Human CTLA-4 ELISA Kit (Colorimetric)
货号：
NBP1-91268 基本售价：
8308.3 元 规格：
96 Tests
产品信息
概述| 货号 | NBP1-91268 |
| 反应种属 | HuSpecies Glossary |
| 应用 | ELISA |
性能| 供应商 | Novus |
| 背景 | Cytotoxic T lymphocyte associated gene -4 (CTLA-4) was initially described as a classical type I glycoprotein on the surface of activated T-cells. CTLA-4 is a member of the Ig gene superfamily and along with its homologue, CD28, is a B7 binding protein. There is evidence that CTLA-4 is a negative regulator of T-cell activation, ligation of CTLA-4 on the T-cell surface initiates a series of biochemical events that attenuate an ongoing immune response. CTLA-4 knock out mice demonstrate profound polyclonal lymphoproliferative disoders that infiltrate most major organ systems and the animals die a few weeks after birth. The animals have increased levels of IgG which illustrates the role of CTLA-4 on humoral immune responses as well. A role for CTLA-4 in autoimmune disease is suggested by the observations that blockade of B7/CTLA-4 interaction exacerbates animal models of autoimmune disease such as experimental autoimmune encephalomyelitis and diabetes.A search for genetic markers that segregate with Graves? disease revealed an association with CTLA-4 polymorphisms. CTLA-4 is further more closely linked to autoimmune thyroid disease (ATD). A native soluble form of CTLA-4 has been described to be present in human serum. A correlation of circulating CTLA-4 and ATD has been shown. |
| 存放说明 | Storage of components varies. See protocol for specific instructions. |
