| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. NLRP3 protects alveolar barrier integrity by an inflammasome-independent increase of epithelial cell adherence
Sci Rep, 2016;6(0):30943.
Species: Mouse
Sample Type: BALF
Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation
J Immunol, 2016;0(0):.
Species: Mouse
Sample Type: Plasma
Activation of murine invariant NKT cells promotes susceptibility to candidiasis by IL-10-induced modulation of phagocyte antifungal activity
Eur J Immunol, 2016;0(0):.
Species: Mouse
Sample Type: PLF
TLR2 limits development of hepatocellular carcinoma by reducing IL18-mediated immunosuppression.
Authors: Li S, Sun R, Chen Y, Wei H, Tian Z
Cancer Res, 2015;75(6):986-95.
Species: Mouse
Sample Type: Serum
Voluntary Exercise Stabilizes Established Angiotensin II-Dependent Atherosclerosis in Mice through Systemic Anti-Inflammatory Effects.
Authors: Pellegrin M, Aubert J, Bouzourene K, Amstutz C, Mazzolai L
PLoS ONE, 2015;10(11):e0143536.
Species: Mouse
Sample Type: Plasma
Impaired bone formation and increased osteoclastogenesis in mice lacking chemokine (C-C motif) ligand 5 (Ccl5).
Authors: Wintges K, Beil F, Albers J, Jeschke A, Schweizer M, Claass B, Tiegs G, Amling M, Schinke T
J Bone Miner Res, 2013;28(10):2070-80.
Species: Mouse
Sample Type: Cell Culture Supernates
Modelling of mouse experimental colitis by global property screens: a holistic approach to assess drug effects in inflammatory bowel disease.
Authors: Gottfries J, Melgar S, Michaelsson E
PLoS ONE, 2012;7(1):e30005.
Species: Mouse
Sample Type: Tissue Homogenates
Lipocalin 2 deficiency dysregulates iron homeostasis and exacerbates endotoxin-induced sepsis.
J. Immunol., 2012;189(4):1911-9.
Species: Mouse
Sample Type: Serum
The interaction between IL-18 and IL-18 receptor limits the magnitude of protective immunity and enhances pathogenic responses following infection with intracellular bacteria.
Authors: Ghose P, Ali AQ, Fang R, Forbes D, Ballard B, Ismail N
J. Immunol., 2011;187(3):1333-46.
Species: Mouse
Sample Type: Serum
Galectin-3 contributes to neonatal hypoxic-ischemic brain injury.
Authors: Doverhag C, Hedtjarn M, Poirier F, Mallard C, Hagberg H, Karlsson A, Savman K
Neurobiol. Dis., 2010;38(1):36-46.
Species: Mouse
Sample Type: Tissue Homogenates
T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes.
Authors: Guarda G, Dostert C, Staehli F, Cabalzar K, Castillo R, Tardivel A, Schneider P, Tschopp J
Nature, 2009;460(7252):269-73.
Species: Mouse
Sample Type: Cell Culture Supernates
Neutralization of Interleukin-18 Ameliorates Ischemia/Reperfusion-induced Myocardial Injury.
Authors: Venkatachalam K, Prabhu SD, Reddy VS, Boylston WH, Valente AJ, Chandrasekar B
J. Biol. Chem., 2009;284(12):7853-65.
Species: Mouse
Sample Type: Tissue Homogenates
Cigarette smoke selectively enhances viral PAMP- and virus-induced pulmonary innate immune and remodeling responses in mice.
Authors: Kang MJ, Lee CG, Lee JY, Dela Cruz CS, Chen ZJ, Enelow R, Elias JA
J. Clin. Invest., 2008;118(8):2771-84.
Species: Mouse
Sample Type: BALF
Antifibrotic action of pirfenidone and prednisolone: different effects on pulmonary cytokines and growth factors in bleomycin-induced murine pulmonary fibrosis.
Authors: Oku H, Shimizu T, Kawabata T, Nagira M, Hikita I, Ueyama A, Matsushima S, Torii M, Arimura A
Eur. J. Pharmacol., 2008;590(1):400-8.
Species: Mouse
Sample Type: Tissue Homogenates
Activation of NOD2 in vivo induces IL-1beta production in the eye via caspase-1 but results in ocular inflammation independently of IL-1 signaling.
Authors: Rosenzweig HL, Martin TM, Planck SR, Galster K, Jann MM, Davey MP, Kobayashi K, Flavell RA, Rosenbaum JT
J. Leukoc. Biol., 2008;84(2):529-36.
Species: Mouse
Sample Type: Tissue Homogenates
Deletion of TLR5 results in spontaneous colitis in mice.
Authors: Vijay-Kumar M, Sanders CJ, Taylor RT, Kumar A, Aitken JD, Sitaraman SV, Neish AS, Uematsu S, Akira S, Williams IR, Gewirtz AT
J. Clin. Invest., 2007;117(12):3909-21.
Species: Mouse
Sample Type: Serum
IL-18 is induced and IL-18 receptor alpha plays a critical role in the pathogenesis of cigarette smoke-induced pulmonary emphysema and inflammation.
Authors: Kang MJ, Homer RJ, Gallo A, Lee CG, Crothers KA, Cho SJ, Rochester C, Cain H, Chupp G, Yoon HJ, Elias JA
J. Immunol., 2007;178(3):1948-59.
Species: Mouse
Sample Type: BALF
IL-1 receptor-associated kinase 1 mediates protection against Staphylococcus aureus infection.
Authors: Verdrengh M, Thomas JA, Hultgren OH
Microbes Infect., 2004;6(14):1268-72.
Species: Mouse
Sample Type: Serum
Regulation of Pseudomonas aeruginosa corneal infection in IL-1 beta converting enzyme (ICE, caspase-1) deficient mice.
Authors: Thakur A, Barrett RP, McClellan S, Hazlett LD
Curr. Eye Res., 2004;29(4):225-33.
Species: Mouse
Sample Type: Tissue Homogenates
A protective role of locally administered immunostimulatory CpG oligodeoxynucleotide in a mouse model of genital herpes infection.
Authors: Harandi AM, Eriksson K, Holmgren J
J. Virol., 2003;77(2):953-62.
Species: Mouse
Sample Type: Serum
|
| 背景 | Interleukin 18 (IL-18), also known as interferon-gamma-inducing factor (IGIF) and IL-1γ, is a cytokine which shares biologic activities with IL-12 and structural similarities with the IL-1 family of proteins. IL-18 was originally cloned from liver cells and has since been shown to be expressed by monocyte/macrophages, osteoblasts and keratinocytes. Caspase-1 (IL-1 beta-converting enzyme) has been implicated in the physiological processing of pro-IL-18 to IL-18. Similarly to IL-12, human IL-18 has been shown to enhance NK cell activity in PBMC cultures. Human IL-18 has also been found to induce the production IFN-γ and GM-CSF while inhibiting the production of IL-10 by PBMC. On enriched human T cells, human IL-18 can enhance Th1 cytokine production and stimulate cell proliferation via an IL-2-dependent pathway. In the mouse system, IL-18 has been shown to be a costimulatory factor for the activation of Th1, but not Th2, cells. IL-18 was found to selectively enhance the FasL-mediated cytotoxicity of Th1, but not Th0 or Th2, cells. IL-18 has also been shown to induce activated B cells to produce IFN-γ that inhibits IgE production. |
