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Mouse IL-12/IL-23 p40 Allele-specific Quantikine SixPak (1 PK)

货号: SM1240 基本售价: 19749.7 元 规格: 1 PACK

产品信息

概述
货号SM1240
描述The Quantikine Mouse IL-12/IL-23 p40 Immunoassay is a 4.5 hour solid phase ELISA designed to measure mouse p40 subunit in IL-12 p70, IL-23, p40 homodimer, and p40 monomer in cell culture supernates and mouse serum. It contains recombinant mouse IL-12 p40 homodimer and antibodies raised against the recombinant factor. This immunoassay has been shown to accurately quantitate the recombinant mouse IL-12/IL-23 p40. Results obtained using natural mouse IL-12/IL-23 p40 showed dose-response curves that were parallel to the standard curves obtained using the recombinant Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural mouse IL-12/IL-23 p40.
别名CLMF2; IL12 p40; IL-12 p40; IL12B; IL-12B; NKSF2;
全称
Interleukin 12/Interleukin 23 p40
反应种属Mouse
目标/特异性Natural and recombinant mouse IL-12/IL-23 p40
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs
3593 (Human); 16160 (Mouse); 64546 (Rat); 403976 (Canine); 493741 (Feline)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

The adaptor molecule CARD9 is essential for tuberculosis control.
Authors: Dorhoi A, Desel C, Yeremeev V, Pradl L, Brinkmann V, Mollenkopf HJ, Hanke K, Gross O, Ruland J, Kaufmann SH
J. Exp. Med., 2011;207(4):777-92.
Species: Mouse
Sample Type: Cell Culture Supernates

Proinflammatory clearance of apoptotic neutrophils induces an IL-12(low)IL-10(high) regulatory phenotype in macrophages.
Authors: Filardy AA, Pires DR, Nunes MP, Takiya CM, Freire-de-Lima CG, Ribeiro-Gomes FL, DosReis GA
J. Immunol., 2010;185(4):2044-50.
Species: Mouse
Sample Type: Cell Culture Supernates

NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway.
Authors: Watanabe T, Asano N, Fichtner-Feigl S, Gorelick PL, Tsuji Y, Matsumoto Y, Chiba T, Fuss IJ, Kitani A, Strober W
J. Clin. Invest., 2010;120(5):1645-62.
Species: Mouse
Sample Type: Cell Culture Supernates

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors.
Authors: Ghiringhelli F, Apetoh L, Tesniere A, Aymeric L, Ma Y, Ortiz C, Vermaelen K, Panaretakis T, Mignot G, Ullrich E, Perfettini JL, Schlemmer F, Tasdemir E, Uhl M, Genin P, Civas A, Ryffel B, Kanellopoulos J, Tschopp J, Andre F, Lidereau R, McLaughlin NM, Haynes NM, Smyth MJ, Kroemer G, Zitvogel L
Nat. Med., 2009;15(10):1170-8.
Species: Mouse
Sample Type: Cells Supernates

Modified adenine (9-benzyl-2-butoxy-8-hydroxyadenine) redirects Th2-mediated murine lung inflammation by triggering TLR7.
Authors: Vultaggio A, Nencini F, Fitch PM, Fili L, Maggi L, Fanti P, deVries A, Beccastrini E, Palandri F, Manuelli C, Bani D, Giudizi MG, Guarna A, Annunziato F, Romagnani S, Maggi E, Howie SE, Parronchi P
J. Immunol., 2009;182(2):880-9.
Species: Mouse
Sample Type: Serum

An eosinophil immune response characterizes the inflammatory skin disease observed in Tie-2 transgenic mice.
Authors: Voskas D, Babichev Y, Ling LS, Alami J, Shaked Y, Kerbel RS, Ciruna B, Dumont DJ
J. Leukoc. Biol., 2008;84(1):59-67.
Species: Mouse
Sample Type: Serum

Fat diet and alcohol-induced steatohepatitis after LPS challenge in mice: role of bioactive TNF and Th1 type cytokines.
Authors: Olleros ML, Martin ML, Vesin D, Fotio AL, Santiago-Raber ML, Rubbia-Brandt L, Spahr L, Hadengue A, Garcia I
Cytokine, 2008;44(1):118-25.
Species: Mouse
Sample Type: Serum

TLR-2 and IL-17A in chitin-induced macrophage activation and acute inflammation.
Authors: Da Silva CA, Hartl D, Liu W, Lee CG, Elias JA
J. Immunol., 2008;181(6):4279-86.
Species: Mouse
Sample Type: BALF

Morphine withdrawal inhibits IL-12 induction in a macrophage cell line through a mechanism that involves cAMP.
Authors: Kelschenbach J, Ninkovic J, Wang J, Krishnan A, Charboneau R, Barke RA, Roy S
J. Immunol., 2008;180(6):3670-9.
Species: Mouse
Sample Type: Cell Culture Supernates

Bcl-xL antisense oligonucleotide and cisplatin combination therapy extends survival in SCID mice with established mesothelioma xenografts.
Authors: Littlejohn JE, Cao X, Miller SD, Ozvaran MK, Jupiter D, Zhang L, Rodarte C, Smythe WR
Int. J. Cancer, 2008;123(1):202-8.
Species: Mouse
Sample Type: Serum

The direct action of 1alpha,25(OH)2-vitamin D3 on purified mouse Langerhans cells.
Authors: Fujita H, Asahina A, Komine M, Tamaki K
Cell. Immunol., 2007;245(2):70-9.
Species: Mouse
Sample Type: Cell Culture Supernates

Intercellular adhesion molecule-1 expression is required on multiple cell types for the development of experimental autoimmune encephalomyelitis.
Authors: Bullard DC, Hu X, Schoeb TR, Collins RG, Beaudet AL, Barnum SR
J. Immunol., 2007;178(2):851-7.
Species: Mouse
Sample Type: Cell Culture Supernates

Inactivated Sendai virus particles eradicate tumors by inducing immune responses through blocking regulatory T cells.
Authors: Kurooka M, Kaneda Y
Cancer Res., 2007;67(1):227-36.
Species: Mouse
Sample Type: Cell Culture Supernates

Toll-like receptor 4 mediates the early inflammatory response after cold ischemia/reperfusion.
Authors: Kaczorowski DJ, Nakao A, Mollen KP, Vallabhaneni R, Sugimoto R, Kohmoto J, Tobita K, Zuckerbraun BS, McCurry KR, Murase N, Billiar TR
Transplantation, 2007;84(10):1279-87.
Species: Mouse
Sample Type: Serum

Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock.
Authors: Vogl T, Tenbrock K, Ludwig S, Leukert N, Ehrhardt C, van Zoelen MA, Nacken W, Foell D, van der Poll T, Sorg C, Roth J
Nat. Med., 2007;13(9):1042-9.
Species: Mouse
Sample Type: Serum

Vaccinia virus infection attenuates innate immune responses and antigen presentation by epidermal dendritic cells.
Authors: Deng L, Dai P, Ding W, Granstein RD, Shuman S
J. Virol., 2006;80(20):9977-87.
Species: Mouse
Sample Type: Cell Culture Supernates

Induction of dendritic cell maturation by pertussis toxin and its B subunit differentially initiate Toll-like receptor 4-dependent signal transduction pathways.
Authors: Wang ZY, Yang D, Chen Q, Leifer CA, Segal DM, Su SB, Caspi RR, Howard ZO, Oppenheim JJ
Exp. Hematol., 2006;34(8):1115-24.
Species: Mouse
Sample Type: Cell Culture Supernates

Roles of the small intestine for induction of toll-like receptor 4-mediated innate resistance in naturally acquired murine toxoplasmosis.
Authors: Furuta T, Yoshikawa Y
Int. Immunol., 2006;18(12):1655-62.
Species: Mouse
Sample Type: Cell Culture Supernates

A multivalent combination of experimental antituberculosis DNA vaccines based on Ag85B and regions of difference antigens.
Authors: Grover A, Ahmed MF, Singh B, Verma I, Sharma P, Khuller GK
Microbes Infect., 2006;8(9):2390-9.
Species: Mouse
Sample Type: Cell Culture Supernates

Endogenous interleukin-12 improves the early antimicrobial host response to murine Escherichia coli peritonitis.
Authors: Weijer S, Florquin S, van der Poll T
Shock, 2005;23(1):54-8.
Species: Mouse
Sample Type: Peritoneal Fluid

Cutting edge: Physiologic attenuation of proinflammatory transcription by the Gs protein-coupled A2A adenosine receptor in vivo.
Authors: Lukashev D, Ohta A, Apasov S, Chen JF, Sitkovsky M
J. Immunol., 2004;173(1):21-4.
Species: Mouse
Sample Type: Peritoneal Exudate

Chemokine and cytokine production during Orientia tsutsugamushi infection in mice.
Authors: Koh YS, Yun JH, Seong SY, Choi MS, Kim IS
Microb. Pathog., 2004;36(1):51-7.
Species: Mouse
Sample Type: Peritoneal Fluid

IL-12 p40 homodimer-dependent macrophage chemotaxis and respiratory viral inflammation are mediated through IL-12 receptor beta 1.
Authors: Russell TD, Yan Q, Fan G, Khalifah AP, Bishop DK, Brody SL, Walter MJ
J. Immunol., 2003;171(12):6866-74.
Species: Mouse
Sample Type: BALF

A profibrotic function of IL-12p40 in experimental pulmonary fibrosis.
Authors: Huaux F, Arras M, Tomasi D, Barbarin V, Delos M, Coutelier JP, Vink A, Phan SH, Renauld JC, Lison D
J. Immunol., 2002;169(5):2653-61.
Species: Mouse
Sample Type: Tissue Homogenates

Administration of either anti-CD40 or interleukin-12 following lethal total body irradiation induces acute lethal toxicity affecting the gut.
Authors: Hixon JA, Anver MR, Blazar BR, Panoskaltsis-Mortari A, Wiltrout RH, Murphy WJ
Biol. Blood Marrow Transplant., 2002;8(6):316-25.
Species: Mouse
Sample Type: Serum

The protein tyrosine kinase inhibitor AG126 prevents the massive microglial cytokine induction by pneumococcal cell walls.
Authors: Hanisch UK, Prinz M, Angstwurm K, Hausler KG, Kann O, Kettenmann H, Weber JR
Eur. J. Immunol., 2001;31(7):2104-15.
Species: Mouse
Sample Type: Cell Culture Supernates

In vitro and in vivo immunostimulatory potential of bone marrow-derived mast cells on B- and T-lymphocyte activation.
Authors: Tkaczyk C, Villa I, Peronet R, David B, Chouaib S, Mecheri S
J. Allergy Clin. Immunol., 2000;105(1):134-42.
Species: Mouse
Sample Type: Cell Culture Supernates

生物活性Cross-reactivity observed with 1 or more available related molecules.< 50% cross-species reactivity observed with species tested.
背景

Interleukin 12 (IL-12), also known as natural killer cell stimulatory factor (NKSF) or cytotoxic lymphocyte maturation factor (CLMF), is a heterodimeric pleiotropic cytokine made up of a 40 kDa (p40) subunit and a 35 kDa (p35) subunit. The IL-12 p40 subunit is shared by IL-23, another heterodimeric cytokine that has biological activities similar to, as well as distinct from, IL-12. IL-12 is produced by macrophages and B cells and has been shown to have multiple effects on T cells and natural killer (NK) cells. While mouse IL-12 is active on both human and mouse cells, human IL-12 is not active on mouse cells.

运输条件Blue Ice
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参考文献
  • Cytokines and Receptors in Allergy and Asthma
  • Cytokines and Receptors in Angiogenesis
  • gamma delta T Cells
  • IL-12 Family
  • Th1 Cells
  • Th17 Cells