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Mouse CCL11/Eotaxin Quantikine ELISA Kit, 2 Plate (1 KT)

货号: MME00 基本售价: 8913.1 元 规格: 1 KIT

产品信息

概述
货号MME00
描述The Quantikine Mouse Eotaxin Immunoassay is a 4.5 hour solid phase ELISA designed to measure mouse Eotaxin in cell culture supernates, serum, and plasma. It contains recombinant mouse Eotaxin and antibodies raised against the recombinant protein. This immunoassay has been shown to quantitate the recombinant protein accurately. Results obtained using natural mouse Eotaxin showed dose curves that were parallel to the standard curves obtained using the E. coli-expressed kit standards. These results indicate that this kit can be used to determine relative mass values for natural mouse Eotaxin.
别名C-C motif chemokine 11; chemokine (C-C motif) ligand 11; Eosinophil chemotactic protein; Eotaxin; eotaxin-1; MGC22554; SCYA11Small-inducible cytokine A11; small inducible cytokine subfamily A (Cys-Cys), member 11 (eotaxin);
反应种属Mouse
目标/特异性Natural and recombinant mouse Eotaxin.  This assay cross-reacts 0.062% with Human Eotaxin and recognizes Rat Eotaxin.
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs
6356 (Human); 20292 (Mouse)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Increased mitochondrial arginine metabolism supports bioenergetics in asthma
J Clin Invest, 2016;0(0):.
Species: Mouse
Sample Type: BAL

G-protein-coupled estrogen receptor agonist suppresses airway inflammation in a mouse model of asthma through IL-10.
Authors: Itoga M, Konno Y, Moritoki Y, Saito Y, Ito W, Tamaki M, Kobayashi Y, Kayaba H, Kikuchi Y, Chihara J, Takeda M, Ueki S, Hirokawa M
PLoS ONE, 2015;10(3):e0123210.
Species: Mouse
Sample Type: BALF

Genetic vaccine for respiratory syncytial virus provides protection without disease potentiation.
Authors: Johnson T, Rangel D, Graham B, Brough D, Gall J
Mol Ther, 2014;22(1):196-205.
Species: Mouse
Sample Type: Cell Culture Supernates

Spontaneous eosinophilic nasal inflammation in a genetically-mutant mouse: comparative study with an allergic inflammation model.
Authors: Cho SH, Oh SY, Zhu Z, Lee J, Lane AP
PLoS ONE, 2012;7(4):e35114.
Species: Mouse
Sample Type: nasal lavage

Dual functions of prostaglandin D2 in murine contact hypersensitivity via DP and CRTH2.
Authors: Yamamoto Y, Otani S, Hirai H, Nagata K, Aritake K, Urade Y, Narumiya S, Yokozeki H, Nakamura M, Satoh T
Am. J. Pathol., 2012;179(1):302-14.
Species: Mouse
Sample Type: Tissue Homogenates

Endogenous IL-33 enhances Th2 cytokine production and T-cell responses during allergic airway inflammation.
Authors: Louten J, Rankin AL, Li Y
Int. Immunol., 2011;23(5):307-15.
Species: Mouse
Sample Type: BALF

IL-33-activated dendritic cells are critical for allergic airway inflammation.
Authors: Besnard AG, Togbe D, Guillou N, Erard F, Quesniaux V, Ryffel B
Eur. J. Immunol., 2011;41(6):1675-86.
Species: Mouse
Sample Type: BALF

Reciprocal expression of IL-25 and IL-17A is important for allergic airways hyperreactivity.
Authors: Barlow JL, Flynn RJ, Ballantyne SJ, McKenzie AN
Clin. Exp. Allergy, 2011;41(10):1447-55.
Species: Mouse
Sample Type: BALF

Impact of adiponectin deficiency on pulmonary responses to acute ozone exposure in mice.
Authors: Zhu M, Hug C, Kasahara DI
Am. J. Respir. Cell Mol. Biol., 2010;43(4):487-97.
Species: Mouse
Sample Type: BALF

House dust mite induces direct airway inflammation in vivo: implications for future disease therapy?
Authors: De Alba J, Raemdonck K, Dekkak A, Collins M, Wong S, Nials AT, Knowles RG, Belvisi MG, Birrell MA
Eur. Respir. J., 2010;35(6):1377-87.
Species: Rat
Sample Type: BALF

The adaptor protein CIKS/Act1 is essential for IL-25-mediated allergic airway inflammation.
Authors: Claudio E, Sonder SU, Saret S, Carvalho G, Ramalingam TR, Wynn TA, Chariot A, Garcia-Perganeda A, Leonardi A, Paun A, Chen A, Ren NY, Wang H, Siebenlist U
J. Immunol., 2009;182(3):1617-30.
Species: Mouse
Sample Type: Cell Culture Supernates

TLR9 agonist, but not TLR7/8, functions as an adjuvant to diminish FI-RSV vaccine-enhanced disease, while either agonist used as therapy during primary RSV infection increases disease severity.
Authors: Johnson TR, Rao S, Seder RA, Chen M, Graham BS
Vaccine, 2009;27(23):3045-52.
Species: Mouse
Sample Type: Cell Culture Supernates

A severe deficiency of coagulation factor VIIa results in attenuation of the asthmatic response in mice.
Authors: Shinagawa K, Ploplis VA, Castellino FJ
Am. J. Physiol. Lung Cell Mol. Physiol., 2009;296(5):L763-70.
Species: Mouse
Sample Type: BALF

CD11b+ myeloid cells are the key mediators of Th2 cell homing into the airway in allergic inflammation.
Authors: Medoff BD, Seung E, Hong S, Thomas SY, Sandall BP, Duffield JS, Kuperman DA, Erle DJ, Luster AD
J. Immunol., 2009;182(1):623-35.
Species: Mouse
Sample Type: BALF

Ablation of type I hypersensitivity in experimental allergic conjunctivitis by eotaxin-1/CCR3 blockade.
Authors: Miyazaki D, Nakamura T, Ohbayashi M, Kuo CH, Komatsu N, Yakura K, Tominaga T, Inoue Y, Higashi H, Murata M, Takeda S, Fukushima A, Liu FT, Rothenberg ME, Ono SJ
Int. Immunol., 2009;21(2):187-201.
Species: Mouse
Sample Type: Cell Culture Supernates

Inhaled multiwalled carbon nanotubes potentiate airway fibrosis in murine allergic asthma.
Authors: Ryman-Rasmussen JP, Tewksbury EW, Moss OR, Cesta MF, Wong BA, Bonner JC
Am. J. Respir. Cell Mol. Biol., 2009;40(3):349-58.
Species: Mouse
Sample Type: BALF

Mouse models of asthma: a comparison between C57BL/6 and BALB/c strains regarding bronchial responsiveness, inflammation, and cytokine production.
Authors: Gueders MM, Paulissen G, Crahay C, Quesada-Calvo F, Hacha J, Van Hove C, Tournoy K, Louis R, Foidart JM, Noel A, Cataldo DD
Inflamm. Res., 2009;58(12):845-54.
Species: Mouse
Sample Type: BALF

Treatment with anti-CC chemokine receptor 3 monoclonal antibody or dexamethasone inhibits the migration and differentiation of bone marrow CD34 progenitor cells in an allergic mouse model.
Authors: Ben S, Li X, Xu F, Xu W, Li W, Wu Z, Huang H, Shi H, Shen H
Allergy, 2008;63(9):1164-76.
Species: Mouse
Sample Type: Serum

Pulmonary eosinophilia requires interleukin-5, eotaxin-1, and CD4+ T cells in mice immunized with respiratory syncytial virus G glycoprotein.
Authors: Johnson TR, Rothenberg ME, Graham BS
J. Leukoc. Biol., 2008;84(3):748-59.
Species: Mouse
Sample Type: Tissue Homogenates

Airway house dust extract exposures modify allergen-induced airway hypersensitivity responses by TLR4-dependent and independent pathways.
Authors: Lam D, Ng N, Lee S, Batzer G, Horner AA
J. Immunol., 2008;181(4):2925-32.
Species: Mouse
Sample Type: BALF

Eosinophil-nerve interactions and neuronal plasticity in rat gut associated lymphoid tissue (GALT) in response to enteric parasitism.
Authors: OBrien LM, Fitzpatrick E, Baird AW, Campion DP
J. Neuroimmunol., 2008;197(1):1-9.
Species: Rat
Sample Type: Tissue Homogenates

Distinct roles for IL-13 and IL-4 via IL-13 receptor alpha1 and the type II IL-4 receptor in asthma pathogenesis.
Authors: Munitz A, Brandt EB, Mingler M, Finkelman FD, Rothenberg ME
Proc. Natl. Acad. Sci. U.S.A., 2008;105(20):7240-5.
Species: Mouse
Sample Type: BALF

Role of the chemokine decoy receptor D6 in balancing inflammation, immune activation, and antimicrobial resistance in Mycobacterium tuberculosis infection.
Authors: Di Liberto D, Locati M, Caccamo N, Vecchi A, Meraviglia S, Salerno A, Sireci G, Nebuloni M, Caceres N, Cardona PJ, Dieli F, Mantovani A
J. Exp. Med., 2008;205(9):2075-84.
Species: Mouse
Sample Type: Serum

Tyrosine phosphatase SHP-1 in oxidative stress and development of allergic airway inflammation.
Authors: Cho YS, Oh SY, Zhu Z
Am. J. Respir. Cell Mol. Biol., 2008;39(4):412-9.
Species: Mouse
Sample Type: BALF

IL-13 receptor alpha2 selectively inhibits IL-13-induced responses in the murine lung.
Authors: Zheng T, Liu W, Oh SY, Zhu Z, Hu B, Homer RJ, Cohn L, Grusby MJ, Elias JA
J. Immunol., 2008;180(1):522-9.
Species: Mouse
Sample Type: BALF

Adenovirus IL-13-induced airway disease in mice: a corticosteroid-resistant model of severe asthma.
Authors: Therien AG, Bernier V, Weicker S, Tawa P, Falgueyret JP, Mathieu MC, Honsberger J, Pomerleau V, Robichaud A, Stocco R, Dufresne L, Houshyar H, Lafleur J, Ramachandran C, ONeill GP, Slipetz D, Tan CM
Am. J. Respir. Cell Mol. Biol., 2008;39(1):26-35.
Species: Mouse
Sample Type: BALF

An eosinophil immune response characterizes the inflammatory skin disease observed in Tie-2 transgenic mice.
Authors: Voskas D, Babichev Y, Ling LS, Alami J, Shaked Y, Kerbel RS, Ciruna B, Dumont DJ
J. Leukoc. Biol., 2008;84(1):59-67.
Species: Mouse
Sample Type: Serum

Protection against inflammation- and autoantibody-caused fetal loss by the chemokine decoy receptor D6.
Authors: Martinez de la Torre Y, Buracchi C, Borroni EM, Dupor J, Bonecchi R, Nebuloni M, Pasqualini F, Doni A, Lauri E, Agostinis C, Bulla R, Cook DN, Haribabu B, Meroni P, Rukavina D, Vago L, Tedesco F, Vecchi A, Lira SA, Locati M, Mantovani A
Proc. Natl. Acad. Sci. U.S.A., 2007;104(7):2319-24.
Species: Mouse
Sample Type: Tissue Homogenates

A critical role for Pin1 in allergic pulmonary eosinophilia in rats.
Authors: Esnault S, Rosenthal LA, Shen ZJ, Sedgwick JB, Szakaly RJ, Sorkness RL, Malter JS
J. Allergy Clin. Immunol., 2007;120(5):1082-8.
Species: Rat
Sample Type: BALF

The JAK-3 inhibitor CP-690550 is a potent anti-inflammatory agent in a murine model of pulmonary eosinophilia.
Authors: Kudlacz E, Conklyn M, Andresen C, Whitney-Pickett C, Changelian P
Eur. J. Pharmacol., 2007;582(1):154-61.
Species: Mouse
Sample Type: BALF

IL-21 administration into the nostril alleviates murine allergic rhinitis.
Authors: Hiromura Y, Kishida T, Nakano H, Hama T, Imanishi J, Hisa Y, Mazda O
J. Immunol., 2007;179(10):7157-65.
Species: Mouse
Sample Type: Serum

Critical role of the Fc receptor gamma-chain on APCs in the development of allergen-induced airway hyperresponsiveness and inflammation.
Authors: Kitamura K, Takeda K, Koya T, Miyahara N, Kodama T, Dakhama A, Takai T, Hirano A, Tanimoto M, Harada M, Gelfand EW
J. Immunol., 2007;178(1):480-8.
Species: Mouse
Sample Type: BALF

Airway epithelial STAT3 is required for allergic inflammation in a murine model of asthma.
Authors: Simeone-Penney MC, Severgnini M, Tu P, Homer RJ, Mariani TJ, Cohn L, Simon AR
J. Immunol., 2007;178(10):6191-9.
Species: Mouse
Sample Type: BALF

Liposomal retinoic acids modulate asthma manifestations in mice.
Authors: Maret M, Ruffie C, Periquet B, Campo AM, Menevret M, Phelep A, Dziewiszek K, Druilhe A, Pretolani M
J. Nutr., 2007;137(12):2730-6.
Species: Mouse
Sample Type: BALF

D-pinitol regulates Th1/Th2 balance via suppressing Th2 immune response in ovalbumin-induced asthma.
Authors: Lee JS, Lee CM, Jeong YI, Jung ID, Kim BH, Seong EY, Kim JI, Choi IW, Chung HY, Park YM
FEBS Lett., 2007;581(1):57-64.
Species: Mouse
Sample Type: BALF

Src homology 2 domain-containing inositol 5-phosphatase 1 deficiency leads to a spontaneous allergic inflammation in the murine lung.
Authors: Oh SY, Zheng T, Bailey ML, Barber DL, Schroeder JT, Kim YK, Zhu Z
J. Allergy Clin. Immunol., 2007;119(1):123-31.
Species: Mouse
Sample Type: BALF

Persistent effects induced by IL-13 in the lung.
Authors: Fulkerson PC, Fischetti CA, Hassman LM, Nikolaidis NM, Rothenberg ME
Am. J. Respir. Cell Mol. Biol., 2006;35(3):337-46.
Species: Mouse
Sample Type: BALF

Intranasal mite allergen induces allergic asthma-like responses in NC/Nga mice.
Authors: Shibamori M, Ogino K, Kambayashi Y, Ishiyama H
Life Sci., 2005;78(9):987-94.
Species: Mouse
Sample Type: BALF

Formulation with CpG oligodeoxynucleotides prevents induction of pulmonary immunopathology following priming with formalin-inactivated or commercial killed bovine respiratory syncytial virus vaccine.
Authors: Oumouna M, Mapletoft JW, Karvonen BC, Babiuk LA
J. Virol., 2005;79(4):2024-32.
Species: Mouse
Sample Type: BALF

Vbeta14(+) T cells mediate the vaccine-enhanced disease induced by immunization with respiratory syncytial virus (RSV) G glycoprotein but not with formalin-inactivated RSV.
Authors: Johnson TR, Varga SM, Braciale TJ, Graham BS
J. Virol., 2004;78(16):8753-60.
Species: Mouse
Sample Type: Tissue Homogenates

Kinetics of change in the eotaxin concentration in serum and cerebrospinal fluid of mice infected with Angiostrongylus cantonensis.
Authors: Chang EE, Chung LY, Yen CM
Parasitol. Res., 2003;92(2):137-41.
Species: Mouse
Sample Type: CSF

The effects of intranasal budesonide on allergen-induced production of interleukin-5 and eotaxin, airways, blood, and bone marrow eosinophilia, and eosinophil progenitor expansion in sensitized mice.
Authors: O'Byrne PM
Am. J. Respir. Crit. Care Med., 2002;166(2):146-53.
Species: Mouse
Sample Type: Bone Marrow Fluid

Rapid up-regulation of CXC chemokines in the airways after Ag-specific CD4+ T cell activation.
Authors: Knott PG, Gater PR, Dunford PJ, Fuentes ME, Bertrand CP
J. Immunol., 2001;166(2):1233-40.
Species: Mouse
Sample Type: Tissue Homogenates

Regulatory effects of eotaxin on acute lung inflammatory injury.
Authors: Guo RF, Lentsch AB, Warner RL, Huber-Lang M, Sarma JV, Hlaing T, Shi MM, Lukacs NW, Ward PA
J. Immunol., 2001;166(8):5208-18.
Species: Mouse
Sample Type: BALF

The protein tyrosine kinase inhibitor AG126 prevents the massive microglial cytokine induction by pneumococcal cell walls.
Authors: Hanisch UK, Prinz M, Angstwurm K, Hausler KG, Kann O, Kettenmann H, Weber JR
Eur. J. Immunol., 2001;31(7):2104-15.
Species: Mouse
Sample Type: Cell Culture Supernates

生物活性< 0.5% cross-reactivity observed with available related molecules.Cross-species reactivity observed with 1 or more species tested.
背景CCL11/Eotaxin is a chemokine that interacts with CCR3 to induce eosinophil, basophil, dendritic cell, and Th2 cell chemoattraction during inflammatory and allergic reactions. Its production is upregulated in airway epithelium, alveolar macrophages, eosinophils, smooth muscle cells, chondrocytes, and fibroblasts following allergen or inflammatory challenge. CCL11 is also involved in the growth of myeloid cell progenitors and the differentiation of mast cells.
运输条件Blue Ice
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参考文献
  • Adult Neurogenesis
  • Airway Inflammation and Remodeling
  • CC Chemokines and Receptors
  • Chemokines and Receptors
  • Chemokines and Receptors in Allergy and Asthma
  • Chemokines and Receptors in Angiogenesis
  • Eosinophils
  • Eotaxin Stimulates Eosinophil Release of Preformed IL-4
  • ICC / IHC Images: CCL11/Eotaxin
  • Macrophage Activation Markers
  • Mini-review: Eotaxin