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Human IL-4 Quantikine HS ELISA Kit (1 KT)

货号: HS400 基本售价: 8496.7 元 规格: 1 Kit

产品信息

概述
货号HS400
描述The Quantikine HS Human IL-4 Immunoassay is a 6.5 hour solid phase ELISA designed to measure IL-4 levels in cell culture supernates and serum. It contains E. coli-expressed recombinant human IL-4 and antibodies raised against the recombinant factor. This immunoassay has been shown to quantitate the recombinant human IL-4 accurately. Results obtained using natural human IL-4 showed linear curves that were parallel to the standard curves obtained using the Quantikine HS kit standards. These results indicate that this kit can be used to determine relative mass values for natural human IL-4.
别名B cell growth factor 1; BCDF; B-cell stimulatory factor 1; BCGF1; BCGF-1; binetrakin; BSF1; BSF-1; IL-4B_cell stimulatory factor 1; interleukin 4; interleukin-4; Lymphocyte stimulatory factor 1; MGC79402; pitrakinra;
全称
Interleukin 4
反应种属Human
目标/特异性Natural and recombinant human IL-4
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs
3565 (Human); 16189 (Mouse); 287287 (Rat); 397225 (Porcine); 280824 (Bovine); 403785 (Canine); 574281 (Primate); 100302454 (Rabbit)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Effects of interval and continuous exercise training on CD4 lymphocyte apoptotic and autophagic responses to hypoxic stress in sedentary men.
Authors: Weng T, Huang S, Chuang Y, Wang J
PLoS ONE, 2013;8(11):e80248.
Species: Human
Sample Type: Plasma

Subnormal cytokine profile in the tear fluid of keratoconus patients.
Authors: Jun AS, Cope L, Speck C, Feng X, Lee S, Meng H, Hamad A, Chakravarti S
PLoS ONE, 2011;6(1):e16437.
Species: Human
Sample Type: Tears

Leptin enhances survival and induces migration, degranulation, and cytokine synthesis of human basophils.
Authors: Suzukawa M, Nagase H, Ogahara I, Han K, Tashimo H, Shibui A, Koketsu R, Nakae S, Yamaguchi M, Ohta K
J. Immunol., 2011;186(9):5254-60.
Species: Human
Sample Type: Cell Culture Supernates

Sensitive plasma protein analysis by microparticle-based proximity ligation assays.
Authors: Darmanis S, Nong RY, Hammond M, Gu J, Alderborn A, Vanelid J, Siegbahn A, Gustafsdottir S, Ericsson O, Landegren U, Kamali-Moghaddam M
Mol. Cell Proteomics, 2010;9(2):327-35.
Species: Human
Sample Type: Plasma

Urinary proinflammatory cytokine response in renal transplant recipients with polyomavirus BK viruria.
Authors: Sadeghi M, Daniel V, Schnitzler P, Lahdou I, Naujokat C, Zeier M, Opelz G
Transplantation, 2009;88(9):1109-16.
Species: Human
Sample Type: Urine

Detection of pancreatic cancer using antibody microarray-based serum protein profiling.
Authors: Ingvarsson J, Wingren C, Carlsson A, Ellmark P, Wahren B, Engstrom G, Harmenberg U, Krogh M, Peterson C, Borrebaeck CA
Proteomics, 2008;8(11):2211-9.
Species: Human
Sample Type: Serum

Dysregulated monocyte iron homeostasis and erythropoietin formation in patients with anemia of chronic disease.
Authors: Theurl I, Mattle V, Seifert M, Mariani M, Marth C, Weiss G
Blood, 2006;107(10):4142-8.
Species: Human
Sample Type: Serum

Expression of interleukin-18 and caspase-1 in cutaneous T-cell lymphoma.
Authors: Yamanaka K, Clark R, Dowgiert R, Hurwitz D, Shibata M, Rich BE, Hirahara K, Jones DA, Eapen S, Mizutani H, Kupper TS
Clin. Cancer Res., 2006;12(2):376-82.
Species: Human
Sample Type: Plasma

Anti-inflammatory cytokines in gingival crevicular fluid in patients with periodontitis and rheumatoid arthritis: a preliminary report.
Authors: Bozkurt FY, Yetkin Ay Z, Berker E, Tepe E, Akkus S
Cytokine, 2006;35(3):180-5.
Species: Human
Sample Type: Gingival Crevicular Fluid (GCF)

Strong inflammatory cytokine response in male and strong anti-inflammatory response in female kidney transplant recipients with urinary tract infection.
Authors: Sadeghi M, Daniel V, Naujokat C, Wiesel M, Hergesell O, Opelz G
Transpl. Int., 2005;18(2):177-85.
Species: Human
Sample Type: Plasma

Cytokines and adhesion molecules in multiple sclerosis patients treated with interferon-beta1b.
Authors: Jensen J, Krakauer M, Sellebjerg F
Cytokine, 2005;29(1):24-30.
Species: Human
Sample Type: Plasma

Correlations between IL-4, IL-12 levels and CCL2, CCL5 levels in serum and cerebrospinal fluid of multiple sclerosis patients.
Authors: Bartosik-Psujek H, Stelmasiak Z
J Neural Transm, 2005;112(6):797-803.
Species: Human
Sample Type: Serum

Th2 predominance and CD8+ memory T cell depletion in patients with severe acute respiratory syndrome.
Authors: Huang JL, Huang J, Duan ZH, Wei J, Min J, Luo XH, Li JG, Tan WP, Wu LZ, Liu RY, Li Y, Shao J, Huang BJ, Zeng YX, Huang W
Microbes Infect., 2005;7(3):427-36.
Species: Human
Sample Type: Serum

Antifungal immune reactivity in nasal polyposis.
Authors: Pitzurra L, Bellocchio S, Nocentini A, Bonifazi P, Scardazza R, Gallucci L, Stracci F, Simoncelli C, Bistoni F, Romani L
Infect. Immun., 2004;72(12):7275-81.
Species: Human
Sample Type: nasal lavage

Immunodetection of a hepatitis C virus (HCV) antigen and Thl/Th2 cytokines in cerebrospinal fluid of meningitis patients.
Authors: Attallah AM, Ibrahim GG
J Immunoassay Immunochem, 2004;25(4):313-20.
Species: Human
Sample Type: Serum

Exhaled breath condensate in children: pearls and pitfalls.
Authors: Rosias PP, Dompeling E, Hendriks HJ, Heijnens JW, Donckerwolcke RA, Jobsis Q
Pediatr Allergy Immunol, 2004;15(1):4-19.
Species: Human
Sample Type: Exhaled Breath Condensate (EBC)

A double-blind, placebo-controlled immunotherapy dose-response study with standardized cat extract.
Authors: Ewbank PA, Murray J, Sanders K, Curran-Everett D, Dreskin S, Nelson HS
J. Allergy Clin. Immunol., 2003;111(1):155-61.
Species: Human
Sample Type: Nasal Fluid

Cytokine profile in Behcet's disease patients. Relationship with disease activity.
Authors: Hamzaoui K, Hamzaoui A, Guemira F, Bessioud M, Hamza M, Ayed K
Scand. J. Rheumatol., 2002;31(4):205-10.
Species: Human
Sample Type: Serum

Modulation of human immune response by Echinococcus granulosus antigen B and its possible role in evading host defenses.
Authors: Rigano R, Profumo E, Bruschi F, Carulli G, Azzara A, Ioppolo S, Buttari B, Ortona E, Margutti P, Teggi A, Siracusano A
Infect. Immun., 2001;69(1):288-96.
Species: Human
Sample Type: Cell Culture Supernates

Low levels of interferon-gamma in nasal fluid accompany raised levels of T-helper 2 cytokines in children with ongoing allergic rhinitis.
Authors: Benson M, Strannegard IL, Wennergren G, Strannegard O
Pediatr Allergy Immunol, 2000;11(1):20-8.
Species: Human
Sample Type: nasal lavage

Cytokine profiles in parotid saliva from HIV-1-infected individuals: changes associated with opportunistic infections in the oral cavity.
Authors: Black, K P, Merrill, K W, Jackson, S, Katz, J
Oral Microbiol Immunol, 2000;15(2):74-81.
Species: Human
Sample Type: Saliva

生物活性< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景IL-4 (Interleukin-4) is a cytokine that is primarily expressed by Th2-biased CD4+ T cells, mast cells, basophils, and eosinophils. It promotes cell proliferation, survival, and immunoglobulin class switch to IgG4 and IgE in human B cells, acquisition of the Th2 phenotype by naïve CD4+ T cells, priming and chemotaxis of mast cells, eosinophils, and basophils, and the proliferation and activation of epithelial cells. IL-4 plays a dominant role in the development of allergic inflammation and asthma. The type I receptor for IL-4, which is expressed on hematopoietic cells, is a heterodimer of the ligand binding IL-4 R? and the common ? chain (a shared subunit of the receptors for IL-2, -7, -9, -15, and -21). The type II receptor on nonhematopoietic cells consists of IL-4 R? and IL-13 R?1. The type II receptor also transduces IL-13 mediated signals.
运输条件Blue Ice
存放说明4℃
参考文献
  • BIObrief: Common gamma-Chain Family Cytokines Play a Pivotal Role in Regulating Immune System Functions
  • Common gamma Chain Receptor Family
  • Common gamma-Chain Family Cytokines Play a Pivotal Role in Regulating Immune System Functions
  • Cytokines and Receptors in Allergy and Asthma
  • Cytokines and Receptors in Angiogenesis
  • Cytokines and Receptors in Tfh Cell Differentiation and Function
  • Dendritic Cell Development
  • Eotaxin Stimulates Eosinophil Release of Preformed IL-4
  • gamma delta T Cells
  • Group 2 ILCs
  • ICC / IHC Images: IL-4
  • Inflammatory Mediators
  • Interactive Pathway: IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types
  • Interactive Pathway: IL-4 Signaling Pathways
  • Multiple Sclerosis and Myelin Related Molecules
  • Natural Killer T (NKT) Cells
  • Regulatory T Cells (Tregs)
  • T Cell Cytokine Signaling
  • Th2 Cells
  • Th9 Cells