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Human IL-7 Quantikine HS ELISA Kit (1 KT)

货号: HS750 基本售价: 8496.7 元 规格: 1 Kit

产品信息

概述
货号HS750
描述The Quantikine HS Human IL-7 Immunoassay is a solid phase ELISA that specifically measures IL-7 in 18-24 hours (with an overnight incubation step). This kit is designed to measure IL-7 levels in cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant human IL-7 and antibodies raised against the recombinant factor. It has been shown to quantitate the recombinant factor accurately. Results obtained using natural IL-7 showed linear curves that were parallel to the standard curves obtained using the kit standards. These results indicate that this kit can be used to determine relative mass values for natural human IL-7.
别名IL-7interleukin-7; interleukin 7; Lymphopoietin-1; PBGF;
全称
Interleukin 7
反应种属Human
目标/特异性Natural and recombinant human IL-7
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs
3574 (Human); 16196 (Mouse); 25647 (Rat)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

T cell reconstitution in allogeneic haematopoietic stem cell transplantation: prognostic significance of plasma interleukin-7.
Authors: Kielsen K, Jordan K, Uhlving H, Pontoppidan P, Shamim Z, Ifversen M, Heilmann C, Nielsen C, Sengelov H, Ryder L, Muller K
Scand J Immunol, 2015;81(1):72-80.
Species: Human
Sample Type: Plasma

Immune Recovery after Allogeneic Hematopoietic Stem Cell Transplantation Following Flu-TBI versus TLI-ATG Conditioning.
Authors: Hannon M, Beguin Y, Ehx G, Servais S, Seidel L, Graux C, Maertens J, Kerre T, Daulne C, De Bock M, Fillet M, Ory A, Willems E, Gothot A, Humblet-Baron S, Baron F
Clin Cancer Res, 2015;21(14):3131-9.
Species: Human
Sample Type: Plasma

Effect of IL-7 Therapy on Naive and Memory T Cell Homeostasis in Aged Rhesus Macaques.
Authors: Okoye A, Rohankhedkar M, Konfe A, Abana C, Reyes M, Clock J, Duell D, Sylwester A, Sammader P, Legasse A, Park B, Axthelm M, Nikolich-Zugich J, Picker L
J Immunol, 2015;195(9):4292-305.
Species: Primate - Macaca mulatta
Sample Type: Plasma

IFN-alpha exerts opposing effects on activation-induced and IL-7-induced proliferation of T cells that may impair homeostatic maintenance of CD4+ T cell numbers in treated HIV infection.
Authors: Cha L, de Jong E, French M, Fernandez S
J Immunol, 2014;193(5):2178-86.
Species: Human
Sample Type: cell culture supernate

Co-culture of human bronchial fibroblasts and CD4+ T cells increases Th17 cytokine signature.
Authors: Loubaki L, Hadj-Salem I, Fakhfakh R, Jacques E, Plante S, Boisvert M, Aoudjit F, Chakir J
PLoS ONE, 2013;8(12):e81983.
Species: Human
Sample Type: Cell Culture Supernates

Decreased systemic IL-7 and soluble IL-7Ralpha in multiple sclerosis patients.
Genes Immun, 2012;13(7):587-92.
Species: Human
Sample Type: Plasma

Treatment with IL-7 prevents the decline of circulating CD4+ T cells during the acute phase of SIV infection in rhesus macaques.
Authors: Vassena L, Miao H, Cimbro R, Malnati MS, Cassina G, Proschan MA, Hirsch VM, Lafont BA, Morre M, Fauci AS, Lusso P
PLoS Pathog., 2012;8(4):e1002636.
Species: Primate - Macaca mulatta (Rhesus monkey)
Sample Type: Plasma

Altered T cell memory and effector cell development in chronic lymphatic filarial infection that is independent of persistent parasite antigen.
Authors: Steel C, Nutman TB
PLoS ONE, 2011;6(4):e19197.
Species: Human
Sample Type: Serum

Dual mechanism of impairment of interleukin-7 (IL-7) responses in human immunodeficiency virus infection: decreased IL-7 binding and abnormal activation of the JAK/STAT5 pathway.
Authors: Juffroy O, Bugault F, Lambotte O, Landires I, Viard JP, Niel L, Fontanet A, Delfraissy JF, Theze J, Chakrabarti LA
J. Virol., 2010;84(1):96-108.
Species: Human
Sample Type: Plasma

Peripheral blood B cell subset skewing is associated with altered cell cycling and intrinsic resistance to apoptosis and reflects a state of immune activation in chronic hepatitis C virus infection.
Authors: Sugalski JM, Rodriguez B, Moir S
J. Immunol., 2010;185(5):3019-27.
Species: Human
Sample Type: Serum

Plasma levels of IL-7 and IL-15 after reduced intensity conditioned allo-SCT and relationship to acute GVHD.
Authors: Thiant S, Labalette M, Trauet J, Coiteux V, de Berranger E, Dessaint JP, Yakoub-Agha I
Bone Marrow Transplant., 2010;46(10):1374-81.
Species: Human
Sample Type: Plasma

Elevated frequencies of highly activated CD4+ T cells in HIV+ patients developing immune reconstitution inflammatory syndrome.
Authors: Antonelli LR, Mahnke Y, Hodge JN, Porter BO, Barber DL, DerSimonian R, Greenwald JH, Roby G, Mican J, Sher A, Roederer M, Sereti I
Blood, 2010;116(19):3818-27.
Species: Human
Sample Type: Serum

Lack of anti-tumour reactivity despite enhanced numbers of circulating natural killer T cells in two patients with metastatic renal cell carcinoma.
Authors: Vyth-Dreese FA, Sein J, van de Kasteele W, Dellemijn TA, van den Bogaard C, Nooijen WJ, de Gast GC, Haanen JB, Bex A
Clin. Exp. Immunol., 2010;162(3):447-59.
Species: Human
Sample Type: Plasma

Plasma levels of IL-7 and IL-15 in the first month after myeloablative BMT are predictive biomarkers of both acute GVHD and relapse.
Authors: Thiant S, Yakoub-Agha I, Magro L, Trauet J, Coiteux V, Jouet JP, Dessaint JP, Labalette M
Bone Marrow Transplant., 2010;45(10):1546-52.
Species: Human
Sample Type: Plasma

Identification and biochemical characterization of human plasma soluble IL-7R: lower concentrations in HIV-1-infected patients.
Authors: Rose T, Lambotte O, Pallier C, Delfraissy JF, Colle JH
J. Immunol., 2009;182(12):7389-97.
Species: Human
Sample Type: Plasma

Functional coexpression of Interleukin (IL)-7 and its receptor (IL-7R) on Hodgkin and Reed-Sternberg cells: Involvement of IL-7 in tumor cell growth and microenvironmental interactions of Hodgkin's lymphoma.
Authors: Cattaruzza L, Gloghini A, Olivo K, Di Francia R, Lorenzon D, De Filippi R, Carbone A, Colombatti A, Pinto A, Aldinucci D
Int. J. Cancer, 2009;125(5):1092-101.
Species: Human
Sample Type: Cell Culture Supernates

Enhancing the in vivo expansion of adoptively transferred EBV-specific CTL with lymphodepleting CD45 monoclonal antibodies in NPC patients.
Authors: Louis CU, Straathof K, Bollard CM, Gerken C, Huls MH, Gresik MV, Wu MF, Weiss HL, Gee AP, Brenner MK, Rooney CM, Heslop HE, Gottschalk S
Blood, 2009;113(11):2442-50.
Species: Human
Sample Type: Plasma

Longitudinal analysis of immune function in the first 3 years of life in thymectomized neonates during cardiac surgery.
Authors: Mancebo E, Clemente J, Sanchez J, Ruiz-Contreras J, De Pablos P, Cortezon S, Romo E, Paz-Artal E, Allende LM
Clin. Exp. Immunol., 2008;154(3):375-83.
Species: Human
Sample Type: Plasma

Identification of interleukin-7 as a candidate disease mediator in spondylarthritis.
Authors: Rihl M, Kellner H, Kellner W, Barthel C, Yu DT, Tak PP, Zeidler H, Baeten D
Arthritis Rheum., 2008;58(11):3430-5.
Species: Human
Sample Type: Synovial Fluid

Lymphocytes and synovial fluid fibroblasts support osteoclastogenesis through RANKL, TNFalpha, and IL-7 in an in vitro model derived from human psoriatic arthritis.
Authors: Colucci S, Brunetti G, Cantatore FP, Oranger A, Mori G, Quarta L, Cirulli N, Mancini L, Corrado A, Grassi FR, Grano M
J. Pathol., 2007;212(1):47-55.
Species: Human
Sample Type: Serum

Potential role for IL-7 in Fas-mediated T cell apoptosis during HIV infection.
Authors: Fluur C, De Milito A, Fry TJ, Vivar N, Eidsmo L, Atlas A, Federici C, Matarrese P, Logozzi M, Rajnavolgyi E, Mackall CL, Fais S, Chiodi F, Rethi B
J. Immunol., 2007;178(8):5340-50.
Species: Human
Sample Type: Serum

Sleep enhances serum interleukin-7 concentrations in humans.
Authors: Benedict C, Dimitrov S, Marshall L, Born J
Brain Behav. Immun., 2007;21(8):1058-62.
Species: Human
Sample Type: Serum

IL-7Ralpha expression on CD4+ T lymphocytes decreases with HIV disease progression and inversely correlates with immune activation.
Authors: Koesters SA, Alimonti JB, Wachihi C, Matu L, Anzala O, Kimani J, Embree JE, Plummer FA, Fowke KR
Eur. J. Immunol., 2006;36(2):336-44.
Species: Human
Sample Type: Plasma

Murine and human IL-7 activate STAT5 and induce proliferation of normal human pro-B cells.
Authors: Johnson SE, Shah N, Panoskaltsis-Mortari A, Lebien TW
J. Immunol., 2005;175(11):7325-31.
Species: Human
Sample Type: Cell Culture Supernates

Elevated interleukin-7 levels not sufficient to maintain T-cell homeostasis during simian immunodeficiency virus-induced disease progression.
Authors: Muthukumar A, Wozniakowski A, Gauduin MC, Paiardini M, McClure HM, Johnson RP, Silvestri G, Sodora DL
Blood, 2004;103(3):973-9.
Species: Primate - Cebus capucinus (Capuchin monkey)
Sample Type: Plasma

Interleukin-7 improves CD4 T-cell reconstitution after autologous CD34 cell transplantation in monkeys.
Authors: Storek J, Gillespy T, Lu H, Joseph A, Dawson MA, Gough M, Morris J, Hackman RC, Horn PA, Sale GE, Andrews RG, Maloney DG, Kiem HP
Blood, 2003;101(10):4209-18.
Species: Primate – Papio cynocephalus (Baboon)
Sample Type: Serum

生物活性< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景IL-7 (Interleukin-7) is a cytokine that plays important roles in lymphocyte differentiation, proliferation, and survival. IL-7 is produced by stromal epithelial cells of the thymus, bone marrow, and intestines. It signals through a receptor complex composed of IL-7 R alpha/CD127 and the Common gamma Chain. gamma c is also a subunit of the receptors for IL-2, -4, -9, -15, and -21. IL-7 contributes to the maintenance of all naïve and memory T cells. It is required for optimal T cell-dendritic cell interaction. In mouse, IL-7 activation of IL-7 R alpha is critical for both T cell and B cell lineage development, while in humans, it is required for T cell but not for B cell development.
运输条件Blue Ice
存放说明4℃
参考文献
  • Acute Lymphoblastic Leukemia
  • BIObrief: Common gamma-Chain Family Cytokines Play a Pivotal Role in Regulating Immune System Functions
  • Common gamma Chain Receptor Family
  • Common gamma-Chain Family Cytokines Play a Pivotal Role in Regulating Immune System Functions
  • Interactive Pathway: IL-7 Signaling Pathways
  • Interleukin-7 Inhibits Lymphocyte Apoptosis & Immunosuppression to Improve Survival in a Mouse Model of Sepsis
  • Isolation, Culture, and Identification of Natural Killer Cells
  • Multiple Myeloma
  • Natural Killer T (NKT) Cells
  • NCR-ILC3
  • Platelets
  • Th2 Cells