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Mouse IL-2 Quantikine ELISA Kit, 2 Plate (1 KT)

货号: M2000 基本售价: 8913.1 元 规格: 1 KIT

产品信息

概述
货号M2000
描述The Quantikine Mouse IL-2 Immunoassay is a 4.5 hour solid phase ELISA designed to measure mouse IL-2 levels in cell culture supernates and serum. It contains E. coli-expressed recombinant mouse IL-2 and antibodies raised against the recombinant factor. This immunoassay has been shown to quantitate the recombinant mouse IL-2 accurately. Results obtained using natural mouse IL-2 showed dose curves that were parallel to the standard curves obtained using the recombinant Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural mouse IL-2.
别名aldesleukin; IL-2lymphokine; interleukin 2; interleukin-2; involved in regulation of T-cell clonal expansion; T cell growth factor; T-cell growth factor; TCGF;
全称
Interleukin 2
反应种属Mouse
目标/特异性Natural and recombinant mouse IL-2
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs
3558 (Human); 16183 (Mouse); 116562 (Rat); 396868 (Porcine); 280822 (Bovine); 403989 (Canine); 100034204 (Equine); 751114 (Feline); 100302458 (Rabbit)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Use of Recombinant Virus Replicon Particles for Vaccination against Mycobacterium ulcerans Disease.
Authors: Bolz M, Kerber S, Zimmer G, Pluschke G
PLoS Negl Trop Dis, 2015;9(8):e0004011.
Species: Mouse
Sample Type: Cell Culture Supernates

IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance.
Authors: Basu R, Whitley S, Bhaumik S, Zindl C, Schoeb T, Benveniste E, Pear W, Hatton R, Weaver C
Nat Immunol, 2015;16(3):286-95.
Species: Mouse
Sample Type: Cell Culture Supernates

MDSC and TGFbeta Are Required for Facilitation of Tumor Growth in the Lungs of Mice Exposed to Carbon Nanotubes.
Authors: Shvedova A, Kisin E, Yanamala N, Tkach A, Gutkin D, Star A, Shurin G, Kagan V, Shurin M
Cancer Res, 2015;75(8):1615-23.
Species: Mouse
Sample Type: Cell Culture Supernates

Activated protein C inhibits pancreatic islet inflammation, stimulates T regulatory cells, and prevents diabetes in non-obese diabetic (NOD) mice.
Authors: Xue M, Dervish S, Harrison LC, Fulcher G, Jackson CJ
J. Biol. Chem., 2012;287(20):16356-64.
Species: Mouse
Sample Type: Cell Culture Supernates

The Role of IL-15 in Activating STAT5 and Fine-Tuning IL-17A Production in CD4 T Lymphocytes.
Authors: Pandiyan P, Yang X, Saravanamuthu S, Zheng L, Ishihara S
J. Immunol., 2012;189(9):4237-46.
Species: Mouse
Sample Type: Cell Culture Supernates

Control of mouse graft-versus-host disease following allogeneic bone marrow transplantation by blocking the CD28/B7 signaling pathway with lentiviral vector-mediated RNA interference.
Authors: Sang W, Zhou C, Cheng N, Li Z, Zeng L, Xu K
Immunol. Lett., 2011;136(2):194-202.
Species: Mouse
Sample Type: Plasma

Origination of new immunological functions in the costimulatory molecule B7-H3: the role of exon duplication in evolution of the immune system.
Authors: Sun J, Fu F, Gu W, Yan R, Zhang G, Shen Z, Zhou Y, Wang H, Shen B, Zhang X
PLoS ONE, 2011;6(9):e24751.
Species: Mouse
Sample Type: Cell Culture Supernates

The adjuvancy of OX40 ligand (CD252) on an HIV-1 canarypox vaccine.
Authors: Liu J, Ngai N, Stone GW, Yue FY, Ostrowski MA
Vaccine, 2009;27(37):5077-84.
Species: Mouse
Sample Type: Cell Culture Supernates

Antigen-loaded ER microsomes from APC induce potent immune responses against viral infection.
Authors: Sofra V, Mansour S, Liu M, Gao B, Primpidou E, Wang P, Li S
Eur. J. Immunol., 2009;39(1):85-95.
Species: Mouse
Sample Type: Cell Culture Supernates

Dietary curcumin and limonin suppress CD4+ T-cell proliferation and interleukin-2 production in mice.
Authors: Kim W, Fan YY, Smith R, Patil B, Jayaprakasha GK, McMurray DN, Chapkin RS
J. Nutr., 2009;139(5):1042-8.
Species: Mouse
Sample Type: Cell Culture Supernates

The LTK63 adjuvant improves protection conferred by Ag85B DNA-protein prime-boosting vaccination against Mycobacterium tuberculosis infection by dampening IFN-gamma response.
Authors: Palma C, Iona E, Giannoni F, Pardini M, Brunori L, Fattorini L, Del Giudice G, Cassone A
Vaccine, 2008;26(33):4237-43.
Species: Mouse
Sample Type: Cell Culture Supernates

Dendritic cells derived from TBP-2-deficient mice are defective in inducing T cell responses.
Authors: Son A, Nakamura H, Okuyama H, Oka S, Yoshihara E, Liu W, Matsuo Y, Kondo N, Masutani H, Ishii Y, Iyoda T, Inaba K, Yodoi J
Eur. J. Immunol., 2008;38(5):1358-67.
Species: Mouse
Sample Type: Cell Culture Supernates

Lipopolysaccharide-activated IL-10-secreting dendritic cells suppress experimental autoimmune uveoretinitis by MHCII-dependent activation of CD62L-expressing regulatory T cells.
Authors: Lau AW, Biester S, Cornall RJ, Forrester JV
J. Immunol., 2008;180(6):3889-99.
Species: Mouse
Sample Type: Cell Culture Supernates

Thymic stromal lymphopoietin and thymic stromal lymphopoietin-conditioned dendritic cells induce regulatory T-cell differentiation and protection of NOD mice against diabetes.
Authors: Besin G, Gaudreau S, Menard M, Guindi C, Dupuis G, Amrani A
Diabetes, 2008;57(8):2107-17.
Species: Mouse
Sample Type: Cell Culture Supernates

The endothelial cell-produced antiangiogenic cytokine vascular endothelial growth inhibitor induces dendritic cell maturation.
Authors: Tian F, Grimaldo S, Fujita M, Fugita M, Cutts J, Vujanovic NL, Li LY
J. Immunol., 2007;179(6):3742-51.
Species: Mouse
Sample Type: Cell Culture Supernates

Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.
Authors: Yamanouchi J, Rainbow D, Serra P, Howlett S, Hunter K, Garner VE, Gonzalez-Munoz A, Clark J, Veijola R, Cubbon R, Chen SL, Rosa R, Cumiskey AM, Serreze DV, Gregory S, Rogers J, Lyons PA, Healy B, Smink LJ, Todd JA, Peterson LB, Wicker LS, Santamaria P
Nat. Genet., 2007;39(3):329-37.
Species: Mouse
Sample Type: Cell Culture Supernates

Granulocyte-macrophage colony-stimulating factor prevents diabetes development in NOD mice by inducing tolerogenic dendritic cells that sustain the suppressive function of CD4+CD25+ regulatory T cells.
Authors: Gaudreau S, Guindi C, Menard M, Besin G, Dupuis G, Amrani A
J. Immunol., 2007;179(6):3638-47.
Species: Mouse
Sample Type: Cell Culture Supernates

Suppression of established experimental autoimmune uveitis by anti-LFA-1alpha Ab.
Authors: Ke Y, Sun D, Zhang P, Jiang G, Kaplan HJ, Shao H
Invest. Ophthalmol. Vis. Sci., 2007;48(6):2667-75.
Species: Mouse
Sample Type: Cell Culture Supernates

Intercellular adhesion molecule-1 expression is required on multiple cell types for the development of experimental autoimmune encephalomyelitis.
Authors: Bullard DC, Hu X, Schoeb TR, Collins RG, Beaudet AL, Barnum SR
J. Immunol., 2007;178(2):851-7.
Species: Mouse
Sample Type: Cell Culture Supernates

PKCtheta and PKA are antagonistic partners in the NF-AT transactivation pathway of primary mouse CD3+ T lymphocytes.
Authors: Hermann-Kleiter N, Thuille N, Pfeifhofer C, Gruber T, Schafer M, Zitt C, Hatzelmann A, Schudt C, Leitges M, Baier G
Blood, 2006;107(12):4841-8.
Species: Mouse
Sample Type: Cell Culture Supernates

Blockade of transforming growth factor-{beta} signaling in tumor-reactive CD8(+) T cells activates the antitumor immune response cycle.
Authors: Zhang Q, Yang XJ, Kundu SD, Pins M, Javonovic B, Meyer R, Kim SJ, Greenberg NM, Kuzel T, Meagher R, Guo Y, Lee C
Mol. Cancer Ther., 2006;5(7):1733-43.
Species: Mouse
Sample Type: Serum

Tetrathiomolybdate is effective in a mouse model of arthritis.
Authors: McCubbin MD, Hou G, Abrams GD, Dick R, Brewer GJ
J. Rheumatol., 2006;33(12):2501-6.
Species: Mouse
Sample Type: Serum

Immunosuppressant triptolide inhibits dendritic cell-mediated chemoattraction of neutrophils and T cells through inhibiting Stat3 phosphorylation and NF-kappaB activation.
Authors: Liu Q, Chen T, Chen G, Li N, Wang J, Ma P, Cao X
Biochem. Biophys. Res. Commun., 2006;345(3):1122-30.
Species: Mouse
Sample Type: Cell Culture Supernates

Dopamine, through the extracellular signal-regulated kinase pathway, downregulates CD4+CD25+ regulatory T-cell activity: implications for neurodegeneration.
Authors: Kipnis J, Cardon M, Avidan H, Lewitus GM, Mordechay S, Rolls A, Shani Y, Schwartz M
J. Neurosci., 2004;24(27):6133-43.
Species: Mouse
Sample Type: Cell Culture Supernates

Increased interleukin-10 associated with low IL-6 concentration correlated with greater survival rates in mice infected by rabies virus vaccinated against it and immunomodulated with P. acnes.
Authors: Megid J, Kaneno R, Nozaki CN, Brito CJ, Almeida MF
Comp. Immunol. Microbiol. Infect. Dis., 2004;27(6):393-411.
Species: Mouse
Sample Type: Serum

EphrinB1 is essential in T-cell-T-cell co-operation during T-cell activation.
Authors: Yu G, Luo H, Wu Y, Wu J
J. Biol. Chem., 2004;279(53):55531-9.
Species: Mouse
Sample Type: Cell Culture Supernates

Anti-tumor mechanism of Z-100, an immunomodulatory Arabinomannan extracted from Mycobacterium tuberculosis strain Aoyama B, on pulmonary metastases of B16F10 melanoma: restoration of helper T cell responses via suppression of glucocorticoid-genesis.
Authors: Oka H, Emori Y, Sasaki H, Shiraishi Y, Yoshinaga K, Kurimoto T
Microbiol. Immunol., 2002;46(5):343-51.

The protein tyrosine kinase inhibitor AG126 prevents the massive microglial cytokine induction by pneumococcal cell walls.
Authors: Hanisch UK, Prinz M, Angstwurm K, Hausler KG, Kann O, Kettenmann H, Weber JR
Eur. J. Immunol., 2001;31(7):2104-15.
Species: Mouse
Sample Type: Cell Culture Supernates

生物活性< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景IL-2 (Interleukin 2) is a critical cytokine in T cell biology. It promotes T cell activation and expansion, the development, maintenance and function of regulatory T cells (Treg), and the differentiation of CD8+ T cells into terminal effector cells and memory cells. IL-2 signals through a receptor complex composed of CD25/IL-2 R alpha, IL-2 R beta, and the Common gamma Chain (gamma c). IL-2 R beta is also a component of the IL-15 receptor complex. Gamma c is also a signaling subunit in the receptors for IL-4, -7, -9, -15, and -21.
运输条件Blue Ice
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参考文献
  • BIObrief: Common gamma-Chain Family Cytokines Play a Pivotal Role in Regulating Immune System Functions
  • Cancer Biomarkers
  • Common gamma Chain Receptor Family
  • Common gamma-Chain Family Cytokines Play a Pivotal Role in Regulating Immune System Functions
  • Conventional/Classical Dendritic Cells
  • Cytokines and Receptors in Allergy and Asthma
  • Cytokines and Receptors in Tfh Cell Differentiation and Function
  • gamma delta T Cells
  • Group 1 ILCs
  • ICC / IHC Images: IL-2
  • Infectious Diseases
  • Inflammatory Mediators
  • Interactive Pathway: IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types
  • Interactive Pathway: IL-2 Signaling Pathways
  • Isolation, Culture, and Identification of Natural Killer Cells
  • Mini-review: Cytolytic Granule-mediated Apoptosis
  • Multiple Sclerosis and Myelin Related Molecules
  • NCR+ILC3
  • Neuroinflammation
  • Preeclampsia
  • Regulatory T Cells (Tregs)
  • T Cell Cytokine Signaling
  • Th1 Cells
  • Th2 Cells
  • Th9 Cells