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Mouse GM-CSF Quantikine SixPak (6 Plates) (1 PK)

货号: SMGM00 基本售价: 19749.7 元 规格: 1 PACK

产品信息

概述
货号SMGM00
描述The Quantikine Mouse GM-CSF Immunoassay is a 4.5 hour solid phase ELISA designed to measure mouse GM-CSF in cell culture supernates and serum. It contains E. coli-expressed recombinant mouse GM-CSF and antibodies raised against the recombinant factor. This immunoassay has been shown to quantitate the recombinant mouse GM-CSF accurately. Results obtained using natural mouse GM-CSF showed dose-response curves that were parallel to the standard curves obtained using the recombinant standards. These results indicate that this kit can be used to determine relative mass values for natural mouse GM-CSF.
别名colony stimulating factor 2 (granulocyte-macrophage); Colony-stimulating factor; CSF; CSF2; GMCSF; GM-CSF; GMCSFgranulocyte-macrophage colony-stimulating factor; granulocyte-macrophage colony stimulating factor; MGC131935; MGC138897; molgramostin; sargramostim;
全称
Granulocyte Macrophage Growth Factor
反应种属Mouse
目标/特异性Natural and recombinant mouse GM-CSF
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs
1437 (Human); 12981 (Mouse); 116630 (Rat); 397208 (Porcine); 403923 (Canine); 493805 (Feline)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Modifying Antigen-Encapsulating Liposomes with KALA Facilitates MHC Class I Antigen Presentation and Enhances Anti-tumor Effects
Authors: N Miura, H Akita, N Tateshita, T Nakamura, H Harashima
Mol. Ther, 2017;0(0):.
Species: Mouse
Sample Type: Serum

Development and Preclinical Application of an Immunocompetent Transplant Model of Basal Breast Cancer with Lung, Liver and Brain Metastases
PLoS ONE, 2016;11(5):e0155262.
Species: Mouse
Sample Type:

Protein malnutrition induces bone marrow mesenchymal stem cells commitment to adipogenic differentiation leading to hematopoietic failure.
Authors: Cunha M, Lima F, Vinolo M, Hastreiter A, Curi R, Borelli P, Fock R
PLoS ONE, 2013;8(3):e58872.
Species: Mouse
Sample Type: Cell Culture Supernates

Keratinocyte Growth Factor Augments Pulmonary Innate Immunity through Epithelium-driven, GM-CSF-dependent Paracrine Activation of Alveolar Macrophages.
Authors: Wu H, Suzuki T, Carey B, Trapnell BC, McCormack FX
J. Biol. Chem., 2011;286(17):14932-40.
Species: Mouse
Sample Type: Tissue Homogenates

Bcl3 prevents acute inflammatory lung injury in mice by restraining emergency granulopoiesis.
Authors: Kreisel D, Sugimoto S, Tietjens J, Zhu J, Yamamoto S, Krupnick AS, Carmody RJ, Gelman AE
J. Clin. Invest., 2011;121(1):265-76.
Species: Mouse
Sample Type: Serum

Histone Deacetylase Inhibitor LAQ824 Augments Inflammatory Responses in Macrophages through Transcriptional Regulation of IL-10.
Authors: Wang H, Cheng F
J. Immunol., 2011;186(0):3986.
Species: Mouse
Sample Type: Cell Culture Supernates

Deletion of tristetraprolin caused spontaneous reactive granulopoiesis by a non-cell-autonomous mechanism without disturbing long-term hematopoietic stem cell quiescence.
Authors: Kaplan IM, Morisot S, Heiser D, Cheng WC, Kim MJ, Civin CI
J. Immunol., 2011;186(5):2826-34.
Species: Mouse
Sample Type: Plasma

Simultaneous absence of surfactant proteins A and D increases lung inflammation and injury after allogeneic HSCT in mice.
Authors: Gram K, Yang S, Steiner M, Somani A, Hawgood S, Blazar BR, Panoskaltsis-Mortari A, Haddad IY
Am. J. Physiol. Lung Cell Mol. Physiol., 2009;296(2):L167-75.
Species: Mouse
Sample Type: BALF

Novel immunocompetent murine tumor model for evaluation of conditionally replication-competent (oncolytic) murine adenoviral vectors.
Authors: Robinson M, Li B, Ge Y, Ko D, Yendluri S, Harding T, VanRoey M, Spindler KR, Jooss K
J. Virol., 2009;83(8):3450-62.
Species: Mouse
Sample Type: Tissue Homogenates

Macrophage tumor necrosis factor-alpha induces epithelial expression of granulocyte-macrophage colony-stimulating factor: impact on alveolar epithelial repair.
Authors: Cakarova L, Marsh LM, Wilhelm J, Mayer K, Grimminger F, Seeger W, Lohmeyer J, Herold S
Am. J. Respir. Crit. Care Med., 2009;180(6):521-32.
Species: Mouse
Sample Type: Cell Culture Supernates

Administration of cyclooxygenase-2 inhibitor reduces joint inflammation but exacerbates osteopenia in IL-1 alpha transgenic mice due to GM-CSF overproduction.
Authors: Niki Y, Takaishi H, Takito J, Miyamoto T, Kosaki N, Matsumoto H, Toyama Y, Tada N
J. Immunol., 2007;179(1):639-46.
Species: Mouse
Sample Type: Cell Culture Supernates

IL-7 induces myelopoiesis and erythropoiesis.
Authors: Aiello FB, Keller JR, Klarmann KD, Dranoff G, Mazzucchelli R, Durum SK
J. Immunol., 2007;178(3):1553-63.
Species: Mouse
Sample Type: Cell Culture Supernates

Lentiviral vector-mediated autonomous differentiation of mouse bone marrow cells into immunologically potent dendritic cell vaccines.
Authors: Koya RC, Kimura T, Ribas A, Rozengurt N, Lawson GW, Faure-Kumar E, Wang HJ, Herschman H, Kasahara N, Stripecke R
Mol. Ther., 2007;15(5):971-80.
Species: Mouse
Sample Type: Serum

Expression of CCL20 and granulocyte-macrophage colony-stimulating factor, but not Flt3-L, from modified vaccinia virus ankara enhances antiviral cellular and humoral immune responses.
Authors: Chavan R, Marfatia KA, An IC, Garber DA, Feinberg MB
J. Virol., 2006;80(15):7676-87.

GM-CSF and the impaired pulmonary innate immune response following hyperoxic stress.
Authors: Baleeiro CE, Christensen PJ, Morris SB, Mendez MP, Wilcoxen SE, Paine R
Am. J. Physiol. Lung Cell Mol. Physiol., 2006;291(6):L1246-55.
Species: Mouse
Sample Type: Tissue Homogenates

Organ-specific role of MyD88 for gene regulation during polymicrobial peritonitis.
Authors: Weighardt H, Mages J, Jusek G, Kaiser-Moore S, Lang R, Holzmann B
Infect. Immun., 2006;74(6):3618-32.
Species: Mouse
Sample Type: Tissue Homogenates

A novel polysaccharide of black soybean promotes myelopoiesis and reconstitutes bone marrow after 5-flurouracil- and irradiation-induced myelosuppression.
Authors: Liao HF, Chen YJ, Yang YC
Life Sci., 2005;77(4):400-13.
Species: Mouse
Sample Type: Cell Culture Supernates

Endogenous granulocyte-macrophage colony-stimulating factor overexpression in vivo results in the long-term recruitment of a distinct dendritic cell population with enhanced immunostimulatory function.
Authors: Miller G, Pillarisetty VG, Shah AB, Lahrs S, Xing Z, DeMatteo RP
J. Immunol., 2002;169(6):2875-85.
Species: Mouse
Sample Type: Serum

Interleukin 3 and granulocyte-macrophage colony-stimulating factor are not required for induction of chronic myeloid leukemia-like myeloproliferative disease in mice by BCR/ABL.
Authors: Li S, Gillessen S, Tomasson MH, Dranoff G, Gilliland DG, Van Etten RA
Blood, 2001;97(5):1442-50.
Species: Mouse
Sample Type: Serum

A secreted and LIF-mediated stromal cell-derived activity that promotes ex vivo expansion of human hematopoietic stem cells.
Authors: Shih CC, Hu MC, Hu J
Blood, 2000;95(6):1957-66.
Species: Mouse
Sample Type: Cell Culture Supernates

生物活性< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景GM-CSF (Granulocyte-Macrophage Colony Stimulating Factor) induces the development of monocytes, neutrophils, eosinophils, and myeloid and dermal dendritic cells. It also acts as a neutrophil and dendritic cell chemoattractant. GM-CSF promotes Th1 and Th17 cell mediated autoimmune inflammation as well as the inflammatory activation of dendritic cells, microglia, alveolar macrophages, and eosinophils. In addition, it cooperates with G-CSF in promoting tumor cell proliferation and invasion. GM-CSF signals through a receptor complex composed of GM-CSF R alpha and the Common beta Chain (beta c) with Syndecan-2 as a potential co-receptor. The beta c subunit is shared by the receptor complexes for IL-3 and IL-5.
运输条件Blue Ice
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参考文献
  • Common beta Chain Receptor Family
  • Cytokines and Receptors in Allergy and Asthma
  • Cytokines and Receptors in Angiogenesis
  • Dendritic Cell Development
  • Gametes and Fertilization
  • gamma delta T Cells
  • Inflammatory Mediators
  • Isolation, Culture, and Identification of Natural Killer Cells
  • Macrophage Activation Markers
  • Myeloid-derived Suppressor Cells (MDSC)
  • Natural Killer T (NKT) Cells
  • T Cell Cytokine Signaling