Species: Mouse Sample Type: Peritoneal Lavage
Early handling increases susceptibility to experimental autoimmune encephalomyelitis (EAE) in C57BL/6 male mice. Authors: Columba-Cabezas S, Iaffaldano G, Chiarotti F, Alleva E, Cirulli F J. Neuroimmunol., 2009;212(1):10-6. Species: Mouse Sample Type: Serum
Spinal leptin contributes to the pathogenesis of neuropathic pain in rodents. Authors: Lim G, Wang S, Zhang Y, Tian Y, Mao J J. Clin. Invest., 2009;119(2):295-304. Species: Rat Sample Type: Plasma
Development of obesity in the Otsuka Long-Evans Tokushima Fatty rat. Authors: Schroeder M, Zagoory-Sharon O, Shbiro L, Marco A, Hyun J, Moran TH, Bi S, Weller A Am. J. Physiol. Regul. Integr. Comp. Physiol., 2009;297(6):R1749-60. Species: Rat Sample Type: Plasma
Stearoyl-CoA desaturase 1 deficiency protects mice from immune-mediated liver injury. Authors: Feng D, Wang Y, Mei Y, Xu Y, Xu H, Lu Y, Luo Q, Zhou S, Kong X, Xu L Lab. Invest., 2009;89(2):222-30. Species: Mouse Sample Type: Plasma
Efficient method for obtaining Lep(ob)/Lep(ob)-derived animal models using adipose tissue transplantations. Authors: Barros CC, Almeida SS, Mori MA, Valero VB, Haro AS, Batista EC, Rosa TS, Bacurau RF, Wurtele M, Araujo RC Int J Obes (Lond), 2009;33(8):938-44. Species: Mouse Sample Type: Serum
Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice. Authors: Osei-Hyiaman D, Liu J, Zhou L, Godlewski G, Harvey-White J, Jeong WI, Batkai S, Marsicano G, Lutz B, Buettner C, Kunos G J. Clin. Invest., 2008;118(9):3160-9. Species: Mouse Sample Type: Plasma
Doubly truncated FosB isoform (Delta2DeltaFosB) induces osteosclerosis in transgenic mice and modulates expression and phosphorylation of Smads in osteoblasts independent of intrinsic AP-1 activity. Authors: Sabatakos G, Rowe GC, Kveiborg M, Wu M, Neff L, Chiusaroli R, Philbrick WM, Baron R J. Bone Miner. Res., 2008;23(5):584-95. Species: Mouse Sample Type: Serum
Identification of ALOX5 as a gene regulating adiposity and pancreatic function. Authors: Mehrabian M, Schulthess FT, Nebohacova M, Castellani LW, Zhou Z, Hartiala J, Oberholzer J, Lusis AJ, Maedler K, Allayee H Diabetologia, 2008;51(6):978-88. Species: Mouse Sample Type: Plasma
Adaptation to lactation in OLETF rats lacking CCK-1 receptors: body weight, fat tissues, leptin and oxytocin. Authors: Zagoory-Sharon O, Schroeder M, Levine A, Moran TH, Weller A Int J Obes (Lond), 2008;32(8):1211-21. Species: Rat Sample Type: Plasma
Novel black soy peptides with antiobesity effects: activation of leptin-like signaling and AMP-activated protein kinase. Authors: Jang EH, Moon JS, Ko JH, Ahn CW, Lee HH, Shin JK, Park CS, Kang JH Int J Obes (Lond), 2008;32(7):1161-70. Species: Mouse Sample Type: Plasma
Signal transducer and activator of transcription-3 is required in hypothalamic agouti-related protein/neuropeptide Y neurons for normal energy homeostasis. Authors: Gong L, Yao F, Hockman K, Heng HH, Morton GJ, Takeda K, Akira S, Low MJ, Rubinstein M, MacKenzie RG Endocrinology, 2008;149(7):3346-54. Species: Mouse Sample Type: Plasma
Octylphenol stimulates resistin gene expression in 3T3-L1 adipocytes via the estrogen receptor and extracellular signal-regulated kinase pathways. Authors: Lee MJ, Lin H, Liu CW, Wu MH, Liao WJ, Chang HH, Ku HC, Chien YS, Ding WH, Kao YH Am. J. Physiol., Cell Physiol., 2008;294(6):C1542-51. Species: Mouse Sample Type: Serum
Role and regulation of adipokines during zymosan-induced peritoneal inflammation in mice. Authors: Pini M, Gove ME, Sennello JA, van Baal JW, Chan L, Fantuzzi G Endocrinology, 2008;149(8):4080-5. Species: Mouse Sample Type: Serum
Leptin induces elongation of cardiac myocytes and causes eccentric left ventricular dilatation with compensation. Authors: Abe Y, Ono K, Kawamura T, Wada H, Kita T, Shimatsu A, Hasegawa K Am. J. Physiol. Heart Circ. Physiol., 2007;292(5):H2387-96. Species: Mouse Sample Type: Plasma
FXR-deficiency confers increased susceptibility to torpor. Authors: Cariou B, Bouchaert E, Abdelkarim M, Dumont J, Caron S, Fruchart JC, Burcelin R, Kuipers F, Staels B FEBS Lett., 2007;581(27):5191-8. Species: Mouse Sample Type: Plasma
High circulating leptin receptors with normal leptin sensitivity in liver-specific insulin receptor knock-out (LIRKO) mice. Authors: Cohen SE, Kokkotou E, Biddinger SB, Kondo T, Gebhardt R, Kratzsch J, Mantzoros CS, Kahn CR J. Biol. Chem., 2007;282(32):23672-8. Species: Mouse Sample Type: Serum
Integrating genetic and network analysis to characterize genes related to mouse weight. Authors: Ghazalpour A, Doss S, Zhang B, Wang S, Plaisier C, Castellanos R, Brozell A, Schadt EE, Drake TA, Lusis AJ, Horvath S PLoS Genet., 2006;2(8):e130. Species: Mouse Sample Type: Plasma
Impaired adipose tissue development in mice with inactivation of placental growth factor function. Authors: Lijnen HR, Christiaens V, Scroyen I, Voros G, Tjwa M, Carmeliet P, Collen D Diabetes, 2006;55(10):2698-704. Species: Mouse Sample Type: Tissue Homogenates
Long-term blockade of angiotensin AT1 receptors increases survival of obese Zucker rats. Authors: O'Connor SE Eur. J. Pharmacol., 2006;534(1):271-9. Species: Mouse Sample Type: Plasma
Metformin restores leptin sensitivity in high-fat-fed obese rats with leptin resistance. Authors: Kim YW, Kim JY, Park YH, Park SY, Won KC, Choi KH, Huh JY, Moon KH Diabetes, 2006;55(3):716-24. Species: Rat Sample Type: CSF
Leptin resistance protects mice from hyperoxia-induced acute lung injury. Authors: Bellmeyer A, Martino JM, Chandel NS, Scott Budinger GR, Dean DA, Mutlu GM Am. J. Respir. Crit. Care Med., 2006;175(6):587-94. Species: Mouse Sample Type: BALF
Role of leptin deficiency in early acute renal failure during endotoxemia in ob/ob mice. Authors: Wang W, Poole B, Mitra A, Falk S, Fantuzzi G, Lucia S, Schrier R J. Am. Soc. Nephrol., 2004;15(3):645-9. Species: Mouse Sample Type: Serum
Diurnal rhythms of leptin and ghrelin in the systemic circulation and in the gastric mucosa are related to food intake in rats. Authors: Sanchez J, Oliver P, Pico C, Palou A Pflugers Arch., 2004;448(5):500-6. Species: Rat Sample Type: Serum
Leptin accelerates autoimmune diabetes in female NOD mice. Authors: Matarese G, Sanna V, Lechler RI, Sarvetnick N, Fontana S, Zappacosta S, La Cava A Diabetes, 2002;51(5):1356-61. Species: Mouse Sample Type: Cell Culture Supernates
The increased bone mass in deltaFosB transgenic mice is independent of circulating leptin levels. Authors: Kveiborg M, Chiusaroli R, Sims NA, Wu M, Sabatakos G, Horne WC, Baron R Endocrinology, 2002;143(11):4304-9. Species: Mouse Sample Type: Serum
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Authors: Yamauchi, T, Kamon, J, Waki, H, Terauchi, Y, Kubota, N, Hara, K, Mori, Y, Ide, T, Murakami, K, Tsuboyama-Kasaoka, N, Ezaki, O, Akanuma, Y, Gavrilova, O, Vinson, C, Reitman, M L, Kagechika, H, Shudo, K, Yoda, M, Nakano, Y, Tobe, K, Nagai, R, Kimura, S, Tomita, M, Froguel, P, Kadowaki, T Nat Med, 2001;7(8):941-6. Species: Mouse Sample Type: Plasma
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