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Mouse IL-4 Quantikine SixPak (6 Plates) (1 PK)

货号: SM4000B 基本售价: 19749.7 元 规格: 1 PACK

产品信息

概述
货号SM4000B
描述The Quantikine Mouse IL-4 Immunoassay is a 4.5 hour solid phase ELISA designed to measure mouse IL-4 levels in cell culture supernates and serum. It contains E. coli-expressed recombinant mouse IL-4 and antibodies raised against the recombinant factor. This immunoassay has been shown to quantitate the recombinant mouse IL-4 accurately. Results obtained using natural mouse IL-4 showed dose curves that were parallel to the standard curves obtained using the recombinant Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural mouse IL-4.
别名B cell growth factor 1; BCDF; B-cell stimulatory factor 1; BCGF1; BCGF-1; binetrakin; BSF1; BSF-1; IL4; IL-4; IL-4B_cell stimulatory factor 1; interleukin 4; interleukin-4; Lymphocyte stimulatory factor 1; MGC79402; pitrakinra;
全称
Interleukin 4
反应种属Mouse
目标/特异性Natural and recombinant mouse IL-4
性能
供应商R&D Systems
Entrez Gene IDs
3565 (Human); 16189 (Mouse); 287287 (Rat); 397225 (Porcine); 280824 (Bovine); 403785 (Canine); 574281 (Primate); 100302454 (Rabbit)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Effect of a retinoid X receptor partial agonist on airway inflammation and hyperresponsiveness in a murine model of asthma
Authors: U Fujii, N Miyahara, A Taniguchi, N Oda, D Morichika, E Murakami, H Nakayama, K Waseda, M Kataoka, H Kakuta, M Tanimoto, A Kanehiro
Respir. Res, 2017;18(1):23.
Species: Mouse
Sample Type: BALF

NLRP3 inflammasome has a protective effect against oxazolone-induced colitis: a possible role in ulcerative colitis
Sci Rep, 2016;6(0):39075.
Species: Mouse
Sample Type: Tissue Homogenates

NLRP3 inflammasome has a protective effect against oxazolone-induced colitis: a possible role in ulcerative colitis
Sci Rep, 2016;6(0):39075.
Species: Mouse
Sample Type: Tissue Homogenates

Immunomodulator-based enhancement of anti smallpox immune responses.
Authors: Martinez O, Miranda E, Ramirez M, Santos S, Rivera C, Vazquez L, Sanchez T, Tremblay R, Rios-Olivares E, Otero M
PLoS ONE, 2015;10(4):e0123113.
Species: Mouse
Sample Type: Cell Culture Supernates

Determining the role of IL-4 induced neuroinflammation in microglial activity and amyloid-beta using BV2 microglial cells and APP/PS1 transgenic mice.
Authors: Latta C, Sudduth T, Weekman E, Brothers H, Abner E, Popa G, Mendenhall M, Gonzalez-Oregon F, Braun K, Wilcock D
J Neuroinflammation, 2015;12(0):41.

Absence of the Adaptor Protein PEA-15 Is Associated with Altered Pattern of Th Cytokines Production by Activated CD4+ T Lymphocytes In Vitro, and Defective Red Blood Cell Alloimmune Response In Vivo.
Authors: Kerbrat S, Vingert B, Junier M, Castellano F, Renault-Mihara F, Dos Reis Tavares S, Surenaud M, Noizat-Pirenne F, Boczkowski J, Guellaen G, Chneiweiss H, Le Gouvello S
PLoS ONE, 2015;10(8):e0136885.
Species: Mouse
Sample Type: Cell Culture Supernates

G-protein-coupled estrogen receptor agonist suppresses airway inflammation in a mouse model of asthma through IL-10.
Authors: Itoga M, Konno Y, Moritoki Y, Saito Y, Ito W, Tamaki M, Kobayashi Y, Kayaba H, Kikuchi Y, Chihara J, Takeda M, Ueki S, Hirokawa M
PLoS ONE, 2015;10(3):e0123210.
Species: Mouse
Sample Type: BALF

Dendritic cells induce Th2-mediated airway inflammatory responses to house dust mite via DNA-dependent protein kinase.
Authors: Mishra, Amarjit, Brown, Alexandr, Yao, Xianglan, Yang, Shutong, Park, Sung-Jun, Liu, Chengyu, Dagur, Pradeep, McCoy, J Philip, Keeran, Karen J, Nugent, Gayle Z, Jeffries, Kenneth, Qu, Xuan, Yu, Zu-Xi, Levine, Stewart, Chung, Jay H
Nat Commun, 2015;6(0):6224.
Species: Mouse
Sample Type: Cell Culture Supernates

IL-33-mediated protection against experimental cerebral malaria is linked to induction of type 2 innate lymphoid cells, M2 macrophages and regulatory T cells.
Authors: Besnard A, Guabiraba R, Niedbala W, Palomo J, Reverchon F, Shaw T, Couper K, Ryffel B, Liew F
PLoS Pathog, 2015;11(2):e1004607.
Species: Mouse
Sample Type: Serum

Propionibacterium acnes Augments Antitumor, Anti-Angiogenesis and Immunomodulatory Effects of Melatonin on Breast Cancer Implanted in Mice.
Authors: Talib W, Saleh S
PLoS ONE, 2015;10(4):e0124384.
Species: Mouse
Sample Type: Serum

Axl receptor blockade ameliorates pulmonary pathology resulting from primary viral infection and viral exacerbation of asthma.
Authors: Shibata T, Habiel D, Coelho A, Kunkel S, Lukacs N, Hogaboam C
J Immunol, 2014;192(8):3569-81.
Species: Mouse
Sample Type: Tissue Homogenates

Genetic vaccine for respiratory syncytial virus provides protection without disease potentiation.
Authors: Johnson T, Rangel D, Graham B, Brough D, Gall J
Mol Ther, 2014;22(1):196-205.
Species: Mouse
Sample Type: Cell Culture Supernates

Leishmania donovani targets tumor necrosis factor receptor-associated factor (TRAF) 3 for impairing TLR4-mediated host response.
Authors: Gupta P, Giri J, Srivastav S, Chande A, Mukhopadhyaya R, Das P, Ukil A
FASEB J, 2014;28(4):1756-68.
Species: Mouse
Sample Type: Cell Culture Supernates

Spironolactone attenuates bleomycin-induced pulmonary injury partially via modulating mononuclear phagocyte phenotype switching in circulating and alveolar compartments.
Authors: Ji W, Ma Y, Zhou X, Zhang Y, Lu R, Guo Z, Sun H, Hu D, Yang G, Li Y, Wei L
PLoS ONE, 2013;8(11):e81090.
Species: Mouse
Sample Type: BALF

Interleukin-33 and alveolar macrophages contribute to the mechanisms underlying the exacerbation of IgE-mediated airway inflammation and remodelling in mice.
Authors: Mizutani N, Nabe T, Yoshino S
Immunology, 2013;139(2):205-18.
Species: Mouse
Sample Type: Tissue Homogenates

Lyn mitigates mouse airway remodeling by downregulating the TGF-beta3 isoform in house dust mite models.
Authors: Li G, Fox J, Liu Z, Liu J, Gao G, Jin Y, Gao H, Wu M
J Immunol, 2013;191(11):5359-70.
Species: Mouse
Sample Type: BALF

Enhanced immunogenicity of a tricomponent mannan tetanus toxoid conjugate vaccine targeted to dendritic cells via Dectin-1 by incorporating beta-glucan.
Authors: Lipinski T, Fitieh A, St Pierre J, Ostergaard H, Bundle D, Touret N
J Immunol, 2013;190(8):4116-28.
Species: Mouse
Sample Type: Cell Culture Supernates

Induction of the specific allergic immune response is independent of proteases from the fungus Alternaria alternata.
Authors: Denis O, Vincent M, Havaux X, De Prins S, Treutens G, Huygen K
Eur J Immunol, 2013;43(4):907-17.
Species: Mouse
Sample Type: Cell Culture Supernates

Monocyte-derived dendritic cell recruitment and allergic T(H)2 responses after exposure to diesel particles are CCR2 dependent.
Authors: Provoost S, Maes T, Joos GF, Tournoy KG
J. Allergy Clin. Immunol., 2012;129(2):483-91.
Species: Mouse
Sample Type: BALF

The Receptor Slamf1 on the Surface of Myeloid Lineage Cells Controls Susceptibility to Infection by Trypanosoma cruzi.
Authors: Calderon J, Maganto-Garcia E, Punzon C, Carrion J, Terhorst C, Fresno M
PLoS Pathog., 2012;8(7):e1002799.
Species: Mouse
Sample Type: Serum

Dual functions of prostaglandin D2 in murine contact hypersensitivity via DP and CRTH2.
Authors: Yamamoto Y, Otani S, Hirai H, Nagata K, Aritake K, Urade Y, Narumiya S, Yokozeki H, Nakamura M, Satoh T
Am. J. Pathol., 2012;179(1):302-14.
Species: Mouse
Sample Type: Tissue Homogenates

TLR-mediated distinct IFN-gamma/IL-10 pattern induces protective immunity against murine visceral leishmaniasis.
Eur. J. Immunol., 2012;42(8):2087-99.
Species: Mouse
Sample Type: Cell Culture Supernates

Control of mouse graft-versus-host disease following allogeneic bone marrow transplantation by blocking the CD28/B7 signaling pathway with lentiviral vector-mediated RNA interference.
Authors: Sang W, Zhou C, Cheng N, Li Z, Zeng L, Xu K
Immunol. Lett., 2011;136(2):194-202.
Species: Mouse
Sample Type: Plasma

Differential host determinants contribute to the pathogenesis of 2009 pandemic H1N1 and human H5N1 influenza A viruses in experimental mouse models.
Authors: Otte A, Sauter M, Alleva L, Baumgarte S, Klingel K, Gabriel G
Am. J. Pathol., 2011;179(1):230-9.
Species: Mouse
Sample Type: Serum

Tumors Suppress In Situ Proliferation of Cytotoxic T Cells by Promoting Differentiation of Gr-1+ Conventional Dendritic Cells through IL-6.
Authors: Diao J, Zhao J, Winter E
J. Immunol., 2011;186(9):5058-67.
Species: Mouse
Sample Type: Cell Culture Supernates

Serotonin activates dendritic cell function in the context of gut inflammation.
Authors: Li N, Ghia JE, Wang H, McClemens J, Cote F, Suehiro Y, Mallet J, Khan WI
Am. J. Pathol., 2011;178(2):662-71.
Species: Mouse
Sample Type: Tissue Homogenates

IL-33-responsive lineage- CD25+ CD44(hi) lymphoid cells mediate innate type 2 immunity and allergic inflammation in the lungs.
Authors: Bartemes KR, Iijima K, Kobayashi T, Kephart GM, McKenzie AN, Kita H
J. Immunol., 2011;188(3):1503-13.
Species: Mouse
Sample Type: BALF

The interaction between IL-18 and IL-18 receptor limits the magnitude of protective immunity and enhances pathogenic responses following infection with intracellular bacteria.
Authors: Ghose P, Ali AQ, Fang R, Forbes D, Ballard B, Ismail N
J. Immunol., 2011;187(3):1333-46.
Species: Mouse
Sample Type: Serum

IL-33-activated dendritic cells are critical for allergic airway inflammation.
Authors: Besnard AG, Togbe D, Guillou N, Erard F, Quesniaux V, Ryffel B
Eur. J. Immunol., 2011;41(6):1675-86.
Species: Mouse
Sample Type: BALF

Over-expression of the LTC4 synthase gene in mice reproduces human aspirin-induced asthma.
Authors: Hirata H, Arima M, Fukushima Y, Honda K, Sugiyama K, Tokuhisa T, Fukuda T
Clin. Exp. Allergy, 2011;41(8):1133-42.
Species: Mouse
Sample Type: BALF

Proinflammatory clearance of apoptotic neutrophils induces an IL-12(low)IL-10(high) regulatory phenotype in macrophages.
Authors: Filardy AA, Pires DR, Nunes MP, Takiya CM, Freire-de-Lima CG, Ribeiro-Gomes FL, DosReis GA
J. Immunol., 2010;185(4):2044-50.
Species: Mouse
Sample Type: Cell Culture Supernates

Epithelial reticulon 4B (Nogo-B) is an endogenous regulator of Th2-driven lung inflammation.
Authors: Wright PL, Yu J, Di YP
J. Exp. Med., 2010;207(12):2595-607.
Species: Mouse
Sample Type: BALF

Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model.
Authors: Yoshizaki A, Yanaba K, Iwata Y
J. Immunol., 2010;185(4):2502-15.
Species: Mouse
Sample Type: Serum

Microbial exposure early in life regulates airway inflammation in mice after infection with Streptococcus pneumoniae with enhancement of local resistance.
Authors: Yasuda Y, Matsumura Y, Kasahara K, Ouji N, Sugiura S, Mikasa K, Kita E
Am. J. Physiol. Lung Cell Mol. Physiol., 2010;298(1):L67-78.
Species: Mouse
Sample Type: BALF

Ovalbumin-induced plasma interleukin-4 levels are reduced in ceramide kinase-deficient DO11.10 RAG1-/- mice.
Authors: Niwa S, Urtz N, Baumruker T, Billich A, Bornancin F
Lipids Health Dis, 2010;9(0):1.
Species: Mouse
Sample Type: Serum

Intranasal challenge with increasing ovalbumin doses differently affects airway hyperresponsiveness and inflammatory cell accumulation in mouse model of asthma.
Authors: Bosnjak B, Ivetic Tkalcevic V, Duric K, Belamaric D, Cuzic S, Ferencic Z, Brajsa K, Glojnaric I, Antolovic R, Hrvacic B
Inflamm. Res., 2009;58(11):773-81.
Species: Mouse
Sample Type: BALF

Effects of a leukotriene B4 receptor antagonist on bleomycin-induced pulmonary fibrosis.
Authors: Izumo T, Kondo M, Nagai A
Eur. Respir. J., 2009;34(6):1444-51.
Species: Mouse
Sample Type: BALF

A severe deficiency of coagulation factor VIIa results in attenuation of the asthmatic response in mice.
Authors: Shinagawa K, Ploplis VA, Castellino FJ
Am. J. Physiol. Lung Cell Mol. Physiol., 2009;296(5):L763-70.
Species: Mouse
Sample Type: BALF

TLR9 agonist, but not TLR7/8, functions as an adjuvant to diminish FI-RSV vaccine-enhanced disease, while either agonist used as therapy during primary RSV infection increases disease severity.
Authors: Johnson TR, Rao S, Seder RA, Chen M, Graham BS
Vaccine, 2009;27(23):3045-52.
Species: Mouse
Sample Type: Cell Culture Supernates

Celastrol suppresses allergen-induced airway inflammation in a mouse allergic asthma model.
Authors: Kim DY, Park JW, Jeoung D, Ro JY
Eur. J. Pharmacol., 2009;612(1):98-105.
Species: Mouse
Sample Type: BALF

A MyD88-dependent early IL-17 production protects mice against airway infection with the obligate intracellular pathogen Chlamydia muridarum.
Authors: Zhang X, Gao L, Lei L, Zhong Y, Dube P, Berton MT, Arulanandam B, Zhang J, Zhong G
J. Immunol., 2009;183(2):1291-300.
Species: Mouse
Sample Type: BALF

Complement C3a regulates late asthmatic response and airway hyperresponsiveness in mice.
Authors: Mizutani N, Nabe T, Yoshino S
J. Immunol., 2009;183(6):4039-46.
Species: Mouse
Sample Type: BALF

The adjuvancy of OX40 ligand (CD252) on an HIV-1 canarypox vaccine.
Authors: Liu J, Ngai N, Stone GW, Yue FY, Ostrowski MA
Vaccine, 2009;27(37):5077-84.
Species: Mouse
Sample Type: Cell Culture Supernates

Mouse models of asthma: a comparison between C57BL/6 and BALB/c strains regarding bronchial responsiveness, inflammation, and cytokine production.
Authors: Gueders MM, Paulissen G, Crahay C, Quesada-Calvo F, Hacha J, Van Hove C, Tournoy K, Louis R, Foidart JM, Noel A, Cataldo DD
Inflamm. Res., 2009;58(12):845-54.
Species: Mouse
Sample Type: BALF

Macrophage migration inhibitory factor homologs of anisakis simplex suppress Th2 response in allergic airway inflammation model via CD4+CD25+Foxp3+ T cell recruitment.
Authors: Park SK, Cho MK, Park HK, Lee KH, Lee SJ, Choi SH, Ock MS, Jeong HJ, Lee MH, Yu HS
J. Immunol., 2009;182(11):6907-14.
Species: Mouse
Sample Type: BALF

Lovastatin inhibits antigen-induced airway eosinophilia without affecting the production of inflammatory mediators in mice.
Authors: Chiba Y, Sato S, Misawa M
Inflamm. Res., 2009;0(0):.
Species: Mouse
Sample Type: BALF

A novel mechanism for CCR4 in the regulation of macrophage activation in bleomycin-induced pulmonary fibrosis.
Authors: Trujillo G, OConnor EC, Kunkel SL, Hogaboam CM
Am. J. Pathol., 2008;172(5):1209-21.
Species: Mouse
Sample Type: Tissue Homogenates

GS143, an IkappaB ubiquitination inhibitor, inhibits allergic airway inflammation in mice.
Authors: Hirose K, Wakashin H, Oki M, Kagami S, Suto A, Ikeda K, Watanabe N, Iwamoto I, Furuichi Y, Nakajima H
Biochem. Biophys. Res. Commun., 2008;374(3):507-11.
Species: Mouse
Sample Type: Cell Culture Supernates

CD40L expressed from the canarypox vector, ALVAC, can boost immunogenicity of HIV-1 canarypox vaccine in mice and enhance the in vitro expansion of viral specific CD8+ T cell memory responses from HIV-1-infected and HIV-1-uninfected individuals.
Authors: Liu J, Yu Q, Stone GW, Yue FY, Ngai N, Jones RB, Kornbluth RS, Ostrowski MA
Vaccine, 2008;26(32):4062-72.
Species: Mouse
Sample Type: Cell Culture Supernates

Crucial role of the interleukin-6/interleukin-17 cytokine axis in the induction of arthritis by glucose-6-phosphate isomerase.
Authors: Iwanami K, Matsumoto I, Tanaka-Watanabe Y, Inoue A, Mihara M, Ohsugi Y, Mamura M, Goto D, Ito S, Tsutsumi A, Kishimoto T, Sumida T
Arthritis Rheum., 2008;58(3):754-63.
Species: Mouse
Sample Type: Cell Culture Supernates

Dendritic cells derived from TBP-2-deficient mice are defective in inducing T cell responses.
Authors: Son A, Nakamura H, Okuyama H, Oka S, Yoshihara E, Liu W, Matsuo Y, Kondo N, Masutani H, Ishii Y, Iyoda T, Inaba K, Yodoi J
Eur. J. Immunol., 2008;38(5):1358-67.
Species: Mouse
Sample Type: Cell Culture Supernates

Thymic stromal lymphopoietin and thymic stromal lymphopoietin-conditioned dendritic cells induce regulatory T-cell differentiation and protection of NOD mice against diabetes.
Authors: Besin G, Gaudreau S, Menard M, Guindi C, Dupuis G, Amrani A
Diabetes, 2008;57(8):2107-17.
Species: Mouse
Sample Type: Cell Culture Supernates

Distinct roles for IL-13 and IL-4 via IL-13 receptor alpha1 and the type II IL-4 receptor in asthma pathogenesis.
Authors: Munitz A, Brandt EB, Mingler M, Finkelman FD, Rothenberg ME
Proc. Natl. Acad. Sci. U.S.A., 2008;105(20):7240-5.
Species: Mouse
Sample Type: BALF

Pulmonary eosinophilia requires interleukin-5, eotaxin-1, and CD4+ T cells in mice immunized with respiratory syncytial virus G glycoprotein.
Authors: Johnson TR, Rothenberg ME, Graham BS
J. Leukoc. Biol., 2008;84(3):748-59.
Species: Mouse
Sample Type: Tissue Homogenates

The novel inosine analogue, INO-2002, protects against diabetes development in multiple low-dose streptozotocin and non-obese diabetic mouse models of type I diabetes.
Authors: Mabley JG, Pacher P, Murthy KG, Williams W, Southan GJ, Salzman AL, Szabo C
J. Endocrinol., 2008;198(3):581-9.
Species: Mouse
Sample Type: Tissue Homogenates

The LTK63 adjuvant improves protection conferred by Ag85B DNA-protein prime-boosting vaccination against Mycobacterium tuberculosis infection by dampening IFN-gamma response.
Authors: Palma C, Iona E, Giannoni F, Pardini M, Brunori L, Fattorini L, Del Giudice G, Cassone A
Vaccine, 2008;26(33):4237-43.
Species: Mouse
Sample Type: Cell Culture Supernates

Novel immunomodulatory properties of berbamine through selective down-regulation of STAT4 and action of IFN-gamma in experimental autoimmune encephalomyelitis.
Authors: Ren Y, Lu L, Guo TB, Qiu J, Yang Y, Liu A, Zhang JZ
J. Immunol., 2008;181(2):1491-8.
Species: Mouse
Sample Type: Cell Culture Supernates

Curcumin attenuates ovalbumin-induced airway inflammation by regulating nitric oxide.
Authors: Moon DO, Kim MO, Lee HJ, Choi YH, Park YM, Heo MS, Kim GY
Biochem. Biophys. Res. Commun., 2008;375(2):275-9.
Species: Mouse
Sample Type: BALF

IL-13 receptor alpha2 selectively inhibits IL-13-induced responses in the murine lung.
Authors: Zheng T, Liu W, Oh SY, Zhu Z, Hu B, Homer RJ, Cohn L, Grusby MJ, Elias JA
J. Immunol., 2008;180(1):522-9.
Species: Mouse
Sample Type: BALF

Antifibrotic action of pirfenidone and prednisolone: different effects on pulmonary cytokines and growth factors in bleomycin-induced murine pulmonary fibrosis.
Authors: Oku H, Shimizu T, Kawabata T, Nagira M, Hikita I, Ueyama A, Matsushima S, Torii M, Arimura A
Eur. J. Pharmacol., 2008;590(1):400-8.
Species: Mouse
Sample Type: Tissue Homogenates

Lycopene suppresses ovalbumin-induced airway inflammation in a murine model of asthma.
Authors: Lee CM, Chang JH, Moon DO, Choi YH, Choi IW, Park YM, Kim GY
Biochem. Biophys. Res. Commun., 2008;374(2):248-52.
Species: Mouse
Sample Type: BALF

NOD2-deficient mice have impaired resistance to Mycobacterium tuberculosis infection through defective innate and adaptive immunity.
Authors: Divangahi M, Mostowy S, Coulombe F, Kozak R, Guillot L, Veyrier F, Kobayashi KS, Flavell RA, Gros P, Behr MA
J. Immunol., 2008;181(10):7157-65.
Species: Mouse
Sample Type: Cell Culture Supernates

Allergic pulmonary inflammation in mice is dependent on eosinophil-induced recruitment of effector T cells.
Authors: Jacobsen EA, Ochkur SI, Pero RS, Taranova AG, Protheroe CA, Colbert DC, Lee NA, Lee JJ
J. Exp. Med., 2008;205(3):699-710.
Species: Mouse
Sample Type: BALF

Toll-like receptor (TLR)2 and TLR3 synergy and cross-inhibition in murine myeloid dendritic cells.
Authors: Vanhoutte F, Paget C, Breuilh L, Fontaine J, Vendeville C, Goriely S, Ryffel B, Faveeuw C, Trottein F
Immunol. Lett., 2007;116(1):86-94.
Species: Mouse
Sample Type: Cell Culture Supernates

Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.
Authors: Yamanouchi J, Rainbow D, Serra P, Howlett S, Hunter K, Garner VE, Gonzalez-Munoz A, Clark J, Veijola R, Cubbon R, Chen SL, Rosa R, Cumiskey AM, Serreze DV, Gregory S, Rogers J, Lyons PA, Healy B, Smink LJ, Todd JA, Peterson LB, Wicker LS, Santamaria P
Nat. Genet., 2007;39(3):329-37.
Species: Mouse
Sample Type: Cell Culture Supernates

Toll-like receptor 4 (TLR4)-dependent proinflammatory and immunomodulatory properties of the glycoinositolphospholipid (GIPL) from Trypanosoma cruzi.
Authors: Medeiros MM, Peixoto JR, Oliveira AC, Cardilo-Reis L, Koatz VL, Van Kaer L, Previato JO, Mendonca-Previato L, Nobrega A, Bellio M
J. Leukoc. Biol., 2007;82(3):488-96.
Species: Mouse
Sample Type: Peritoneal Fluid

Lentiviral vector-mediated autonomous differentiation of mouse bone marrow cells into immunologically potent dendritic cell vaccines.
Authors: Koya RC, Kimura T, Ribas A, Rozengurt N, Lawson GW, Faure-Kumar E, Wang HJ, Herschman H, Kasahara N, Stripecke R
Mol. Ther., 2007;15(5):971-80.
Species: Mouse
Sample Type: Serum

Src homology 2 domain-containing inositol 5-phosphatase 1 deficiency leads to a spontaneous allergic inflammation in the murine lung.
Authors: Oh SY, Zheng T, Bailey ML, Barber DL, Schroeder JT, Kim YK, Zhu Z
J. Allergy Clin. Immunol., 2007;119(1):123-31.
Species: Mouse
Sample Type: BALF

Therapeutic targeting of CC ligand 21 or CC chemokine receptor 7 abrogates pulmonary fibrosis induced by the adoptive transfer of human pulmonary fibroblasts to immunodeficient mice.
Authors: Pierce EM, Carpenter K, Jakubzick C, Kunkel SL, Flaherty KR, Martinez FJ, Hogaboam CM
Am. J. Pathol., 2007;170(4):1152-64.
Species: Mouse
Sample Type: Tissue Homogenates

Granulocyte-macrophage colony-stimulating factor prevents diabetes development in NOD mice by inducing tolerogenic dendritic cells that sustain the suppressive function of CD4+CD25+ regulatory T cells.
Authors: Gaudreau S, Guindi C, Menard M, Besin G, Dupuis G, Amrani A
J. Immunol., 2007;179(6):3638-47.
Species: Mouse
Sample Type: Cell Culture Supernates

Prolonged inhaled allergen exposure can induce persistent tolerance.
Authors: Van Hove CL, Maes T, Joos GF, Tournoy KG
Am. J. Respir. Cell Mol. Biol., 2007;36(5):573-84.
Species: Mouse
Sample Type: BALF

Critical role of the Fc receptor gamma-chain on APCs in the development of allergen-induced airway hyperresponsiveness and inflammation.
Authors: Kitamura K, Takeda K, Koya T, Miyahara N, Kodama T, Dakhama A, Takai T, Hirano A, Tanimoto M, Harada M, Gelfand EW
J. Immunol., 2007;178(1):480-8.
Species: Mouse
Sample Type: BALF

Chronic intranasal administration of mould spores or extracts to unsensitized mice leads to lung allergic inflammation, hyper-reactivity and remodelling.
Authors: Denis O, van den Brule S, Heymans J, Havaux X, Rochard C, Huaux F, Huygen K
Immunology, 2007;122(2):268-78.
Species: Mouse
Sample Type: BALF

IL-27 suppresses Th2 cell development and Th2 cytokines production from polarized Th2 cells: a novel therapeutic way for Th2-mediated allergic inflammation.
Authors: Yoshimoto T, Yoshimoto T, Yasuda K, Mizuguchi J, Nakanishi K
J. Immunol., 2007;179(7):4415-23.
Species: Mouse
Sample Type: Serum

Using pCIN-mIL-4 DNA vector to express mRNA and protein and to improve herpes simplex virus-induced Behcets disease symptoms in mice.
Authors: Lee SI, Kwon HJ, Lee ES, Yang BC, Bang D, Lee S, Sohn S
Vaccine, 2007;25(41):7047-55.
Species: Mouse
Sample Type: Serum

Intercellular adhesion molecule-1 expression is required on multiple cell types for the development of experimental autoimmune encephalomyelitis.
Authors: Bullard DC, Hu X, Schoeb TR, Collins RG, Beaudet AL, Barnum SR
J. Immunol., 2007;178(2):851-7.
Species: Mouse
Sample Type: Cell Culture Supernates

The immunomodulation of endotoxin-induced acute lung injury by hesperidin in vivo and in vitro.
Authors: Yeh CC, Kao SJ, Lin CC, Wang SD, Liu CJ, Kao ST
Life Sci., 2007;80(20):1821-31.
Species: Mouse
Sample Type: BALF

D-pinitol regulates Th1/Th2 balance via suppressing Th2 immune response in ovalbumin-induced asthma.
Authors: Lee JS, Lee CM, Jeong YI, Jung ID, Kim BH, Seong EY, Kim JI, Choi IW, Chung HY, Park YM
FEBS Lett., 2007;581(1):57-64.
Species: Mouse
Sample Type: BALF

FTY720 ameliorates oxazolone colitis in mice by directly affecting T helper type 2 functions.
Authors: Daniel C, Sartory NA, Zahn N
Mol. Immunol., 2007;44(13):3305-16.
Species: Mouse
Sample Type: Cell Culture Supernates

Reversion of immune tolerance in advanced malignancy: modulation of myeloid-derived suppressor cell development by blockade of stem-cell factor function.
Authors: Pan PY, Wang GX, Yin B, Ozao J, Ku T, Divino CM, Chen SH
Blood, 2007;111(1):219-28.
Species: Mouse
Sample Type: Cell Culture Supernates

Inhalation tolerance is induced selectively in thoracic lymph nodes but executed pervasively at distant mucosal and nonmucosal tissues.
Authors: Alvarez D, Swirski FK, Yang TC, Fattouh R, Croitoru K, Bramson JL, Stampfli MR, Jordana M
J. Immunol., 2006;176(4):2568-80.
Species: Mouse
Sample Type: Serum

Prevention of murine experimental autoimmune encephalomyelitis by in vivo expression of a novel recombinant immunotoxin DT390-RANTES.
Authors: Jia Y, Li H, Chen W, Li M, Lv M, Feng P, Hu H, Zhang L
Gene Ther., 2006;13(18):1351-9.
Species: Mouse
Sample Type: Serum

The differential effects of low dose and high dose concanavalin A on cytokine profile and their importance in liver injury.
Authors: Xu X, Wei H, Dong Z, Chen Y, Tian Z
Inflamm. Res., 2006;55(4):144-52.
Species: Mouse
Sample Type: Serum

Roles of the small intestine for induction of toll-like receptor 4-mediated innate resistance in naturally acquired murine toxoplasmosis.
Authors: Furuta T, Yoshikawa Y
Int. Immunol., 2006;18(12):1655-62.
Species: Mouse
Sample Type: Cell Culture Supernates

CCL17 transgenic mice show an enhanced Th2-type response to both allergic and non-allergic stimuli.
Authors: Tsunemi Y, Saeki H, Nakamura K, Nagakubo D, Nakayama T, Yoshie O, Kagami S, Shimazu K, Kadono T, Sugaya M, Komine M, Matsushima K, Tamaki K
Eur. J. Immunol., 2006;36(8):2116-27.
Species: Mouse
Sample Type: Tissue Homogenates

CD27 contributes to the early systemic immune response to Mycobacterium tuberculosis infection but does not affect outcome.
Authors: Wieland CW, Kerver ME, Florquin S, Nolte MA, Borst J, van Lier R, van Oers MH, van der Poll T
Int. Immunol., 2006;18(11):1531-9.
Species: Mouse
Sample Type: Tissue Homogenates

Short-term dietary administration of celecoxib enhances the efficacy of tumor lysate-pulsed dendritic cell vaccines in treating murine breast cancer.
Authors: Hahn T, Alvarez I, Kobie JJ, Ramanathapuram L, Dial S, Fulton A, Besselsen D, Walker E, Akporiaye ET
Int. J. Cancer, 2006;118(9):2220-31.
Species: Mouse
Sample Type: Cell Culture Supernates

Allergic airway inflammation inhibits pulmonary antibacterial host defense.
Authors: Beisswenger C, Kandler K, Hess C, Garn H, Felgentreff K, Wegmann M, Renz H, Vogelmeier C, Bals R
J. Immunol., 2006;177(3):1833-7.
Species: Mouse
Sample Type: BALF

Oral administration of an immunostimulatory DNA sequence from Bifidobacterium longum improves Th1/Th2 balance in a murine model.
Authors: Takahashi N, Kitazawa H, Iwabuchi N, Xiao JZ, Miyaji K, Iwatsuki K, Saito T
Biosci. Biotechnol. Biochem., 2006;70(8):2013-7.
Species: Mouse
Sample Type: Cell Culture Supernates

Matrix metalloproteinase-8 deficiency promotes granulocytic allergen-induced airway inflammation.
Authors: Gueders MM, Balbin M, Rocks N, Foidart JM, Gosset P, Louis R, Shapiro S, Lopez-Otin C, Noel A, Cataldo DD
J. Immunol., 2005;175(4):2589-97.
Species: Mouse
Sample Type: BALF

DNA vaccine encoding Der p 2 allergen generates immunologic protection in recombinant Der p 2 allergen-induced allergic airway inflammation mice model.
Authors: Li GP, Liu ZG, Ran PX, Zhong NS
Chin. Med. J., 2005;118(7):534-40.
Species: Mouse
Sample Type: Cell Culture Supernates

Intranasal mite allergen induces allergic asthma-like responses in NC/Nga mice.
Authors: Shibamori M, Ogino K, Kambayashi Y, Ishiyama H
Life Sci., 2005;78(9):987-94.
Species: Mouse
Sample Type: BALF

MyD88-dependent induction of allergic Th2 responses to intranasal antigen.
Authors: Piggott DA, Eisenbarth SC, Xu L, Constant SL, Huleatt JW, Herrick CA, Bottomly K
J. Clin. Invest., 2005;115(2):459-67.
Species: Human
Sample Type: Cell Culture Supernates

Cytokine expression in experimental chronic otitis media with effusion in mice.
Authors: Maeda K, Hirano T, Ichimiya I, Kurono Y, Suzuki M, Mogi G
Laryngoscope, 2004;114(11):1967-72.
Species: Mouse
Sample Type: middle ear effusion

EphrinB1 is essential in T-cell-T-cell co-operation during T-cell activation.
Authors: Yu G, Luo H, Wu Y, Wu J
J. Biol. Chem., 2004;279(53):55531-9.
Species: Mouse
Sample Type: Cell Culture Supernates

Increased and long-term generation of dendritic cells with reduced function from IL-6-deficient bone marrow.
Authors: Bleier JI, Pillarisetty VG, Shah AB, DeMatteo RP
J. Immunol., 2004;172(12):7408-16.
Species: Mouse
Sample Type: Cell Culture Supernates

Control of Leishmania major in the absence of Tyk2 kinase.
Authors: Schleicher U, Mattner J, Blos M, Schindler H, Rollinghoff M, Karaghiosoff M, Muller M, Werner-Felmayer G, Bogdan C
Eur. J. Immunol., 2004;34(2):519-29.
Species: Mouse
Sample Type: Cell Culture Supernates

Vbeta14(+) T cells mediate the vaccine-enhanced disease induced by immunization with respiratory syncytial virus (RSV) G glycoprotein but not with formalin-inactivated RSV.
Authors: Johnson TR, Varga SM, Braciale TJ, Graham BS
J. Virol., 2004;78(16):8753-60.
Species: Mouse
Sample Type: Tissue Homogenates

Increased interleukin-10 associated with low IL-6 concentration correlated with greater survival rates in mice infected by rabies virus vaccinated against it and immunomodulated with P. acnes.
Authors: Megid J, Kaneno R, Nozaki CN, Brito CJ, Almeida MF
Comp. Immunol. Microbiol. Infect. Dis., 2004;27(6):393-411.
Species: Mouse
Sample Type: Serum

A protective role of locally administered immunostimulatory CpG oligodeoxynucleotide in a mouse model of genital herpes infection.
Authors: Harandi AM, Eriksson K, Holmgren J
J. Virol., 2003;77(2):953-62.
Species: Mouse
Sample Type: Serum

A profibrotic function of IL-12p40 in experimental pulmonary fibrosis.
Authors: Huaux F, Arras M, Tomasi D, Barbarin V, Delos M, Coutelier JP, Vink A, Phan SH, Renauld JC, Lison D
J. Immunol., 2002;169(5):2653-61.
Species: Mouse
Sample Type: Tissue Homogenates

Anti-tumor mechanism of Z-100, an immunomodulatory Arabinomannan extracted from Mycobacterium tuberculosis strain Aoyama B, on pulmonary metastases of B16F10 melanoma: restoration of helper T cell responses via suppression of glucocorticoid-genesis.
Authors: Oka H, Emori Y, Sasaki H, Shiraishi Y, Yoshinaga K, Kurimoto T
Microbiol. Immunol., 2002;46(5):343-51.
Species: Mouse
Sample Type: Cell Culture Supernates

Leptin accelerates autoimmune diabetes in female NOD mice.
Authors: Matarese G, Sanna V, Lechler RI, Sarvetnick N, Fontana S, Zappacosta S, La Cava A
Diabetes, 2002;51(5):1356-61.
Species: Mouse
Sample Type: Cell Culture Supernates

生物活性< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景IL-4 (Interleukin-4) is a cytokine that is primarily expressed by Th2-biased CD4+ T cells, mast cells, basophils, and eosinophils. It promotes cell proliferation, survival, and immunoglobulin class switch to IgG4 and IgE in human B cells, acquisition of the Th2 phenotype by naïve CD4+ T cells, priming and chemotaxis of mast cells, eosinophils, and basophils, and the proliferation and activation of epithelial cells. IL-4 plays a dominant role in the development of allergic inflammation and asthma. The type I receptor for IL-4, which is expressed on hematopoietic cells, is a heterodimer of the ligand binding IL-4 R? and the common ? chain (a shared subunit of the receptors for IL-2, -7, -9, -15, and -21). The type II receptor on nonhematopoietic cells consists of IL-4 R? and IL-13 R?1. The type II receptor also transduces IL-13 mediated signals.
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参考文献
  • Common gamma Chain Receptor Family
  • Cytokines and Receptors in Allergy and Asthma
  • Cytokines and Receptors in Angiogenesis
  • Cytokines and Receptors in Tfh Cell Differentiation and Function
  • Dendritic Cell Development
  • gamma delta T Cells
  • Group 2 ILCs
  • Inflammatory Mediators
  • Multiple Sclerosis and Myelin Related Molecules
  • Natural Killer T (NKT) Cells
  • Regulatory T Cells (Tregs)
  • T Cell Cytokine Signaling
  • Th2 Cells
  • Th9 Cells