| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Increased mitochondrial arginine metabolism supports bioenergetics in asthma
J Clin Invest, 2016;0(0):.
Species: Mouse
Sample Type: BAL
CF Lung Infection and Inflammation: IL-17 Pathophysiology and Therapeutic Intervention
Authors: Daniel Hsu
Infect Immun, 2016;0(0):.
Species: Mouse
Sample Type: BALF
Toll-Like Receptor 4 Signaling Pathway Mediates Inhalant Organic Dust-Induced Bone Loss
PLoS ONE, 2016;11(8):e0158735.
Species: Mouse
Sample Type: Serum
Critical role for IL-18 in spontaneous lung inflammation caused by autophagy deficiency.
Authors: Abdel Fattah E, Bhattacharya A, Herron A, Safdar Z, Eissa N
J Immunol, 2015;194(11):5407-16.
Species: Mouse
Sample Type: BALF
IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance.
Authors: Basu R, Whitley S, Bhaumik S, Zindl C, Schoeb T, Benveniste E, Pear W, Hatton R, Weaver C
Nat Immunol, 2015;16(3):286-95.
Species: Mouse
Sample Type: Cell Culture Supernates
Thalidomide inhibits alternative activation of macrophages in vivo and in vitro: a potential mechanism of anti-asthmatic effect of thalidomide.
Authors: Lee, Hyun Seu, Kwon, Hyouk-So, Park, Da-Eun, Woo, Yeon Duk, Kim, Hye Youn, Kim, Hang-Rae, Cho, Sang-Heo, Min, Kyung-Up, Kang, Hye-Ryun, Chang, Yoon-Seo
PLoS ONE, 2015;10(4):e0123094.
Species: Mouse
Sample Type: BALF
Protection against Streptococcus pneumoniae lung infection after nasopharyngeal colonization requires both humoral and cellular immune responses.
Authors: Wilson R, Cohen J, Jose R, de Vogel C, Baxendale H, Brown J
Mucosal Immunol, 2015;8(3):627-39.
Species: Mouse
Sample Type: Homogenized Tissue
Prostaglandin E2 negatively regulates the production of inflammatory cytokines/chemokines and IL-17 in visceral leishmaniasis.
Authors: Saha A, Biswas A, Srivastav S, Mukherjee M, Das P, Ukil A
J Immunol, 2014;193(5):2330-9.
Interleukin 17A promotes pneumococcal clearance by recruiting neutrophils and inducing apoptosis through a p38 mitogen-activated protein kinase-dependent mechanism in acute otitis media.
Authors: Wang, Wei, Zhou, Aie, Zhang, Xuemei, Xiang, Yun, Huang, Yifei, Wang, Lei, Zhang, Shuai, Liu, Yusi, Yin, Yibing, He, Yujuan
Infect Immun, 2014;82(6):2368-77.
Species: Mouse
Sample Type: MELF
Staphylococcus aureus sarA regulates inflammation and colonization during central nervous system biofilm formation.
Authors: Snowden J, Beaver M, Beenken K, Smeltzer M, Horswill A, Kielian T
PLoS ONE, 2013;8(12):e84089.
Species: Mouse
Sample Type: Homogenized Tissue
Steady-state neutrophil homeostasis is dependent on TLR4/TRIF signaling.
Authors: Bugl S, Wirths S, Radsak M, Schild H, Stein P, Andre M, Muller M, Malenke E, Wiesner T, Marklin M, Frick J, Handgretinger R, Rammensee H, Kanz L, Kopp H
Blood, 2013;121(5):723-33.
Species: Mouse
Sample Type: Plasma
AMPKalpha1 deficiency amplifies proinflammatory myeloid APC activity and CD40 signaling.
Authors: Carroll K, Viollet B, Suttles J
J Leukoc Biol, 2013;94(6):1113-21.
Species: Mouse
Sample Type: cell culture supernate
Sirt2 suppresses inflammatory responses in collagen-induced arthritis.
Authors: Lin J, Sun B, Jiang C, Hong H, Zheng Y
Biochem Biophys Res Commun, 2013;441(4):897-903.
Species: Mouse
Sample Type: Serum
Dual functions of prostaglandin D2 in murine contact hypersensitivity via DP and CRTH2.
Authors: Yamamoto Y, Otani S, Hirai H, Nagata K, Aritake K, Urade Y, Narumiya S, Yokozeki H, Nakamura M, Satoh T
Am. J. Pathol., 2012;179(1):302-14.
Species: Mouse
Sample Type: Tissue Homogenates
Salmonella enterica induces joint inflammation and expression of interleukin-17 in draining lymph nodes early after onset of enterocolitis in mice.
Authors: Noto Llana M, Sarnacki SH, Vazquez MV, Gartner AS, Giacomodonato MN, Cerquetti MC
Infect. Immun., 2012;80(6):2231-9.
Species: Mouse
Sample Type: Tissue Homogenates
Elevating body temperature enhances hematopoiesis and neutrophil recovery after total body irradiation in an IL-1-, IL-17-, and G-CSF-dependent manner.
Blood, 2012;120(13):2600-9.
Species: Mouse
Sample Type: tissue lysates
The Receptor Slamf1 on the Surface of Myeloid Lineage Cells Controls Susceptibility to Infection by Trypanosoma cruzi.
Authors: Calderon J, Maganto-Garcia E, Punzon C, Carrion J, Terhorst C, Fresno M
PLoS Pathog., 2012;8(7):e1002799.
Species: Mouse
Sample Type: Serum
The Role of IL-15 in Activating STAT5 and Fine-Tuning IL-17A Production in CD4 T Lymphocytes.
Authors: Pandiyan P, Yang X, Saravanamuthu S, Zheng L, Ishihara S
J. Immunol., 2012;189(9):4237-46.
Species: Mouse
Sample Type: Cell Culture Supernates
ChemR23 dampens lung inflammation and enhances anti-viral immunity in a mouse model of acute viral pneumonia.
Authors: Bondue B, Vosters O, de Nadai P, Glineur S, De Henau O, Luangsay S, Van Gool F, Communi D, De Vuyst P, Desmecht D, Parmentier M
PLoS Pathog., 2011;7(11):e1002358.
Species: Mouse
Sample Type: Tissue Homogenates
The TLR7 ligand 9-benzyl-2-butoxy-8-hydroxy adenine inhibits IL-17 response by eliciting IL-10 and IL-10-inducing cytokines.
Authors: Vultaggio A, Nencini F, Pratesi S, Maggi L, Guarna A, Annunziato F, Romagnani S, Parronchi P, Maggi E
J. Immunol., 2011;186(8):4707-15.
Species: Mouse
Sample Type: Serum
Serotonin activates dendritic cell function in the context of gut inflammation.
Authors: Li N, Ghia JE, Wang H, McClemens J, Cote F, Suehiro Y, Mallet J, Khan WI
Am. J. Pathol., 2011;178(2):662-71.
Species: Mouse
Sample Type: Cell Culture Supernates
IL-23-Mediated Epidermal Hyperplasia Is Dependent on IL-6.
Authors: Lindroos J, Svensson L, Norsgaard H
J. Invest. Dermatol., 2011;131(5):1110-8.
Species: Mouse
Sample Type: Tissue Homogenates
IL-33-responsive lineage- CD25+ CD44(hi) lymphoid cells mediate innate type 2 immunity and allergic inflammation in the lungs.
Authors: Bartemes KR, Iijima K, Kobayashi T, Kephart GM, McKenzie AN, Kita H
J. Immunol., 2011;188(3):1503-13.
Species: Mouse
Sample Type: BALF
Reciprocal expression of IL-25 and IL-17A is important for allergic airways hyperreactivity.
Authors: Barlow JL, Flynn RJ, Ballantyne SJ, McKenzie AN
Clin. Exp. Allergy, 2011;41(10):1447-55.
Species: Mouse
Sample Type: BALF
IL-17-producing invariant NKT cells in lymphoid organs are recent thymic emigrants identified by neuropilin-1 expression.
Authors: Milpied P, Massot B, Renand A, Diem S, Herbelin A, Leite-de-Moraes M, Rubio MT, Hermine O
Blood, 2011;118(11):2993-3002.
Species: Mouse
Sample Type: Cell Culture Supernates
Role of IL-17A in neutrophil recruitment and hepatic injury after warm ischemia-reperfusion mice.
Authors: Kono H, Fujii H, Ogiku M, Hosomura N, Amemiya H, Tsuchiya M, Hara M
J. Immunol., 2011;187(9):4818-25.
Species: Mouse
Sample Type: Serum
Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens.
Authors: DePaolo RW, Abadie V, Tang F
Nature, 2011;471(7337):220-4.
Species: Mouse
Sample Type: Cell Culture Supernates
Morphine disrupts interleukin-23 (IL-23)/IL-17-mediated pulmonary mucosal host defense against Streptococcus pneumoniae infection.
Authors: Ma J, Wang J, Wan J, Charboneau R, Chang Y, Barke RA, Roy S
Infect. Immun., 2010;78(2):830-7.
Species: Mouse
Sample Type: BALF
Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice.
Authors: Chalaris A, Adam N, Sina C, Rosenstiel P, Lehmann-Koch J, Schirmacher P, Hartmann D, Cichy J, Gavrilova O, Schreiber S, Jostock T, Matthews V, Hasler R, Becker C, Neurath MF, Reiss K, Saftig P, Scheller J, Rose-John S
J. Exp. Med., 2010;207(8):1617-24.
Species: Mouse
Sample Type: Cell Culture Supernates
Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model.
Authors: Yoshizaki A, Yanaba K, Iwata Y
J. Immunol., 2010;185(4):2502-15.
Species: Mouse
Sample Type: Serum
Antigen-specific Th9 cells exhibit uniqueness in their kinetics of cytokine production and short retention at the inflammatory site.
Authors: Tan C, Aziz MK, Lovaas JD, Vistica BP, Shi G, Wawrousek EF, Gery I
J. Immunol., 2010;185(11):6795-801.
Species: Mouse
Sample Type: Cell Culture Supernates
IL-23 and IL-17A, but not IL-12 and IL-22, are required for optimal skin host defense against Candida albicans.
Authors: Kagami S, Rizzo HL, Kurtz SE
J. Immunol., 2010;185(9):5453-62.
Species: Mouse
Sample Type: Tissue Homogenates
Prostaglandin I2-IP signaling promotes Th1 differentiation in a mouse model of contact hypersensitivity.
Authors: Nakajima S, Honda T, Sakata D, Egawa G, Tanizaki H, Otsuka A, Moniaga CS, Watanabe T, Miyachi Y, Narumiya S, Kabashima K
J. Immunol., 2010;184(10):5595-603.
Species: Mouse
Sample Type: Cell Culture Supernates
Enhanced production of IL-17A during zymosan-induced peritonitis in obese mice.
Authors: Pini M, Fantuzzi G
J. Leukoc. Biol., 2010;87(1):51-8.
Species: Mouse
Sample Type: Peritoneal Lavage
TLR4 activation is required for IL-17-induced multiple tissue inflammation and wasting in mice.
Authors: Tang H, Pang S, Wang M
J. Immunol., 2010;185(4):2563-9.
Species: Mouse
Sample Type: Tissue Homogenates
Phosphodiesterase 7A inhibitor ASB16165 suppresses proliferation and cytokine production of NKT cells.
Authors: Goto M, Murakawa M, Kadoshima-Yamaoka K, Tanaka Y, Inoue H, Murafuji H, Hayashi Y, Miura K, Nakatsuka T, Nagahira K, Chamoto K, Fukuda Y, Nishimura T
Cell. Immunol., 2009;258(2):147-51.
Species: Mouse
Sample Type: Cell Culture Supernates
A MyD88-dependent early IL-17 production protects mice against airway infection with the obligate intracellular pathogen Chlamydia muridarum.
Authors: Zhang X, Gao L, Lei L, Zhong Y, Dube P, Berton MT, Arulanandam B, Zhang J, Zhong G
J. Immunol., 2009;183(2):1291-300.
Species: Mouse
Sample Type: BALF
IL-17 receptor signaling is required to control polymicrobial sepsis.
Authors: Freitas A, Alves-Filho JC, Victoni T, Secher T, Lemos HP, Sonego F, Cunha FQ, Ryffel B
J. Immunol., 2009;182(12):7846-54.
Species: Mouse
Sample Type: Peritoneal Exudate
Inhibition of monocyte-derived inflammatory cytokines by IL-25 occurs via p38 Map kinase-dependent induction of Socs-3.
Authors: Caruso R, Stolfi C, Sarra M, Rizzo A, Fantini MC, Pallone F, MacDonald TT, Monteleone G
Blood, 2009;113(15):3512-9.
Species: Mouse
Sample Type: Serum
Differential IL-23 requirement for IL-22 and IL-17A production during innate immunity against Salmonella enterica serovar Enteritidis.
Authors: Siegemund S, Schutze N, Schulz S, Wolk K, Nasilowska K, Straubinger RK, Sabat R, Alber G
Int. Immunol., 2009;21(5):555-65.
Species: Mouse
Sample Type: Serum
Exaggerated IL-17 response to epicutaneous sensitization mediates airway inflammation in the absence of IL-4 and IL-13.
Authors: He R, Kim HY, Yoon J, Oyoshi MK, MacGinnitie A, Goya S, Freyschmidt EJ, Bryce P, McKenzie AN, Umetsu DT, Oettgen HC, Geha RS
J. Allergy Clin. Immunol., 2009;124(4):761-70.e1.
Species: Mouse
Sample Type: Serum
TLR2 deficiency leads to increased Th17 infiltrates in experimental brain abscesses.
Authors: Nichols JR, Aldrich AL, Mariani MM, Vidlak D, Esen N, Kielian T
J. Immunol., 2009;182(11):7119-30.
Species: Mouse
Sample Type: Tissue Homogenates
Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling.
Authors: Boniface K, Bak-Jensen KS, Li Y, Blumenschein WM, McGeachy MJ, McClanahan TK, McKenzie BS, Kastelein RA, Cua DJ, de Waal Malefyt R
J. Exp. Med., 2009;206(3):535-48.
Species: Mouse
Sample Type: Cell Culture Supernates
Mouse models of asthma: a comparison between C57BL/6 and BALB/c strains regarding bronchial responsiveness, inflammation, and cytokine production.
Authors: Gueders MM, Paulissen G, Crahay C, Quesada-Calvo F, Hacha J, Van Hove C, Tournoy K, Louis R, Foidart JM, Noel A, Cataldo DD
Inflamm. Res., 2009;58(12):845-54.
Species: Mouse
Sample Type: BALF
TLR-2 and IL-17A in chitin-induced macrophage activation and acute inflammation.
Authors: Da Silva CA, Hartl D, Liu W, Lee CG, Elias JA
J. Immunol., 2008;181(6):4279-86.
Species: Mouse
Sample Type: BALF
Adverse functions of IL-17A in experimental sepsis.
Authors: Flierl MA, Rittirsch D, Gao H, Hoesel LM, Nadeau BA, Day DE, Zetoune FS, Sarma JV, Huber-Lang MS, Ferrara JL, Ward PA
FASEB J., 2008;22(7):2198-205.
Species: Mouse
Sample Type: Plasma
An L-selectin ligand distinct from P-selectin glycoprotein ligand-1 is expressed on endothelial cells and promotes neutrophil rolling in inflammation.
Authors: Shigeta A, Matsumoto M, Tedder TF, Lowe JB, Miyasaka M, Hirata T
Blood, 2008;112(13):4915-23.
Species: Mouse
Sample Type: Serum
Resveratrol inhibits high glucose-induced PI3K/Akt/ERK-dependent interleukin-17 expression in primary mouse cardiac fibroblasts.
Authors: Venkatachalam K, Mummidi S, Cortez DM, Prabhu SD, Valente AJ, Chandrasekar B
Am. J. Physiol. Heart Circ. Physiol., 2008;294(5):H2078-87.
Species: Mouse
Sample Type: Cell Culture Supernates
Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: role of intracellular osteopontin.
Authors: Shinohara ML, Kim JH, Garcia VA, Cantor H
Immunity, 2008;29(1):68-78.
Species: Mouse
Sample Type: Cell Culture Supernates
Crucial role of the interleukin-6/interleukin-17 cytokine axis in the induction of arthritis by glucose-6-phosphate isomerase.
Authors: Iwanami K, Matsumoto I, Tanaka-Watanabe Y, Inoue A, Mihara M, Ohsugi Y, Mamura M, Goto D, Ito S, Tsutsumi A, Kishimoto T, Sumida T
Arthritis Rheum., 2008;58(3):754-63.
Species: Mouse
Sample Type: Cell Culture Supernates
Novel immunomodulatory properties of berbamine through selective down-regulation of STAT4 and action of IFN-gamma in experimental autoimmune encephalomyelitis.
Authors: Ren Y, Lu L, Guo TB, Qiu J, Yang Y, Liu A, Zhang JZ
J. Immunol., 2008;181(2):1491-8.
Species: Mouse
Sample Type: Cell Culture Supernates
T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance.
Authors: Pesu M, Watford WT, Wei L, Xu L, Fuss I, Strober W, Andersson J, Shevach EM, Quezado M, Bouladoux N, Roebroek A, Belkaid Y, Creemers J, OShea JJ
Nature, 2008;455(7210):246-50.
Species: Mouse
Sample Type: Cell Culture Supernates
Intercellular adhesion molecule-1 expression is required on multiple cell types for the development of experimental autoimmune encephalomyelitis.
Authors: Bullard DC, Hu X, Schoeb TR, Collins RG, Beaudet AL, Barnum SR
J. Immunol., 2007;178(2):851-7.
Species: Mouse
Sample Type: Cell Culture Supernates
TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology.
Authors: McGeachy MJ, Bak-Jensen KS, Chen Y, Tato CM, Blumenschein W, McClanahan T, Cua DJ
Nat. Immunol., 2007;8(12):1390-7.
Species: Mouse
Sample Type: Cell Culture Supernates
Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death.
Authors: Toscano MA, Bianco GA, Ilarregui JM, Croci DO, Correale J, Hernandez JD, Zwirner NW, Poirier F, Riley EM, Baum LG, Rabinovich GA
Nat. Immunol., 2007;8(8):825-34.
Species: Mouse
Sample Type: Cell Culture Supernates
The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4.
Authors: Brustle A, Heink S, Huber M, Rosenplanter C, Stadelmann C, Yu P, Arpaia E, Mak TW, Kamradt T, Lohoff M
Nat. Immunol., 2007;8(9):958-66.
Species: Mouse
Sample Type: Cell Culture Supernates
T-bet inhibits both TH2 cell-mediated eosinophil recruitment and TH17 cell-mediated neutrophil recruitment into the airways.
Authors: Fujiwara M, Hirose K, Kagami S, Takatori H, Wakashin H, Tamachi T, Watanabe N, Saito Y, Iwamoto I, Nakajima H
J. Allergy Clin. Immunol., 2007;119(3):662-70.
Species: Mouse
Sample Type: BALF
IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner.
Authors: Wei L, Laurence A, Elias KM, OShea JJ
J. Biol. Chem., 2007;282(48):34605-10.
Species: Mouse
Sample Type: Cell Culture Supernates
Functional relevance of the IL-23-IL-17 axis in lungs in vivo.
Authors: Ivanov S, Bozinovski S, Bossios A, Valadi H, Vlahos R, Malmhall C, Sjostrand M, Kolls JK, Anderson GP, Linden A
Am. J. Respir. Cell Mol. Biol., 2007;36(4):442-51.
Species: Mouse
Sample Type: BALF
IL-17 receptor signaling influences virus-induced corneal inflammation.
Authors: Molesworth-Kenyon SJ, Yin R, Oakes JE, Lausch RN
J. Leukoc. Biol., 2007;83(2):401-8.
Species: Mouse
Sample Type: Cell Culture Supernates
Matrix metalloproteinase-8 deficiency promotes granulocytic allergen-induced airway inflammation.
Authors: Gueders MM, Balbin M, Rocks N, Foidart JM, Gosset P, Louis R, Shapiro S, Lopez-Otin C, Noel A, Cataldo DD
J. Immunol., 2005;175(4):2589-97.
Species: Mouse
Sample Type: BALF
A novel polysaccharide of black soybean promotes myelopoiesis and reconstitutes bone marrow after 5-flurouracil- and irradiation-induced myelosuppression.
Authors: Liao HF, Chen YJ, Yang YC
Life Sci., 2005;77(4):400-13.
Species: Mouse
Sample Type: Cell Culture Supernates
IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger.
Authors: Ferretti S, Bonneau O, Dubois GR, Jones CE, Trifilieff A
J. Immunol., 2003;170(4):2106-12.
Species: Mouse
Sample Type: BALF
Endogenous IL-17 as a mediator of neutrophil recruitment caused by endotoxin exposure in mouse airways.
Authors: Miyamoto M, Prause O, Sjostrand M, Laan M, Lotvall J, Linden A
J. Immunol., 2003;170(9):4665-72.
Species: Mouse
Sample Type: Cell Culture Supernates
IL-1-independent role of IL-17 in synovial inflammation and joint destruction during collagen-induced arthritis.
Authors: Lubberts E, Joosten LA, Oppers B, van den Bersselaar L, Coenen-de Roo CJ, Kolls JK, Schwarzenberger P, van de Loo FA, van den Berg WB
J. Immunol., 2001;167(2):1004-13.
Species: Mouse
Sample Type: Cell Culture Supernates
Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense.
Authors: Ye P, Rodriguez FH, Kanaly S, Stocking KL, Schurr J, Schwarzenberger P, Oliver P, Huang W, Zhang P, Zhang J, Shellito JE, Bagby GJ, Nelson S, Charrier K, Peschon JJ, Kolls JK
J. Exp. Med., 2001;194(4):519-27.
Species: Mouse
Sample Type: BALF
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