Serum Interleukin-18, Fetuin-A, Soluble Intercellular Adhesion Molecule-1, and Endothelin-1 in Ankylosing Spondylitis, Psoriatic Arthritis, and SAPHO Syndrome
Int J Mol Sci, 2016;17(8):.
Species: Human
Sample Type: Serum

Rickettsia australis Activates Inflammasome in Human and Murine Macrophages
PLoS ONE, 2016;11(6):e0157231.
Species: Human
Sample Type: Cell Culture Supernates

Lipopolysaccharide Primes the NALP3 Inflammasome by Inhibiting Its Ubiquitination and Degradation Mediated by the SCFFBXL2 E3 Ligase.
Authors: Han S, Lear T, Jerome J, Rajbhandari S, Snavely C, Gulick D, Gibson K, Zou C, Chen B, Mallampalli R
J Biol Chem, 2015;290(29):18124-33.
Species: Human
Sample Type: Cell Culture Supernates

Novel gene variants predict serum levels of the cytokines IL-18 and IL-1ra in older adults.
Authors: Matteini A, Li J, Lange E, Tanaka T, Lange L, Tracy R, Wang Y, Biggs M, Arking D, Fallin M, Chakravarti A, Psaty B, Bandinelli S, Ferrucci L, Reiner A, Walston J
Cytokine, 2014;65(1):10-6.
Species: Human
Sample Type: Serum

A bone substitute with high affinity for vitamin D-binding protein--relationship with niche of osteoclasts.
Authors: Ikeda T, Kasai M, Tatsukawa E, Kamitakahara M, Shibata Y, Yokoi T, Nemoto T, Ioku K
J Cell Mol Med, 2014;18(1):170-80.
Species: Human
Sample Type: BALF

Toll-like receptor 8 agonist and bacteria trigger potent activation of innate immune cells in human liver.
Authors: Jo J, Tan A, Ussher J, Sandalova E, Tang X, Tan-Garcia A, To N, Hong M, Chia A, Gill U, Kennedy P, Tan K, Lee K, De Libero G, Gehring A, Willberg C, Klenerman P, Bertoletti A
PLoS Pathog, 2014;10(6):e1004210.
Species: Human
Sample Type: Cell Culture Supernates

Regulation of viral and cellular gene expression by Kaposi's sarcoma-associated herpes virus polyadenylated nuclear RNA.
Authors: Rossetto, Cyprian, Tarrant-Elorza, Margaret, Verma, Subhash, Purushothaman, Pravinku, Pari, Gregory
J Virol, 2013;87(10):5540-53.
Species: Human
Sample Type: Whole Cells

Quiescent innate response to infective filariae by human Langerhans cells suggests a strategy of immune evasion.
Authors: Boyd A, Bennuru S, Wang Y, Sanprasert V, Law M, Chaussabel D, Nutman T, Semnani R
Infect Immun, 2013;81(5):1420-9.
Species: Human
Sample Type: Cell Culture Supernates

Acute kidney injury biomarkers for patients in a coronary care unit: a prospective cohort study.
Authors: Chen TH, Chang CH, Lin CY, Jenq CC, Chang MY, Tian YC, Hung CC, Fang JT, Yang CW, Wen MS, Lin FC, Chen YC
PLoS ONE, 2012;7(2):e32328.
Species: Human
Sample Type: Serum

Compensated inflammation in systemic juvenile idiopathic arthritis: role of alternatively activated macrophages.
Authors: Shimizu M, Yachie A
Cytokine, 2012;60(1):226-32.
Species: Human
Sample Type: Serum

IL-8 dictates glycosaminoglycan binding and stability of IL-18 in cystic fibrosis.
Authors: Reeves EP, Williamson M, Byrne B, Bergin DA, Smith SG, Greally P, OKennedy R, ONeill SJ, McElvaney NG
J. Immunol., 2010;184(3):1642-52.
Species: Human
Sample Type: Serum

Changes in cytokine levels during acute hyperinsulinemia in offspring of type 2 diabetic subjects.
Authors: Ruotsalainen E, Stancakova A, Vauhkonen I, Salmenniemi U, Pihlajamaki J, Punnonen K, Laakso M
Atherosclerosis, 2010;210(2):536-41.
Species: Human
Sample Type: Plasma

AIDS progression is associated with the emergence of IL-17-producing cells early after simian immunodeficiency virus infection.
Authors: Campillo-Gimenez L, Cumont MC, Fay M, Kared H, Monceaux V, Diop O, Muller-Trutwin M, Hurtrel B, Levy Y, Zaunders J, Dy M, Leite-de-Moraes MC, Elbim C, Estaquier J
J. Immunol., 2010;184(2):984-92.
Species: Primate - Macaca mulatta (Rhesus monkey)
Sample Type: Plasma

Differentiation of human SH-SY5Y neuroblastoma cells by all-trans retinoic acid activates the interleukin-18 system.
Authors: Sallmon H, Hoene V, Weber SC, Dame C
J. Interferon Cytokine Res., 2010;30(2):55-8.
Species: Human
Sample Type: Cell Culture Supernates

The imbalance in serum concentration of Th-1- and Th-2-derived chemokines as one of the factors involved in pathogenesis of atopic dermatitis.
Authors: Narbutt J, Lesiak A, Sysa-Jedrzeiowska A, Zakrzewski M, Bogaczewicz J, Stelmach I, Kuna P
Mediators Inflamm., 2009;2009(0):269541.
Species: Human
Sample Type: Serum

Gender specific associations between matrix metalloproteinases and inflammatory markers in post myocardial infarction patients.
Authors: Samnegard A, Hulthe J, Silveira A, Ericsson CG, Hamsten A, Eriksson P
Atherosclerosis, 2009;202(2):550-6.
Species: Human
Sample Type: Plasma

Associations of circulating TNFalpha and IL-18 with myocardial infarction and cardiovascular risk markers: the Glasgow Myocardial Infarction Study.
Authors: Welsh P, Woodward M, Rumley A, Lowe G
Cytokine, 2009;47(2):143-7.
Species: Human
Sample Type: Plasma

Interleukin-18 predicts atherosclerosis progression in SIV-infected and uninfected rhesus monkeys (Macaca mulatta) on a high-fat/high-cholesterol diet.
Authors: Yearley JH, Xia D, Pearson CB, Carville A, Shannon RP, Mansfield KG
Lab. Invest., 2009;89(6):657-67.
Species: Primate - Macaca mulatta (Rhesus monkey)
Sample Type: Plasma

Interleukin-18 and the risk of future cardiovascular disease among initially healthy women.
Authors: Everett BM, Bansal S, Rifai N, Buring JE, Ridker PM
Atherosclerosis, 2009;202(1):282-8.
Species: Human
Sample Type: Plasma

Neisseria gonorrhoeae activates the proteinase cathepsin B to mediate the signaling activities of the NLRP3 and ASC-containing inflammasome.
Authors: Duncan JA, Gao X, Huang MT, OConnor BP, Thomas CE, Willingham SB, Bergstralh DT, Jarvis GA, Sparling PF, Ting JP
J. Immunol., 2009;182(10):6460-9.
Species: Human
Sample Type: Cell Culture Supernates

Resveratrol blocks interleukin-18-EMMPRIN cross-regulation and smooth muscle cell migration.
Authors: Venkatesan B, Valente AJ, Reddy VS, Siwik DA, Chandrasekar B
Am. J. Physiol. Heart Circ. Physiol., 2009;297(2):H874-86.

Contribution of novel biomarkers to incident stable angina and acute coronary syndrome: the PRIME Study.
Authors: Empana JP, Canoui-Poitrine F, Luc G, Juhan-Vague I, Morange P, Arveiler D, Ferrieres J, Amouyel P, Bingham A, Montaye M, Ruidavets JB, Haas B, Evans A, Ducimetiere P
Eur. Heart J., 2008;29(16):1966-74.
Species: Human
Sample Type: Plasma

Antigenic stimulation in the simian model of HIV infection yields dilated cardiomyopathy through effects of TNFalpha.
Authors: Yearley JH, Mansfield KG, Carville AA, Sokos GG, Xia D, Pearson CB, Shannon RP
AIDS, 2008;22(5):585-94.
Species: Human
Sample Type: Plasma

IL-18 is induced and IL-18 receptor alpha plays a critical role in the pathogenesis of cigarette smoke-induced pulmonary emphysema and inflammation.
Authors: Kang MJ, Homer RJ, Gallo A, Lee CG, Crothers KA, Cho SJ, Rochester C, Cain H, Chupp G, Yoon HJ, Elias JA
J. Immunol., 2007;178(3):1948-59.
Species: Human
Sample Type: Serum

Haplotypes of the caspase-1 gene, plasma caspase-1 levels, and cardiovascular risk.
Authors: Blankenberg S, Godefroy T, Poirier O, Rupprecht HJ, Barbaux S, Bickel C, Nicaud V, Schnabel R, Kee F, Morrison C, Evans A, Lackner KJ, Cambien F, Munzel T, Tiret L,
Circ. Res., 2006;99(1):102-8.
Species: Human
Sample Type: Plasma

Expression of interleukin-18 and caspase-1 in cutaneous T-cell lymphoma.
Authors: Yamanaka K, Clark R, Dowgiert R, Hurwitz D, Shibata M, Rich BE, Hirahara K, Jones DA, Eapen S, Mizutani H, Kupper TS
Clin. Cancer Res., 2006;12(2):376-82.
Species: Human
Sample Type: Plasma

Soluble interleukin-1 receptor type II, IL-18 and caspase-1 in mild cognitive impairment and severe Alzheimer's disease.
Authors: Lindberg C, Chromek M, Ahrengart L, Brauner A, Schultzberg M, Garlind A
Neurochem. Int., 2005;46(7):551-7.
Species: Human
Sample Type: Serum

The proatherogenic cytokine interleukin-18 is secreted by human adipocytes.
Authors: Skurk T, Kolb H, Muller-Scholze S, Rohrig K, Hauner H, Herder C
Eur. J. Endocrinol., 2005;152(6):863-8.
Species: Human
Sample Type: Cell Culture Supernates

Interleukin-18 levels correlate with severe ovarian hyperstimulation syndrome.
Authors: Barak V, Elchalal U, Edelstein M, Kalickman I, Lewin A, Abramov Y
Fertil. Steril., 2004;82(2):415-20.
Species: Human
Sample Type: Plasma

Reduced levels of transforming growth factor-beta1, interleukin-12 and increased migration inhibitory factor are associated with severe malaria.
Authors: Chaiyaroj SC, Rutta AS, Muenthaisong K, Watkins P, Na Ubol M, Looareesuwan S
Acta Trop., 2004;89(3):319-27.
Species: Human
Sample Type: Plasma

NK cells regulate CD8+ T cell effector function in response to an intracellular pathogen.
Authors: Vankayalapati R, Klucar P, Wizel B, Weis SE, Samten B, Safi H, Shams H, Barnes PF
J. Immunol., 2004;172(1):130-7.
Species: Human
Sample Type: Cell Culture Supernates

The effect of the physical characteristics of hydroxyapatite particles on human monocytes IL-18 production in vitro.
Authors: Grandjean-Laquerriere A, Laquerriere P, Laurent-Maquin D, Guenounou M, Phillips TM
Biomaterials, 2004;25(28):5921-7.
Species: Human
Sample Type: Cell Culture Supernates

Production of interferon gamma in respiratory syncytial virus infection of humans is not associated with interleukins 12 and 18.
Authors: Garofalo RP, Hintz KH, Hill V, Ogra PL, Welliver RC
J. Med. Virol., 2004;73(2):289-94.
Species: Human
Sample Type: Nasopharyngeal Secretions

Pathogenesis of Ebola hemorrhagic fever in cynomolgus macaques: evidence that dendritic cells are early and sustained targets of infection.
Authors: Geisbert TW, Hensley LE, Larsen T, Young HA, Reed DS, Geisbert JB, Scott DP, Kagan E, Jahrling PB, Davis KJ
Am. J. Pathol., 2003;163(6):2347-70.
Species: Primate - Macaca fascicularis (Crab-eating or Cynomolgus macaque)
Sample Type: Serum

Local immunostimulation induced by intravesical administration of autologous interferon-gamma-activated macrophages in patients with superficial bladder cancer.
Authors: Pages F, Lebel-Binay S, Vieillefond A, Deneux L, Cambillau M, Soubrane O, Debre B, Tardy D, Lemonne JL, Abastado JP, Fridman WH, Thiounn N
Clin. Exp. Immunol., 2002;127(2):303-9.
Species: Human
Sample Type: Urine

Cytokine profile in Behcet's disease patients. Relationship with disease activity.
Authors: Hamzaoui K, Hamzaoui A, Guemira F, Bessioud M, Hamza M, Ayed K
Scand. J. Rheumatol., 2002;31(4):205-10.
Species: Human
Sample Type: Serum

Interleukin 18 (IL-18), also known as interferon-gamma-inducing factor (IGIF) and IL-1γ, is a cytokine which shares biologic activities with IL-12 and structural similarities with the IL-1 family of proteins. IL-18 was originally cloned from liver cells and has since been shown to be expressed by monocyte/macrophages, osteoblasts and keratinocytes. Caspase-1 (IL-1 beta-converting enzyme) has been implicated in the physiological processing of pro-IL-18 to IL-18. Similarly to IL-12, human IL-18 has been shown to enhance NK cell activity in PBMC cultures. Human IL-18 has also been found to induce the production IFN-γ and GM-CSF while inhibiting the production of IL-10 by PBMC. On enriched human T cells, human IL-18 can enhance Th1 cytokine production and stimulate cell proliferation via an IL-2-dependent pathway. In the mouse system, IL-18 has been shown to be a costimulatory factor for the activation of Th1, but not Th2, cells. IL-18 was found to selectively enhance the FasL-mediated cytotoxicity of Th1, but not Th0 or Th2, cells. IL-18 has also been shown to induce activated B cells to produce IFN-γ that inhibits IgE production.

• Cytokines and Receptors in Angiogenesis
• Group 1 ILCs
• IL-1 Family
• Inflammasomes: Intracellular Regulators of Pathogen
• Interactive Pathway: IL-1 Family Signaling Pathways
• Isolation, Culture, and Identification of Natural Killer Cells
• Macrophage Activation Markers
• Mini-review: Interleukin 18 (IL-18)
• Multiple Sclerosis and Myelin Related Molecules
• Neuroinflammation
• NOD-like Receptors and the Inflammasome
• T Cell Cytokine Signaling
• Th1 Cells
• The Nlrp3 Inflammasome & IL-18 Regulate Intestinal Homeostasis