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Mouse IL-5 Quantikine SixPak (6 Plates) (1 PK)

货号: SM5000 基本售价: 19749.7 元 规格: 1 PACK

产品信息

概述
货号SM5000
描述The Quantikine Mouse IL-5 Immunoassay is a 4.5 hour solid phase ELISA designed to measure mouse IL-5 in cell culture supernates and mouse serum. It contains Sf 21-expressed recombinant mouse IL-5 and antibodies raised against the recombinant factor. This immunoassay has been shown to accurately quantitate recombinant mouse IL-5. Results obtained using natural mouse IL-5 showed linear curves that were parallel to the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural mouse IL-5.
别名BCDF mu; B-cell differentiation factor I; BCGFII; EDF; Eo-CSF; Eosinophil differentiation factor; IL5; IL-5; IL-5T-cell replacing factor; interleukin 5 (colony-stimulating factor, eosinophil); interleukin-5; TRF; TRFB cell differentiation factor I;
全称
Interleukin 5
反应种属Mouse
目标/特异性Natural and recombinant mouse IL-5
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs
3567 (Human); 16191 (Mouse); 24497 (Rat); 397409 (Porcine); 280825 (Bovine); 403790 (Canine); 493803 (Feline)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Bach2 Controls Homeostasis of Eosinophils by Restricting the Type-2 Helper Function of T Cells
Authors: Y Sato, H Kato, R Ebina-Shib, A Itoh-Nakad, R Okuyama, K Igarashi
Tohoku J. Exp. Med, 2017;241(3):175-182.
Species: Mouse
Sample Type: Serum

Beneficial effects of Galectin-9 on allergen-specific sublingual immunotherapy in a Dermatophagoides farinae-induced mouse model�of chronic asthma
Allergol Int, 2016;0(0):.
Species: Mouse
Sample Type: Other

G-protein-coupled estrogen receptor agonist suppresses airway inflammation in a mouse model of asthma through IL-10.
Authors: Itoga M, Konno Y, Moritoki Y, Saito Y, Ito W, Tamaki M, Kobayashi Y, Kayaba H, Kikuchi Y, Chihara J, Takeda M, Ueki S, Hirokawa M
PLoS ONE, 2015;10(3):e0123210.
Species: Mouse
Sample Type: BALF

IL-33-mediated protection against experimental cerebral malaria is linked to induction of type 2 innate lymphoid cells, M2 macrophages and regulatory T cells.
Authors: Besnard A, Guabiraba R, Niedbala W, Palomo J, Reverchon F, Shaw T, Couper K, Ryffel B, Liew F
PLoS Pathog, 2015;11(2):e1004607.
Species: Mouse
Sample Type: Serum

Dendritic cells induce Th2-mediated airway inflammatory responses to house dust mite via DNA-dependent protein kinase.
Authors: Mishra, Amarjit, Brown, Alexandr, Yao, Xianglan, Yang, Shutong, Park, Sung-Jun, Liu, Chengyu, Dagur, Pradeep, McCoy, J Philip, Keeran, Karen J, Nugent, Gayle Z, Jeffries, Kenneth, Qu, Xuan, Yu, Zu-Xi, Levine, Stewart, Chung, Jay H
Nat Commun, 2015;6(0):6224.
Species: Mouse
Sample Type: Cell Culture Supernates

Eosinophils regulate peripheral B cell numbers in both mice and humans.
Authors: Wong, Tina W, Doyle, Alfred D, Lee, James J, Jelinek, Diane F
J Immunol, 2014;192(8):3548-58.
Species: Mouse
Sample Type: Serum

Interleukin-33 and alveolar macrophages contribute to the mechanisms underlying the exacerbation of IgE-mediated airway inflammation and remodelling in mice.
Authors: Mizutani N, Nabe T, Yoshino S
Immunology, 2013;139(2):205-18.
Species: Mouse
Sample Type: Tissue Homogenates

Dual functions of prostaglandin D2 in murine contact hypersensitivity via DP and CRTH2.
Authors: Yamamoto Y, Otani S, Hirai H, Nagata K, Aritake K, Urade Y, Narumiya S, Yokozeki H, Nakamura M, Satoh T
Am. J. Pathol., 2012;179(1):302-14.
Species: Mouse
Sample Type: Tissue Homogenates

IL-33-activated dendritic cells are critical for allergic airway inflammation.
Authors: Besnard AG, Togbe D, Guillou N, Erard F, Quesniaux V, Ryffel B
Eur. J. Immunol., 2011;41(6):1675-86.
Species: Mouse
Sample Type: BALF

IL-33-responsive lineage- CD25+ CD44(hi) lymphoid cells mediate innate type 2 immunity and allergic inflammation in the lungs.
Authors: Bartemes KR, Iijima K, Kobayashi T, Kephart GM, McKenzie AN, Kita H
J. Immunol., 2011;188(3):1503-13.
Species: Mouse
Sample Type: BALF

Endogenous IL-33 enhances Th2 cytokine production and T-cell responses during allergic airway inflammation.
Authors: Louten J, Rankin AL, Li Y
Int. Immunol., 2011;23(5):307-15.
Species: Mouse
Sample Type: BALF

Over-expression of the LTC4 synthase gene in mice reproduces human aspirin-induced asthma.
Authors: Hirata H, Arima M, Fukushima Y, Honda K, Sugiyama K, Tokuhisa T, Fukuda T
Clin. Exp. Allergy, 2011;41(8):1133-42.
Species: Mouse
Sample Type: BALF

Control of mouse graft-versus-host disease following allogeneic bone marrow transplantation by blocking the CD28/B7 signaling pathway with lentiviral vector-mediated RNA interference.
Authors: Sang W, Zhou C, Cheng N, Li Z, Zeng L, Xu K
Immunol. Lett., 2011;136(2):194-202.
Species: Mouse
Sample Type: Plasma

Epithelial reticulon 4B (Nogo-B) is an endogenous regulator of Th2-driven lung inflammation.
Authors: Wright PL, Yu J, Di YP
J. Exp. Med., 2010;207(12):2595-607.
Species: Mouse
Sample Type: BALF

Peroxisome proliferator-activated receptor gamma agonist down-regulates IL-17 expression in a murine model of allergic airway inflammation.
Authors: Park SJ, Lee KS, Kim SR, Min KH, Choe YH, Moon H, Chae HJ, Yoo WH, Lee YC
J. Immunol., 2009;183(5):3259-67.
Species: Mouse
Sample Type: BALF

Modified adenine (9-benzyl-2-butoxy-8-hydroxyadenine) redirects Th2-mediated murine lung inflammation by triggering TLR7.
Authors: Vultaggio A, Nencini F, Fitch PM, Fili L, Maggi L, Fanti P, deVries A, Beccastrini E, Palandri F, Manuelli C, Bani D, Giudizi MG, Guarna A, Annunziato F, Romagnani S, Maggi E, Howie SE, Parronchi P
J. Immunol., 2009;182(2):880-9.
Species: Mouse
Sample Type: Cell Culture Supernates

Eosinophil viability is increased by acidic pH in a cAMP- and GPR65-dependent manner.
Authors: Kottyan LC, Collier AR, Cao KH, Niese KA, Hedgebeth M, Radu CG, Witte ON, Khurana Hershey GK, Rothenberg ME, Zimmermann N
Blood, 2009;114(13):2774-82.
Species: Mouse
Sample Type: Cell Lysates

Mouse models of asthma: a comparison between C57BL/6 and BALB/c strains regarding bronchial responsiveness, inflammation, and cytokine production.
Authors: Gueders MM, Paulissen G, Crahay C, Quesada-Calvo F, Hacha J, Van Hove C, Tournoy K, Louis R, Foidart JM, Noel A, Cataldo DD
Inflamm. Res., 2009;58(12):845-54.
Species: Mouse
Sample Type: BALF

Macrophage migration inhibitory factor homologs of anisakis simplex suppress Th2 response in allergic airway inflammation model via CD4+CD25+Foxp3+ T cell recruitment.
Authors: Park SK, Cho MK, Park HK, Lee KH, Lee SJ, Choi SH, Ock MS, Jeong HJ, Lee MH, Yu HS
J. Immunol., 2009;182(11):6907-14.
Species: Mouse
Sample Type: BALF

A MyD88-dependent early IL-17 production protects mice against airway infection with the obligate intracellular pathogen Chlamydia muridarum.
Authors: Zhang X, Gao L, Lei L, Zhong Y, Dube P, Berton MT, Arulanandam B, Zhang J, Zhong G
J. Immunol., 2009;183(2):1291-300.
Species: Mouse
Sample Type: BALF

Complement C3a regulates late asthmatic response and airway hyperresponsiveness in mice.
Authors: Mizutani N, Nabe T, Yoshino S
J. Immunol., 2009;183(6):4039-46.
Species: Mouse
Sample Type: BALF

TLR9 agonist, but not TLR7/8, functions as an adjuvant to diminish FI-RSV vaccine-enhanced disease, while either agonist used as therapy during primary RSV infection increases disease severity.
Authors: Johnson TR, Rao S, Seder RA, Chen M, Graham BS
Vaccine, 2009;27(23):3045-52.
Species: Mouse
Sample Type: Cell Culture Supernates

Inhibition of interleukin-33 signaling attenuates the severity of experimental arthritis.
Authors: Palmer G, Talabot-Ayer D, Lamacchia C, Toy D, Seemayer CA, Viatte S, Finckh A, Smith DE, Gabay C
Arthritis Rheum., 2009;60(3):738-49.
Species: Mouse
Sample Type: BALF

Celastrol suppresses allergen-induced airway inflammation in a mouse allergic asthma model.
Authors: Kim DY, Park JW, Jeoung D, Ro JY
Eur. J. Pharmacol., 2009;612(1):98-105.
Species: Mouse
Sample Type: BALF

A severe deficiency of coagulation factor VIIa results in attenuation of the asthmatic response in mice.
Authors: Shinagawa K, Ploplis VA, Castellino FJ
Am. J. Physiol. Lung Cell Mol. Physiol., 2009;296(5):L763-70.
Species: Mouse
Sample Type: BALF

A TLR2 agonist in German cockroach frass activates MMP-9 release and is protective against allergic inflammation in mice.
Authors: Page K, Ledford JR, Zhou P, Wills-Karp M
J. Immunol., 2009;183(5):3400-8.
Species: Mouse
Sample Type: Tissue Homogenates

Cyclooxygenase inhibition during allergic sensitization increases STAT6-independent primary and memory Th2 responses.
Authors: Zhou W, Newcomb DC, Moore ML, Goleniewska K, ONeal JF, Peebles RS
J. Immunol., 2008;181(8):5360-7.
Species: Mouse
Sample Type: Tissue Homogenates

Curcumin attenuates ovalbumin-induced airway inflammation by regulating nitric oxide.
Authors: Moon DO, Kim MO, Lee HJ, Choi YH, Park YM, Heo MS, Kim GY
Biochem. Biophys. Res. Commun., 2008;375(2):275-9.
Species: Mouse
Sample Type: BALF

Pulmonary eosinophilia requires interleukin-5, eotaxin-1, and CD4+ T cells in mice immunized with respiratory syncytial virus G glycoprotein.
Authors: Johnson TR, Rothenberg ME, Graham BS
J. Leukoc. Biol., 2008;84(3):748-59.
Species: Mouse
Sample Type: Tissue Homogenates

T-bet expression by dendritic cells is required for the repolarization of allergic airway inflammation.
Authors: Heckman KL, Radhakrishnan S, Peikert T, Iijima K, McGregor HC, Bell MP, Kita H, Pease LR
Eur. J. Immunol., 2008;38(9):2464-74.
Species: Mouse
Sample Type: BALF

Allergic pulmonary inflammation in mice is dependent on eosinophil-induced recruitment of effector T cells.
Authors: Jacobsen EA, Ochkur SI, Pero RS, Taranova AG, Protheroe CA, Colbert DC, Lee NA, Lee JJ
J. Exp. Med., 2008;205(3):699-710.
Species: Mouse
Sample Type: BALF

GS143, an IkappaB ubiquitination inhibitor, inhibits allergic airway inflammation in mice.
Authors: Hirose K, Wakashin H, Oki M, Kagami S, Suto A, Ikeda K, Watanabe N, Iwamoto I, Furuichi Y, Nakajima H
Biochem. Biophys. Res. Commun., 2008;374(3):507-11.
Species: Mouse
Sample Type: Cell Culture Supernates

Novel immunomodulatory properties of berbamine through selective down-regulation of STAT4 and action of IFN-gamma in experimental autoimmune encephalomyelitis.
Authors: Ren Y, Lu L, Guo TB, Qiu J, Yang Y, Liu A, Zhang JZ
J. Immunol., 2008;181(2):1491-8.
Species: Mouse
Sample Type: Cell Culture Supernates

Eosinophil-nerve interactions and neuronal plasticity in rat gut associated lymphoid tissue (GALT) in response to enteric parasitism.
Authors: OBrien LM, Fitzpatrick E, Baird AW, Campion DP
J. Neuroimmunol., 2008;197(1):1-9.
Species: Rat
Sample Type: Tissue Homogenates

Antifibrotic action of pirfenidone and prednisolone: different effects on pulmonary cytokines and growth factors in bleomycin-induced murine pulmonary fibrosis.
Authors: Oku H, Shimizu T, Kawabata T, Nagira M, Hikita I, Ueyama A, Matsushima S, Torii M, Arimura A
Eur. J. Pharmacol., 2008;590(1):400-8.
Species: Mouse
Sample Type: Tissue Homogenates

Regulation of allergen-induced bone marrow eosinophilopoiesis: role of CD4+ and CD8+ T cells.
Authors: Radinger M, Bossios A, Alm AS, Jeurink P, Lu Y, Malmhall C, Sjostrand M, Lotvall J
Allergy, 2007;62(12):1410-8.
Species: Mouse
Sample Type: BALF

Chronic intranasal administration of mould spores or extracts to unsensitized mice leads to lung allergic inflammation, hyper-reactivity and remodelling.
Authors: Denis O, van den Brule S, Heymans J, Havaux X, Rochard C, Huaux F, Huygen K
Immunology, 2007;122(2):268-78.
Species: Mouse
Sample Type: BALF

D-pinitol regulates Th1/Th2 balance via suppressing Th2 immune response in ovalbumin-induced asthma.
Authors: Lee JS, Lee CM, Jeong YI, Jung ID, Kim BH, Seong EY, Kim JI, Choi IW, Chung HY, Park YM
FEBS Lett., 2007;581(1):57-64.
Species: Mouse
Sample Type: BALF

Critical role of the Fc receptor gamma-chain on APCs in the development of allergen-induced airway hyperresponsiveness and inflammation.
Authors: Kitamura K, Takeda K, Koya T, Miyahara N, Kodama T, Dakhama A, Takai T, Hirano A, Tanimoto M, Harada M, Gelfand EW
J. Immunol., 2007;178(1):480-8.
Species: Mouse
Sample Type: BALF

Protectin D1 is generated in asthma and dampens airway inflammation and hyperresponsiveness.
Authors: Levy BD, Kohli P, Gotlinger K, Haworth O, Hong S, Kazani S, Israel E, Haley KJ, Serhan CN
J. Immunol., 2007;178(1):496-502.
Species: Mouse
Sample Type: BALF

IL-27 suppresses Th2 cell development and Th2 cytokines production from polarized Th2 cells: a novel therapeutic way for Th2-mediated allergic inflammation.
Authors: Yoshimoto T, Yoshimoto T, Yasuda K, Mizuguchi J, Nakanishi K
J. Immunol., 2007;179(7):4415-23.
Species: Mouse
Sample Type: Serum

Prolonged inhaled allergen exposure can induce persistent tolerance.
Authors: Van Hove CL, Maes T, Joos GF, Tournoy KG
Am. J. Respir. Cell Mol. Biol., 2007;36(5):573-84.
Species: Mouse
Sample Type: Cell Culture Supernates

Src homology 2 domain-containing inositol 5-phosphatase 1 deficiency leads to a spontaneous allergic inflammation in the murine lung.
Authors: Oh SY, Zheng T, Bailey ML, Barber DL, Schroeder JT, Kim YK, Zhu Z
J. Allergy Clin. Immunol., 2007;119(1):123-31.
Species: Mouse
Sample Type: BALF

Liposomal retinoic acids modulate asthma manifestations in mice.
Authors: Maret M, Ruffie C, Periquet B, Campo AM, Menevret M, Phelep A, Dziewiszek K, Druilhe A, Pretolani M
J. Nutr., 2007;137(12):2730-6.
Species: Mouse
Sample Type: BALF

FTY720 ameliorates oxazolone colitis in mice by directly affecting T helper type 2 functions.
Authors: Daniel C, Sartory NA, Zahn N
Mol. Immunol., 2007;44(13):3305-16.
Species: Mouse
Sample Type: Cell Culture Supernates

Oral administration of an immunostimulatory DNA sequence from Bifidobacterium longum improves Th1/Th2 balance in a murine model.
Authors: Takahashi N, Kitazawa H, Iwabuchi N, Xiao JZ, Miyaji K, Iwatsuki K, Saito T
Biosci. Biotechnol. Biochem., 2006;70(8):2013-7.
Species: Mouse
Sample Type: Cell Culture Supernates

Inhalation tolerance is induced selectively in thoracic lymph nodes but executed pervasively at distant mucosal and nonmucosal tissues.
Authors: Alvarez D, Swirski FK, Yang TC, Fattouh R, Croitoru K, Bramson JL, Stampfli MR, Jordana M
J. Immunol., 2006;176(4):2568-80.
Species: Mouse
Sample Type: Serum

Immunization with gp120-depleted whole killed HIV immunogen and a second-generation CpG DNA elicits strong HIV-specific responses in mice.
Authors: Trabattoni D, Clivio A, Bray DH, Bhagat L, Beltrami S, Maffeis G, Cesana E, Lowry P, Lissoni F, Kandimalla ER, Sullivan T, Agrawal S, Bartholomew R, Clerici M
Vaccine, 2005;24(9):1470-7.
Species: Mouse
Sample Type: Cell Culture Supernates

Formulation with CpG oligodeoxynucleotides prevents induction of pulmonary immunopathology following priming with formalin-inactivated or commercial killed bovine respiratory syncytial virus vaccine.
Authors: Oumouna M, Mapletoft JW, Karvonen BC, Babiuk LA
J. Virol., 2005;79(4):2024-32.
Species: Mouse
Sample Type: BALF

Suppression of autoimmune retinal disease by lovastatin does not require Th2 cytokine induction.
Authors: Gegg ME, Harry R, Hankey D, Zambarakji H, Pryce G, Baker D, Adamson P, Calder V, Greenwood J
J. Immunol., 2005;174(4):2327-35.
Species: Rat
Sample Type: Cell Culture Supernates

Intranasal mite allergen induces allergic asthma-like responses in NC/Nga mice.
Authors: Shibamori M, Ogino K, Kambayashi Y, Ishiyama H
Life Sci., 2005;78(9):987-94.
Species: Mouse
Sample Type: BALF

Matrix metalloproteinase-8 deficiency promotes granulocytic allergen-induced airway inflammation.
Authors: Gueders MM, Balbin M, Rocks N, Foidart JM, Gosset P, Louis R, Shapiro S, Lopez-Otin C, Noel A, Cataldo DD
J. Immunol., 2005;175(4):2589-97.
Species: Mouse
Sample Type: BALF

MyD88-dependent induction of allergic Th2 responses to intranasal antigen.
Authors: Piggott DA, Eisenbarth SC, Xu L, Constant SL, Huleatt JW, Herrick CA, Bottomly K
J. Clin. Invest., 2005;115(2):459-67.
Species: Human
Sample Type: Cell Culture Supernates

Effects of poly(ADP-ribose) polymerase inhibition on inflammatory cell migration in a murine model of asthma.
Authors: Virag L, Bai P, Bak I, Pacher P, Mabley JG, Liaudet L, Bakondi E, Gergely P, Kollai M, Szabo C
Med. Sci. Monit., 2004;10(3):BR77-83.
Species: Mouse
Sample Type: BALF

Increased interleukin-10 associated with low IL-6 concentration correlated with greater survival rates in mice infected by rabies virus vaccinated against it and immunomodulated with P. acnes.
Authors: Megid J, Kaneno R, Nozaki CN, Brito CJ, Almeida MF
Comp. Immunol. Microbiol. Infect. Dis., 2004;27(6):393-411.
Species: Mouse
Sample Type: Serum

Vbeta14(+) T cells mediate the vaccine-enhanced disease induced by immunization with respiratory syncytial virus (RSV) G glycoprotein but not with formalin-inactivated RSV.
Authors: Johnson TR, Varga SM, Braciale TJ, Graham BS
J. Virol., 2004;78(16):8753-60.
Species: Mouse
Sample Type: Tissue Homogenates

Marked airway eosinophilia prevents development of airway hyper-responsiveness during an allergic response in IL-5 transgenic mice.
Authors: Kobayashi T, Iijima K, Kita H
J. Immunol., 2003;170(11):5756-63.
Species: Mouse
Sample Type: BALF

Absence of the complement anaphylatoxin C3a receptor suppresses Th2 effector functions in a murine model of pulmonary allergy.
Authors: Drouin SM, Corry DB, Hollman TJ, Kildsgaard J, Wetsel RA
J. Immunol., 2002;169(10):5926-33.
Species: Mouse
Sample Type: BALF

Structural features of peptide analogs of human histocompatibility leukocyte antigen class I epitopes that are more potent and immunogenic than wild-type peptide.
Authors: Tangri S, Ishioka GY, Huang X, Sidney J, Southwood S, Fikes J, Sette A
J. Exp. Med., 2001;194(6):833-46.
Species: Mouse
Sample Type: Cell Culture Supernates

Local anticandidal immune responses in a rat model of vaginal infection by and protection against Candida albicans.
Authors: de Bernardis F, Santoni G, Boccanera M, Spreghini E, Adriani D, Morelli L, Cassone A
Infect. Immun., 2000;68(6):3297-304.
Species: Rat
Sample Type: Vaginal Fluid

Pulmonary eosinophilia and production of MIP-1alpha are prominent responses to infection with pneumonia virus of mice.
Authors: Domachowske JB, Bonville CA, Dyer KD, Easton AJ, Rosenberg HF
Cell. Immunol., 2000;200(2):98-104.
Species: Mouse
Sample Type: BALF

生物活性< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景IL-5 (Interleukin-5) is a secreted cytokine that is expressed as a covalent dimer. It is produced by activated Th2 cells, eosinophils, mast cells, and iNKT cells and promotes eosinophilic and basophilic differentiation and activation. IL-5 signals through a receptor complex containing IL-5 R alpha and the Common beta Chain/CD131 on eosinophils and basophils. Naturally occurring soluble forms of IL-5 R alpha retain the ability to bind IL-5 and limit its bioavailability.
运输条件Blue Ice
存放说明4℃
参考文献
  • Common beta Chain Receptor Family
  • Cytokines and Receptors in Allergy and Asthma
  • Cytokines and Receptors in Tfh Cell Differentiation and Function
  • gamma delta T Cells
  • Granulocyte Markers
  • Group 2 ILCs
  • Inflammatory Mediators
  • T Cell Cytokine Signaling
  • Th2 Cells